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公开(公告)号：US20200179935A1
公开(公告)日：2020-06-11
申请号：US16790147
申请日：2020-02-13
Applicant: Illumina, Inc. , Illumina Cambridge Limited
Inventor： Xavier von Hatten , Michel Perbost , Heng Huang , Nicole Lee , Vicky V. Lam , Nilda Juan , Timothy J. Merkel , John M. Beierle
Abstract: Disclosed herein are compositions and fluidic devices that include a filler fluid having a siloxane block co-polymer solubilized in the filler fluid. Also disclosed herein are related kits and methods for using the fluidic devices for various uses, such as the polymerase chain reaction or preparations for sequencing reactions.
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公开(公告)号：US10605766B2
公开(公告)日：2020-03-31
申请号：US14798762
申请日：2015-07-14
Applicant: ILLUMINA, INC.
Inventor： Boyan Boyanov , Jeffrey G. Mandell , Jingwei Bai , Kevin L. Gunderson , Cheng-Yao Chen , Michel Perbost
IPC: C12Q1/68 , G01N27/414 , C12Q1/6869 , C12Q1/6825 , B82Y15/00
Abstract: A method of nucleic acid sequencing. The method can include the steps of (a) providing a polymerase tethered to a solid support charge sensor; (b) providing one or more nucleotides, whereby the presence of the nucleotide can be detected by the charge sensor; and (c) detecting incorporation of the nucleotide into a nascent strand complementary to a template nucleic acid.
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公开(公告)号：US20160017416A1
公开(公告)日：2016-01-21
申请号：US14798762
申请日：2015-07-14
Applicant: ILLUMINA, INC
Inventor： Boyan BOYANOV , Jeffrey G. MANDELL , Jingwei BAI , Kevin L. GUNDERSON , Cheng-Yao CHEN , Michel Perbost
IPC: C12Q1/68 , G01N27/414
CPC classification number: G01N27/4145 , B01J2219/00653 , B01J2219/00722 , B82Y15/00 , C12Q1/6825 , C12Q1/6869 , C12Q2525/197 , C12Q2535/122 , C12Q2563/113 , C12Q2563/116 , C12Q2565/107 , C12Q2565/607 , C12Q2565/629 , C12Q2521/101 , C12Q2523/307 , C12Q2523/319
Abstract: A method of nucleic acid sequencing. The method can include the steps of (a) providing a polymerase tethered to a solid support charge sensor; (b) providing one or more nucleotides, whereby the presence of the nucleotide can be detected by the charge sensor; and (c) detecting incorporation of the nucleotide into a nascent strand complementary to a template nucleic acid.
Abstract translation: 核酸测序方法。 该方法可以包括以下步骤：（a）提供拴在固体支持物电荷传感器上的聚合酶; （b）提供一个或多个核苷酸，由此可以通过电荷传感器检测核苷酸的存在; 和（c）检测核苷酸掺入到与模板核酸互补的新生链中。
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Patent Agency Ranking
4.发明授权公开(公告)号：US09023638B2
公开(公告)日：2015-05-05
申请号：US13969050
申请日：2013-08-16
Applicant: Illumina, Inc.
Inventor： John A. Moon , M. Shane Bowen , Ryan C. Smith , Michel Perbost , Michal Lebl , Steven H. Modiano
CPC classification number: G01N33/50 , B01J19/0046 , B01J2219/00306 , B01J2219/00511 , B01J2219/0052 , B01J2219/00524 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00673 , B01J2219/00702 , B01J2219/0072 , B01L3/502761 , B01L3/5082 , B01L3/50857 , B01L3/5088 , B01L3/545 , C40B20/04 , G01N21/01 , G01N21/253 , G01N21/6452 , G01N35/00732
Abstract: A plurality of isolated microvessels including a plurality of encoded microvessels each having a microbody and a reservoir core. The microbody is configured to separate a biological or chemical substance in the reservoir core from an ambient environment surrounding the microbody. The microbody includes a transparent material that at least partially surrounds the reservoir core and facilitates detection of an optical characteristic of the substance within the reservoir core. The microbody of each microvessel includes an identifiable code that distinguishes individual microvessels of the plurality of encoded microvessels from each other. The plurality of isolated microvessels also includes a plurality of compartments each configured to separate individual microvessels of the plurality of encoded microvessels from each other.
Abstract translation: 多个分离的微血管包括多个编码的微血管，每个具有微体和储存器芯。 微体构造成将储层芯中的生物或化学物质与围绕微体的周围环境分离。 微体包括透明材料，其至少部分地围绕储存器芯并且便于检测储存器芯内的物质的光学特性。 每个微血管的微体包括将多个编码微血管的各个微血管彼此区分开的可识别代码。 多个分离的微血管还包括多个隔室，每个隔室被配置为将多个编码微血管中的各个微血管彼此分开。
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公开(公告)号：US10545115B2
公开(公告)日：2020-01-28
申请号：US15839795
申请日：2017-12-12
Applicant: ILLUMINA, INC.
Inventor： Boyan Boyanov , Jeffrey G. Mandell , Jingwei Bai , Kevin L. Gunderson , Cheng-Yao Chen , Michel Perbost
IPC: C12N9/00 , C12N9/96 , G01N27/414 , C12Q1/6869
Abstract: A method of nucleic acid sequencing. The method can include the steps of (a) providing a polymerase tethered to a solid support charge sensor; (b) providing one or more nucleotides, whereby the presence of the nucleotide can be detected by the charge sensor; and (c) detecting incorporation of the nucleotide into a nascent strand complementary to a template nucleic acid.
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6.发明申请MICROVESSELS, MICROPARTICLES, AND METHODS OF MANUFACTURING AND USING THE SAME 有权MICROVESSELS，MICROPARTICLES，AND METHODS OF MANUFACTURING AND USING THE SAME公开(公告)号：US20140100123A1
公开(公告)日：2014-04-10
申请号：US13969050
申请日：2013-08-16
Applicant: Illumina, Inc.
Inventor： John A. Moon , M. Shane Bowen , Ryan C. Smith , Michel Perbost , Michal Lebl , Steven H. Modiano
IPC: G01N33/50
CPC classification number: G01N33/50 , B01J19/0046 , B01J2219/00306 , B01J2219/00511 , B01J2219/0052 , B01J2219/00524 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00673 , B01J2219/00702 , B01J2219/0072 , B01L3/502761 , B01L3/5082 , B01L3/50857 , B01L3/5088 , B01L3/545 , C40B20/04 , G01N21/01 , G01N21/253 , G01N21/6452 , G01N35/00732
Abstract: A plurality of isolated microvessels including a plurality of encoded microvessels each having a microbody and a reservoir core. The microbody is configured to separate a biological or chemical substance in the reservoir core from an ambient environment surrounding the microbody. The microbody includes a transparent material that at least partially surrounds the reservoir core and facilitates detection of an optical characteristic of the substance within the reservoir core. The microbody of each microvessel includes an identifiable code that distinguishes individual microvessels of the plurality of encoded microvessels from each other. The plurality of isolated microvessels also includes a plurality of compartments each configured to separate individual microvessels of the plurality of encoded microvessels from each other.
Abstract translation: 多个分离的微血管包括多个编码的微血管，每个具有微体和储存器芯。 微体构造成将储层芯中的生物或化学物质与围绕微体的周围环境分离。 微体包括透明材料，其至少部分地围绕储存器芯并且便于检测储存器芯内的物质的光学特性。 每个微血管的微体包括将多个编码微血管的各个微血管彼此区分开的可识别代码。 多个分离的微血管还包括多个隔室，每个隔室被配置为将多个编码微血管中的各个微血管彼此分开。
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公开(公告)号：US20190217300A1
公开(公告)日：2019-07-18
申请号：US15770017
申请日：2016-10-20
Applicant: Illumina, Inc. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Xavier von Hatten , Michel Perbost , Heng Huang , Nicole Lee , Vicky V. Lam , Nilda Juan , Timothy J. Merkel , John M. Beierle
CPC classification number: B01L3/502792 , B01J19/0093 , B01J2219/00813 , B01L2300/12 , B01L2400/0418 , B01L2400/0421 , B01L2400/0424 , B01L2400/0427 , C08G77/04 , C08G77/388 , C08G77/392 , C08G77/44 , C08L83/10 , C08L83/00
Abstract: Disclosed herein are compositions and fluidic devices that include a filler fluid having a siloxane block co-polymer solubilized in the filler fluid. Also disclosed herein are related kits and methods for using the fluidic devices for various uses, such as the polymerase chain reaction or preparations for sequencing reactions.
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公开(公告)号：US09649614B2
公开(公告)日：2017-05-16
申请号：US14726325
申请日：2015-05-29
Applicant: ILLUMINA, INC.
Inventor： Michal Lebl , Michel Perbost , Chad F. Derosier , Mark J. Nibbe , Steve R. Burgett , David L. Heiner
CPC classification number: B01J19/22 , B01J14/005 , B01J19/0046 , B01J2219/00306 , B01J2219/00324 , B01J2219/00351 , B01J2219/0036 , B01J2219/00378 , B01J2219/0038 , B01J2219/00495 , B01J2219/00518 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00686 , B01J2219/00693 , B01J2219/00722 , B01L3/50851 , B01L7/5255 , B01L2300/069 , B01L2300/0812 , B01L2300/0829 , B01L2300/123
Abstract: Disclosed herein are compositions, methods and systems for the processing of chemical reactions, such as the synthesis of polymers.
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