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公开(公告)号：US12258546B2
公开(公告)日：2025-03-25
申请号：US17561117
申请日：2021-12-23
Applicant: Industrial Technology Research Institute
Inventor： Hsin-Yi Hsu , Yang-Cheng Lin , Chao-Hong Hsu , Yu-Bing Liou , Li-Hsin Lin , Hsin-Hsin Shen , Yu-Chi Wang , Chang-Chou Li , Chih-Hung Huang
Abstract: A cell and tissue sheet forming package includes a container body, a membrane, a sliding door plate and a sealing film. The sliding door plate is disposed slidably on a top of the container body to cover or expose the membrane. The sliding door plate has a hole and a passive magnetic assembly. The cell injection equipment includes a carrier, an injection mechanism and a drive mechanism. The carrier carries the package, and the drive mechanism moves the carrier and the injection mechanism to have the injection mechanism to inject a solution, through the hole, into the package. A heating element of the carrier is introduced to heat the membrane and the solution to transform the solution into a colloid sheet on the membrane. Then, the positive magnetic assembly engages magnetically the passive magnetic assembly to slide the sliding door plate to expose the colloid sheet on the membrane.
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公开(公告)号：US11458715B2
公开(公告)日：2022-10-04
申请号：US16675838
申请日：2019-11-06
Applicant: Industrial Technology Research Institute
Inventor： Hsin-Hsin Shen , Yu-Chi Wang , Ming-Chia Yang , Yu-Bing Liou , Wei-Hong Chang , Yun-Han Lin , Hsin-Yi Hsu , Yun-Chung Teng , Chia-Jung Lu , Yi-Hsuan Lee , Jian-Wei Lin , Kun-Mao Kuo , Ching-Mei Chen
IPC: B32B27/36 , B05D7/00 , B05D5/08 , B32B27/24 , B32B27/30 , B32B38/00 , B32B37/02 , B32B38/16 , B32B37/26
Abstract: A method for preparing a bifunctional film, including: (a) drying a first polymer solution to form a film to form an anti-adhesion layer; and (b) drying a second polymer solution over the anti-adhesion layer to form a film to form an attachment layer. The first polymer solution includes a first hydrophobic solution and a first hydrophilic solution, and in the first polymer solution, the weight ratio of the solute of the first hydrophobic solution to the solute of the first hydrophilic solution is 1:0.01-1. Moreover, the second polymer solution consists of a second hydrophilic solution.
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公开(公告)号：US20200170838A1
公开(公告)日：2020-06-04
申请号：US16683277
申请日：2019-11-14
Applicant: Industrial Technology Research Institute
Inventor： Yun-Chung Teng , Yu-Bing Liou , Hsin-Yi Hsu , Ying-Wen Shen , Sen-Lu Chen , Yu-Chi Wang , Hsin-Hsin Shen
IPC: A61F9/00
Abstract: An eye wearing device is provided, including a body, at least one reservoir and at least one microchannel. The body has a first surface, a second surface, a center, a first outer edge of the first surface and a second outer edge of the second surface. The reservoir is disposed in the body to load the drug. The microchannel is disposed near the first outer edge of the first surface and the second outer edge of the second surface. One end of the microchannel is connected to the reservoir for filling the drug into the reservoir. The other end of the microchannel is an opening facing an edge of the eye wearing device for contacting the cornea and/or the sclera, and the opening is connected to the first outer edge of the first surface and the second outer edge of the second surface.
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公开(公告)号：US10143530B2
公开(公告)日：2018-12-04
申请号：US15211141
申请日：2016-07-15
Inventor： Yu-Bing Liou , Hsiu-Ying Wang , Hsin-Yi Hsu , Wei-Li Chen , Chin-Tsung Huang , Hsin-Hsin Shen
Abstract: According to embodiments, a membrane with a flat or curved surface is provided for protection of intraocular tissues. The membrane can be used to cover the cornea for protecting corneal endothelial cells, to cover the anterior and posterior surface of the iris, or to cover the surface of the posterior capsule for separating the intraocular tissues. The membrane has a layered structure, which is composed of a collagen and a hydrophilic biopolymer or an organic polymer material. In particular, the membrane has high transparency and high water retention in a wet state.
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Patent Agency Ranking
公开(公告)号：US12054612B2
公开(公告)日：2024-08-06
申请号：US17561133
申请日：2021-12-23
Applicant: Industrial Technology Research Institute
Inventor： Yun-Chung Teng , Jen-Huang Huang , Ying-Wen Shen , Yu-Bing Liou , Hsin-Yi Hsu , Li-Hsin Lin , Yuchi Wang , Hsin-Hsin Shen
CPC classification number: C08L89/06 , A61L27/26 , A61L27/52 , B33Y80/00 , C08J3/24 , C12N5/0018 , C08J2389/06 , C08J2489/06 , C08L2203/02 , C08L2205/02 , C08L2205/16 , C08L2312/00 , C12N2500/34
Abstract: A bioprintable material is provided. The bioprintable material includes a hydrogel and microfilaments mixed in the hydrogel. The hydrogel includes a first collagen. The microfilament includes a second collagen. The diameter of the microfilament is ranging from 5 microns to 200 microns. The weight ratio of the microfilaments to the first collagen is ranging from 0.01:1 to 10:1.
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公开(公告)号：US11904581B2
公开(公告)日：2024-02-20
申请号：US17885874
申请日：2022-08-11
Applicant: Industrial Technology Research Institute
Inventor： Hsin-Hsin Shen , Yu-Chi Wang , Ming-Chia Yang , Yu-Bing Liou , Wei-Hong Chang , Yun-Han Lin , Hsin-Yi Hsu , Yun-Chung Teng , Chia-Jung Lu , Yi-Hsuan Lee , Jian-Wei Lin , Kun-Mao Kuo , Ching-Mei Chen
IPC: B32B27/36 , B32B27/24 , B32B27/30 , B05D7/00 , B05D5/08 , B32B38/00 , B32B37/02 , B32B38/16 , B32B37/26
CPC classification number: B32B27/36 , B05D5/08 , B05D7/544 , B05D7/584 , B32B27/24 , B32B27/306 , B32B37/02 , B32B37/26 , B32B38/164 , B32B2038/168 , B32B2307/728 , B32B2307/73 , B32B2535/00
Abstract: A method for preparing a bifunctional film, including: (a) drying a first polymer solution to form a film to form an anti-adhesion layer, and (b) drying a second polymer solution over the anti-adhesion layer to form a film to form an attachment layer. The first polymer solution includes a first hydrophobic solution and a first hydrophilic solution, and in the first polymer solution, the weight ratio of the solute of the first hydrophobic solution to the solute of the first hydrophilic solution is 1:0.01-1. Moreover, the second polymer solution is composed of a second hydrophilic solution.
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公开(公告)号：US11103446B2
公开(公告)日：2021-08-31
申请号：US16731966
申请日：2019-12-31
Applicant: Industrial Technology Research Institute
Inventor： Yu-Bing Liou , Hsin-Yi Hsu , Ying-Wen Shen , Yun-Chung Teng , Yuchi Wang , Hsin-Hsin Shen
Abstract: An ophthalmic drug delivery device and a method for fabricating the same are provided. The ophthalmic drug delivery device includes a shield element and a drug release element. The shield element has a light transmittance more than or equal to 80%. The drug release element is an annular body so that the drug release element surrounds the shield element. The drug release element is neutral and includes a cross-linked neutral collagen, a first hydrophilic biodegradable polymer and a drug. The shield element is acidic and includes a cross-linked acidic collagen and a second hydrophilic biodegradable polymer.
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公开(公告)号：US10918474B2
公开(公告)日：2021-02-16
申请号：US16122438
申请日：2018-09-05
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Yu-Bing Liou , Ming-Chia Yang , Hsin-Yi Hsu , Yun-Han Lin , Wei-Hong Chang , I-Jong Wang , Hsin-Hsin Shen
Abstract: An implanting device is used for implanting a membrane in a biological tissue. The implanting device includes a sleeve, a membrane storage element, an injection element and a bubble generating element. The membrane storage element is fixed at the sleeve. The injection element is inserted in the sleeve and the membrane storage element, and includes a capturing end and connecting end. The capturing end is for capturing the membrane and has a hole. The bubble generating element is connected to the connecting end, and is for providing a gas that is then outputted via the hole. By the rotation of the injection element, the capturing end extends straight out of the membrane storage element or retracts straight into the membrane storage element.
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公开(公告)号：US20130144069A1
公开(公告)日：2013-06-06
申请号：US13754561
申请日：2013-01-30
Applicant: Industrial Technology Research Institute
Inventor： Yung-Liang Tung , Jia-Yin Wu , Jen-An Chen , Hsin-Yi Hsu , Chun-Guey Wu , Min-Fong Jhong , Song-Yeu Tsai
IPC: H01L51/00 , C07D495/02 , H01L31/00
CPC classification number: H01L51/0074 , C07D495/04 , C07D495/14 , C07D519/00 , Y02E10/542
Abstract: Organic dyes and photoelectric conversion devices are provided. The Organic dye has the structure represented by formula (I) wherein i is an integer of 0-2; j is an integer of 0-2, and the sum of i and j is an integer of 1-4; X is independently selected from the group consisting of and and R3 is independent and comprise hydrogen, halogen, nitro group, amino group, C1-18 alkyl group, C1-18 alkoxy group, C1-18 sulfanyl group, C3-18 heteroalkyl group, C3-20 aryl group, C3-20 heteroaryl group, C3-20 cycloaliphatic group or C3-20 cycloalkyl group.
Abstract translation: 提供有机染料和光电转换装置。 有机染料具有由式（I）表示的结构，其中i是0-2的整数; j是0-2的整数，i和j的和是1-4的整数; X独立地选自并且R 3是独立的，并且包含氢，卤素，硝基，氨基，C 1-18烷基，C 1-18烷氧基，C 1-18硫烷基，C 3-18杂烷基， C 3-20芳基，C 3-20杂芳基，C 3-20脂环族基或C 3-20环烷基。
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