摘要:
A contact lens is provided in which tunable nanoparticles are embedded or otherwise coated on the lens to extinguish near-infrared energy. In one preferred embodiment, the tunable nanoparticles are nanoshells consisting of a dielectric core and a metal shell, wherein the plasmon resonance frequency is determined by the relative size of the core and the metal shell. With the capability to alter the relative size of the core and the metal shell, nanoshells are uniquely tunable nanoparticles, allowing a range of optical extinctions. In another embodiment, the nanoshells are tuned to extinguish energy from other parts of the energy spectrum. In one desired embodiment of the invention, these plasmon resonant structures are introduced into the lens polymer prior to formation or manufacturing of a lens. In another embodiment of the invention, these nanoshells are coated on a contact lens after formation of the lens.
摘要:
A process for producing turbine rotors and other large rotating components of power-generating gas turbine engines using powder metallurgy techniques. The process involves forming a powder of a gamma prime or gamma double prime precipitation-strengthened nickel-based superalloy whose particles are about 0.100 mm in diameter or smaller. The powder is placed in a can and consolidated to produce an essentially fully dense consolidation, which is then hot worked to produce a billet of a size sufficient to form a forging of at least 2300 kg. The billet is forged at a temperature and strain rate to produce a forging with a uniform fine grain of ASTM 10 or finer. Thereafter, the forging may undergo a heat treatment to achieve a desired balance of mechanical properties while retaining a uniform grain size of ASTM 10 or finer.
摘要:
An aircraft flight surface control system and method simultaneously provides the benefits of both an active/active system architecture and in active/standby system architecture. The system is preferably implemented using hydraulic actuator assemblies and electromechanical actuator assemblies coupled to the same flight control surface. During normal system operations the electromechanical actuator assemblies are energized to supply a relatively minimal force to associated flight control surfaces. In effect, the electromechanical actuators, although energized, may be pulled along by the associated hydraulic actuator assemblies, until needed. Thus, the electromechanical actuator assemblies are controlled in a manner that closely resembles the active/standby architecture.
摘要:
The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including (i) a column plate having an array of minicolumns into which samples can be placed, (ii) a discrete filter element disposed in each minicolumn, (iii) a drip-director plate having a corresponding array of drip directors through which filtrate may egress, and (iv) a receiving-well plate having a corresponding array of receiving wells into which filtrate can flow. The invention provides multi-well microfiltration arrangements that are relatively simple to manufacture and that overcome many of the problems associated with the prior arrangements relating to (i) cross-contamination due to wicking across a common filter sheet or (ii) individual filter elements entrapping sample constituents within substantial dead volumes. Further, the invention provides multi-well microfiltration arrangements that adequately support discrete filter elements disposed in the wells without creating substantial preferential flow. Additionally, the invention provides multi-well microfiltration arrangements that avoid cross-contamination due to aerosol formation, pendent drops and/or splattering. Other disclosed features of the invention provide for the automated covering or heat-sealing of filtrate samples separately collected in an array of wells.
摘要:
The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including (i) a column plate having an array of minicolumns into which samples can be placed, (ii) a discrete filter element disposed in each minicolumn, (iii) a drip-director plate having a corresponding array of drip directors through which filtrate may egress, and (iv) a receiving-well plate having a corresponding array of receiving wells into which filtrate can flow. The invention provides multi-well microfiltration arrangements that are relatively simple to manufacture and that overcome many of the problems associated with is the prior arrangements relating to (i) cross-contamination due to wicking across a common filter sheet or (ii) individual filter elements entrapping sample constituents within substantial dead volumes. Further, the invention provides multi-well microfiltration arrangements that adequately support discrete filter elements disposed in the wells without creating substantial preferential flow. Additionally, the invention provides multi-well microfiltration arrangements that avoid cross-contamination due to aerosol formation, pendent drops and/or splattering. Other disclosed features of the invention provide for the automated covering or heat-sealing of filtrate samples separately collected in an array of wells.
摘要:
The present invention provides a sensor that includes an optical device as a support for a thin film formed by a matrix containing resonant nanoparticles. The nanoparticles may be optically coupled to the optical device by virtue of the geometry of placement of the thin film. Further, the namoparticles are adapted to resonantly enhance the spectral signature of analytes located near the surfaces of the nanoparticles. Thus, via the nanoparticles, the optical device is addressable so as to detect a measurable property of a sample in contact with the sensor. The sensors include chemical sensors and thermal sensors. The optical devices include reflective devices and waveguide devices. Still further, the nanoparticles include solid metal particles and metal nanoshells. Yet further, the nanoparticles may be part of a nano-structure that further includes nanotubes.
摘要:
The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including (i) a column plate having an array of minicolumns into which samples can be placed, (ii) a discrete filter element disposed in each minicolumn, (iii) a drip-director plate having a corresponding array of drip directors through which filtrate may egress, and (iv) a receiving-well plate having a corresponding array of receiving wells into which filtrate can flow. The invention provides multi-well microfiltration arrangements that are relatively simple to manufacture and that overcome many of the problems associated with the prior arrangements relating to (i) cross-contamination due to wicking across a common filter sheet or (ii) individual filter elements entrapping sample constituents within substantial dead volumes. Further, the invention provides multi-well microfiltration arrangements that adequately support discrete filter elements disposed in the wells without creating substantial preferential flow. Additionally, the invention provides multi-well microfiltration arrangements that avoid cross-contamination due to aerosol formation, pendent drops and/or splattering. Other disclosed features of the invention provide for the automated covering or heat-sealing of filtrate samples separately collected in an array of wells.
摘要:
A latch having a pop-up knob is disclosed. When the knob is extended it provides a handle for pulling on a door. The door can be closed with the knob either up or down. With the knob up, the latch pawl can be disengaged from a keeper attached to the door frame by pulling the door open. With the knob down, the latch pawl remains in an extended position behind the keeper and the door cannot be pulled open. The latch further includes means for selectively retaining the knob in the down position, and means to block the rotational movement of the latch pawl when the knob is in the down position.