COAGULATION FACTOR-TARGETING TO TLT-1 ON ACTIVATED PLATELETS
    1.
    发明申请
    COAGULATION FACTOR-TARGETING TO TLT-1 ON ACTIVATED PLATELETS 审中-公开
    凝血因子对TLT-1在活化板上的靶向

    公开(公告)号:US20130337537A1

    公开(公告)日:2013-12-19

    申请号:US13982360

    申请日:2012-03-02

    IPC分类号: C12N9/96

    摘要: The current invention relates to: procoagulant proteins which may, for example, be fusion proteins or chemical conjugates; methods of producing said procoagulant proteins; polynucleotides that encode said fusion proteins and cells that expresses them. Furthermore, the current invention relates to procoagulant proteins for use as a medicament. Individuals that have a coagulopathy, such as haemophilia A and B with or without inhibitors, may be treated with the procoagulant proteins of the current invention.

    摘要翻译: 本发明涉及:促凝血蛋白,其可以是例如融合蛋白或化学结合物; 生产所述促凝血蛋白的方法; 编码所述融合蛋白的多核苷酸和表达它们的细胞。 此外,本发明涉及用作药物的促凝血蛋白。 具有凝血病的个体,例如具有或不具有抑制剂的血友病A和B,可用本发明的促凝血蛋白进行治疗。

    Fungicidally active compounds
    9.
    发明授权
    Fungicidally active compounds 失效
    杀真菌活性化合物

    公开(公告)号:US5631223A

    公开(公告)日:1997-05-20

    申请号:US468157

    申请日:1995-06-06

    CPC分类号: A01N63/04 C07K11/02 C07K7/06

    摘要: Novel compounds of the general composition I, Lactate (1), Glycine (1), Valine (1), Isoleucine (1), pipecolic acid (1), Aspanic acid (1), Tyrosine (1), wherein each amino acid residue independently may occur in L- or D- form, and wherein the number in parenthesis indicates the number of occurrences of each moiety, and derivatives thereof are disclosed. The compounds are producible by aerobic cultivation on suitable nutrient media under suitable conditions of a strain of the fungus Culvularia sp., subsequent recovery of the active component from the fermentation medium, and optionally modifying the active compound to obtain a compound of the desired general composition. Disclosed are also microorganisms capable of producing said compounds, compositions containing said compounds, and the use of such compositions for controlling fungi in crops, and in the preservation of wood, paints, cosmetics, and edible products.

    摘要翻译: 一般组合物I,乳酸(1),甘氨酸(1),缬氨酸(1),异亮氨酸(1),哌可酸(1),阿拉伯酸(1),酪氨酸(1))的新型化合物,其中每个氨基酸残基 独立地可以以L-或D-形式存在,并且其中括号中的数字表示每个部分的出现次数,并且其衍生物被公开。 这些化合物可以通过在合适的营养培养基上在真菌Culvularia sp菌株的合适条件下进行需氧培养来生产,随后从发酵培养基中回收活性成分,以及任选地改性活性化合物以获得所需的一般组成的化合物 。 还公开了能够产生所述化合物的微生物,含有所述化合物的组合物,以及这些组合物用于控制作物中的真菌以及保护木材,油漆,化妆品和可食用产品的用途。