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    Carcinoembryonic antigen (CEA) peptides
    4.
    发明申请
    Carcinoembryonic antigen (CEA) peptides 审中-公开
    癌胚抗原（CEA）肽

    公开(公告)号：US20070048860A1

    公开(公告)日：2007-03-01

    申请号：US11321868

    申请日：2005-12-30

    申请人： Jeffrey Schlom ,  James Hodge ,  Sam Zaremba ,  Maria Salazar

    发明人： Jeffrey Schlom ,  James Hodge ,  Sam Zaremba ,  Maria Salazar

    IPC分类号： A61K39/12 ,  C12N15/00

    CPC分类号： A61K39/0011 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/70503 ,  C12N2700/00 ,  C12N2710/10343 ,  C12N2710/24043 ,  C12N2710/24143

    摘要： The present invention relates to novel modified CEA agonist (or antagonist) peptides, polypeptides and proteins containing a modified epitope therein, nucleic acids coding therefor, vectors comprising said nucleic acids, mixtures and compositions of the aforementioned agents, and their advantageous use in generating CEA-specific immune responses and/or in the treatment of cancers and the present invention further relates to the foregoing combined with one or more costimulatory molecules.

    摘要翻译： 本发明涉及新型修饰的CEA激动剂（或拮抗剂）肽，其中含有修饰的表位的多肽和蛋白质，其编码的核酸，包含所述核酸的载体，前述试剂的混合物和组合物及其在产生CEA中的有利用途 特异性免疫应答和/或治疗癌症，并且本发明进一步涉及与一种或多种共刺激分子组合的前述物质。

    Recombinant vector expressing multiple costimulatory molecules and uses thereof
    5.
    发明授权
    Recombinant vector expressing multiple costimulatory molecules and uses thereof 有权
    表达多种共刺激分子的重组载体及其用途

    公开(公告)号：US06969609B1

    公开(公告)日：2005-11-29

    申请号：US09856988

    申请日：1999-11-12

    申请人： Jeffrey Schlom ,  James Hodge ,  Dennis Panicali

    发明人： Jeffrey Schlom ,  James Hodge ,  Dennis Panicali

    IPC分类号： A61K35/12 ,  A61K39/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/863 ,  C12N5/10 ,  C12N5/16 ,  C12N5/22 ,  C12N15/85 ,  A16K48/00

    CPC分类号： C12N15/86 ,  A61K35/12 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/57 ,  C07K14/70503 ,  C07K14/70525 ,  C07K14/70528 ,  C07K14/70532 ,  C12N2710/24043 ,  C12N2710/24143 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/464 ,  Y02A50/478

    摘要： The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of them costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater that the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4+and CD8+T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced and antigen-presenting functions.

    摘要翻译： 本发明是编码并表达至少三种或更多共刺激分子的重组载体。 重组载体可另外含有编码一种或多种靶抗原或其免疫表位的基因。 证明了它们共刺激分子对增强的T细胞活化的协同作用。 使用含有编码三个共刺激分子的基因的重组载体的T细胞活化程度远远大于含有一个共刺激分子的重组载体构建物的总和，并且使用两个共刺激分子更大。 使用三重共刺激载体的结果在低水平的第一信号或低刺激剂与T细胞比率的条件下最显着。 在分离的CD4 +和/或CD8 + T细胞中都观察到这种现象。 本发明的重组载体可用作抗癌和致病微生物的免疫原和疫苗，并且提供宿主细胞，包括具有增强和抗原呈递功能的树突状细胞和脾细胞。

    Recombinant vector expressing multiple costimulatory molecules and uses thereof
    7.
    发明授权
    Recombinant vector expressing multiple costimulatory molecules and uses thereof 有权
    表达多种共刺激分子的重组载体及其用途

    公开(公告)号：US07211432B2

    公开(公告)日：2007-05-01

    申请号：US10406317

    申请日：2003-04-04

    申请人： Jeffrey Schlom ,  James Hodge ,  Dennis Panicali

    发明人： Jeffrey Schlom ,  James Hodge ,  Dennis Panicali

    IPC分类号： C12N15/00 ,  C12N15/39 ,  C12N15/19 ,  C12N7/00

    CPC分类号： C12N15/86 ,  A61K35/12 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/57 ,  C07K14/70503 ,  C07K14/70525 ,  C07K14/70528 ,  C07K14/70532 ,  C12N2710/24043 ,  C12N2710/24143 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/464 ,  Y02A50/478

    摘要： The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4+ and CD8+ T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions.

    摘要翻译： 本发明是编码并表达至少三种或更多共刺激分子的重组载体。 重组载体可另外含有编码一种或多种靶抗原或其免疫表位的基因。 证明了这些共刺激分子对增强的T细胞活化的协同作用。 使用含有编码三个共刺激分子的基因的重组载体的T细胞活化程度远远大于含有一个共刺激分子并且大于使用两个共刺激分子的重组载体构建体的总和。 使用三重共刺激载体的结果在低水平的第一信号或低刺激剂与T细胞比率的条件下最显着。 在分离的CD4 +和/或CD8 + T细胞中都观察到这种现象。 本发明的重组载体可用作抗癌和致病微生物的免疫原和疫苗，以及提供宿主细胞，包括具有增强的抗原呈递功能的树突状细胞和脾细胞。

    Recombinant vector expressing multiple costimulatory molecules and uses thereof
    9.
    发明申请
    Recombinant vector expressing multiple costimulatory molecules and uses thereof 有权
    表达多种共刺激分子的重组载体及其用途

    公开(公告)号：US20090041804A1

    公开(公告)日：2009-02-12

    申请号：US11723666

    申请日：2007-03-21

    申请人： Jeffrey Schlom ,  James Hodge ,  Dennis Panicali

    发明人： Jeffrey Schlom ,  James Hodge ,  Dennis Panicali

    IPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/275 ,  A61K39/235 ,  A61K39/125

    CPC分类号： C12N15/86 ,  A61K35/12 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/57 ,  C07K14/70503 ,  C07K14/70525 ,  C07K14/70528 ,  C07K14/70532 ,  C12N2710/24043 ,  C12N2710/24143 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/464 ,  Y02A50/478

    摘要： The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of Tell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4+ and CD8+ T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions.

    摘要翻译： 本发明是编码并表达至少三种或更多共刺激分子的重组载体。 重组载体可另外含有编码一种或多种靶抗原或其免疫表位的基因。 证明了这些共刺激分子对增强的T细胞活化的协同作用。 使用含有编码三个共刺激分子的基因的重组载体的Tell活化程度远远大于含有一个共刺激分子并且大于使用两个共刺激分子的重组载体构建物的总和。 使用三重共刺激载体的结果在低水平的第一信号或低刺激剂与T细胞比率的条件下最显着。 用分离的CD4 +和CD8 + T细胞观察到这种现象。 本发明的重组载体可用作抗癌和致病微生物的免疫原和疫苗，并且提供宿主细胞，包括具有增强的抗原呈递功能的树突状细胞和脾细胞。

    Recombinant vector expressing multiple costimulatory molecules and uses thereof
    10.
    发明授权
    Recombinant vector expressing multiple costimulatory molecules and uses thereof 有权
    表达多种共刺激分子的重组载体及其用途

    公开(公告)号：US07771715B2

    公开(公告)日：2010-08-10

    申请号：US11723666

    申请日：2007-03-21

    申请人： Jeffrey Schlom ,  James Hodge ,  Dennis Panicali

    发明人： Jeffrey Schlom ,  James Hodge ,  Dennis Panicali

    IPC分类号： A61K48/00 ,  C12N15/00

    CPC分类号： C12N15/86 ,  A61K35/12 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/57 ,  C07K14/70503 ,  C07K14/70525 ,  C07K14/70528 ,  C07K14/70532 ,  C12N2710/24043 ,  C12N2710/24143 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/464 ,  Y02A50/478

    摘要： The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4+ and CD8+ T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions.

    摘要翻译： 本发明是编码并表达至少三种或更多共刺激分子的重组载体。 重组载体可另外含有编码一种或多种靶抗原或其免疫表位的基因。 证明了这些共刺激分子对增强的T细胞活化的协同作用。 使用含有编码三个共刺激分子的基因的重组载体的T细胞活化程度远远大于含有一个共刺激分子并且大于使用两个共刺激分子的重组载体构建体的总和。 使用三重共刺激载体的结果在低水平的第一信号或低刺激剂与T细胞比率的条件下最显着。 用分离的CD4 +和CD8 + T细胞观察到这种现象。 本发明的重组载体可用作抗癌和致病微生物的免疫原和疫苗，以及提供宿主细胞，包括具有增强的抗原呈递功能的树突状细胞和脾细胞。