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公开(公告)号：US5885803A
公开(公告)日：1999-03-23
申请号：US878989
申请日：1997-06-19
申请人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
发明人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention provides human disease associated protein kinases and polynucleotides (collectively designated DAPK) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing and treating disorders associated with expression of human disease associated protein kinases.
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公开(公告)号：US5973130A
公开(公告)日：1999-10-26
申请号：US846790
申请日：1997-04-30
摘要： The present invention provides a human Ras-like protein (RLP) and polynucleotides which identify and encode RLP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing RLP and for treating or preventing disorders associated with expression of RLP.
摘要翻译： 本发明提供了人Ras样蛋白（RLP）和识别并编码RLP的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 此外，本发明提供了产生RLP和治疗或预防与RLP表达相关的疾病的方法。
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公开(公告)号：US06207148B1
公开(公告)日：2001-03-27
申请号：US09272796
申请日：1999-03-19
申请人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
发明人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
IPC分类号： A61K3843
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention provides human disease associated protein kinases and polynucleotides (collectively designated DAPK) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing and treating disorders associated with expression of human disease associated protein kinases.
摘要翻译： 本发明提供了识别和编码它们的人类疾病相关蛋白激酶和多核苷酸（统称为DAPK）。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供用于诊断和治疗与人类疾病相关蛋白激酶的表达相关的疾病的方法。
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公开(公告)号：US6156523A
公开(公告)日：2000-12-05
申请号：US153939
申请日：1998-09-16
申请人： Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
发明人： Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K45/00 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/10 , A61P5/14 , A61P5/38 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P27/02 , A61P27/06 , A61P27/12 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/08 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/68 , A61K38/43 , C07K14/00 , C12N9/00 , C12N15/52 , G01N23/53
CPC分类号： C12N9/1205 , C12Y207/01037 , A61K38/00
摘要： The invention provides human serine/threonine protein kinases (HSTK) and polynucleotides which identify and encode HSTK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HSTK.
摘要翻译： 本发明提供人丝氨酸/苏氨酸蛋白激酶（HSTK）和识别和编码HSTK的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与HSTK表达相关的病症的方法。
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公开(公告)号：US5831052A
公开(公告)日：1998-11-03
申请号：US852809
申请日：1997-05-07
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C07H21/02 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a human translocation associated protein (Gp25L-H) and polynucleotides which identify and encode Gp25L-H. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of Gp25L-H, as well as diagnostic assays.
摘要翻译： 本发明提供了识别和编码Gp25L-H的人易位相关蛋白（Gp25L-H）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体和拮抗剂。 本发明还提供了用于预防和治疗与Gp25L-H表达相关的疾病以及诊断测定法的方法。
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公开(公告)号：US06399345B2
公开(公告)日：2002-06-04
申请号：US09151412
申请日：1998-09-10
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N906
CPC分类号： C12N9/0036 , A61K38/00
摘要： The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.
摘要翻译： 本发明提供四种NADH脱氢酶亚基（分别称为NDS-1，NDS-2，NDS-3和NDS-4，统称为NDS）和鉴定和编码NDS的多核苷酸。 本发明还提供了遗传工程改造的表达载体和包含编码NDS的核酸序列和产生NDS的方法的宿主细胞。 本发明还提供使用NDS和特异性结合NDS的激动剂，抗体或拮抗剂来预防和治疗与NDS表达相关的疾病。 另外，本发明提供反义分子用于编码NDS的多核苷酸用于治疗与NDS表达相关的疾病。 本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合NDS的抗体的诊断测定法。
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公开(公告)号：US06307021B1
公开(公告)日：2001-10-23
申请号：US09199892
申请日：1998-11-24
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C07K100
摘要： The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding APRG and a method for producing APRG. The invention also provides for agonists, antibodies, or antagonists specifically binding APRG, and their use, in the prevention and treatment of diseases associated with expression of APRG. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding APRG for the treatment of diseases associated with the expression of APRG. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding APRG.
摘要翻译： 本发明提供了鉴定和编码APRG的人细胞凋亡调节蛋白（APRG）和多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码APRG的核酸序列和生产APRG的方法。 本发明还提供了特异性结合APRG的激动剂，抗体或拮抗剂及其在预防和治疗与APRG表达相关的疾病中的用途。 此外，本发明提供了反义分子用于编码APRG的多核苷酸用于治疗与APRG表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合APRG的抗体的诊断测定法。
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公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译： 本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。 系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。 序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。 与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。
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公开(公告)号：US6136314A
公开(公告)日：2000-10-24
申请号：US353688
申请日：1999-07-14
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention provides a human histone fusion protein (HFP) and polynucleotides which identify and encode HFP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention also provides methods for producing HFP and for treating or preventing disorders associated with expression of HFP.
摘要翻译： 本发明提供了人组蛋白融合蛋白（HFP）和识别和编码HFP的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 此外，本发明还提供了用于生产HFP和用于治疗或预防与HFP表达相关的病症的方法。
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公开(公告)号：US6083704A
公开(公告)日：2000-07-04
申请号：US178881
申请日：1998-10-26
摘要： The present invention provides a human cytochrome b5 (HCB5) and polynucleotides which encode HCB5. The invention also provides genetically engineered expression vectors and host cells and a method for producing HCBS. The invention also provides for agonists, antisense molecules, antibodies, or antagonists of HCB5, and their use in the prevention and treatment of diseases associated with expression of HCB5. The invention also provides a method for detecting polynucleotides which encode HCB5.
摘要翻译： 本发明提供人细胞色素b5（HCB5）和编码HCB5的多核苷酸。 本发明还提供基因工程表达载体和宿主细胞以及生产HCBS的方法。 本发明还提供HCB5的激动剂，反义分子，抗体或拮抗剂及其在预防和治疗与HCB5表达有关的疾病中的用途。 本发明还提供了一种检测编码HCB5的多核苷酸的方法。
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