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公开(公告)号：US20100273167A1
公开(公告)日：2010-10-28
申请号：US12763789
申请日：2010-04-20
申请人： Jennifer Hipp , Jason D. Hipp , Shay Soker
发明人： Jennifer Hipp , Jason D. Hipp , Shay Soker
CPC分类号： C12Q1/6883 , C12Q1/68 , C12Q1/6837 , C12Q2600/158
摘要： Provided herein are methods for determining ethanol exposure of a prenatal subject, including measuring whether or not amniotic fluid stem cells collected from amniotic fluid surrounding the prenatal subject have a upregulation or expression of one or more genes of a first predetermined combination and/or a downregulation of expression of one or more genes of a second predetermined combination. Also provided are methods for determining ethanol exposure of a prenatal subject which methods include measuring alkaline phosphatase activity and/or calcium deposition of amniotic fluid stem cells collected from amniotic fluid surrounding the prenatal subject.
摘要翻译： 本文提供了用于测定产前受试者的乙醇暴露的方法，包括测量从产前受试者周围的羊水收集的羊水干细胞是否具有上调或表达第一预定组合的一个或多个基因和/或下调 表达第二预定组合的一种或多种基因。 还提供了用于测定产前受试者的乙醇暴露的方法，所述方法包括测量从产前受试者周围的羊水收集的羊水干细胞的碱性磷酸酶活性和/或钙沉积。
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公开(公告)号：US08491457B2
公开(公告)日：2013-07-23
申请号：US11372743
申请日：2006-03-10
申请人： Anthony Atala , Shay Soker , James Yoo
发明人： Anthony Atala , Shay Soker , James Yoo
IPC分类号： A61F2/06
CPC分类号： A61L27/3604 , A61F2/06 , A61F2/062 , A61K35/44 , A61L27/3808 , A61L27/50 , A61L27/507 , A61L2430/36 , B82Y5/00 , B82Y10/00
摘要： The invention is directed to methods for preparing artificial blood vessels by preconditioning a matrix seeded with endothelial cells to fluid flow conditions that mimic blood flow.
摘要翻译： 本发明涉及通过将接种有内皮细胞的基质预处理以模拟血液流动的流体流动条件来制备人造血管的方法。
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3.发明授权公开(公告)号：US07883847B2
公开(公告)日：2011-02-08
申请号：US11394766
申请日：2006-03-31
申请人： Jason Hipp , Shay Soker
发明人： Jason Hipp , Shay Soker
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/158 , C12Q2600/16
摘要： The present invention concerns methods of screening cells for differentiation or de-differentiation, and/or for status as a pluripotent or multipotent (e.g., “stem”) cell, by detecting the differential expression (e.g., upregulation, downregulation) of genes.
摘要翻译： 本发明涉及通过检测基因的差异表达（例如上调，下调）筛选用于分化或去分化的细胞和/或作为多潜能或多能（例如“干”）细胞的状态的方法。
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公开(公告)号：US20100215717A1
公开(公告)日：2010-08-26
申请号：US12712832
申请日：2010-02-25
CPC分类号： A61K35/44 , A61F2/142 , A61K9/0051 , A61K35/12 , A61L27/3604 , A61L27/3808 , A61L2430/16
摘要： Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells seeded thereon. Methods of treating a patient in need of corneal endothelial transplant are also provided, including implanting the scaffold as described herein onto a cornea of the patient (e.g., by deep keratectomy).
摘要翻译： 本文提供的是包含脱细胞角膜基质的或由其组成的内皮支架。 在一些实施方案中，支架具有接种于其上的培养的内皮细胞。 还提供了治疗需要角膜内皮移植的患者的方法，包括将本文所述的支架植入患者的角膜（例如，通过深部角膜切除术）。
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5.发明授权公开(公告)号：US09938502B2
公开(公告)日：2018-04-10
申请号：US13882429
申请日：2011-11-04
申请人： Yuanyuan Zhang , Shay Soker , Anthony Atala , Aleksander Skardal
发明人： Yuanyuan Zhang , Shay Soker , Anthony Atala , Aleksander Skardal
CPC分类号： C12N5/0671 , C12N5/0068 , C12N2513/00 , C12N2533/54 , C12N2533/80 , C12N2533/90
摘要： The present invention relates to compositions and methods for mimicking an in vivo environment for culturing cells in vitro. The in vivo mimicking environment is based on the generation of a tissue-specific extracellular matrix wherein the matrix provides a substrate for which the cultured cell originated from. The tissue-specific extracellular matrix can further comprise a component of a whole tissue-specific homogenate.
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6.发明授权公开(公告)号：US09062346B2
公开(公告)日：2015-06-23
申请号：US12969070
申请日：2010-12-15
申请人： Jason Hipp , Shay Soker
发明人： Jason Hipp , Shay Soker
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/158 , C12Q2600/16
摘要： The present invention concerns methods of screening cells for differentiation or de-differentiation, and/or for status as a pluripotent or multipotent (e.g., “stem”) cell, by detecting the differential expression (e.g., upregulation, downregulation) of genes.
摘要翻译： 本发明涉及通过检测基因的差异表达（例如上调，下调）筛选用于分化或去分化的细胞和/或作为多潜能或多能（例如“干”）细胞的状态的方法。
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7.发明授权Enhancement of angiogenesis to grafts using cells engineered to produce growth factors 有权使用工程化生产生长因子的细胞增强移植物的血管生成公开(公告)号：US08940292B2
公开(公告)日：2015-01-27
申请号：US10766642
申请日：2004-01-28
申请人： Anthony Atala , Shay Soker
发明人： Anthony Atala , Shay Soker
IPC分类号： A61L27/38 , A61K48/00 , C12N5/077 , C12N5/071 , A61K38/18 , A61K35/34 , A61K35/44 , A61K35/12
CPC分类号： A61L27/3886 , A61K35/12 , A61K35/34 , A61K35/44 , A61K38/1866 , A61K48/00 , A61L27/3808 , A61L27/3834 , C12N5/0658 , C12N5/0686 , C12N5/0697 , C12N2501/165 , C12N2502/1347 , C12N2502/253 , C12N2502/28 , C12N2502/99 , C12N2533/32 , C12N2533/52 , C12N2533/54 , C12N2533/72 , C12N2533/90
摘要： The present invention provides methods and compositions of engineered cells for use in the continuous or transient delivery of growth factors and angiogenesis modulating agents, such as vascular endothelial growth factor (VEGF), in conjunction with constructs for replacing or augmenting organ functions. In one aspect of the invention, the genetically engineered cells can be immature cells that are capable of differentiating and assimilating into the target region. The methods of the present invention can be used to enhance vascularization locally at a target site in need of repair, growth, or implantation through the incorporation of autologous cells which have been genetically engineered to secrete a growth factor or angiogenesis modulating agent.
摘要翻译： 本发明提供了用于连续或瞬时递送生长因子和血管生成调节剂（例如血管内皮生长因子（VEGF））的工程细胞的方法和组合，以及用于替代或增加器官功能的构建体。 在本发明的一个方面，基因工程细胞可以是能够分化和同化到靶区域中的未成熟细胞。 本发明的方法可用于在需要修复，生长或植入的靶位点局部增强血管化，这是通过掺入已被遗传工程化以分泌生长因子或血管生成调节剂的自体细胞。
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公开(公告)号：US20110002919A1
公开(公告)日：2011-01-06
申请号：US12726171
申请日：2010-03-17
IPC分类号： A61K39/395 , C07K16/28 , A61P35/04
CPC分类号： C07K16/2863 , A61K38/00 , A61K39/39558 , A61K48/00 , C07K14/71 , C07K16/28
摘要： The present invention relates to antagonists of neuropilin receptor fuction and use thereof in the treatment of cancer, particularly metastatic cancer, and angiogenic diseases.
摘要翻译： 本发明涉及神经丝氨酸受体功能的拮抗剂及其在治疗癌症，特别是转移性癌症和血管生成疾病中的用途。
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公开(公告)号：US07731959B2
公开(公告)日：2010-06-08
申请号：US10104440
申请日：2002-03-22
申请人： Michael Klagsbrun , Shay Soker , Hua-Quan Miao , Seiji Takashima
发明人： Michael Klagsbrun , Shay Soker , Hua-Quan Miao , Seiji Takashima
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K38/00 , A61K39/39558 , A61K48/00 , C07K14/71 , C07K16/28
摘要： The present invention relates to antagonists of neuropilin receptor fuction and use thereof in the treatment of cancer, particularly metastatic cancer, and angiogenic diseases.
摘要翻译： 本发明涉及神经丝氨酸受体功能的拮抗剂及其在治疗癌症，特别是转移性癌症和血管发生疾病中的应用。
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公开(公告)号：US20070031384A1
公开(公告)日：2007-02-08
申请号：US11327074
申请日：2006-01-06
申请人： Anthony Atala , Anna Milanesi , Shay Soker
发明人： Anthony Atala , Anna Milanesi , Shay Soker
IPC分类号： A61K35/39
CPC分类号： A61K35/39 , A61K9/0019 , A61K35/12 , A61K35/50 , A61K38/00 , A61K38/1709 , C12N5/0605 , C12N5/0607 , C12N5/0676 , C12N2501/60 , C12N2506/02 , C12N2506/03 , C12N2510/00
摘要： A method of treating diabetes in a mammalian subject is carried out by: (a) providing mammalian amniotic fluid stem cells, and then (b) administering the cells to the subject in an amount effective to treat diabetes. Optionally, the cells may be differentiated into pancreatic-like cells or at least treated to initiate subsequent differentiation into-pancreatic-like cells, prior to administration.
摘要翻译： 通过以下方式进行哺乳动物受试者中的糖尿病治疗的方法：（a）提供哺乳动物羊水干细胞，然后（b）以有效治疗糖尿病的量向对象施用细胞。 任选地，在施用前，细胞可以分化为胰腺样细胞或至少被处理以引发随后的分化成胰腺样细胞。
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