Co-immobilized enzyme, preparation method and use thereof

    公开(公告)号:US20230025239A1

    公开(公告)日:2023-01-26

    申请号:US17781823

    申请日:2019-12-02

    IPC分类号: C12N11/18 C12N11/089

    摘要: Provided are a co-immobilized enzyme, a preparation method and use thereof. The co-immobilized enzyme includes: an amino resin carrier, a main enzyme, and a coenzyme. The main enzyme and the coenzyme are co-immobilized on the amino resin carrier, herein the main enzyme is covalent-immobilized on the amino resin carrier, and the coenzyme is immobilized on the amino resin carrier by a mode of covalent and/or non-covalent; and the main enzyme is selected from any one of the following enzymes: transaminase, amino acid dehydrogenase, imine reductase, ketoreductase, enoyl reductase, and monooxygenase. The main enzyme and the coenzyme thereof are co-immobilized on the amino resin carrier for co-immobilization, so the activity and the recycling efficiency of the enzyme are improved.

    Continuous Processing Method of 2-methyltetrahydrofuran
    3.
    发明申请
    Continuous Processing Method of 2-methyltetrahydrofuran 审中-公开
    2-甲基四氢呋喃的连续加工方法

    公开(公告)号:US20150299153A1

    公开(公告)日:2015-10-22

    申请号:US14351337

    申请日:2012-10-25

    IPC分类号: C07D307/08

    CPC分类号: C07D307/08 C07D307/06

    摘要: The disclosure claims a continuous processing method of 2-Methyltetrahydrofuran (2-MeTHF), including the steps as follows: introducing gasification furfural and hydrogen into a first reaction zone and processing a first catalytic hydrogenation reaction; introducing the gas which is output from the first reaction zone to a second reaction zone to implement a secondary catalytic hydrogenation reaction; and condensing the gas output from the second reaction zone to obtain the 2-MeTHF; wherein, the first reaction zone is filled with a catalyst which is used for aldehyde group reduction, and the second reaction zone is filled with the catalyst for aromatic saturation hydrogenation. By adopting the low-toxicity catalyst which is cheap and easy to get, the high-purity 2-MeTHF can be produced by implementing the gas-phase continuous reaction by the furfural under low pressure or ambient pressure, the traditional process which has high pressure, high investment and high risk can be changed.

    摘要翻译: 本发明要求2-甲基四氢呋喃(2-MeTHF)的连续处理方法,其包括以下步骤:将糠醛和氢气气化引入第一反应区并处理第一催化氢化反应; 将从第一反应区输出的气体引入第二反应区以实施二次催化氢化反应; 并冷凝来自第二反应区的气体输出以获得2-MeTHF; 其中,第一反应区填充有用于醛基还原的催化剂,第二反应区填充有用于芳族饱和氢化的催化剂。 通过采用便宜而易于获得的低毒催化剂,可以通过在低压或环境压力下通过糠醛实现气相连续反应来生产高纯度2-MeTHF,传统方法具有高压 投资高,风险高可以改变。