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1.
公开(公告)号:US07138411B2
公开(公告)日:2006-11-21
申请号:US10303150
申请日:2002-11-22
申请人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号: A61K31/47 , A61K31/38 , A61K31/35 , C07D307/77 , C07D335/04
CPC分类号: C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译: 描述了一类苯并吡喃,苯并噻喃,二氢喹啉,二氢萘及其类似物,用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义,其中X,A 1,A 2,A 3,A 4, SUP>,R,R“,R”1“和”R“2如说明书中所述。
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2.
公开(公告)号:US06271253B1
公开(公告)日:2001-08-07
申请号:US09569383
申请日:2000-05-11
申请人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号: A61K3138
CPC分类号: C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译: 描述了一类苯并吡喃,苯并噻喃,二氢喹啉,二氢萘及其类似物,用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义,其中X,A1,A2,A3,A4,R,R“,R1和R2如说明书中所述。
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3.
公开(公告)号:US07109211B2
公开(公告)日:2006-09-19
申请号:US10922036
申请日:2004-08-19
申请人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J. Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J. Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号: A61K31/47 , C07D211/30
CPC分类号: C07D335/06 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要: A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译: 描述了一类苯并吡喃衍生物用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义,其中X,A 1,A 2,A 3,A 4, SUP>,R,R“,R”1“和”R“2如说明书中所述。
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公开(公告)号:US06492390B2
公开(公告)日:2002-12-10
申请号:US09865177
申请日:2001-05-24
申请人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号: A61K3138
CPC分类号: C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译: 描述了一类苯并吡喃,苯并噻喃,二氢喹啉,二氢萘及其类似物用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义,其中X,A1,A2,A3,A4,R,R“,R1和R2如说明书中所述。
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公开(公告)号:US6077850A
公开(公告)日:2000-06-20
申请号:US175584
申请日:1998-10-20
申请人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J. Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J. Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号: C07D335/06 , A61K20060101 , A61K31/35 , A61K31/352 , A61K31/381 , A61K31/382 , A61K31/4184 , A61K31/443 , A61K31/4433 , A61K31/453 , A61K31/47 , A61K31/5377 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D215/54 , C07D221/00 , C07D307/00 , C07D311/00 , C07D311/12 , C07D311/22 , C07D311/38 , C07D311/58 , C07D311/92 , C07D317/00 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/12 , C07D471/04 , C07D491/04 , C07D491/052 , C07D493/04 , A61K31/44 , A61K31/495 , C07D215/16 , C07D221/06
CPC分类号: C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I'wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification.
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公开(公告)号:US06806288B1
公开(公告)日:2004-10-19
申请号:US09496695
申请日:2000-02-02
申请人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartman , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartman , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号: A61K31385
CPC分类号: C07D335/06 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要: A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译: 描述了一类苯并吡喃衍生物用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义,其中X,A 1,A 2,A 3,A 4,R,R“,R 1和R 2分别为 在说明书中描述。
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7.
公开(公告)号:US6034256A
公开(公告)日:2000-03-07
申请号:US062537
申请日:1998-04-17
申请人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan R Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz
发明人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan R Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz
IPC分类号: A61K31/35 , A61K31/352 , A61K31/36 , A61K31/382 , A61K31/4184 , A61K31/436 , A61K31/4375 , A61K31/47 , A61P29/00 , A61P43/00 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/052 , C07D493/04 , A61K31/44 , A61K31/535 , C07D311/04 , C07D413/00
CPC分类号: C07D335/06 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要: A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification.
摘要翻译: 描述了一类苯并吡喃衍生物用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义,其中X,A1,A2,A3,A4,R,R“,R1和R2如说明书中所述。
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8.Process for preparing prodrugs of benzenesulfonamide-containing cox-2 inhibitors 失效
标题翻译: 制备含苯磺酰胺的cox-2抑制剂的前药的方法公开(公告)号:US06815460B2
公开(公告)日:2004-11-09
申请号:US10178697
申请日:2002-06-24
申请人: John J Talley , James W Malecha , Stephen Bertenshaw , Matthew J Graneto , Jeffery Carter , Jinglin Li , Srinivasan Nagarajan , David L Brown , Donald J Rogier, Jr. , Thomas D Penning , Ish K Khanna , Xiangdong Xu , Richard M Weier
发明人: John J Talley , James W Malecha , Stephen Bertenshaw , Matthew J Graneto , Jeffery Carter , Jinglin Li , Srinivasan Nagarajan , David L Brown , Donald J Rogier, Jr. , Thomas D Penning , Ish K Khanna , Xiangdong Xu , Richard M Weier
IPC分类号: A61K3142
CPC分类号: C07D207/33 , A61K31/18 , A61K31/415 , A61K31/42 , A61K31/635 , C07C311/16 , C07C311/51 , C07C2601/10 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D307/58 , C07D401/04 , C07D417/04 , C07D495/04
摘要: Prodrugs of COX-2 inhibitors and methods of their preparation are described. The prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders.
摘要翻译: 描述了COX-2抑制剂的前体药物及其制备方法。 COX-2抑制剂的前药被描述为可用于治疗炎症和炎症相关疾病。
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公开(公告)号:US5932598A
公开(公告)日:1999-08-03
申请号:US5610
申请日:1998-01-12
申请人: John J Talley , James W Malecha , Stephen Bertenshaw , Matthew J Graneto , Jeffery Carter , Jinglin Li , Srinivasan Nagarajan , David L Brown , Donald J Rogier, Jr. , Thomas D Penning , Ish K Khanna , Xiangdong Xu , Richard M Weier
发明人: John J Talley , James W Malecha , Stephen Bertenshaw , Matthew J Graneto , Jeffery Carter , Jinglin Li , Srinivasan Nagarajan , David L Brown , Donald J Rogier, Jr. , Thomas D Penning , Ish K Khanna , Xiangdong Xu , Richard M Weier
IPC分类号: C07D233/64 , A61K31/00 , A61K31/18 , A61K31/34 , A61K31/341 , A61K31/365 , A61K31/40 , A61K31/415 , A61K31/4162 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/635 , A61P1/02 , A61P1/04 , A61P3/10 , A61P5/16 , A61P7/06 , A61P9/10 , A61P11/02 , A61P11/06 , A61P11/08 , A61P13/12 , A61P15/06 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/08 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/28 , A61P27/02 , A61P27/12 , A61P29/00 , A61P29/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07C311/16 , C07C311/39 , C07C311/51 , C07D20060101 , C07D207/32 , C07D207/327 , C07D207/33 , C07D231/12 , C07D233/54 , C07D233/62 , C07D261/08 , C07D263/32 , C07D307/46 , C07D307/58 , C07D401/04 , C07D417/04 , C07D495/04 , A61K31/16 , C07D207/00 , C07D207/12 , C07D211/72 , C07D211/84 , C07D223/04 , C07D231/10 , C07D403/02
CPC分类号: C07D207/33 , A61K31/18 , A61K31/415 , A61K31/42 , A61K31/635 , C07C311/16 , C07C311/51 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D307/58 , C07D401/04 , C07D417/04 , C07D495/04 , C07C2101/10
摘要: Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders.
摘要翻译: 描述了COX-2抑制剂的前药用于治疗炎症和炎症相关疾病。
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10.Process for preparing prodrugs of benzenesulfonamide-containing cox-2 inhibitors 有权
标题翻译: 制备含苯磺酰胺的cox-2抑制剂的前药的方法公开(公告)号:US06436967B1
公开(公告)日:2002-08-20
申请号:US09661859
申请日:2000-09-14
申请人: John J Talley , James W Malecha , Stephen Bertenshaw , Matthew J Graneto , Jeffery Carter , Jinglin Li , Srinivasan Nagarajan , David L Brown , Donald J Rogier, Jr. , Thomas D Penning , Ish K Khanna , Xiangdong Xu , Richard M Weier
发明人: John J Talley , James W Malecha , Stephen Bertenshaw , Matthew J Graneto , Jeffery Carter , Jinglin Li , Srinivasan Nagarajan , David L Brown , Donald J Rogier, Jr. , Thomas D Penning , Ish K Khanna , Xiangdong Xu , Richard M Weier
IPC分类号: A61K3144
CPC分类号: C07D207/33 , A61K31/18 , A61K31/415 , A61K31/42 , A61K31/635 , C07C311/16 , C07C311/51 , C07C2601/10 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D307/58 , C07D401/04 , C07D417/04 , C07D495/04
摘要: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to prodrugs of compounds which selectively inhibit cyclooxygenase-2. The use of non-steroidal antiinflammatory drugs (NSAIDs) in treating pain and the swelling associated with inflammation also produce severe side effects, including life threatening ulcers. The recent discovery of an inducible enzyme associated with inflammation (“prostaglandin G/H synthase II” or “cyclooxygenase-2 (COX-2)”) provides a viable target of inhibition which more effectively reduces inflammation and produces fewer and less drastic side effects.
摘要翻译: 本发明涉及抗炎药物领域,具体涉及选择性抑制环加氧酶-2的化合物的前药。非甾体抗炎药(NSAID)在治疗疼痛和与炎症有关的肿胀中的应用也产生严重的副作用, 包括危及生命的溃疡。 最近发现与炎症相关的可诱导酶(“前列腺素G / H合酶II”或“环加氧酶-2(COX-2)”)提供了可行的抑制靶标,其更有效地减少炎症并产生越来越少的副作用 。
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