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公开(公告)号：US07138411B2
公开(公告)日：2006-11-21
申请号：US10303150
申请日：2002-11-22
申请人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号： A61K31/47 , A61K31/38 , A61K31/35 , C07D307/77 , C07D335/04
CPC分类号： C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要： A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译： 描述了一类苯并吡喃，苯并噻喃，二氢喹啉，二氢萘及其类似物，用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义，其中X，A 1，A 2，A 3，A 4， SUP>，R，R“，R”1“和”R“2如说明书中所述。
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公开(公告)号：US06271253B1
公开(公告)日：2001-08-07
申请号：US09569383
申请日：2000-05-11
申请人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号： A61K3138
CPC分类号： C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要： A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译： 描述了一类苯并吡喃，苯并噻喃，二氢喹啉，二氢萘及其类似物，用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义，其中X，A1，A2，A3，A4，R，R“，R1和R2如说明书中所述。
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公开(公告)号：US07109211B2
公开(公告)日：2006-09-19
申请号：US10922036
申请日：2004-08-19
申请人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J. Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J. Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号： A61K31/47 , C07D211/30
CPC分类号： C07D335/06 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要： A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译： 描述了一类苯并吡喃衍生物用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义，其中X，A 1，A 2，A 3，A 4， SUP>，R，R“，R”1“和”R“2如说明书中所述。
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公开(公告)号：US06492390B2
公开(公告)日：2002-12-10
申请号：US09865177
申请日：2001-05-24
申请人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号： A61K3138
CPC分类号： C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要： A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译： 描述了一类苯并吡喃，苯并噻喃，二氢喹啉，二氢萘及其类似物用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义，其中X，A1，A2，A3，A4，R，R“，R1和R2如说明书中所述。
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公开(公告)号：US6077850A
公开(公告)日：2000-06-20
申请号：US175584
申请日：1998-10-20
申请人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J. Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J. Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号： C07D335/06 , A61K20060101 , A61K31/35 , A61K31/352 , A61K31/381 , A61K31/382 , A61K31/4184 , A61K31/443 , A61K31/4433 , A61K31/453 , A61K31/47 , A61K31/5377 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D215/54 , C07D221/00 , C07D307/00 , C07D311/00 , C07D311/12 , C07D311/22 , C07D311/38 , C07D311/58 , C07D311/92 , C07D317/00 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/12 , C07D471/04 , C07D491/04 , C07D491/052 , C07D493/04 , A61K31/44 , A61K31/495 , C07D215/16 , C07D221/06
CPC分类号： C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要： A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I'wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification.
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公开(公告)号：US06806288B1
公开(公告)日：2004-10-19
申请号：US09496695
申请日：2000-02-02
申请人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartman , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartman , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号： A61K31385
CPC分类号： C07D335/06 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要： A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译： 描述了一类苯并吡喃衍生物用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义，其中X，A 1，A 2，A 3，A 4，R，R“，R 1和R 2分别为 在说明书中描述。
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公开(公告)号：US6034256A
公开(公告)日：2000-03-07
申请号：US062537
申请日：1998-04-17
申请人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan R Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz
发明人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan R Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz
IPC分类号： A61K31/35 , A61K31/352 , A61K31/36 , A61K31/382 , A61K31/4184 , A61K31/436 , A61K31/4375 , A61K31/47 , A61P29/00 , A61P43/00 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/052 , C07D493/04 , A61K31/44 , A61K31/535 , C07D311/04 , C07D413/00
CPC分类号： C07D335/06 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要： A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification.
摘要翻译： 描述了一类苯并吡喃衍生物用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义，其中X，A1，A2，A3，A4，R，R“，R1和R2如说明书中所述。
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公开(公告)号：US06750338B2
公开(公告)日：2004-06-15
申请号：US10268818
申请日：2002-10-10
申请人： Matthew J. Graneto , Michael L. Vazquez , Susan J. Hartmann , Suzanne Metz , John J. Talley , David L. Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
发明人： Matthew J. Graneto , Michael L. Vazquez , Susan J. Hartmann , Suzanne Metz , John J. Talley , David L. Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
IPC分类号： C07D40104
CPC分类号： C07D401/14 , C07D231/18 , C07D339/00 , C07D401/04 , C07D405/14 , C07D409/06
摘要： This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
摘要翻译： 本发明涉及制备用作p38激酶和COX-2抑制剂的选择的5-取代的吡唑的新方法。
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公开(公告)号：US6143892A
公开(公告)日：2000-11-07
申请号：US442971
申请日：1999-11-18
申请人： Matthew J. Graneto , Michael L. Vazquez , Susan J. Hartmann , Suzanne Metz , John J. Talley , David L. Brown , Richard M. Weier , Michael A. Stealey , Xiaodong C. Xu
发明人： Matthew J. Graneto , Michael L. Vazquez , Susan J. Hartmann , Suzanne Metz , John J. Talley , David L. Brown , Richard M. Weier , Michael A. Stealey , Xiaodong C. Xu
IPC分类号： C07D239/26 , C07D213/50 , C07D231/18 , C07D339/00 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/06 , C07D413/14 , C07D417/14
CPC分类号： C07D401/14 , C07D231/18 , C07D339/00 , C07D401/04 , C07D405/14 , C07D409/06
摘要： This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
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公开(公告)号：US06242612B1
公开(公告)日：2001-06-05
申请号：US09633726
申请日：2000-08-07
申请人： Matthew J. Graneto , Michael L. Vazquez , Susan J. Hartmann , Suzanne Metz , John J. Talley , David L. Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
发明人： Matthew J. Graneto , Michael L. Vazquez , Susan J. Hartmann , Suzanne Metz , John J. Talley , David L. Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
IPC分类号： C07D23120
CPC分类号： C07D401/14 , C07D231/18 , C07D339/00 , C07D401/04 , C07D405/14 , C07D409/06
摘要： This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
摘要翻译： 本发明涉及制备用作p38激酶和COX-2抑制剂的选择的5-取代的吡唑的新方法。
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