-
公开(公告)号:US20080261970A1
公开(公告)日:2008-10-23
申请号:US11574943
申请日:2005-09-27
IPC分类号: A61K31/18 , C07C307/02 , A61K31/437 , C07D487/04 , A61K31/5377 , A61P3/10 , A61P3/00 , A61P3/04
CPC分类号: C07D471/04
摘要: Compounds of formula (I), including methods of making and methods of using are described in formula (I).
摘要翻译: 式(I)的化合物,包括制备方法和使用方法在式(I)中描述。
-
公开(公告)号:US09328077B2
公开(公告)日:2016-05-03
申请号:US13996286
申请日:2011-12-21
IPC分类号: C07D265/36 , C07D265/18 , C07D413/12
CPC分类号: C07D413/12 , C07D265/18 , C07D265/36
摘要: Compounds and compositions comprising compounds that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that activate PKM2 in the treatment of cancer.
摘要翻译: 包含激活丙酮酸激酶M2(PKM2)的化合物的化合物和组合物在本文中描述。 本文还描述了使用激活PKM2的化合物治疗癌症的方法。
-
公开(公告)号:US08785450B2
公开(公告)日:2014-07-22
申请号:US12826630
申请日:2010-06-29
IPC分类号: A61K31/496 , A61K31/4709 , C07D215/36 , C07D401/12 , C07D401/14 , C07D405/06 , C07D471/00
CPC分类号: C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , Y02P20/582
摘要: Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
-
公开(公告)号:US20120122849A1
公开(公告)日:2012-05-17
申请号:US13289551
申请日:2011-11-04
IPC分类号: A61K31/551 , C07D417/12 , C07D413/12 , C07D339/06 , C07D409/12 , A61P35/00 , A61K31/428 , A61K31/385 , A61K31/4436 , A61K31/496 , A61K31/4709 , C07D263/58 , A61K31/423
CPC分类号: C07D263/58 , C07D277/68 , C07D339/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要: Compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are pharmaceutical compositions comprising the compounds, and methods of using the compounds in the treatment of cancer.
摘要翻译: 本文描述了调节丙酮酸激酶M2(PKM2)的化合物。 本文还描述了包含该化合物的药物组合物,以及使用该化合物治疗癌症的方法。
-
公开(公告)号:US20120088747A1
公开(公告)日:2012-04-12
申请号:US13126613
申请日:2009-10-30
申请人: Jeffrey O. Saunders
发明人: Jeffrey O. Saunders
IPC分类号: A61K31/5377 , C07D403/04 , C07D413/04 , C07D405/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D411/06 , C07D403/12 , C07D403/14 , C07D417/12 , C07D401/12 , A61K31/4196 , A61K31/433 , A61K31/454 , A61K31/498 , A61K31/506 , A61P3/10 , A61P27/02 , A61P25/00 , A61P13/12 , A61P3/00 , A61P9/00 , C07D249/08
CPC分类号: C07D249/08 , A61K31/40 , A61K31/44 , C07D249/10 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/06 , C07D411/06 , C07D413/04
摘要: Compounds, compositions and methods for treating GHS-R mediated disorders are described herein.
摘要翻译: 本文描述了用于治疗GHS-R介导的病症的化合物,组合物和方法。
-
公开(公告)号:US20100331307A1
公开(公告)日:2010-12-30
申请号:US12826630
申请日:2010-06-29
IPC分类号: A61K31/5513 , A61P35/00 , A61K31/497 , C07D401/12 , C07D417/14 , C07D405/14 , C07D401/14
CPC分类号: C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , Y02P20/582
摘要: Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
摘要翻译: 包含调节丙酮酸激酶M2(PKM2)的化合物的化合物和组合物在本文中描述。 本文还描述了使用调节PKM2的化合物治疗癌症的方法。
-
公开(公告)号:US07432290B2
公开(公告)日:2008-10-07
申请号:US10997810
申请日:2004-11-24
申请人: Dean Stamos , Martin Trudeau , Randy S. Bethiel , Steven M. Ronkin , Michael C. Badia , Jeffrey O. Saunders
发明人: Dean Stamos , Martin Trudeau , Randy S. Bethiel , Steven M. Ronkin , Michael C. Badia , Jeffrey O. Saunders
IPC分类号: A61K31/41 , A61K31/425 , C07D263/00 , C07D263/02
CPC分类号: C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
摘要: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
摘要翻译: 本发明涉及抑制IMPDH的化合物。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性,因此可有利地用作IMPDH介导的方法的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。
-
公开(公告)号:US06653309B1
公开(公告)日:2003-11-25
申请号:US09702991
申请日:2000-10-30
申请人: Jeffrey O. Saunders , Daniel Elbaum , Perry M. Novak , Douglas Naegele , Randy S. Bethiel , Steven M. Ronkin , Michael C. Badia , Catharine Frank , Dean P. Stamos , William Walters , David Pearlman
发明人: Jeffrey O. Saunders , Daniel Elbaum , Perry M. Novak , Douglas Naegele , Randy S. Bethiel , Steven M. Ronkin , Michael C. Badia , Catharine Frank , Dean P. Stamos , William Walters , David Pearlman
IPC分类号: C07D25102
CPC分类号: C07D213/75 , A61K31/4965 , A61K31/53 , C07C217/84 , C07C235/64 , C07C311/21 , C07C311/29 , C07C317/40 , C07C323/42 , C07C333/08 , C07D263/32 , C07D271/06 , C07D307/91 , C07D317/68 , C07D413/12
摘要: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
摘要翻译: 本发明涉及抑制IMPDH的化合物。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适合于抑制IMPDH酶活性,因此可有利地用作IMPDH介导的方法的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。
-
公开(公告)号:US5264455A
公开(公告)日:1993-11-23
申请号:US724272
申请日:1991-07-01
IPC分类号: C07C317/46 , C07C323/61 , C07C323/65 , A61K31/35 , A61K31/215 , C07D339/00
CPC分类号: C07C317/46 , C07C323/61 , C07C323/65 , C07C2101/08 , C07C2101/14 , C07C2102/10
摘要: X is hydrogen or --S(O).sub.m --R.sup.1 and Y is hydrogen or S(O).sub.n --R.sup.2, except that X and Y are not both hydrogen, or one of X and Y is --S--alkyl--SH and the other is hydrogen; ##STR2## and the remaining symbols are as defined in the specification.
摘要翻译: 其作为细胞选择性HMG-CoA还原酶抑制剂具有活性,因此可用作抗高胆固醇血症药。 在上式中,X是氢或-S(O)m -R 1,Y是氢或S(O)n -R 2,不同之处在于X和Y不同时为氢,X和Y之一为-S- 烷基-SH,另一个是氢; < IMAGE>其余符号如说明书中所定义。
-
公开(公告)号:US5192773A
公开(公告)日:1993-03-09
申请号:US547814
申请日:1990-07-02
IPC分类号: A61K31/34 , A61K31/16 , A61K31/165 , A61K31/341 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/4545 , A61P25/02 , A61P37/06 , C07C233/56 , C07C235/12 , C07C235/34 , C07D207/08 , C07D207/16 , C07D211/60 , C07D307/54 , C07D317/60 , C07D333/24 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/06 , C07D409/06
CPC分类号: C07D401/06 , C07C233/56 , C07C235/34 , C07D211/60 , C07D317/60 , C07D403/06 , C07D405/06 , Y10S514/885
摘要: This invention relates to a novel class of immunosuppressive compounds having an affinity for the FK-506 binding protein (FKBP). Once bound to this protein, the immunosuppressive compounds inhibit the prolyl peptidyl cis-trans isomerase (rotamase) activity of the FKBP and inhibit T cell activation. As such, the compounds of this invention can be used as immunosuppressive drugs to prevent or significantly reduce graft rejection in bone marrow and organ transplantations and for use in the treatment of a wide variety of autoimmune diseases in humans and other mammals.
摘要翻译: 本发明涉及对FK-506结合蛋白(FKBP)具有亲和力的新一类免疫抑制化合物。 一旦结合到该蛋白质上,免疫抑制化合物抑制FKBP的脯氨酰基顺式 - 反式异构酶(旋转异构酶)活性并抑制T细胞活化。 因此,本发明的化合物可用作免疫抑制药物,以预防或显着降低骨髓和器官移植中的移植排斥反应,并用于治疗人类和其他哺乳动物中各种自身免疫性疾病。
-
-
-
-
-
-
-
-
-