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公开(公告)号:US20130337537A1
公开(公告)日:2013-12-19
申请号:US13982360
申请日:2012-03-02
申请人: Ida Hilden , Bernd Peschke , Jens Breinholt , Mikael Kofod-Hansen
发明人: Ida Hilden , Bernd Peschke , Jens Breinholt , Mikael Kofod-Hansen
IPC分类号: C12N9/96
摘要: The current invention relates to: procoagulant proteins which may, for example, be fusion proteins or chemical conjugates; methods of producing said procoagulant proteins; polynucleotides that encode said fusion proteins and cells that expresses them. Furthermore, the current invention relates to procoagulant proteins for use as a medicament. Individuals that have a coagulopathy, such as haemophilia A and B with or without inhibitors, may be treated with the procoagulant proteins of the current invention.
摘要翻译: 本发明涉及:促凝血蛋白,其可以是例如融合蛋白或化学结合物; 生产所述促凝血蛋白的方法; 编码所述融合蛋白的多核苷酸和表达它们的细胞。 此外,本发明涉及用作药物的促凝血蛋白。 具有凝血病的个体,例如具有或不具有抑制剂的血友病A和B,可用本发明的促凝血蛋白进行治疗。
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公开(公告)号:US20120178908A1
公开(公告)日:2012-07-12
申请号:US13391755
申请日:2010-08-26
申请人: Ida Hilden , Lars Christian Petersen , Jens Breinholt , Mette Dahl Andersen , Jais Rose Bjeike , Thomas Egebjerg
发明人: Ida Hilden , Lars Christian Petersen , Jens Breinholt , Mette Dahl Andersen , Jais Rose Bjeike , Thomas Egebjerg
CPC分类号: C07K16/2803 , A61K38/00 , C07K14/745 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/92 , C07K2319/33
摘要: The current invention relates to procoagulant fusion proteins, polynucleotides that encode said fusion proteins and cells that expresses said fusion proteins. Furthermore, the current invention relates to fusion proteins for use as a medicament. Individuals that have a coagulopathy, such as haemophilia A and B with or without inhibitors, may be treated with fusions proteins of the current invention.
摘要翻译: 本发明涉及促凝血融合蛋白,编码所述融合蛋白的多核苷酸和表达所述融合蛋白的细胞。 此外,本发明涉及用作药物的融合蛋白。 具有凝血病的个体,例如具有或不具有抑制剂的血友病A和B,可以用本发明的融合蛋白进行治疗。
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公开(公告)号:US08361469B2
公开(公告)日:2013-01-29
申请号:US13140296
申请日:2009-12-18
申请人: Ida Hilden , Berit Olsen Krogh , Jes Thorn Clausen , Ole Hvilsted Olsen , Jens Breinholt , Brian Lauritzen , Brit Binow Sørensen
发明人: Ida Hilden , Berit Olsen Krogh , Jes Thorn Clausen , Ole Hvilsted Olsen , Jens Breinholt , Brian Lauritzen , Brit Binow Sørensen
IPC分类号: A61K39/395
CPC分类号: C07K16/38 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要: The invention relates to antibodies that specifically bind to tissue factor pathway inhibitor (TFPI) and that reduce the clotting time of blood. Such antibodies have utility in the treatment of subjects with a coagulopathy.
摘要翻译: 本发明涉及特异性结合组织因子途径抑制剂(TFPI)并降低血液凝固时间的抗体。 这样的抗体可用于治疗具有凝血病的受试者。
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公开(公告)号:US20110318356A1
公开(公告)日:2011-12-29
申请号:US13140296
申请日:2009-12-18
申请人: Ida Hilden , Berit Olsen Krogh , Jes Thorn Clausen , Ole Hvilsted Olsen , Jens Breinholt , Brian Lauritzen , Brit Binow Sørensen
发明人: Ida Hilden , Berit Olsen Krogh , Jes Thorn Clausen , Ole Hvilsted Olsen , Jens Breinholt , Brian Lauritzen , Brit Binow Sørensen
CPC分类号: C07K16/38 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要: The invention relates to antibodies that specifically bind to tissue factor pathway inhibitor (TFPI) and that reduce the clotting time of blood. Such antibodies have utility in the treatment of subjects with a coagulopathy.
摘要翻译: 本发明涉及特异性结合组织因子途径抑制剂(TFPI)并降低血液凝固时间的抗体。 这样的抗体可用于治疗具有凝血病的受试者。
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公开(公告)号:US20100249029A1
公开(公告)日:2010-09-30
申请号:US12667778
申请日:2008-03-07
申请人: Jens Breinholt , Kent Bondensgaard , Leif Christensen , Leif Nørskov-Lauritzen , Wang Lingyun , Gong Wei , Liu Yun , Sean Hu , Quinhong Ma
发明人: Jens Breinholt , Kent Bondensgaard , Leif Christensen , Leif Nørskov-Lauritzen , Wang Lingyun , Gong Wei , Liu Yun , Sean Hu , Quinhong Ma
CPC分类号: C07K14/57554 , A61K38/00
摘要: The invention relates to variants of prolactin, which variants have high affinity for the prolactin receptor.
摘要翻译: 本发明涉及催乳素的变体,该变体对催乳素受体具有高亲和力。
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公开(公告)号:US07238350B2
公开(公告)日:2007-07-03
申请号:US09999214
申请日:2001-11-30
申请人: Soren Flensted Lassen , Lisbeth Bech , Anders Ohmann , Jens Breinholt , Claus Crone Fuglsang , Peter Rahbek Ostergaard
发明人: Soren Flensted Lassen , Lisbeth Bech , Anders Ohmann , Jens Breinholt , Claus Crone Fuglsang , Peter Rahbek Ostergaard
CPC分类号: C12Y301/03026 , A23K20/189 , A23L5/25 , A23L29/06 , A63B57/00 , A63B57/357 , A63B57/40 , C12N9/16 , C12P3/00
摘要: The present invention relates to isolated polypeptides having phytase activity, the corresponding cloned DNA sequences, a process for preparing such polypeptides, and the use thereof for a number of industrial applications. In particular, the invention relates to phytases derived from the phyllum Basidiomycota, phytases of certain consensus sequences and fungal 6-phytases.
摘要翻译: 本发明涉及具有植酸酶活性的分离的多肽,相应的克隆的DNA序列,制备该多肽的方法及其在许多工业应用中的应用。 特别地,本发明涉及源自担子菌的植酸酶,某些共有序列的植酸酶和真菌6-肌醇六磷酸酶。
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公开(公告)号:US20050101573A1
公开(公告)日:2005-05-12
申请号:US11014153
申请日:2004-12-16
IPC分类号: A61K31/575 , A61P43/00 , C07J9/00 , C07J21/00 , C07J41/00 , C07J43/00 , C07J53/00 , A61K31/66 , A61K31/56 , C07J1/00
CPC分类号: C07J41/0094 , C07J9/00 , C07J53/004
摘要: Certain novel sterol derivatives can be used for regulating the meiosis in oocytes and in male germ cells.
摘要翻译: 某些新的甾醇衍生物可用于调节卵母细胞和雄性生殖细胞中的减数分裂。
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公开(公告)号:US5641804A
公开(公告)日:1997-06-24
申请号:US392879
申请日:1995-03-03
申请人: Jens Breinholt , Ruby Ione Nielsen
发明人: Jens Breinholt , Ruby Ione Nielsen
IPC分类号: A01N43/90 , A23K3/00 , A23L3/3499 , A23L3/3544 , A61K8/00 , A61K8/49 , A61K8/99 , B27K3/34 , C07D323/00 , C12P17/08 , C12R1/80 , C12P1/02
CPC分类号: C12P17/08 , A01N43/90 , A23K30/00 , A23L3/3499 , A23L3/3544 , C07D323/00 , B27K3/343 , B27K3/38
摘要: The invention is directed to compounds having general formula (I) or general formula (II). Compounds of formulae (I) or (II) have interesting antifungal activities and may, accordingly, be used as active ingredients in fungicidal compositions. ##STR1##
摘要翻译: PCT No.PCT / DK93 / 00293 Sec。 371日期1995年3月3日 102(e)1995年3月3日PCT PCT 1993年9月14日PCT公布。 出版物WO94 / 06788 日期:1994年3月31日本发明涉及具有通式(I)或通式(II)的化合物。 式(I)或(II)的化合物具有有趣的抗真菌活性,因此可用作杀真菌组合物中的活性成分。
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公开(公告)号:US5631223A
公开(公告)日:1997-05-20
申请号:US468157
申请日:1995-06-06
申请人: Jens Breinholt , Ruby I. Nielsen , Georg W. Jensen
发明人: Jens Breinholt , Ruby I. Nielsen , Georg W. Jensen
IPC分类号: A01N63/04 , A23K1/16 , A23L3/3571 , A61K8/00 , A61K8/30 , A61K8/40 , A61K8/42 , A61K8/46 , A61K8/49 , A61K8/64 , A61K8/99 , A61K38/00 , A61P31/04 , A61P31/10 , B27K3/34 , C07K1/113 , C07K7/06 , C07K11/02 , C07K14/005 , C07K14/195 , C07K14/41 , C12N1/14 , C12P21/02 , C12P21/04 , C12R1/645
摘要: Novel compounds of the general composition I, Lactate (1), Glycine (1), Valine (1), Isoleucine (1), pipecolic acid (1), Aspanic acid (1), Tyrosine (1), wherein each amino acid residue independently may occur in L- or D- form, and wherein the number in parenthesis indicates the number of occurrences of each moiety, and derivatives thereof are disclosed. The compounds are producible by aerobic cultivation on suitable nutrient media under suitable conditions of a strain of the fungus Culvularia sp., subsequent recovery of the active component from the fermentation medium, and optionally modifying the active compound to obtain a compound of the desired general composition. Disclosed are also microorganisms capable of producing said compounds, compositions containing said compounds, and the use of such compositions for controlling fungi in crops, and in the preservation of wood, paints, cosmetics, and edible products.
摘要翻译: 一般组合物I,乳酸(1),甘氨酸(1),缬氨酸(1),异亮氨酸(1),哌可酸(1),阿拉伯酸(1),酪氨酸(1))的新型化合物,其中每个氨基酸残基 独立地可以以L-或D-形式存在,并且其中括号中的数字表示每个部分的出现次数,并且其衍生物被公开。 这些化合物可以通过在合适的营养培养基上在真菌Culvularia sp菌株的合适条件下进行需氧培养来生产,随后从发酵培养基中回收活性成分,以及任选地改性活性化合物以获得所需的一般组成的化合物 。 还公开了能够产生所述化合物的微生物,含有所述化合物的组合物,以及这些组合物用于控制作物中的真菌以及保护木材,油漆,化妆品和可食用产品的用途。
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公开(公告)号:US20110306548A1
公开(公告)日:2011-12-15
申请号:US13144757
申请日:2010-01-22
申请人: Ole Hvilsted Olsen , Jens Breinholt , Christine Bruun Schiødt , Helle Demuth , Leif Nørskov-Lauritsen , Peter Thygesen
发明人: Ole Hvilsted Olsen , Jens Breinholt , Christine Bruun Schiødt , Helle Demuth , Leif Nørskov-Lauritsen , Peter Thygesen
摘要: The present invention relates to stable growth hormone (GH) compounds, which through the introduction of cysteine residues have disulphide bridges, which make the compounds resistant to proteolytic degradation.
摘要翻译: 本发明涉及稳定生长激素(GH)化合物,其通过引入半胱氨酸残基具有二硫键,这使得化合物对蛋白水解降解具有抗性。
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