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公开(公告)号：US20180261127A1
公开(公告)日：2018-09-13
申请号：US15761486
申请日：2016-09-23
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SORBONNE UNIVERSITÉ , UNIVERSITÉ PARIS DIDEROT - PARIS 7 , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
CPC分类号： G09B23/286 , A61B8/00 , A61B8/06 , A61B8/0816 , A61B8/42 , A61B8/4209 , A61B8/483 , G06T7/0012 , G06T2207/10136 , G06T2207/30016 , G16H50/50
摘要： The invention relates to a method for obtaining a numerical model, the numerical model associating at least one objective measurement to a subjective sensation, the method comprising the steps of: a) imaging the at least one area of the brain by using unfocused waves produced by a transcranial ultrasound probe (20), to obtain at least one acquired image of the activity of the area, b) evaluating a physical quantity representative of the activity of the at least one area based on the acquired images, to obtain at least one objective measurement, c) obtaining from the subject at least one numerical value representative of a subjective sensation, and d) determining the numerical model by using the obtained objective measurement and the obtained numerical value.
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公开(公告)号：US20180177487A1
公开(公告)日：2018-06-28
申请号：US15735759
申请日：2016-06-16
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6) , UNIVERSITÉ PARIS DIDEROT - PARIS 7 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
CPC分类号： A61B8/4209 , A61B5/0077 , A61B5/0478 , A61B8/0808 , A61B8/0816 , A61B8/145 , A61B8/4411 , A61B8/4416 , A61B8/4461 , A61B8/4488 , A61B8/488 , A61B8/543 , A61B2503/40 , A61B2562/0219
摘要： The invention concerns a detecting apparatus (12) for imaging at least two areas of a brain of a subject (10), the detecting apparatus (12) comprising:—a holder comprising:—a frame (14) devoted to be cemented on the skull of the subject (10), the frame (14) delimitating an inner portion (18) which is transparent to ultrasound waves,—a removable imaging device comprising:—a platform (16) delimitating an inner space (28), the inner space (28) facing the inner portion (18),—a fixing element (30) adapted to temporary fix and lock the platform (16) to the holder,—an ultrasound probe (32), and—a moving stage (34) holding the ultrasound probe (32) and being adapted to move the ultrasound probe (32) within the inner space (28).
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公开(公告)号：US20220346749A1
公开(公告)日：2022-11-03
申请号：US17763259
申请日：2020-09-25
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE PARIS , SORBONNE UNIVERSITÉ , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
摘要： Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method, which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.
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公开(公告)号：US20180153507A1
公开(公告)日：2018-06-07
申请号：US15580026
申请日：2016-06-09
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre national de la recherche scientifique , Université Pierre et Marie Curie (Paris 6) , Université Paris Diderot - Paris 7 , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIME INDUSTRIELLES DE LA VILLE DE PARIS
IPC分类号： A61B8/00 , A61B5/0478 , A61B5/11 , A61B8/06
CPC分类号： A61B8/4416 , A61B5/04001 , A61B5/0478 , A61B5/11 , A61B5/1118 , A61B8/06 , A61B8/0808 , A61B8/4209 , A61B8/481 , A61B8/488 , A61B2503/40 , A61B2562/0209 , A61B2562/0219 , A61B2562/066 , A61B2562/166
摘要： The invention concerns a detecting apparatus (12) comprising:—at least two sensors (24, 26, 28), with at least one sensor (24) being an ultrasound transducer adapted to produce ultrasound waves, and—a positioning device (16) defining several compartments (22), each compartment (22) being adapted to hold a sensor (24, 26, 28) and each compartment (22) being located at predetermined location, the positioning device (16) comprising a holder adapted to be fixed on the skull of a subject, the positioning device (16) being adapted to be maintained on the head of the subject using the holder.
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公开(公告)号：US20190247011A1
公开(公告)日：2019-08-15
申请号：US16330948
申请日：2017-09-15
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , UNIVERSITE PARIS DIDEROT - PARIS 7 , SORBONNE UNIVERSITÉ
发明人： Zsolt LENKEI , Mathieu PERNOT , Mickael TANTER , Thomas DEFFIEUX
CPC分类号： A61B8/06 , A61B8/085 , A61B8/0891 , A61B8/14 , A61B8/145 , A61B8/4494 , A61B8/488 , A61B8/5207 , G01S7/52077 , G01S15/8925 , G01S15/8927 , G01S15/8981
摘要： The present invention aims at improving the Doppler imaging of a biological sample comprising blood. For this, it is proposed a method for imaging a biological sample (10), the sample (10) comprising blood (14) comprising diffusors and solid tissue (16), the method comprising obtaining observation, each observation being characterized by a different point spread function associating a signal to each location of the region of interest, the signal comprising a first contribution representative of the diffusors of blood vessels within the location, a second contribution representative of the tissue diffusors and a third contribution representative of blood signal associated to blood diffusors outside of the location, and estimating, for each location, the blood flow by using a statistical analysis.
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公开(公告)号：US20220346748A1
公开(公告)日：2022-11-03
申请号：US17763268
申请日：2020-09-25
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE PARIS , SORBONNE UNIVERSITÉ , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIME INDUSTRIELES DE LA VILLE DE PARIS
摘要： Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.
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公开(公告)号：US20170128036A1
公开(公告)日：2017-05-11
申请号：US15323305
申请日：2015-06-29
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , ECOLE SUPERIEURE DE PHYSIQUUE ET DE CHIME INDUSTRI DE LA VILLE PARIS , Universite Paris Diderot-Paris
CPC分类号： A61B8/06 , A61B8/0808 , A61B8/0891 , A61B8/483 , A61B8/488 , A61B8/5223 , A61B8/523 , A61B8/5246 , G06T7/0016 , G06T7/12 , G06T7/149 , G06T7/174 , G06T2207/10072 , G06T2207/10136 , G06T2207/20128 , G06T2207/30016 , G06T2207/30104
摘要： Method for functional imaging of the brain, comprising the following steps: (a) a brain is imaged by ultrasound imaging in order to obtain a vascular image to be studied (IVO), (b) the vascular image to he studied (IVO) is compared automatically, by shape recognition, with a cerebral vascular atlas (AV), and the vascular image to be studied (IVO) is thus located in the cerebral vascular atlas (AV), (c) a cerebral functional atlas (AF) corresponding to said cerebral vascular atlas (AV) and comprising cerebral functional zones (1c) located in this cerebral vascular atlas (AV) is used in such a way as to identify cerebral functional zones (1e) on the vascular image to be studied (IVO).
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