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    Hydrophilic polymers with pendant functional groups and method thereof
    6.
    发明申请
    Hydrophilic polymers with pendant functional groups and method thereof 审中-公开

    公开(公告)号：US20060263328A1

    公开(公告)日：2006-11-23

    申请号：US11134820

    申请日：2005-05-19

    申请人： Sang Van ,  Lei Yu

    发明人： Sang Van ,  Lei Yu

    IPC分类号： A61K31/787 ,  C08G63/91 ,  C08G63/48

    CPC分类号： C08G69/26 ,  A61K47/595 ,  A61K47/60 ,  C08G69/02

    摘要： A polymer comprising a recurring unit of the formula (I) is described. In the formula (I), X is selected from the group consisting of —(CH2CH2O)m—CH2CH2— and —CH2CH2CH2O—(CH2CH2O)m—CH2CH2CH2—, wherein m is an integer in the range of 1 to 100; Y is selected from the group consisting of —C*HCH2—, —C*HCH2CH2—, —C*H—NHC(═O)—CH2CH2—, —C*H—NHC(═O)—CH2CH2CH2—, —CH2CH2N*CH2CH2—, —CH2CH2CH2N*CH2CH2CH2—, C2 to C20 alkyl, and C6 to C20 aryl, wherein C* and N* represent atoms to which Z is bonded; and Z is selected from the group consisting of —NHR1, —NH—C(═O)—(CH2)nC(═O)NR1R1, —NH—C(═O)—(CH2)nC(═O)OR1, —(CH2)nC(═O)NR1R2, —(CH2)nC(═O)OR1, —(CH2)nC(═O)SR1, and —(CH2)nNR1R2, wherein n is an integer in the range of 1 to 3, wherein R1 and R2 are each independently selected from the group consisting of hydrogen, C1 to C20 alkyl, C6 to C20 aryl, anticancer drugs, peptides, antibody fragment, lactose, galactose, mannose, transferrin, magnetic resonance imaging agents, succinimyl, and alkali metal.

    END-CAPPED POLYMERS
    9.
    发明申请
    END-CAPPED POLYMERS 审中-公开
    封端聚合物

    公开(公告)号：US20120052015A1

    公开(公告)日：2012-03-01

    申请号：US13213037

    申请日：2011-08-18

    申请人： Lei Yu ,  Hai Wang ,  Kwok Yin Tsang ,  Yi Jin ,  Sang Van

    发明人： Lei Yu ,  Hai Wang ,  Kwok Yin Tsang ,  Yi Jin ,  Sang Van

    IPC分类号： A61K47/48 ,  A61K49/12 ,  A61P35/00 ,  C08G69/48

    CPC分类号： A61K49/146 ,  A61K47/645 ,  C08G69/48

    摘要： Polymers that can include an end-cap selected from Formula (I) and/or Formula (II) and a recurring unit of the Formulae (III), and/or (IV). The polymers can include various substituents such as drug, targeting agents, stabilizing agents, imaging agent and polydentate ligands. Such polymer can be useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.

    摘要翻译： 可以包括选自式（I）和/或式（II）的端帽和式（III）和/或（IV）的重复单元的聚合物。 聚合物可以包括各种取代基，例如药物，靶向剂，稳定剂，显像剂和多齿配体。 这种聚合物可用于各种药物，靶向，稳定和/或成像剂递送应用。