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公开(公告)号:US06908737B2
公开(公告)日:2005-06-21
申请号:US10119814
申请日:2002-04-09
IPC分类号: B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B40/10 , G01N33/543 , G01N33/58 , C12Q1/68
CPC分类号: G01N33/587 , B01J19/0046 , B01J2219/00497 , B01J2219/005 , B01J2219/0052 , B01J2219/00524 , B01J2219/00527 , B01J2219/0054 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00657 , B01J2219/00659 , B01J2219/00673 , B01J2219/00702 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , G01N33/54366 , Y10S435/808 , Y10S435/968 , Y10S436/807
摘要: A method for multiplexed detection and quantification of analytes by reacting them with probe molecules attached to specific and identifiable carriers. These carriers can be of different size, shape, color, and composition. Different probe molecules are attached to different types of carriers prior to analysis. After the reaction takes place, the carriers can be automatically analyzed. This invention obviates cumbersome instruments used for the deposition of probe molecules in geometrically defined arrays. In the present invention, the analytes are identified by their association with the defined carrier, and not (or not only) by their position. Moreover, the use of carriers provides a more homogenous and reproducible representation for probe molecules and reaction products than two-dimensional imprinted arrays or DNA chips.
摘要翻译: 通过使分析物与附着于特定和可鉴定载体的探针分子反应来多重检测和定量分析物的方法。 这些载体可以具有不同的尺寸,形状,颜色和组成。 在分析之前,不同的探针分子连接到不同类型的载体上。 反应发生后,可以自动分析载体。 本发明避免了用于在几何定义的阵列中沉积探针分子的麻烦的仪器。 在本发明中,分析物通过它们与所定义的载体的缔合而被识别,而不是(或不仅)它们的位置。 此外,与二维印迹阵列或DNA芯片相比,载体的使用为探针分子和反应产物提供了更均匀和可重复的表示。
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公开(公告)号:US07557070B2
公开(公告)日:2009-07-07
申请号:US10120900
申请日:2002-04-10
IPC分类号: C40B60/00
CPC分类号: B01J19/0046
摘要: Systems including apparatus, methods, compositions, and kits for multiplexed analysis of biological systems using nonpositional and/or positional arrays of coded carriers.
摘要翻译: 包括使用编码载体的非位置和/或位置阵列的生物系统多重分析的装置,方法,组合物和试剂盒的系统。
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公开(公告)号:US07488451B2
公开(公告)日:2009-02-10
申请号:US10901942
申请日:2004-07-28
IPC分类号: G01N35/10
CPC分类号: G01N35/1011 , B01J2219/00364 , B01J2219/00414 , B01J2219/00423 , B01J2219/00466 , B01J2219/005 , B01L3/021 , B01L3/5085 , B01L2200/025 , B01L2200/0642 , B01L2200/0647 , B01L2200/0657 , B01L2200/143 , B01L2300/0627 , B01L2300/0681 , B01L2300/0829 , B01L2300/0851 , B01L2300/0867 , B01L2300/0887 , B01L2300/168 , B01L2400/0487 , C12M33/04 , G01N35/026
摘要: Systems, including methods and apparatus, for particle manipulation to perform assays.
摘要翻译: 用于进行测定的粒子操作的系统,包括方法和装置。
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公开(公告)号:US5550060A
公开(公告)日:1996-08-27
申请号:US237095
申请日:1994-05-03
CPC分类号: A61K35/18 , C12N15/8289 , Y10T436/115831
摘要: Methods and apparatus for separating red blood cells by density are described. Older red blood cells are more dense than younger ones. Certain changes in the physiology are recorded in changes in hemoglobin or the red blood cells. By assaying different aged red blood cells, one can determine the historical physiological changes over a period of many weeks. Improved separation of red blood cells is accomplished by using rigid capillary tubes having an inner surface which augments the density equilibrium of red blood cells and/or incrementally increasing the centrifugation forces, as well as by chemically treating red blood cells to improve their deformability.
摘要翻译: 描述了通过密度分离红细胞的方法和装置。 较老的红细胞比较年轻的血细胞更密集。 生理学中的某些变化记录在血红蛋白或红细胞的变化中。 通过分析不同的老年红细胞,可以确定多周的历史生理变化。 通过使用具有增加红细胞的密度平衡的内表面和/或逐渐增加离心力的内表面的刚性毛细管以及通过化学处理红细胞以改善其变形能力来实现红细胞分离的改进。
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公开(公告)号:US5334529A
公开(公告)日:1994-08-02
申请号:US988009
申请日:1992-12-10
CPC分类号: A01H5/10
摘要: Stably transformed Coffea arabica plant cells, derived from protoplasts and capable of regeneration, are disclosed.
摘要翻译: 公开了源自原生质体并能够再生的稳定转化的咖啡阿拉伯咖啡植物细胞。
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