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    Sustained release drug formulations containing a carrier peptide
    2.
    发明授权
    Sustained release drug formulations containing a carrier peptide 有权
    含有载体肽的缓释药物制剂

    公开(公告)号：US07943575B2

    公开(公告)日：2011-05-17

    申请号：US10506263

    申请日：2003-03-04

    申请人： Jacques-Pierre Moreau ,  Roland Cherif-Cheikh

    发明人： Jacques-Pierre Moreau ,  Roland Cherif-Cheikh

    IPC分类号： A61K38/22

    CPC分类号： A61K9/0024 ,  A61K9/0019 ,  A61K31/13 ,  A61K31/4045 ,  A61K31/428 ,  A61K31/473 ,  A61K31/48 ,  A61K31/4985 ,  A61K38/23 ,  A61K38/24 ,  A61K38/25 ,  A61K38/29 ,  A61K47/26 ,  A61K47/42

    摘要： The invention features a method of administering one or more therapeutic agents to a patient and delivering said agent or agents continuously over an extended period of time, said method comprising: obtaining a pharmaceutical composition including a peptide carrier, one or more therapeutic agents, and up to 30 percent, by weight, of a pharmaceutically acceptable, soluble, monomeric carrier; and parenterally administering said pharmaceutical composition to a subject by injection, wherein said composition automatically forms a gel after interaction with the patient's bodily fluids and releases said peptide carrier and said agent or agents continuously within the patient over an extended period.

    摘要翻译： 本发明的特征在于向患者施用一种或多种治疗剂并且在延长的时间段内连续递送所述药剂或药剂的方法，所述方法包括：获得药物组合物，其包含肽载体，一种或多种治疗剂和上 至30重量％的药学上可接受的可溶性单体载体; 并通过注射将所述药物组合物肠胃外施用于受试者，其中所述组合物在与患者的体液相互作用后自动形成凝胶，并在长时间内将所述肽载体和所述药剂或药剂在患者体内连续释放。

    Long-acting solid formulation comprising triptorelin acetate
    7.
    发明申请
    Long-acting solid formulation comprising triptorelin acetate 审中-公开
    长效固体制剂，包括醋酸曲普瑞林

    公开(公告)号：US20070031500A1

    公开(公告)日：2007-02-08

    申请号：US11499777

    申请日：2006-08-07

    申请人： Roland Cherif-Cheikh ,  Francesc Navarro Pujol

    发明人： Roland Cherif-Cheikh ,  Francesc Navarro Pujol

    IPC分类号： A61K9/14 ,  A61K31/4439

    CPC分类号： A61K9/0024 ,  A61K9/204 ,  A61K9/2095 ,  A61K38/09

    摘要： The invention relates to a long-acting solid formulation for parenteral administration, comprising a) triptorelin acetate and b) one or more excipients comprising a polymer or copolymer of lactic and/or glycolic acid or a mixture of polymers and/or copolymers of lactic acid and/or glycolic acid, said formulation containing 10 to 99% of triptorelin acetate by weight with relation to the total weight of the formulation. Said formulation is obtained by means of a method comprising the fusion of a mixture of triptorelin acetate and the excipient(s) on the fusion/extrusion of the triptorelin acetate with the excipient(s), said formulation being embodied such as to release the triptorelin acetate over a duration of at least one week, once administered parenterally to a patient.

    摘要翻译： 本发明涉及用于肠胃外给药的长效固体制剂，其包含a）醋酸曲普瑞林和b）一种或多种赋形剂，其包含乳酸和/或乙醇酸的聚合物或共聚物或乳酸的聚合物和/或共聚物的混合物 和/或乙醇酸，所述制剂含有10至99％的醋酸曲普瑞林，其重量与制剂的总重量相关。 所述制剂通过包括将醋酸曲普瑞林与赋形剂的混合物在醋酸曲普瑞司酯与赋形剂的融合/挤出物上融合的方法获得，所述制剂被实施为释放曲普瑞林 乙酸盐，持续至少一周，一次胃肠外给予患者。

    Device for injecting a pharmaceutical active principle
    10.
    发明授权
    Device for injecting a pharmaceutical active principle 失效
    用于注射药物活性成分的装置

    公开(公告)号：US08348881B2

    公开(公告)日：2013-01-08

    申请号：US11720534

    申请日：2005-11-15

    申请人： Christophe Aubert ,  Roland Cherif-Cheikh ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud

    发明人： Christophe Aubert ,  Roland Cherif-Cheikh ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud

    IPC分类号： A61M31/00

    CPC分类号： A61M37/00 ,  A61M37/0069

    摘要： The invention concerns a device for injecting a solid medicine (10) comprising a body (2) inside which moves along a general forward moving axis (X-X) a bevelled (34) needle (4) wherein is introduced the medicine (10), said injection device (1) further comprising retaining means for preventing the medicine from falling (10) prior to being injected. The invention is characterized in that the medicine (10) is retained through an elastic deformation imparted to the needle (4) by the retaining means or by an elastic deformation of the retaining means themselves, or still by the combined flexibility of those two means.

    摘要翻译： 本发明涉及一种用于注射固体药物（10）的装置，该固体药物（10）包括主体（2），其内部沿着总体向前移动轴线（XX）移动，其中引入药物（10）的斜头（34）针（4） 注射装置（1）还包括用于防止药物在注射之前落下（10）的保持装置。 本发明的特征在于，药物（10）通过保持装置赋予针（4）的弹性变形或通过保持装置本身的弹性变形或者仍然通过这两种装置的组合柔性来保持。