公开(公告)号：US11733258B2

公开(公告)日：2023-08-22

申请号：US17113115

申请日：2020-12-07

Applicant: Industrial Technology Research Institute

Inventor： Chih-Wen Yang ,  Ruey-Shyan Hong ,  Tzu-Hui Wu ,  Ting-Hsuan Chen

IPC: G01N35/10 ,  C12N15/10 ,  B01F27/072 ,  B01F27/90 ,  B01F27/1125 ,  G01N35/00

CPC classification number: G01N35/1065 ,  B01F27/0724 ,  B01F27/11251 ,  B01F27/90 ,  C12N15/1003 ,  C12N15/1013 ,  G01N2035/00534 ,  G01N2035/00564 ,  G01N2035/1053

Abstract: A nucleic acid extracting device includes a reagent containing unit, a mixing unit, and a flow channel unit. The reagent containing unit contains a specimen, a magnetic bead, and a reagent for extracting. The mixing unit includes a mixing chamber and a stirring assembly. The mixing chamber includes a chamber portion and a tube portion. The stirring assembly includes a main body and an extension. The main body is provided in the chamber portion. The tube portion connects the chamber portion. And the extension connects the main body and extends into the tube portion. The extension and an inner wall of the tube portion have first and second gaps therebetween respectively along first and second directions of the tube portion. The first gap is less than the second gap. The flow channel unit is connected between the reagent containing unit and the mixing unit.

公开(公告)号：US20210172972A1

公开(公告)日：2021-06-10

申请号：US17113115

申请日：2020-12-07

Applicant: Industrial Technology Research Institute

Inventor： Chih-Wen Yang ,  Ruey-Shyan Hong ,  Tzu-Hui Wu ,  Ting-Hsuan Chen

IPC: G01N35/10 ,  C12N15/10

Abstract: A nucleic acid extracting device includes a reagent containing unit, a mixing unit, and a flow channel unit. The reagent containing unit contains a specimen, a magnetic bead, and a reagent for extracting. The mixing unit includes a mixing chamber and a stirring assembly. The mixing chamber includes a chamber portion and a tube portion. The stirring assembly includes a main body and an extension. The main body is provided in the chamber portion. The tube portion connects the chamber portion. And the extension connects the main body and extends into the tube portion. The extension and an inner wall of the tube portion have first and second gaps therebetween respectively along first and second directions of the tube portion. The first gap is less than the second gap. The flow channel unit is connected between the reagent containing unit and the mixing unit.

公开(公告)号：US11648034B2

公开(公告)日：2023-05-16

申请号：US17145513

申请日：2021-01-11

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Chih-Wen Yang ,  Po-Jen Cheng ,  Ting-Hsuan Chen ,  Tseng-Huang Liu

IPC: A61B17/42 ,  A61B17/44 ,  A61B17/12 ,  A61B90/30

CPC classification number: A61B17/44 ,  A61B17/12009 ,  A61B17/42 ,  A61B90/30 ,  A61B2017/4225

Abstract: A device, an instrument and a belt for tying the cervix are provided. The device includes the belt and the instrument. The belt is used to tie the cervix. The instrument includes a first outer pipe, a second outer pipe and two fork structures. The first outer pipe and the second outer pipe are rotatable to each other. The two fork structures are connected individually to corresponding axial ends of the first outer pipe and the second outer pipe, respectively, and insert into the belt detachably.

公开(公告)号：US10918414B2

公开(公告)日：2021-02-16

申请号：US16220221

申请日：2018-12-14

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE ,  Chang Gung Medical Foundation Lin-Kou Chang Gung Memorial Hospital

Inventor： Chih-Wen Yang ,  Po-Jen Cheng ,  Ting-Hsuan Chen ,  Tseng-Huang Liu

IPC: A61B17/44 ,  A61B17/12 ,  A61B17/42 ,  A61B90/30

Abstract: A device, an instrument and a belt for tying the cervix are provided. The device includes the belt and the instrument. The belt is used to tie the cervix. The instrument includes a first outer pipe, a second outer pipe and two fork structures. The first outer pipe and the second outer pipe are rotatable to each other. The two fork structures are connected individually to corresponding axial ends of the first outer pipe and the second outer pipe, respectively, and insert into the belt detachably.

公开(公告)号：US08703070B1

公开(公告)日：2014-04-22

申请号：US13667341

申请日：2012-11-02

Applicant: Industrial Technology Research Institute

Inventor： Shaw-Hwa Parng ,  Chih-Wen Yang ,  Yu-Yin Tsai ,  Yi-Chau Huang

IPC: B01L3/00 ,  G01N21/64

CPC classification number: B01L3/5025 ,  B01L3/5027 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0672 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/043 ,  B01L2400/0683 ,  G01N21/6452 ,  G01N35/00069 ,  G01N2035/0439 ,  G01N2035/0449 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/117497 ,  Y10T436/118339

Abstract: Apparatus for immunoassay includes: a cartridge, including at least one test unit; a pin-film assembly, having a second sealing film, a plurality of pierce mechanisms, and a first actuation unit; a plurality of magnetic particles; at least one first magnetic unit; and at least one second magnetic unit. The test unit includes a plurality of fluid chambers, a plurality of pin chambers, a microchannel structure, a buffer chamber, a detection chamber and a waste chamber. The first actuation unit drives the pierce mechanisms to enable a working fluid to flow into the detection chamber storing the magnetic particles. As the second magnetic unit has a magnetic force larger than that of the first magnetic unit and can move reciprocatingly between a third position and a fourth position, the magnetic particles are driven to move reciprocatingly inside the detection chamber, thereby fully mixing the magnetic particles with the working fluid.

Abstract translation: 用于免疫测定的装置包括：盒，包括至少一个测试单元; 销片组件，具有第二密封膜，多个穿孔机构和第一致动单元; 多个磁性粒子; 至少一个第一磁性单元; 和至少一个第二磁性单元。 测试单元包括多个流体室，多个销腔，微通道结构，缓冲室，检测室和废物室。 第一致动单元驱动穿孔机构以使工作流体流入存储磁性颗粒的检测室。 由于第二磁性单元的磁力大于第一磁性单元的磁力，并且能够在第三位置与第四位置之间往复运动，驱动磁性颗粒在检测室内往复运动，从而将磁性颗粒与 工作流体。