摘要:
One aspect of the present invention relates to an immobilized nucleic acid comprising a nucleic acid and a matrix where the nucleic acid is a Spiegelmer and the Spiegelmer is functionally active. Another aspect of the invention concerns an immobilized nucleic acid comprising a nucleic acid and a matrix where the nucleic acid is coupled to the matrix at least via its 3′ end and the nucleic acid is a functional nucleic acid. Finally a further aspect of the invention concerns the use of such immobilized nucleic acids as affinity ligands for example in chromatography and in apheresis.
摘要:
The present invention provides for amplification methods for cloning and copying genetic material on surfaces as well as copying biological material insofar as, in a broader sense, it can be classified as a ligand-receptor system. The invention therefore relates in particular to a method for propagating ligands and receptors on at least two surfaces, comprising (a) immobilizing a first ligand on a first surface of a substantially solid phase; (b) adding a solution of receptors and binding complementary receptors to the first ligand; (c) transferring the receptor to a second surface and immobilizing the receptor at that location; (d) attaching an additional ligand to the immobilized receptor; and (e) transferring the additional ligand to the first surface and immobilizing it at that location, wherein the steps set forth above may be repeated,multiple times.
摘要:
Example embodiments presented herein are directed towards a universal printing controller, and corresponding method, for universal printing control. A universal printing controller is presented herein which may provide instructions and/or control functionality to printers of various print technologies. Based on a particular print-head type, the universal controller may choose a print technology format from a variety of different print technology formats. The universal printing controller may also provide print instructions for printing an image description based on the chosen print technology format.
摘要:
A storage medium on which geographic data of a geographic region are stored together as map units, a corresponding method for generating a map from the geographic data, and a corresponding navigation device. In order to reduce the amount of data to be processed, the map units are structured hierarchically, map units of an nth order respectively corresponding to one geographic partial region, n being a natural number, and map units of an (n+1)th order respectively corresponding to one geographic subregion of one of the partial regions.
摘要:
The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a GLP-1 receptor agonist and a DPP-4 inhibitor.
摘要:
The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a DPP-4 inhibitor and a long-acting insulin. The invention further relates to a DPP-4 inhibitor for subcutaneous or transdermal use.
摘要:
The invention relates to a system for the automatic, rapid and dynamic allocation of biological cells for transplantation, therapy, or research purposes between collection centers or banks (storage sites) and hospitals, transplant centers or research facilities, and for monitoring and supporting the processes from request transmission up to delivery of a cell preparation suitable for allogeneic transplantation, via the use of allocated preparations up to tracking the results in the patient and providing these data for statistical and other purposes, as well as assigning molecular-diagnostic results of individuals with the aim of verifying options—even in advance—of transplantations among the inventory of registers or banks. Using said system, it is possible for the first time—even in advance and online and with automatic retries—to propose complete solutions in the form of transplantations in specific and individual cases.
摘要:
The present invention relates to a machine operator seat of a construction machine having a seat surface, a backrest, which is situated opposite to the front seat edge in the longitudinal direction of the seat surface, and at least one armrest situated laterally to the seat surface, comprising a base part, an arm support, and at least one operating element, the arm support being situated in the rear area in the longitudinal direction and the at least one operating element being situated in the front area of the armrest in the longitudinal direction. Furthermore, the present invention relates to a construction machine, in particular a road miller, recycler, stabilizer, or a road roller, in particular a tandem roller, having such a machine operator seat.
摘要:
A method for detecting an imperfect mounting of an essentially rod-shaped metallic object in a metallic hollow shaft is provided. The imperfect mounting may lead to the formation of metallic particles. The rod-shaped object is mounted electrically insulated from the hollow shaft. The electrical resistance between the rod-shaped object and the hollow shaft is measured. An alert is issued when the electrical resistance is lower than a predefined level. A device includes a spin unit with a hollow drive shaft and a nozzle mounted inside the hollow shaft. The device is configured to use the inventive method.