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1.发明授权公开(公告)号：US06214294B1
公开(公告)日：2001-04-10
申请号：US09136517
申请日：1998-08-19
IPC分类号： B01L300
CPC分类号： B01F11/0258 , B01F2215/0037 , G01N2035/00534
摘要： A stirring device has an actuator like a plate, a cover shaped like a rectangular box and covering the actuator, a blade designed to be vibrated by the actuator, and a connecting device connecting the blade to the actuator, positioning an axis of vibration amplitude of the blade substantially in one side of the cover.
摘要翻译： 搅拌装置具有类似板的致动器，形状类似矩形盒的盖，并且覆盖致动器，设计成由致动器振动的叶片以及将叶片连接到致动器的连接装置，将振动轴的振动幅度 叶片基本上在盖的一侧。
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公开(公告)号：US5554811A
公开(公告)日：1996-09-10
申请号：US380998
申请日：1995-01-31
申请人： Kyuji Rokugawa , Kouji Matsumoto , Morito Inoue
发明人： Kyuji Rokugawa , Kouji Matsumoto , Morito Inoue
CPC分类号： G01N35/1016 , F04B43/046 , G01N2035/1025
摘要： A sampling system, favorably applicable to an automatic chemical analyzer, is provided for sampling by sucking and discharging liquid, such as specimens and reagents. The sampling system comprises a pump having a container in which an inner space of a certain volume is formed and an actuator arranged in the inner space to fore a pumping chamber therein. The actuator comprises a base plate having both sides thereon and a piezoelectric element attached to the base plate. Further provided are a tube having one end connected to the pumping cheer, a nozzle connected to another end of the tube, and an element for controlling a driving voltage applied to the piezoelectric element. For instance, the piezoelectric element is composed of two piezoelectric plates attached each to both the sides of the base plate. A piezoelectric sensor is attached to the base plate for detecting distortion of the actuator, a liquid level of specimens and reagents, and error operations such as air suction and jamming. The piezoelectric sensor is attached to a cutout portion, partly cut out in either one of two piezoelectric plates. In case of being applied to the automatic chemical analyzer, an output signal from the piezoelectric sensor is used for correction of absorbance data.
摘要翻译： 提供了一种适用于自动化学分析仪的采样系统，用于通过吸取和排出诸如标本和试剂的液体进行取样。 采样系统包括具有容器的泵，其中形成有一定体积的内部空间，以及布置在内部空间中的致动器前面的致动器的致动器。 致动器包括其两侧的基板和附接到基板的压电元件。 还提供了一个管，其一端连接到泵送加速器，连接到管的另一端的喷嘴和用于控制施加到压电元件的驱动电压的元件。 例如，压电元件由在基板的两侧各自附接的两个压电板构成。 压电传感器连接到基板上，用于检测致动器的变形，试样和试剂的液位，以及诸如空气吸入和卡住的错误操作。 压电传感器附接到切口部分，部分切出两个压电板中的任一个。 在应用于自动化学分析仪的情况下，来自压电传感器的输出信号用于校正吸光度数据。
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公开(公告)号：US5449493A
公开(公告)日：1995-09-12
申请号：US173934
申请日：1993-12-28
申请人： Kyuji Rokugawa , Morito Inoue , Soichiro Sakaguchi , Hideo Oya , Noboru Aoki , Masato Saitoh
发明人： Kyuji Rokugawa , Morito Inoue , Soichiro Sakaguchi , Hideo Oya , Noboru Aoki , Masato Saitoh
CPC分类号： B01F11/0088 , B01F2215/0037 , G01N2035/00534
摘要： Piezoelectric elements are attached to both sides of a flexible metal thin plate, thus forming a bimorph-type piezoelectric vibrator. A portion of the metal thin plate is extended to form a stirring blade. A suitable weight is attached to a part of the metal plate such that the amplitude of the blade is made greater than the amplitude of the vibrator itself. The voltage to be applied to the vibrator and the frequency are adjusted, and the vibrator is vibrated in a second-order mode. Thereby, the entire solution is moved simultaneously, vertical motion is caused, and the stirring efficiency is enhanced.
摘要翻译： 压电元件附着在柔性金属薄板的两侧，从而形成双压电晶片式压电振动器。 金属薄板的一部分被延伸以形成搅拌叶片。 合适的重量附着在金属板的一部分上，使得叶片的振幅大于振动器本身的振幅。 调整施加到振动器的电压和频率，并且振动器以二次振动。 因此，整个溶液同时移动，引起垂直运动，并且提高了搅拌效率。
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公开(公告)号：US5108934A
公开(公告)日：1992-04-28
申请号：US157772
申请日：1988-02-19
申请人： Kyuji Rokugawa , Masako Hatoh , Yoshio Ishimori
发明人： Kyuji Rokugawa , Masako Hatoh , Yoshio Ishimori
IPC分类号： G01N33/532 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54353 , G01N33/532 , G01N33/586 , Y10S436/826 , Y10S436/829
摘要： There is disclosed, in an immunoassay employing an immunoassay reagent comprising liposomes comprised of at least any one of phospholipids and glycolipids, a marker material enclosed in said liposomes, and an antibody or part of the antibody, or an antigen, immobilized on said liposomes by a cross-linking method, the improvement wherein a material for preventing nonspecific lysis of the liposomes is made present together in a reaction mixture.
摘要翻译： 公开了使用包含由磷脂和糖脂中的至少任一种构成的脂质体的免疫测定试剂的免疫测定法，封闭在所述脂质体中的标记材料，以及通过上述脂质体固定在所述脂质体上的抗体或部分抗原或抗原 交联方法，其中在反应混合物中一起存在用于防止脂质体非特异性裂解的材料的改进。
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5.发明授权
公开(公告)号：US6110338A
公开(公告)日：2000-08-29
申请号：US290546
申请日：1999-04-12
申请人： Kyuji Rokugawa
发明人： Kyuji Rokugawa
IPC分类号： G01N27/333 , G01N27/403 , G01N27/26
CPC分类号： G01N27/403 , Y10T29/49117
摘要： An ion selective electrode of flowthrough type is used for electrochemical measurement of ion species contained in a biological fluid by the electrode method. In the electrode method, the reaction of an ion and a sensing substance contained in an ion-sensing membrane is electrochemically detected.plurality of holes are made on a part of the wall of a path for letting the biological fluid flow therethrough. An ion-sensing membrane is formed in the plurality of holes such that each membrane includes a different sensitive ion from the other and the inner surface of the path is kept smooth.
摘要翻译： 流通型离子选择电极用于通过电极法电化学测量包含在生物流体中的离子物质。 在电极法中，离子感测膜中包含的离子与感测物质的反应进行电化学检测。 在用于使生物流体流过其中的路径的一部分壁上形成多个孔。 离子传感膜形成在多个孔中，使得每个膜包括彼此不同的敏感离子，并且路径的内表面保持平滑。
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6.发明授权
公开(公告)号：US4623618A
公开(公告)日：1986-11-18
申请号：US547353
申请日：1983-10-31
申请人： Kyuji Rokugawa
发明人： Kyuji Rokugawa
IPC分类号： G01N33/53 , G01N33/536 , G01N33/543 , G01N33/544 , G01N33/555 , G01N33/573 , G01N33/574 , G01N33/58 , C12Q1/68 , G01N33/54
CPC分类号： G01N33/573 , G01N33/53 , G01N33/536 , G01N33/5432 , G01N33/555 , G01N33/574 , G01N33/586 , Y10S435/973 , Y10S436/819 , Y10S436/829
摘要： An immunoassay by which a plurality of kinds of antigens or antibodies in one test sample may be simultaneously quantified. Each of a plurality of kinds of microcapsules is first provided for each kind of a plurality of antigens or antibodies to be quantified such that the microcapsules bind an antibody or antigen specific to one kind of the plurality of antigens or antibodies to be quantified. The microcapsules are formed of a membrane capable of being lysed by the complement activity, and each kind of microcapsules contains therein a substance that is quantifiable and does not interact with another quantifiable substance contained in other kinds of microcapsules. The plurality of kinds of microcapsules are mixed with a test sample and complement, and the quantifiable substances are released from the microcapsules upon lysis of the microcapsules by the complement activity. The quantifiable substances are then quantified.
摘要翻译： 可以同时量化一个测试样品中的多种抗原或抗体的免疫测定。 首先针对要定量的多种抗原或抗体提供多种微胶囊中的每一种，使得微胶囊结合要定量的一种多种抗原或抗体特异的抗体或抗原。 微胶囊由能够通过补体活性裂解的膜形成，并且每种微胶囊含有可量化的物质，并且不与其它种类的微胶囊中所含的其它可定量物质相互作用。 多种微胶囊与测试样品和补体混合，并且通过补体活性裂解微胶囊，可量化物质从微胶囊中释放出来。 然后量化量化物质。
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公开(公告)号：US4621059A
公开(公告)日：1986-11-04
申请号：US708509
申请日：1985-03-05
申请人： Kyuji Rokugawa
发明人： Kyuji Rokugawa
摘要： An enzyme is immobilized to a capillary column, and a solution which contains a chemical substance and a luminescent substance flows through the column. A plurality of optical fibers are arranged along the longitudinal direction of the column, and the luminescence in the column is introduced to a photodiode array through the fibers. The distribution of the luminescent intensity along the longitudinal direction of the column is detected by the photodiode array. Thus, the rate of quantity increase of the product produced by the enzyme reaction can be measured while the solution is flowing through the column, thereby producing the enzyme activity by the end assay and the rate assay.
摘要翻译： 将酶固定在毛细管柱上，含有化学物质和发光物质的溶液流过色谱柱。 多个光纤沿着柱的长度方向布置，并且柱中的发光通过光纤引入光电二极管阵列。 通过光电二极管阵列检测沿着柱的纵向的发光强度的分布。 因此，可以在溶液流过柱时测量由酶反应产生的产物的量增加速率，从而通过末端测定和速率测定法产生酶活性。
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公开(公告)号：US5415051A
公开(公告)日：1995-05-16
申请号：US70995
申请日：1993-06-04
申请人： Kyuji Rokugawa , Kouji Matsumoto , Morito Inoue
发明人： Kyuji Rokugawa , Kouji Matsumoto , Morito Inoue
CPC分类号： G01N35/1016 , F04B43/046 , G01N2035/1025
摘要： A sampling system, favorably applicable to an automatic chemical analyzer, is provided for sampling by sucking and discharging liquid, such as specimens and reagents. The sampling system comprises a pump having a container in which an inner space of a certain volume is formed and an actuator arranged in the inner space to form a pumping chamber therein. The actuator comprises a base plate having both sides thereon and a piezoelectric element attached to the base plate. Further provided are a tube having one end connected to the pumping chamber, a nozzle conntected to another end of the tube, and an element for controlling a driving voltage applied to the piezoelectric element. For instance, the piezoelectric element is composed of two piezoelectric plates attached each to both the sides of the base plate. A piezoelectric sensor is attached to the base plate for detecting distortion of the actuator, a liquid level of specimens and reagents, and error operations such as air suction and jamming. The piezoelectric sensor is attachted to a cutout portion, partly cut out in either one of two piezoelectric plates. In case of being applied to the automatic chemical analyzer, an output signal from the piezoelectric sensor is used for correction of absorbance data.
摘要翻译： 提供了一种适用于自动化学分析仪的采样系统，用于通过吸取和排出诸如标本和试剂的液体进行取样。 采样系统包括具有容器的泵，其中形成有一定体积的内部空间和布置在内部空间中以在其内形成泵送室的致动器。 致动器包括其两侧的基板和附接到基板的压电元件。 还提供了一个管，其一端连接到泵送室，与管的另一端连接的喷嘴，以及用于控制施加到压电元件的驱动电压的元件。 例如，压电元件由在基板的两侧各自附接的两个压电板构成。 压电传感器连接到基板上，用于检测致动器的变形，试样和试剂的液位，以及诸如空气吸入和卡住的错误操作。 压电传感器附接到切口部分，部分地切割在两个压电板中的任一个中。 在应用于自动化学分析仪的情况下，来自压电传感器的输出信号用于校正吸光度数据。
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公开(公告)号：US4844868A
公开(公告)日：1989-07-04
申请号：US872814
申请日：1986-06-11
申请人： Kyuji Rokugawa
发明人： Kyuji Rokugawa
CPC分类号： G01N35/021 , G01N35/1002 , G01N35/1083
摘要： An analysis apparatus is disclosed, which comprises guide rails for supporting a plurality of sample-containing reaction tubes in a straight row, a plunger for moving the reaction tubes supported on the guide rails in the direction of arrangement, a first rotary table for supporting a plurality of sample-containing reaction tubes along a circular line, and a motor for rotating the rotary table. Second rotary tables are disposed above the straight and circular arrangements of reaction tubes. These second rotary tables support at least two reagent distributors for distributing reagent into the reaction tubes. Each reagent distributor includes a reagent phial containing a reagent and a pump integral with the reagent phial for withdrawing the reagent in the reagent vessel. The pump has a nozzle through which the reagent is discharged. The rotary table is rotated by a motor such that the nozzle of a reagent distributor used for reagent distribution is brought to a position right above a pertinent reaction tube. The pump of the reagent distributor used for the reagent distribution is driven by a plunger.
摘要翻译： 公开了一种分析装置，其包括用于支撑直列的多个含样本的反应管的导轨，用于沿着布置方向移动支撑在导轨上的反作用管的柱塞，用于支撑 沿着圆形线的多个含样本的反应管，以及用于旋转所述旋转台的马达。 第二旋转台设置在反应管的直线和圆形布置之上。 这些第二旋转台支撑至少两个用于将试剂分配到反应管中的试剂分配器。 每个试剂分配器包括含有试剂的试剂瓶和与试剂池一体的泵，用于取出试剂容器中的试剂。 泵具有喷嘴，试剂通过该喷嘴排出。 旋转台由电动机旋转，使得用于试剂分配的试剂分配器的喷嘴进入相关反应管正上方的位置。 用于试剂分配的试剂分配器的泵由柱塞驱动。
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10.发明授权Immunoassays involving complement lysing of chromophore containing microcapsules 失效涉及含有发色团的微胶囊的补体溶解的免疫测定
公开(公告)号：US4714672A
公开(公告)日：1987-12-22
申请号：US618936
申请日：1984-06-08
申请人： Kyuji Rokugawa , Yasuko Tamayama
发明人： Kyuji Rokugawa , Yasuko Tamayama
IPC分类号： G01N33/544 , G01N33/542 , G01N33/543 , G01N33/555 , G01N33/53
CPC分类号： G01N33/555 , G01N33/542 , Y10S435/966 , Y10S436/805 , Y10S436/821 , Y10S436/829
摘要： An immunoassay of the type which utilizes the hemolysis of microcapsules such as red blood cells. Microcapsules which can be lysed by complement activity, which contain an optically determinable substance, on whose surfaces an antibody to be quantified is bound are prepared. The microcapsules, a test sample containing the antigen or the antibody to be quantified, and complement are mixed to react each other. Thereafter, an optical measurement is conducted at different wavelengths for the reaction mixture which is still suspending the intact microcapsules.
摘要翻译： 利用红细胞等微囊溶血的类型的免疫测定法。 制备可以通过补体活性裂解含有可光学确定的物质的微胶囊，其表面上待定量的抗体结合。 将微胶囊，含有要定量的抗原或抗体的检验样品和补体混合以进行反应。 此后，对仍然悬浮完整微胶囊的反应混合物进行不同波长的光学测量。
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