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公开(公告)号：US12109563B2
公开(公告)日：2024-10-08
申请号：US17309918
申请日：2020-09-29
发明人： Beng Keong Ang , Shyun Long Wang , Heng Kuang Cheng , Chow Jin Chng , Ai Wee Lee , Yashwanth Panduga
CPC分类号： B01L3/502738 , B01L7/00 , G01N35/1097 , B01L2300/0663 , B01L2400/0644
摘要： A test cartridge for insertion into an analysis instrument having an actuation mechanism, the test cartridge having one or more sensors for measuring an aspect of the actuation mechanism.
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公开(公告)号：US20240116047A1
公开(公告)日：2024-04-11
申请号：US18375205
申请日：2023-09-29
发明人： Panteleimon Athanasiou , Beng Keong Ang , Justin Davidson , Norman Khoo , Heng Kuang Cheng , Hao Yu , Zhenning Cao
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502723 , B01L2200/0684 , B01L2200/0689
摘要： Liquid reservoirs, cartridge assemblies and related systems and methods are disclosed. An example implementation includes an apparatus that includes a body, a cover, and a lid assembly. The body includes a top surface and a storage chamber having an opening at the top surface. The cover covers or is positioned within the opening of the storage chamber. The lid assembly is coupled to the top surface and covers the opening of the storage chamber. The top surface and the first portion define a plenum. The cover is at least one of piercable, breakable, or movable to allow the storage chamber to be fluidly coupled to the plenum without venting the plenum to atmosphere.
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公开(公告)号：US20220387998A1
公开(公告)日：2022-12-08
申请号：US17888318
申请日：2022-08-15
摘要： A cartridge assembly comprises a housing having an illumination chamber and a well plate. The well plate is maintained within the housing and has liquid wells to receive desired amounts of liquids. The well plate includes a fluidics analysis station aligned with the illumination chamber, and an interface window and interface ports located at the fluidics analysis station. The well plate includes a valve station and pump station. A piercer unit is provided in the housing and positioned proximate to the wells. The piercer unit includes a piercer element and is to be moved to a piercing position where the piercer element pierces a cover for the corresponding well. A pump assembly on the well plate at the pump station manages fluid flow through the channels between the pump station and the fluidics analysis station. The housing includes a flow cell chamber to receive a removable flow cell cartridge.
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公开(公告)号：US20210170406A1
公开(公告)日：2021-06-10
申请号：US17115430
申请日：2020-12-08
发明人： Shyun Long Wang , Beng Keong Ang
摘要： Actuation systems and methods for use with flow cells. An example apparatus includes a flow cell assembly including a flow cell including at least one channel, a flow cell inlet, and a flow cell outlet. The flow cell assembly includes a gasket assembly operatively fluidically coupled to the flow cell and having a flow cell inlet gasket and a flow cell outlet gasket. The flow cell inlet gasket having a through bore and being fluidically coupled to the flow cell inlet. The flow cell outlet gasket having a through bore and being fluidically coupled to the flow cell outlet. The apparatus includes a reagent cartridge adapted to receive the flow cell assembly and including a pair of reagent cartridge ports adapted to be fluidly coupled to the flow cell inlet gasket and the flow cell outlet gasket.
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5.发明申请公开(公告)号：US20180217170A1
公开(公告)日：2018-08-02
申请号：US15936365
申请日：2018-03-26
摘要： Detection apparatus includes a microfluorometer having an objective, an excitation radiation source, and a detector. The detection apparatus also includes a fluidic system for delivering reagents from a reagent cartridge to a flow cell. The fluidic system includes a manifold body having a plurality of fluidic channels configured for fluid communication between the reagent cartridge and the flow cell. The fluidic system also includes a plurality of reagent sippers. The fluidic system also includes a valve configured to mediate fluid between reagent reservoirs and the flow cell. The detection apparatus also includes a flow cell latch clamp module having a clamp cover for holding the flow cell. The objective is configured to direct excitation radiation from the radiation source to the flow cell and to direct emission from the flow cell to the detector. The microfluorometer is movable to acquire wide-field images of different areas of the flow cell.
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公开(公告)号：US20190299210A1
公开(公告)日：2019-10-03
申请号：US16443727
申请日：2019-06-17
摘要： A cartridge assembly comprises a housing having an illumination chamber and a well plate. The well plate is maintained within the housing and has liquid wells to receive desired amounts of liquids. The well plate includes a fluidics analysis station aligned with the illumination chamber, and an interface window and interface ports located at the fluidics analysis station. The well plate includes a valve station and pump station. A piercer unit is provided in the housing and positioned proximate to the wells. The piercer unit includes a piercer element and is to be moved to a piercing position where the piercer element pierces a cover for the corresponding well. A pump assembly on the well plate at the pump station manages fluid flow through the channels between the pump station and the fluidics analysis station. The housing includes a flow cell chamber to receive a removable flow cell cartridge.
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7.发明授权公开(公告)号：US09958465B2
公开(公告)日：2018-05-01
申请号：US15403896
申请日：2017-01-11
CPC分类号： G01N35/00029 , B01L3/502715 , B01L9/527 , G01N21/6428 , G01N21/645 , G01N21/6456 , G01N21/6486 , G01N35/0099 , G01N35/021 , G01N35/04 , G01N35/1002 , G01N35/1095 , G01N2021/6482 , G01N2035/00158 , G01N2035/00237 , G01N2035/00326 , G01N2035/00356 , G01N2035/0465
摘要： Detection apparatus includes a microfluorometer having an objective, an excitation radiation source, and a detector. The detection apparatus also includes a fluidic system for delivering reagents from a reagent cartridge to a flow cell. The fluidic system includes a manifold body having a plurality of fluidic channels configured for fluid communication between the reagent cartridge and the flow cell. The fluidic system also includes a plurality of reagent sippers. The fluidic system also includes a valve configured to mediate fluid between reagent reservoirs and the flow cell. The detection apparatus also includes a flow cell latch clamp module having a clamp cover for holding the flow cell. The objective is configured to direct excitation radiation from the radiation source to the flow cell and to direct emission from the flow cell to the detector. The microfluorometer is movable to acquire wide-field images of different areas of the flow cell.
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8.发明申请公开(公告)号：US20170199210A1
公开(公告)日：2017-07-13
申请号：US15403896
申请日：2017-01-11
发明人： Beng Keong Ang , Heng Kuang Cheng , John M. Beirle , Brad Drews , David Kaplan
CPC分类号： G01N35/00029 , B01L3/502715 , B01L9/527 , G01N21/6428 , G01N21/645 , G01N21/6456 , G01N21/6486 , G01N35/0099 , G01N35/021 , G01N35/04 , G01N35/1002 , G01N35/1095 , G01N2021/6482 , G01N2035/00158 , G01N2035/00237 , G01N2035/00326 , G01N2035/00356 , G01N2035/0465
摘要： Detection apparatus includes a microfluorometer having an objective, an excitation radiation source, and a detector. The detection apparatus also includes a fluidic system for delivering reagents from a reagent cartridge to a flow cell. The fluidic system includes a manifold body having a plurality of fluidic channels configured for fluid communication between the reagent cartridge and the flow cell. The fluidic system also includes a plurality of reagent sippers. The fluidic system also includes a valve configured to mediate fluid between reagent reservoirs and the flow cell. The detection apparatus also includes a flow cell latch clamp module having a clamp cover for holding the flow cell. The objective is configured to direct excitation radiation from the radiation source to the flow cell and to direct emission from the flow cell to the detector. The microfluorometer is movable to acquire wide-field images of different areas of the flow cell.
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9.发明授权公开(公告)号：US10830781B2
公开(公告)日：2020-11-10
申请号：US15936365
申请日：2018-03-26
IPC分类号： G01N35/00 , B01L3/00 , G01N1/28 , G01N1/00 , G01N21/64 , G01N35/04 , G01N35/10 , B01L9/00 , G01N1/31 , G01N21/17 , G01N35/02
摘要： Detection apparatus includes a microfluorometer having an objective, an excitation radiation source, and a detector. The detection apparatus also includes a fluidic system for delivering reagents from a reagent cartridge to a flow cell. The fluidic system includes a manifold body having a plurality of fluidic channels configured for fluid communication between the reagent cartridge and the flow cell. The fluidic system also includes a plurality of reagent sippers. The fluidic system also includes a valve configured to mediate fluid between reagent reservoirs and the flow cell. The detection apparatus also includes a flow cell latch clamp module having a clamp cover for holding the flow cell. The objective is configured to direct excitation radiation from the radiation source to the flow cell and to direct emission from the flow cell to the detector. The microfluorometer is movable to acquire wide-field images of different areas of the flow cell.
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公开(公告)号：USD848020S1
公开(公告)日：2019-05-07
申请号：US29617029
申请日：2017-09-11
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