公开(公告)号：US08933225B2

公开(公告)日：2015-01-13

申请号：US12221399

申请日：2008-08-01

申请人： Ian Armitage ,  Eric L. Elliott ,  Marianne Langston ,  Steven P. Langston ,  Quentin J. McCubbin ,  Hirotake Mizutani ,  Matthew Stirling ,  Lei Zhu

发明人： Ian Armitage ,  Eric L. Elliott ,  Marianne Langston ,  Steven P. Langston ,  Quentin J. McCubbin ,  Hirotake Mizutani ,  Matthew Stirling ,  Lei Zhu

IPC分类号： C07D487/04 ,  C07C219/24 ,  C07D241/50 ,  C07D211/96 ,  C07D295/22 ,  C07C217/52 ,  C07D471/08 ,  C07C215/44 ,  C07D213/89 ,  C07D239/30 ,  C07C211/35

CPC分类号： C07D487/04 ,  C07C215/44 ,  C07C217/52 ,  C07C219/24 ,  C07C315/04 ,  C07C317/50 ,  C07C2601/08 ,  C07D211/96 ,  C07D213/89 ,  C07D241/50 ,  C07D295/22 ,  C07D305/08 ,  C07D471/08 ,  Y02P20/55

摘要： Disclosed are processes and synthetic intermediates for the synthesis of compounds of formula (V) wherein the variables have the definitions contained herein. Such compounds are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.

摘要翻译： 公开了用于合成式（V）化合物的方法和合成中间体，其中变量具有本文所含的定义。 这些化合物是E1活化酶抑制剂，并且可用于治疗细胞增殖，特别是癌症和与E1活性相关的其它病症的病症。

公开(公告)号：US20090036678A1

公开(公告)日：2009-02-05

申请号：US12221399

申请日：2008-08-01

申请人： Ian Armitage ,  Eric L. Elliott ,  Marianne Langston ,  Steven P. Langston ,  Quentin J. McCubbin ,  Hirotake Mizutani ,  Matthew Stirling ,  Lei Zhu

发明人： Ian Armitage ,  Eric L. Elliott ,  Marianne Langston ,  Steven P. Langston ,  Quentin J. McCubbin ,  Hirotake Mizutani ,  Matthew Stirling ,  Lei Zhu

IPC分类号： C07D487/04 ,  C07C211/00

CPC分类号： C07D487/04 ,  C07C215/44 ,  C07C217/52 ,  C07C219/24 ,  C07C315/04 ,  C07C317/50 ,  C07C2601/08 ,  C07D211/96 ,  C07D213/89 ,  C07D241/50 ,  C07D295/22 ,  C07D305/08 ,  C07D471/08 ,  Y02P20/55

摘要： The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1S,2S,4R)-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates, which are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.

摘要翻译： 本发明提供合成4-取代的（（1S，2S，4R）-2-羟基-4- {7H-吡咯并[2,3-d]嘧啶-7-基}环戊基）甲基的方法和合成中间体 氨基磺酸盐，其是E1活化酶抑制剂，并且可用于治疗细胞增殖，特别是癌症和与E1活性相关的其它病症的病症。

公开(公告)号：US20180354957A1

公开(公告)日：2018-12-13

申请号：US16058299

申请日：2018-08-08

申请人： Konstantin Petrukhin ,  Christopher Cioffi ,  Graham Johnson ,  Rando Allikmets ,  Emily Freeman ,  Ping Chen ,  Michael Conlon ,  Lei Zhu

发明人： Konstantin Petrukhin ,  Christopher Cioffi ,  Graham Johnson ,  Rando Allikmets ,  Emily Freeman ,  Ping Chen ,  Michael Conlon ,  Lei Zhu

IPC分类号： C07D487/04 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180222919A1

公开(公告)日：2018-08-09

申请号：US15944334

申请日：2018-04-03

申请人： Konstantin Petrukhin ,  Christopher Cioffi ,  Graham Johnson ,  Nicoleta Dobri ,  Emily Freeman ,  Ping Chen ,  Michael Conlon ,  Lei Zhu

发明人： Konstantin Petrukhin ,  Christopher Cioffi ,  Graham Johnson ,  Nicoleta Dobri ,  Emily Freeman ,  Ping Chen ,  Michael Conlon ,  Lei Zhu

IPC分类号： C07D498/04 ,  C07D213/79 ,  C07D213/80 ,  C07D231/56 ,  C07D237/24 ,  C07C233/56 ,  C07D249/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D239/28

CPC分类号： C07D498/04 ,  C07C233/56 ,  C07D213/79 ,  C07D213/80 ,  C07D231/56 ,  C07D237/24 ,  C07D239/28 ,  C07D249/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

摘要： The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US08995609B2

公开(公告)日：2015-03-31

申请号：US13565337

申请日：2012-08-02

申请人： Lei Zhu ,  Tianye Niu

发明人： Lei Zhu ,  Tianye Niu

IPC分类号： A61B6/00 ,  G01N23/04 ,  G21K1/02 ,  A61B6/03

CPC分类号： G01N23/046 ,  A61B6/032 ,  A61B6/4078 ,  A61B6/4233 ,  A61B6/483 ,  A61B6/508 ,  G01N2223/419 ,  G01N2223/612 ,  G21K1/02 ,  G21K2207/005

摘要： Briefly described, in an exemplary form, the present invention discloses a system, method and apparatus for X-ray Compton scatter imaging. In one exemplary embodiment, the present invention uses two detectors in a volumetric CT system. A first detector is positioned generally in-line with the angle of attack of the incoming energy, or, generally in-line of path x, where x is the path of the incoming energy. The first, or primary, detector detects various forms of radiation emanating from an object undergoing testing. In some embodiments, the present invention further comprises a Compton scattering system positioned generally normal to path x. In some embodiments, the Compton scattering subsystem comprises a second detector and a pin-hole collimator. The second detector detects Compton scattering energy from the object being tested.

摘要翻译： 简要描述，在示例性形式中，本发明公开了一种用于X射线康普顿散射成像的系统，方法和装置。 在一个示例性实施例中，本发明在体积CT系统中使用两个检测器。 第一检测器通常与入射能量的迎角定位，或者通常沿着路径x排列，其中x是入射能量的路径。 第一或第一检测器检测从经历测试的对象发出的各种形式的辐射。 在一些实施例中，本发明还包括通常垂直于路径x定位的康普顿散射系统。 在一些实施例中，康普顿散射子系统包括第二检测器和针孔准直器。 第二个检测器检测来自被测物体的康普顿散射能量。

公开(公告)号：US08809906B2

公开(公告)日：2014-08-19

申请号：US13613177

申请日：2012-09-13

申请人： Lei Zhu ,  Shigeaki Sekiguchi ,  Shinsuke Tanaka ,  Kenichi Kawaguchi

发明人： Lei Zhu ,  Shigeaki Sekiguchi ,  Shinsuke Tanaka ,  Kenichi Kawaguchi

IPC分类号： H01L31/102

CPC分类号： G02B6/122 ,  G02B6/29352 ,  G02B2006/121 ,  G02F1/025 ,  H01L31/105

摘要： A semiconductor optical device includes a first clad layer, a second clad layer and an optical waveguide layer sandwiched between the first clad layer and the second clad layer, wherein the optical waveguide layer includes a first semiconductor layer, a second semiconductor layer disposed on the first semiconductor layer and extending in one direction, and a third semiconductor layer covering a top surface of the second semiconductor layer, and wherein the first semiconductor layer includes an n-type region disposed on one side of the second semiconductor layer, a p-type region disposed on the other side of the second semiconductor layer, and an i-type region disposed between the n-type region and the p-type region, and wherein the second semiconductor layer has a band gap narrower than band gaps of the first semiconductor layer and the third semiconductor layer.

摘要翻译： 半导体光学器件包括第一覆盖层，第二覆盖层和夹在第一覆盖层和第二覆盖层之间的光波导层，其中，光波导层包括第一半导体层，第二半导体层，设置在第一覆盖层 半导体层并且沿一个方向延伸，以及覆盖第二半导体层的顶表面的第三半导体层，并且其中第一半导体层包括设置在第二半导体层一侧的n型区域，p型区域 设置在第二半导体层的另一侧，以及设置在n型区域和p型区域之间的i型区域，并且其中第二半导体层具有比第一半导体层的带隙窄的带隙 和第三半导体层。

公开(公告)号：US08705827B2

公开(公告)日：2014-04-22

申请号：US13088134

申请日：2011-04-15

申请人： Lei Zhu ,  Tianye Niu

发明人： Lei Zhu ,  Tianye Niu

IPC分类号： G06K9/00

CPC分类号： G06T5/002 ,  G06T5/50 ,  G06T11/005 ,  G06T2207/10081 ,  G06T2207/20224

摘要： Described herein are improved methods for correcting cone beam computed tomography signals to reduce scatter contamination contained therein. Generally, the improved methods involve generating a plurality of two-dimensional projection images of a subject from a three-dimensional multi-detector computed tomography image of the subject. This is followed by subtracting the plurality of two-dimensional projection images from a plurality of two-dimensional cone beam projection images of the subject to produce a plurality of two-dimensional estimated error projections that comprise an estimated error in the plurality of two-dimensional cone beam projection images. The plurality of two-dimensional estimated error projection images are subtracted from the plurality of two-dimensional cone beam projection images to generate a plurality of two-dimensional corrected cone beam projection images. A three-dimensional corrected cone beam computed tomography image of the subject is then constructed from the plurality of two-dimensional corrected cone beam projection images.

摘要翻译： 这里描述了用于校正锥形束计算机断层摄影信号以减少其中包含的散射污染的改进方法。 通常，改进的方法包括从受试者的三维多检测器计算机断层摄影图像生成受试者的多个二维投影图像。 随后从对象的多个二维锥形束投影图像中减去多个二维投影图像，以产生多个二维估计误差投影，其包括多个二维投影图像中的估计误差 锥形投影图像。 从多个二维锥形束投影图像中减去多个二维估计误差投影图像，以产生多个二维校正锥束投影图像。 然后从多个二维校正的锥形束投影图像中构建被摄体的三维校正锥束计算机断层摄影图像。

公开(公告)号：US20130032715A1

公开(公告)日：2013-02-07

申请号：US13565337

申请日：2012-08-02

申请人： Lei Zhu ,  Tianye Niu

发明人： Lei Zhu ,  Tianye Niu

IPC分类号： G01N23/02 ,  G21K1/02 ,  A61B6/03

CPC分类号： G01N23/046 ,  A61B6/032 ,  A61B6/4078 ,  A61B6/4233 ,  A61B6/483 ,  A61B6/508 ,  G01N2223/419 ,  G01N2223/612 ,  G21K1/02 ,  G21K2207/005

摘要： Briefly described, in an exemplary form, the present invention discloses a system, method and apparatus for X-ray Compton scatter imaging. In one exemplary embodiment, the present invention uses two detectors in a volumetric CT system. A first detector is positioned generally in-line with the angle of attack of the incoming energy, or, generally in-line of path x, where x is the path of the incoming energy. The first, or primary, detector detects various forms of radiation emanating from an object undergoing testing. In some embodiments, the present invention further comprises a Compton scattering system positioned generally normal to path x. In some embodiments, the Compton scattering subsystem comprises a second detector and a pin-hole collimator. The second detector detects Compton scattering energy from the object being tested.

摘要翻译： 简要描述，在示例性形式中，本发明公开了一种用于X射线康普顿散射成像的系统，方法和装置。 在一个示例性实施例中，本发明在体积CT系统中使用两个检测器。 第一检测器通常与入射能量的迎角定位，或者通常沿着路径x排列，其中x是入射能量的路径。 第一或第一检测器检测从经历测试的对象发出的各种形式的辐射。 在一些实施例中，本发明还包括通常垂直于路径x定位的康普顿散射系统。 在一些实施例中，康普顿散射子系统包括第二检测器和针孔准直器。 第二个检测器检测来自被测物体的康普顿散射能量。

公开(公告)号：US20130023653A1

公开(公告)日：2013-01-24

申请号：US13550488

申请日：2012-07-16

申请人： Lei Zhu ,  Wen Zhou ,  Robert J. Etches

发明人： Lei Zhu ,  Wen Zhou ,  Robert J. Etches

IPC分类号： C07K16/02 ,  A01K67/027 ,  C12P21/08

CPC分类号： A01K67/0275 ,  A01K67/0278 ,  A01K2217/052 ,  A01K2227/30 ,  A01K2267/01 ,  C07K16/02 ,  C07K2317/11 ,  C07K2317/732 ,  C07K2317/77 ,  C12N15/8509

摘要： Transgenes encoding exogenous antibodies are stably integrated into donor cells and are present in the somatic tissue of chimeric birds. The transgenes encode exogenous antibodies and are preferably expressed in the oviduct for collection in the egg. Tissue specificity is provided by selecting the content of the transgene accordingly. Birds whose genome is comprised of trangene-derived exogenous antibody-encoding DNA express exogenous antibodies having desirable chemical properties with increased therapeutic utility compared to antibodies derived from bacterial expression systems.

摘要翻译： 编码外源抗体的转基因稳定整合到供体细胞中，并存在于嵌合鸟的体细胞组织中。 转基因编码外源抗体，优选在输卵管中表达以在卵中收集。 通过选择转基因的含量来提供组织特异性。 其基因组由转基因衍生的外源抗体编码DNA组成的鸟类表达具有理想化学性质的外源性抗体，与来自细菌表达系统的抗体相比具有更高的治疗效用。

公开(公告)号：US20110306605A1

公开(公告)日：2011-12-15

申请号：US13140791

申请日：2009-12-21

申请人： Lei Zhu ,  Hakim Djaballah ,  Yueming Li ,  Christopher Chad Shelton

发明人： Lei Zhu ,  Hakim Djaballah ,  Yueming Li ,  Christopher Chad Shelton

IPC分类号： A61K31/5513 ,  A61P35/00 ,  A61P29/00 ,  A61K31/381

CPC分类号： C07D493/04 ,  C07D213/69 ,  C07D215/20 ,  C07D215/22 ,  C07D309/38 ,  C07D311/56 ,  C07D335/06 ,  C07D491/04 ,  C07D495/04

摘要： Compounds including those of the Formula I where X, R1, R2 and subscript t are as defined herein, useful as γ-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compounds for treating or preventing neurodegenerative diseases, such as, for instance, Alzheimer's disease.

摘要翻译： 提供了包括式I的化合物，其中X，R 1，R 2和下标t如本文所定义，可用作γ-分泌酶抑制剂，以及包含该化合物的组合物以及用于治疗或 预防神经变性疾病，例如阿尔茨海默氏病。