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公开(公告)号：US07279507B2
公开(公告)日：2007-10-09
申请号：US10937868
申请日：2004-08-02
申请人： Hopin Hu , Charles R. Briggs , Tung Nguyen , Hue Tran , Filene Rossberg
发明人： Hopin Hu , Charles R. Briggs , Tung Nguyen , Hue Tran , Filene Rossberg
IPC分类号： G02C7/04
CPC分类号： C08F291/18 , C08F265/04 , C08F271/02 , C08F283/00 , C08F283/12 , G02B1/043 , C08L51/00
摘要： An interpenetrating polymer network (IPN) composition and a process for the manufacture of hydrogel contact lens using the invention material. The polymeric materials are formed by polymerization of: (1) an unsaturated alkyl(meth)acrylate or its derivatives such as 2-hydroxyethyl methacrylate as the principle monomer; (2) optionally vinyl containing comonomer(s) to enhance the resulting hydrogel water absorbing capability; (3) polymerizable multi-functional crosslinking agent(s); (4) an irradiation initiator and/or thermal initiator; (5) optionally other additives to impart the resulting hydrogel specific properties such as ultra-violet blocking ability and handling colors; in the presence of a soluble, hydrophilic IPN agent such as polyvinylpyrrolidone (PVP) or poly-2-ethyl-2-oxazoline (PEOX) with a specific molecular weight range. The novel hydrophilic hydrogel material in the present invention can be used to produce a spherical contact lens, a toric contact lens, a multifocal contact lens, a toric-multifocal contact lens, and other medical devices. The inventive hydrogel material shows a low degree of surface friction, a low dehydration rate, and a high degree of biodeposit resistance.
摘要翻译： 互穿聚合物网络（IPN）组合物和使用本发明材料制造水凝胶隐形眼镜的方法。 聚合物材料通过以下方式聚合形成：（1）不饱和烷基（甲基）丙烯酸酯或其衍生物如甲基丙烯酸2-羟乙酯作为主要单体; （2）任选的含乙烯基的共聚单体以增强所得的水凝胶吸水能力; （3）可聚合多官能交联剂; （4）照射引发剂和/或热引发剂; （5）任选的其它添加剂以赋予所得水凝胶特异性如紫外阻挡能力和处理颜色; 在具有特定分子量范围的可溶性亲水性IPN剂如聚乙烯吡咯烷酮（PVP）或聚-2-乙基-2-恶唑啉（PEOX）的存在下进行。 本发明的新型亲水性水凝胶材料可用于制造球形隐形眼镜，复曲面隐形眼镜，多焦点隐形眼镜，复曲面多焦点隐形眼镜及其他医疗装置。 本发明的水凝胶材料表现出低的表面摩擦，低的脱水率和高的生物沉积抗性。
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2.发明申请公开(公告)号：US20050148682A1
公开(公告)日：2005-07-07
申请号：US10937868
申请日：2004-08-02
申请人： Hopin Hu , Charles Briggs , Tung Nguyen , Hue Tran , Filene Rossberg
发明人： Hopin Hu , Charles Briggs , Tung Nguyen , Hue Tran , Filene Rossberg
IPC分类号： C08F265/04 , C08F271/02 , C08F283/00 , C08F283/12 , C08F291/18 , G02B1/04 , C08K3/00
CPC分类号： C08F291/18 , C08F265/04 , C08F271/02 , C08F283/00 , C08F283/12 , G02B1/043 , C08L51/00
摘要： An interpenetrating polymer network (IPN) composition and a process for the manufacture of hydrogel contact lens using the invention material. The polymeric materials are formed by polymerization of: (1) an unsaturated alkyl(meth)acrylate or its derivatives such as 2-hydroxyethyl methacrylate as the principle monomer; (2) optionally vinyl containing comonomer(s) to enhance the resulting hydrogel water absorbing capability; (3) polymerizable multi-functional crosslinking agent(s); (4) an irradiation initiator and/or thermal initiator; (5) optionally other additives to impart the resulting hydrogel specific properties such as ultra-violet blocking ability and handling colors; in the presence of a soluble, hydrophilic IPN agent such as polyvinylpyrrolidone (PVP) or poly-2-ethyl-2-oxazoline (PEOX) with a specific molecular weight range. The novel hydrophilic hydrogel material in the present invention can be used to produce a spherical contact lens, a toric contact lens, a multifocal contact lens, a toric-multifocal contact lens, and other medical devices. The inventive hydrogel material shows a low degree of surface friction, a low dehydration rate, and a high degree of biodeposit resistance.
摘要翻译： 互穿聚合物网络（IPN）组合物和使用本发明材料制造水凝胶隐形眼镜的方法。 聚合物材料通过以下方式聚合形成：（1）不饱和烷基（甲基）丙烯酸酯或其衍生物如甲基丙烯酸2-羟乙酯作为主要单体; （2）任选的含乙烯基的共聚单体以增强所得的水凝胶吸水能力; （3）可聚合多官能交联剂; （4）照射引发剂和/或热引发剂; （5）任选的其它添加剂以赋予所得水凝胶特异性如紫外阻挡能力和处理颜色; 在具有特定分子量范围的可溶性亲水性IPN剂如聚乙烯吡咯烷酮（PVP）或聚-2-乙基-2-恶唑啉（PEOX）的存在下进行。 本发明的新型亲水性水凝胶材料可用于制造球形隐形眼镜，复曲面隐形眼镜，多焦点隐形眼镜，复曲面多焦点隐形眼镜及其他医疗装置。 本发明的水凝胶材料表现出低的表面摩擦，低的脱水率和高的生物沉积抗性。
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公开(公告)号：US5531893A
公开(公告)日：1996-07-02
申请号：US160427
申请日：1993-12-01
申请人： Hopin Hu , Chung-Jen Hou
发明人： Hopin Hu , Chung-Jen Hou
IPC分类号： B01D71/38 , B01D67/00 , B01D69/14 , B01D71/52 , B01D71/64 , B01D71/68 , C08G59/20 , C08G59/22 , C08L71/02 , C08L81/00 , C08L81/06
CPC分类号： B01D71/68 , B01D67/0011 , B01D69/141 , B01D2323/30 , B01D2325/14 , B01D2325/36
摘要： Hydrophilic inter-penetrating network charge modified microporous membranes are provided as well as a method of preparing the membranes by casting a membrane matrix blend containing matrix polymer, a solvent system, a wetting polymer compatible with the matrix polymer, and a charge modified system which forms a cross-linked interpenetrating network structure within the microporous membrane substrate during the membrane fabrication process which network structure optionally can be locked in by heat curing. The membranes are useful for filtering ultrapure water with 18 megaohm-cm resistivity for the electronic industry, and they can also be used for the removal of a variety of contaminants from fluid media, such as very fine negatively charged particles, bacteria and endotoxins, with greatly enhanced filtration efficiency.
摘要翻译： 提供亲水互穿网络电荷改性微孔膜，以及通过浇铸含有基质聚合物，溶剂系统，与基质聚合物相容的润湿聚合物的膜基质共混物和形成电荷的改进体系制备膜的方法 在膜制造过程中微孔膜基底内的交联互穿网络结构，该网络结构任选地可以通过热固化而被锁定。 该膜可用于过滤用于电子工业的18兆欧姆 - 厘米电阻率的超纯水，它们还可用于从流体介质中除去各种污染物，例如非常细的带负电荷的颗粒，细菌和内毒素，具有 大大提高了过滤效率。
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公开(公告)号：US5277812A
公开(公告)日：1994-01-11
申请号：US17036
申请日：1993-02-12
申请人： Hopin Hu , Chung-Jen Hou
发明人： Hopin Hu , Chung-Jen Hou
CPC分类号： B01D71/68 , B01D67/0011 , B01D69/141 , B01D2323/30 , B01D2325/14 , B01D2325/36
摘要： Hydrophilic inter-penetrating network charge modified microporous membranes are provided as well as a method of preparing the membranes by casting a membrane matrix blend containing matrix polymer, a solvent system, a wetting polymer compatible with the matrix polymer, and a charge modified system which forms a cross-linked inter-penetrating network structure within the microporous membrane substrate during the membrane fabrication process which network structure optionally can be locked in by heat curing. The membranes are useful for filtering ultra pure water with 18 megaohm-cm resistivity for the electronic industry, and they can also be used for the removal of a variety of contaminants from fluid media, such as very fine negatively charged particles, bacteria and endotoxins, with greatly enhanced filtration efficiency.
摘要翻译： 提供亲水互穿网络电荷改性微孔膜，以及通过浇铸含有基质聚合物，溶剂系统，与基质聚合物相容的润湿聚合物的膜基质共混物和形成电荷的改进体系制备膜的方法 在膜制造过程中在微孔膜基底内的交联的穿透网络结构，其中该网络结构任选地可以通过热固化被锁定。 该膜可用于过滤用于电子工业的具有18兆欧姆 - 厘米电阻率的超纯水，并且它们还可用于从流体介质（例如非常细的带负电荷的颗粒，细菌和内毒素）中除去各种污染物， 大大提高了过滤效率。
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公开(公告)号：US06552103B1
公开(公告)日：2003-04-22
申请号：US09574938
申请日：2000-05-19
IPC分类号： G02C704
CPC分类号： G02B1/043 , A61L27/16 , A61L27/52 , A61L2430/16 , C08F220/38 , C08F220/54 , Y10S524/916 , C08L51/02 , C08L33/14
摘要： Novel biomimetic hydrogel materials and methods for their preparation. Hydrogels containing acrylamide-functionalized carbohydrate, sulfoxide, sulfide or sulfone copolymerized with a hydrophilic or hydrophobic copolymerizing material selected from the group consisting of an acrylamide, methacrylamide, acrylate, methacrylate, vinyl and a derivative thereof present in concentration from about 1 to about 99 wt %. and methods for their preparation. The method of use of the new hydrogels for fabrication of soft contact lenses and biomedical implants.
摘要翻译： 新型仿生水凝胶材料及其制备方法。 含有丙烯酰胺官能化碳水化合物，亚砜，硫化物或砜的水凝胶与选自丙烯酰胺，甲基丙烯酰胺，丙烯酸酯，甲基丙烯酸酯，乙烯基及其衍生物的亲水或疏水共聚材料共聚合，其浓度为约1至约99重量％ ％。 及其制备方法。 使用新型水凝胶制造软性隐形眼镜和生物医学植入物的方法。
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公开(公告)号：US6107365A
公开(公告)日：2000-08-22
申请号：US145507
申请日：1998-09-02
IPC分类号： G02C7/04 , A61F2/16 , A61L27/16 , A61L27/52 , C08F220/38 , C08F220/54 , C08J3/05 , C08L33/00 , C08L57/00 , C08L89/00 , G02B1/04 , C08L33/14
CPC分类号： G02B1/043 , A61L27/16 , A61L27/52 , C08F220/38 , C08F220/54 , A61L2430/16 , Y10S524/916
摘要： Novel biomimetic hydrogel materials and methods for their preparation. Hydrogels containing acrylamide-functionalized carbohydrate, sulfoxide, sulfide or sulfone copolymerized with a hydrophilic or hydrophobic copolymerizing material selected from the group consisting of an acrylamide, methacrylamide, acrylate, methacrylate, vinyl and a derivative thereof present in concentration from about 1 to about 99 wt %. and methods for their preparation. The method of use of the new hydrogels for fabrication of soft contact lenses and biomedical implants.
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7.发明授权Hydrophilic membranes prepared from polyethersulfone/poly-2-oxazoline/polyvinylpyrrolidone blend 失效由聚醚砜/聚-2-恶唑啉/聚乙烯吡咯烷酮混合物制备的亲水膜
公开(公告)号：US5178765A
公开(公告)日：1993-01-12
申请号：US810234
申请日：1991-12-19
申请人： Hopin Hu , Inessa Katsnelson , Xiaosong Wu
发明人： Hopin Hu , Inessa Katsnelson , Xiaosong Wu
CPC分类号： B01D71/68 , B01D67/0011 , B01D71/44 , B01D71/58 , B01D2323/12 , B01D2325/34 , B01D2325/36
摘要： Porous blended hydrophilic copolymer (polyethersulfone resin, poly-2-oxazoline resin, and polyvinylpyrrolidone resin) microporous membranes are provided which are useful for filtering macromolecules or particles from fluids. The invention also concerns a process for filtering matter from a fluid, employing the membranes.
摘要翻译： 提供了多孔共混亲水共聚物（聚醚砜树脂，聚-2-恶唑啉树脂和聚乙烯吡咯烷酮树脂）微孔膜，其可用于从流体中过滤大分子或颗粒。 本发明还涉及使用膜从流体中过滤物质的方法。
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公开(公告)号：US5209849A
公开(公告)日：1993-05-11
申请号：US874480
申请日：1992-04-24
申请人： Hopin Hu , Zhihua Cai
发明人： Hopin Hu , Zhihua Cai
CPC分类号： B01D67/0093 , C08J9/405 , B01D2323/385 , C08J2323/02 , C08J2327/12
摘要： A hydrophilic microporous membrane, is provided comprising a hydrophobic membrane substrate exemplified by a polyolefin or partially fluorinated polyolefin membrane. A process is also provided for preparing a hydrophilic membrane by grafting a water soluble polymer to the hydrophobic membrane substrate surface by irradiation means, e.g., ultraviolet irradiation. The invention further concerns a method for making the membrane and process means for filtering a fluid through such membrane.
摘要翻译： 提供了一种亲水微孔膜，其包含疏水性膜基材，例如聚烯烃或部分氟化的聚烯烃膜。 还提供了一种制备亲水膜的方法，其通过诸如紫外线照射的照射手段将水溶性聚合物接枝到疏水性膜基材表面。 本发明还涉及制造用于过滤通过这种膜的流体的膜和工艺装置的方法。
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