摘要:
Ophthalmic devices suitable for implantation into the eye through small incisions are disclosed. These devices are made from a composition comprising crystalline or semi-crystalline polymeric materials which have a glass transition temperature (Tg) of from about −100° C. to about 20° C., a melting point temperature (Tm) of from about 0° C. to about 37° C., and wherein Tg for the material is lower than Tm for the composition. Disclosed devices include intraocular lenses, corneal inlays, ocular drug delivery devices and implants for reducing intraocular pressure in glaucoma patients; intraocular lenses are preferred.
摘要:
A method of preparing phakic intraocular lenses from hydrophobic materials is described. In this process, the lens is tested to determine whether it can float submerged in an aqueous medium. If it cannot (e.g., if it remains on top of the aqueous medium), the lens is surface treated (for example, by vacuum UV or corona discharge processes) to increase its wetting ability (e.g., to reduce its hydrophobicity). The lenses prepared by this process are also described.
摘要:
A phakic refractive lens which conforms to the structure of the eye, particularly to the ciliary sulcus, is disclosed. This lens minimizes stresses of the lens on the interior structure of the eye and eliminates excessive vaulting of the lens which tends to deform the shape of the eye and/or structures in the eye. The lenses comprise an optical body and at least one haptic body. The haptic body(ies) is made up of a first portion adjacent to the optical body, a second portion which extends outwardly from the first haptic portion, and a transition zone between the first and second haptic portions (for example, a groove or score line in the lens surface) which permits the second haptic portion to conform to the shape of the ciliary sulcus of the eye.
摘要:
An accommodative intraocular lens is disclosed. The lens provides multiple focuses as the result of a bi-directional shift along the eye's optical axis, and also minimizes or prevents posterior chamber opacification. The lens includes a first component which consists of an optical body and a haptic body, a second component which is structurally adapted to maintain substantial contact with the posterior surface of the capsular bag of the eye (when implanted in the eye), and a transition zone connecting the first and second components. The method of implanting the lens in the eye and the method of making the lens are also disclosed.
摘要:
A lens for placement in a human eye, such as an intraocular lens, has at least some of its optical properties modified with a laser. The lens preferably contains at least 5% by weight UV absorber so commercially feasible rates of manufacture can be achieved. The laser forms modified loci in the lens where the modified loci have a different refractive index than the refractive index of the material before modification. The same laser modification technique can be used on the cornea in situ.
摘要:
A shape transformable medical implant or optical lens capable of substantial recoverable deformation in all dimensions is rapidly inserted and positioned into a target site such as an eye through an ejector having a small diameter, elongate, generally tubular outlet. The medical implant or optical lens is formed of a material having an elongation at break greater than 100% facilitating its ejection into the eye through a tubular outlet having an inner diameter of 3 mm or less. The ejector is provided with a precisely pressurizable chamber for the controlled displacement of the medical implant or optical lens through the small diameter, elongate, generally tubular outlet.
摘要:
Organosiloxane compositions curable to optically clear, high refractive index elastomers are disclosed. The cured compositions have superior post-folding high resolution recovery making them suitable for fabricating foldable intraocular lenses used in small-incision ophthalmic surgeries. The organosiloxane compositions include first and second vinyl terminated organosiloxanes differing in molecular weights, each containing diphenylsiloxane and dimethylsiloxane, and, in addition, fumed silica, a crosslinking reagent, a platinum containing catalyst, and optionally an ultraviolet absorbing compound.
摘要:
Optically transparent, high refractive index hydrogels are provided. Expansile hydrogel intraocular lenses are fabricated from the hydrogels by heating them above their elastic deformation temperatures and deforming them into an elongated configuration having at least one reduced dimension suitable for insertion through a small surgical incision. The lenses are allowed to cool in this configuration and retain the deformed shape prior to surgical implantation. Following implantation the lenses hydrate into an enlarged elastic form reassuming the original lens configuration of full capsule size.
摘要:
Random or block copolymers with (1-hydro-1-R-1-sila-cis-pent-3-ene), poly(1-hydro-1-R-3,4 benzo-1-sila pent-3-ene), and disubstituted 1-silapent-3-ene repeating units of the general formula ##STR1## where R is hydrogen, an alkyl radical containing from one to four carbon atoms or phenyl, R.sup.1 is hydrogen, an alkyl radical containing from one to four carbon atoms, phenyl or a halogen and R.sup.2 is hydrogen, or R.sup.1 and R.sup.2 are combined to form a phenyl ring, are prepared by the anionic ring opening polymerization of silacyclopent-3-enes or 2-silaindans with an organometallic base and cation coordinating ligand catalyst system or a metathesis ring opening catalyst system.
摘要:
An accommodative intraocular lens system for treating presbyopic is disclosed. The system includes a first lens having negative optic power adapted for placement in the posterior chamber of the eye and capable of moving forward and back along the optic axis; and a second lens having a positive optic power which is implanted within the capsular bag. The second lens can be the natural crystalline lens of the eye. The position of the first lens, forward or back relative to the second lens, focuses the eye for seeing distant or close-in objects.