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1.发明授权Variable view imaging system with combination of telecentric scanner and double wedge prisms 失效可变视图成像系统，结合远心扫描仪和双楔形棱镜公开(公告)号：US08274721B2
公开(公告)日：2012-09-25
申请号：US12396836
申请日：2009-03-03
申请人： Hyungsuck Cho , Xiaodong Tao
发明人： Hyungsuck Cho , Xiaodong Tao
CPC分类号： G02B26/108 , G02B13/22 , G02B21/002 , G02B26/06
摘要： A variable view imaging system for observation of micro object with variable view orientation and position includes a telecentric lens group, a scanning mirror, wedge prisms, a deformable mirror and related optical elements. The combination of a scanning mirror and a telecentric lens group decouples the motion of scanning mirror and the view angle. The view angle is determined only by the angle of the wedge prisms. This design increases the zenith angle of the view and simplifies the kinematics of the system. The wedge prisms and the scanning mirror can supply a flexible view in a compact way. The wavefront error induced by the wedge prisms is corrected by the deformable mirror. In order to achieve the desired view state during operation, the scanning mirror angle and the wedge prisms angle are calculated iteratively based on the kinematics and Jacobian matrix of system.
摘要翻译： 用于观察具有可变视角取向和位置的微物体的可变视图成像系统包括远心透镜组，扫描镜，楔形棱镜，可变形反射镜和相关的光学元件。 扫描镜和远心镜组的组合使扫描镜的运动和视角分离。 视角仅由楔形棱镜的角度确定。 该设计增加了视野的天顶角，简化了系统的运动学。 楔形棱镜和扫描镜可以以紧凑的方式提供灵活的视图。 由楔形棱镜引起的波前误差由可变形镜校正。 为了在操作期间实现期望的视图状态，基于系统的运动学和雅可比矩阵迭代地计算扫描镜角度和楔形棱镜角度。
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2.发明申请VARIABLE VIEW IMAGING SYSTEM WITH COMBINATION OF TELECENTRIC SCANNER AND DOUBLE WEDGE PRISMS 失效具有组合扫描仪和双重视角的可变视图成像系统公开(公告)号：US20100202030A1
公开(公告)日：2010-08-12
申请号：US12396836
申请日：2009-03-03
申请人： Hyungsuck Cho , Xiaodong Tao
发明人： Hyungsuck Cho , Xiaodong Tao
CPC分类号： G02B26/108 , G02B13/22 , G02B21/002 , G02B26/06
摘要： A variable view imaging system for observation of micro object with variable view orientation and position includes a telecentric lens group, a scanning mirror, wedge prisms, a deformable mirror and related optical elements. The combination of a scanning mirror and a telecentric lens group decouples the motion of scanning mirror and the view angle. The view angle is determined only by the angle of the wedge prisms. This design increases the zenith angle of the view and simplifies the kinematics of the system. The wedge prisms and the scanning mirror can supply a flexible view in a compact way. The wavefront error induced by the wedge prisms is corrected by the deformable mirror. In order to achieve the desired view state during operation, the scanning mirror angle and the wedge prisms angle are calculated iteratively based on the kinematics and Jacobian matrix of system.
摘要翻译： 用于观察具有可变视角取向和位置的微物体的可变视图成像系统包括远心透镜组，扫描镜，楔形棱镜，可变形反射镜和相关的光学元件。 扫描镜和远心镜组的组合使扫描镜的运动和视角分离。 视角仅由楔形棱镜的角度确定。 该设计增加了视野的天顶角，简化了系统的运动学。 楔形棱镜和扫描镜可以以紧凑的方式提供灵活的视图。 由楔形棱镜引起的波前误差由可变形镜校正。 为了在操作期间实现期望的视图状态，基于系统的运动学和雅可比矩阵迭代地计算扫描镜角度和楔形棱镜角度。
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3.发明授权公开(公告)号：US08885904B2
公开(公告)日：2014-11-11
申请号：US13451228
申请日：2012-04-19
IPC分类号： G06K9/00
CPC分类号： A61B5/055 , G01R33/543
摘要： Systems and methods for landmark correction in Magnetic Resonance Imaging (MRI) are provided. One method includes acquiring at least one calibration image or at least one localizer image of an object, identifying in the calibration or localizer images a region of the object as a reference point, wherein the reference point defines a landmark position. The method further includes determining an offset between an initial landmark position and the identified landmark position. The method also includes using the determined offset for MRI.
摘要翻译： 提供了磁共振成像（MRI）中地标校正的系统和方法。 一种方法包括获取对象的至少一个校准图像或至少一个定位器图像，在校准或定位器图像中识别作为参考点的对象的区域，其中参考点定义界标位置。 该方法还包括确定初始界标位置与所识别的界标位置之间的偏移。 该方法还包括使用确定的MRI偏移。
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公开(公告)号：US08036462B2
公开(公告)日：2011-10-11
申请号：US11680063
申请日：2007-02-28
IPC分类号： G06K9/34
CPC分类号： G06T7/0012 , G06K9/0061 , G06T7/41 , G06T2207/10116 , G06T2207/30068
摘要： Methods and systems for segmenting images, wherein the image pixels are categorized into a plurality of subsets using one or more indexes, then a log-likelihood function of one or more of the indexes is determined, and one or more maps are generated based on the determination of the log-likelihood function of one or more of the indexes.
摘要翻译： 用于分割图像的方法和系统，其中使用一个或多个索引将图像像素分类为多个子集，然后确定一个或多个索引的对数似然函数，并且基于 确定一个或多个索引的对数似然函数。
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5.发明申请SYSTEM AND METHOD FOR AUTOMATED SCAN PLANNING USING SYMMETRY DETECTION AND IMAGE REGISTRATION 审中-公开使用对称检测和图像注册的自动扫描规划的系统和方法公开(公告)号：US20100129005A1
公开(公告)日：2010-05-27
申请号：US12603778
申请日：2009-10-22
IPC分类号： G06K9/36
CPC分类号： G06K9/6203 , G01R33/4833 , G01R33/543 , G06K2209/05 , G06T7/74 , G06T2207/10088 , G06T2207/30016
摘要： A method of determining an anatomically consistent scan protocol for an object of interest includes obtaining a volumetric image of an object of interest to be imaged, transforming the volumetric image, estimating the position and orientation of the object using the volumetric image and the transformed volumetric image, and modifying the imaging scan protocol using the estimated object position and orientation.
摘要翻译： 确定感兴趣对象的解剖学上一致的扫描协议的方法包括获得要成像的感兴趣对象的体积图像，变换体积图像，使用体积图像和变换的体积图像估计对象的位置和取向 并且使用所估计的对象位置和取向修改成像扫描协议。
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公开(公告)号：US20090245611A1
公开(公告)日：2009-10-01
申请号：US12056078
申请日：2008-03-26
申请人： Ali Can , Michael John Gerdes , Musodiq Olatayo Bello , Xiaodong Tao , Francis Edward Pavan-Woolfe , Roshni Bhagalia
发明人： Ali Can , Michael John Gerdes , Musodiq Olatayo Bello , Xiaodong Tao , Francis Edward Pavan-Woolfe , Roshni Bhagalia
IPC分类号： G06K9/00
CPC分类号： G06K9/0014 , G01N21/6458
摘要： Techniques for removing image autoflourescence from fluorescently stained biological images are provided herein. The techniques utilize non-negative matrix factorization that may constrain mixing coefficients to be non-negative. The probability of convergence to local minima is reduced by using smoothness constraints. The non-negative matrix factorization algorithm provides the advantage of removing both dark current and autofluorescence.
摘要翻译： 本文提供了从荧光染色的生物图像中去除图像自动曝光的技术。 这些技术利用可以将混合系数限制为非负的非负矩阵分解。 通过使用平滑度约束来减少收敛到局部最小值的概率。 非负矩阵分解算法提供了去除暗电流和自发荧光的优点。
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公开(公告)号：US20080031521A1
公开(公告)日：2008-02-07
申请号：US11680063
申请日：2007-02-28
IPC分类号： G06K9/34
CPC分类号： G06T7/0012 , G06K9/0061 , G06T7/41 , G06T2207/10116 , G06T2207/30068
摘要： Methods and systems for segmenting images, wherein the image pixels are categorized into a plurality of subsets using one or more indexes, then a log-likelihood function of one or more of the indexes is determined, and one or more maps are generated based on the determination of the log-likelihood function of one or more of the indexes.
摘要翻译： 用于分割图像的方法和系统，其中使用一个或多个索引将图像像素分类为多个子集，然后确定一个或多个索引的对数似然函数，并且基于 确定一个或多个索引的对数似然函数。
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8.发明申请SYSTEMS AND METHODS FOR LANDMARK CORRECTION IN MAGNETIC RESONANCE IMAGING 有权用于磁共振成像中的LANDMARK校正的系统和方法公开(公告)号：US20130279779A1
公开(公告)日：2013-10-24
申请号：US13451228
申请日：2012-04-19
IPC分类号： G06K9/00
CPC分类号： A61B5/055 , G01R33/543
摘要： Systems and methods for landmark correction in Magnetic Resonance Imaging (MRI) are provided. One method includes acquiring at least one calibration image or at least one localizer image of an object, identifying in the calibration or localizer images a region of the object as a reference point, wherein the reference point defines a landmark position. The method further includes determining an offset between an initial landmark position and the identified landmark position. The method also includes using the determined offset for MRI.
摘要翻译： 提供了磁共振成像（MRI）中地标校正的系统和方法。 一种方法包括获取对象的至少一个校准图像或至少一个定位器图像，在校准或定位器图像中识别作为参考点的对象的区域，其中参考点定义界标位置。 该方法还包括确定初始界标位置与所识别的界标位置之间的偏移。 该方法还包括使用确定的MRI偏移。
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9.发明授权公开(公告)号：US08369600B2
公开(公告)日：2013-02-05
申请号：US12055038
申请日：2008-03-25
CPC分类号： G01N1/312 , G01N2001/368 , G01N2800/60
摘要： The present techniques provide systems and methods for registering images of tissue spots on a tissue microarray (TMA). In studies involving multiple biomarkers being studied on the same TMA, the TMA slide is removed from the microscope, stained, and then imaged, often multiple times. The present techniques relate to validation of the registration of the acquired images of the same TMA. An automatic approach to register the images and detect registration failures as provided herein may enhance the rapid analysis of the tissues. Artifacts such as tissue folding and tissue loss are also determined automatically.
摘要翻译： 本技术提供了用于在组织微阵列（TMA）上记录组织斑点的图像的系统和方法。 在涉及在相同TMA上研究的多种生物标志物的研究中，将TMA载玻片从显微镜中除去，染色，然后成像，通常多次。 本技术涉及对相同TMA的所获取的图像的注册的验证。 如本文所提供的注册图像和检测登记失败的自动方法可以增强组织的快速分析。 人工制品如组织折叠和组织损失也自动确定。
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公开(公告)号：US08238642B2
公开(公告)日：2012-08-07
申请号：US12274687
申请日：2008-11-20
申请人： Yanyan Wu , Donald Robert Howard , Harry Israel Ringermacher , Robert August Kaucic , Zhaohui Sun , Francis Howard Little , Xiaodong Tao , Patrick Joseph Howard , Matthew Edward Dragovich , Eric Scott Foster
发明人： Yanyan Wu , Donald Robert Howard , Harry Israel Ringermacher , Robert August Kaucic , Zhaohui Sun , Francis Howard Little , Xiaodong Tao , Patrick Joseph Howard , Matthew Edward Dragovich , Eric Scott Foster
CPC分类号： G01B11/02 , G01B11/24 , G06T7/001 , G06T7/337 , G06T2207/10048 , G06T2207/30164
摘要： A method for determining 3D distances on a 2D pixelized image of a part or object includes acquiring a real 2D pixelized image of the object, creating a simulated image of the object using the 3D CAD model and the 2D pixelized image, determining a specified cost function comparing the simulated image with the real 2D pixilated image and repositioning the simulated image in accordance with iterated adjustments of a relative position between the CAD model and the 2D pixilated image to change the simulated image until the specified cost function is below a specified value. Then, the workstation is used to generate a 3D distance scale matrix using the repositioned simulated image, and to measure and display distances between selected pixels on a surface of the real image using 2D distances on the 2D pixelized image of the object and the 3D distance scale matrix.
摘要翻译： 一种用于确定部分或对象的2D像素化图像上的3D距离的方法包括获取对象的真实2D像素化图像，使用3D CAD模型和2D像素化图像创建对象的模拟图像，确定指定的成本函数 将模拟图像与真实2D像素化图像进行比较，并根据CAD模型和2D像素化图像之间的相对位置的迭代调整重新定位模拟图像，以改变模拟图像，直到指定的成本函数低于指定值。 然后，工作站用于使用重新定位的模拟图像生成3D距离尺度矩阵，并且使用对象的2D像素化图像上的2D距离来测量和显示在实际图像的表面上的所选像素之间的距离，并且3D距离 比例矩阵。
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