公开(公告)号：US20100166773A1

公开(公告)日：2010-07-01

申请号：US12528601

申请日：2008-03-21

Applicant: James D. Marks ,  Isin N. Geren ,  Maria Consuelo Garcia ,  Jianlong Lou ,  Ali Razai

Inventor： James D. Marks ,  Isin N. Geren ,  Maria Consuelo Garcia ,  Jianlong Lou ,  Ali Razai

IPC: A61K39/40 ,  C07K16/12 ,  A61P31/04

CPC classification number: C07K16/40 ,  C07K16/1282 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本发明提供了特异性结合并典型地中和肉毒杆菌神经毒素（例如BoNT / A，BoNT / B，BoNT / E等）和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。

公开(公告)号：US09000131B2

公开(公告)日：2015-04-07

申请号：US13055436

申请日：2009-07-30

Applicant: James D. Marks ,  Isin N. Geren

Inventor： James D. Marks ,  Isin N. Geren

IPC: A61K38/00 ,  A61K38/16 ,  A61K39/385 ,  A61K39/40 ,  A61K39/42 ,  A01N37/18 ,  C07K16/00 ,  C12P21/08 ,  G01N33/00 ,  C07K16/12 ,  A61K39/00

CPC classification number: C07K16/1282 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: This disclosure provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本公开提供了特异性结合并通常中和肉毒杆菌神经毒素（例如BoNT / A，BoNT / B，BoNT / E等）和由那些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。

公开(公告)号：US08598321B2

公开(公告)日：2013-12-03

申请号：US12528601

申请日：2008-03-21

Applicant: James D. Marks ,  Isin N. Geren ,  Jianlong Lou

Inventor： James D. Marks ,  Isin N. Geren ,  Jianlong Lou

IPC: A61K38/00 ,  A61K38/16 ,  A61K39/385 ,  A61K39/40 ,  A61K39/42 ,  A01N37/18 ,  C07K16/00 ,  C12P21/08 ,  G01N33/00

CPC classification number: C07K16/40 ,  C07K16/1282 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

公开(公告)号：US20110200615A1

公开(公告)日：2011-08-18

申请号：US13055436

申请日：2009-07-30

Applicant: James D. Marks ,  Jianlong Lou ,  Maria Consuelos Garcia Rodriguez ,  Isin N. Geren

Inventor： James D. Marks ,  Jianlong Lou ,  Maria Consuelos Garcia Rodriguez ,  Isin N. Geren

IPC: A61K39/40 ,  C07K16/12 ,  C07H21/04 ,  C12N1/19 ,  A61P31/04 ,  A61P39/02

CPC classification number: C07K16/1282 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: This disclosure provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本公开提供了特异性结合并通常中和肉毒杆菌神经毒素（例如BoNT / A，BoNT / B，BoNT / E等）和由那些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。

公开(公告)号：US09145462B2

公开(公告)日：2015-09-29

申请号：US13172759

申请日：2011-06-29

Applicant: Bin Liu ,  James D. Marks ,  Xiaodong Zhu ,  Scott Bidlingmaier

Inventor： Bin Liu ,  James D. Marks ,  Xiaodong Zhu ,  Scott Bidlingmaier

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  C12N5/095 ,  G01N33/574

CPC classification number: C07K16/18 ,  A61K47/6843 ,  A61K51/1045 ,  C07K16/2896 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  C12N5/0695 ,  G01N33/57407

Abstract: The present disclosure is generally related to antibodies that bind specifically to glioblastoma multiforme (GBM) cells. In particular, the present disclosure provides compositions comprising human single chain or full-length antibodies that bind tumor cells. Additionally the present disclosure provides methods of using the anti-GBM antibodies.

Abstract translation: 本公开通常涉及特异性结合多形性胶质母细胞瘤（GBM）细胞的抗体。 特别地，本公开提供了包含结合肿瘤细胞的人单链或全长抗体的组合物。 另外，本公开提供了使用抗GBM抗体的方法。

公开(公告)号：US20150030600A1

公开(公告)日：2015-01-29

申请号：US13813623

申请日：2011-08-31

Applicant: James D. Marks ,  Yongfeng Fan ,  Jianlong Lou ,  Maria Consuelo Garcia Rodriguez ,  Shude Yan ,  Isin Nergiz Geren ,  Wenwu Zhai ,  Subhendu Chakraborti

Inventor： James D. Marks ,  Yongfeng Fan ,  Jianlong Lou ,  Maria Consuelo Garcia Rodriguez ,  Shude Yan ,  Isin Nergiz Geren ,  Wenwu Zhai ,  Subhendu Chakraborti

IPC: C07K16/12 ,  G01N33/569 ,  G01N33/573

CPC classification number: C07K16/40 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/1282 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56911 ,  G01N33/573 ,  G01N2333/33 ,  G01N2333/952

Abstract: The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本公开提供了特异性结合肉毒杆菌神经毒素（例如BoNT / A，BoNT / B，BoNT / C，BoNT / D，BoNT / E，BoNT / F，BoNT / G等）的抗体， 那些抗体。 特异性结合本文提供的中和表位的抗体及其衍生物可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。

公开(公告)号：US08263747B2

公开(公告)日：2012-09-11

申请号：US12353237

申请日：2009-01-13

Applicant: James D. Marks ,  Peter Amersdorfer ,  Ali Razai

Inventor： James D. Marks ,  Peter Amersdorfer ,  Ali Razai

IPC: A61K38/00 ,  A61K38/16 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  A01N37/18 ,  C07K16/00 ,  C12P21/08 ,  G01N33/00

CPC classification number: C07K16/1282 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622

Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

公开(公告)号：US07892554B2

公开(公告)日：2011-02-22

申请号：US11809773

申请日：2007-06-01

Applicant: James D. Marks ,  Marie Alix Poul

Inventor： James D. Marks ,  Marie Alix Poul

IPC: A61K39/395 ,  A61K51/10 ,  C07K16/46

CPC classification number: A61K47/48823 ,  A61K9/0019 ,  A61K31/704 ,  A61K38/00 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6913 ,  C07K16/2863 ,  C07K16/2881 ,  C07K16/3053 ,  C07K16/32 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C12N15/86 ,  C12N2795/10043 ,  C12N2810/859 ,  Y10S424/812

Abstract: This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.

公开(公告)号：US07582736B2

公开(公告)日：2009-09-01

申请号：US11972130

申请日：2008-01-10

Applicant: Bin Liu ,  James D. Marks

Inventor： Bin Liu ,  James D. Marks

IPC: C12P21/08

CPC classification number: C07K16/3069 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77

Abstract: This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an effector (e.g. a cytotoxin, an imaging reagent, a drug, etc.) to a prostate tumor site.

Abstract translation: 本发明提供了新型前列腺癌特异性内化人抗体。 抗体本身可用于预防前列腺癌细胞的生长和/或增殖。 抗体还可以配制成嵌合分子以将效应物（例如细胞毒素，成像试剂，药物等）引导至前列腺肿瘤部位。

公开(公告)号：US20080124328A1

公开(公告)日：2008-05-29

申请号：US11342271

申请日：2006-01-26

Applicant: James D. Marks ,  Peter Amersdorfer ,  Isin Geren ,  Jianlong Lou ,  Ali Razai ,  Maria Consuelos Garcia

Inventor： James D. Marks ,  Peter Amersdorfer ,  Isin Geren ,  Jianlong Lou ,  Ali Razai ,  Maria Consuelos Garcia

IPC: A61K39/40 ,  A61K39/395 ,  A61P43/00 ,  C07H19/00 ,  C07K16/00 ,  C12N1/00 ,  C12N5/00

CPC classification number: C07K16/1282 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本发明提供了特异性结合并中和A型（BoNT / A）肉毒杆菌神经毒素和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。