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公开(公告)号：US5192748A
公开(公告)日：1993-03-09
申请号：US740827
申请日：1991-08-05
申请人： Jill E. Hochlowski , Mark H. Buytendorp , Randal H. Chen , James B. McAlpine , Robert J. Theriault , Marianna Jackson , James P. Karwowski
发明人： Jill E. Hochlowski , Mark H. Buytendorp , Randal H. Chen , James B. McAlpine , Robert J. Theriault , Marianna Jackson , James P. Karwowski
CPC分类号： C07H13/04 , C07H15/26 , C07H7/02 , Y10S435/888
摘要： New antibiotics, unphenelfamycin and phenelfamycins A-D, are produced by microorganisms belonging to the genus Streptomyces. The antibiotics have antibacterial activity against gram-positive and gram-negative anaerobic organisms and are effective in improving the feed efficiency and growth rate of livestock, including poultry.
摘要翻译： 新型抗生素，非芬那霉素和苯丙胺霉素A-D由属于链霉菌属的微生物产生。 抗生素对革兰氏阳性和革兰氏阴性厌氧菌具有抗菌活性，有效提高家畜，包括家禽的饲料效率和生长速度。
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公开(公告)号：US5171740A
公开(公告)日：1992-12-15
申请号：US743311
申请日：1991-05-28
申请人： James B. McAlpine , Robert J. Theriault , James P. Karwowski , Marianna Jackson , Randal H. Chen
发明人： James B. McAlpine , Robert J. Theriault , James P. Karwowski , Marianna Jackson , Randal H. Chen
IPC分类号： C07H15/203 , C12P19/44
CPC分类号： C07H15/203 , C12P19/44 , Y10S435/822
摘要： A mixture of new coumamidine compounds are produced by a microorganism, belonging to the genus Saccharopolyspora. The compounds have antibiotic activity against a broad spectrum of bacteria.
摘要翻译： PCT No.PCT / US89 / 04556 Sec。 371日期1991年5月28日 102（e）日期1991年5月28日PCT 1989年10月10日提交PCT。由属于Saccharopolyspora属的微生物产生新的芳香胺化合物的混合物。 该化合物对广谱细菌具有抗生素活性。
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公开(公告)号：US5589485A
公开(公告)日：1996-12-31
申请号：US429405
申请日：1995-04-26
申请人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
发明人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
IPC分类号： C07D211/88 , C07D211/40 , A61K31/44 , A61K31/445 , C07D211/76
CPC分类号： C07D211/88
摘要： Novel antifungal and antitumor agents having the formula ##STR1## as well as pharmaceutically acceptable salts, esters, amides and pro-drugs thereof, wherein R is selected from the group consisting of ##STR2## Also disclosed are pharmaceutical compositions comprising such compounds, and methods of treatment and processes of manufacture relating thereto.
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公开(公告)号：US5484799A
公开(公告)日：1996-01-16
申请号：US164234
申请日：1993-12-09
申请人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
发明人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
IPC分类号： C07D211/88 , A61K31/44 , A61K31/45 , C07D211/40 , C07D211/76
CPC分类号： C07D211/88
摘要： Novel antifungal and antitumor agents having the formula ##STR1## as well as pharmaceutically acceptable salts, esters, amides and pro-drugs thereof, wherein R is selected from the group consisting of ##STR2## Also disclosed are pharmaceutical compositions comprising such compounds, and methods of treatment and processes of manufacture relating thereto.
摘要翻译： 具有式（I）的新型抗真菌剂和抗肿瘤剂以及其药学上可接受的盐，酯，酰胺和前体药物，其中R选自由下列组成的组：IMAMA（Ia）和（IMA） Ib）还公开了包含这些化合物的药物组合物，与其有关的治疗方法和制造方法。
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公开(公告)号：US5585251A
公开(公告)日：1996-12-17
申请号：US370934
申请日：1995-01-10
摘要： Novel antifungal agents having the formula: ##STR1## wherein R is hydrogen or a radical of the formula ##STR2## and pharmaceutically acceptable prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.
摘要翻译： 具有下式的新颖的抗真菌剂：其中R是氢或下式的基团及其药学上可接受的前药，以及（i）包含这些化合物的药物组合物，（ii）使用这些化合物的治疗方法 ，和（iv）有用的方法和真菌培养物。
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公开(公告)号：US5773421A
公开(公告)日：1998-06-30
申请号：US548803
申请日：1995-12-21
申请人： Lisa A. Alder , Marianna Jackson , Neal S. Burres , James B. McAlpine , Jill E. Hochlowski , Larry L. Klein , Paul A. Lartey , Clinton Yeung
发明人： Lisa A. Alder , Marianna Jackson , Neal S. Burres , James B. McAlpine , Jill E. Hochlowski , Larry L. Klein , Paul A. Lartey , Clinton Yeung
IPC分类号： C12P17/06 , A01N43/16 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P31/10 , C07H15/10 , C07H17/04 , C12R1/645 , A61K31/71 , C07H15/00 , C12P19/44
摘要： Novel antifungal agents having the formula: ##STR1## wherein R is hydrogen or --C(O)--R.sub.1 wherein R.sub.1 is alkenyl, C.sub.2 -C.sub.12 -alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.
摘要翻译： 具有下式的新型抗真菌剂：其中R是氢或-C（O）-R1，其中R 1是烯基，C 2 -C 12烷基，芳基，芳基烯基，芳基烷基，芳基 - 芳基 - ，芳基烷氧基 芳基 - 芳基 - 芳基 - 芳基 - 芳基 - 芳基 - 或芳基烷氧基 - 芳基 - 芳基 - 或其药学上可接受的盐，酯或前药，以及（i）包含这些化合物的药物组合物，（ii） 使用这种化合物的治疗，以及（iv）可用于制备该化合物的方法和真菌培养物。
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公开(公告)号：US5284947A
公开(公告)日：1994-02-08
申请号：US945302
申请日：1992-09-15
IPC分类号： C07D487/22 , A61K31/495
CPC分类号： C07D487/22
摘要： A compound having the structural formula ##STR1## or a pharmaceutically acceptable salts and prodrugs thereof, wherein R.sup.1 is selected from the group consisting of hydrogen and loweracyl, and R.sup.2 is selected from the group consisting of hydrogen, hydroxyl and methoxyl, as well as methods for the preparation and use thereof.
摘要翻译： 具有结构式“IMAGE”的化合物或其药学上可接受的盐和前药，其中R 1选自氢和低级酰基，R 2选自氢，羟基和甲氧基，以及方法 用于制备和使用。
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公开(公告)号：US4918174A
公开(公告)日：1990-04-17
申请号：US912438
申请日：1986-09-26
摘要： New compounds, tiacumicins, are produced by a microorganism belonging to the genus Dactylosporangium. The compounds are effective Gram-positive antibiotics.
摘要翻译： 新化合物，tiacumicins，由属于Dactylosporangium属的微生物产生。 这些化合物是有效的革兰氏阳性抗生素。
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公开(公告)号：US5767096A
公开(公告)日：1998-06-16
申请号：US678906
申请日：1996-07-12
CPC分类号： C07H17/08
摘要： Antimicrobial compounds having the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen and C.sub.1 -to-C.sub.4 alkanoyl; R.sup.3 and R.sup.4 are selected from the group consisting of (a) R.sup.3 is hydrogen and R.sup.4 is hydroxy, (b) R.sup.3 is hydroxy and R.sup.4 is hydrogen, (c) R.sup.3 and R.sup.4 taken together are .dbd.O; or selected from the group consisting of hydrogen and hydroxy; and R.sup.5 and R.sup.6 are independently selected from the group consisting of hydrogen, bromine and chlorine, with the proviso that at least one of R.sup.5 and R.sup.6 must be bromine. Also disclosed are pharmaceutical compositions comprising such compounds, methods of treating bacterial infection by the administration thereof and a process for preparing said compounds.
摘要翻译： 具有式“IMAGE”的抗微生物化合物，其中R 1和R 2独立地选自氢和C 1 -C 4烷酰基; R3和R4选自（a）R3是氢，R4是羟基，（b）R3是羟基，R4是氢，（c）R3和R4一起是= O; 或选自氢和羟基; 并且R 5和R 6独立地选自氢，溴和氯，条件是R 5和R 6中的至少一个必须是溴。 还公开了包含这些化合物的药物组合物，通过其给药治疗细菌感染的方法和制备所述化合物的方法。
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公开(公告)号：US07101872B2
公开(公告)日：2006-09-05
申请号：US10762107
申请日：2004-01-21
IPC分类号： C07D243/10 , A61K31/55
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.
摘要翻译： 本发明涉及名为ECO-04601的新型法呢基化二苯并二氮杂酮，其药学上可接受的盐和衍生物，以及获得这些化合物的方法。 获得ECO-04601化合物的一种方法是通过培养一种新型的小单孢菌属菌株046-ECO11; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。 本发明还涉及小单孢菌属 应用046-ECO11，使用ECO-04601及其药学上可接受的盐和衍生物作为药物，特别是其作为癌细胞生长抑制剂，细菌细胞生长，哺乳动物脂氧合酶的用途，以及包含ECO-04601或 其药学上可接受的盐或衍生物。 最后，本发明涉及参与ECO-04601的生物合成的新型多核苷酸序列及其编码的蛋白质。
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