公开(公告)号：US4761381A

公开(公告)日：1988-08-02

申请号：US20185

申请日：1987-02-26

申请人： Joel M. Blatt ,  Robert Heiland ,  James R. Morris ,  Jerry Pugh ,  Frank W. Wogoman

发明人： Joel M. Blatt ,  Robert Heiland ,  James R. Morris ,  Jerry Pugh ,  Frank W. Wogoman

IPC分类号： B01L3/00 ,  G01N21/78 ,  G01N33/52

CPC分类号： B01L3/502738 ,  B01L2200/0605 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L3/502746

摘要： A method for controlling a liquid volume flowing onto a reactive surface which includes a sample application port, two systems of capillary channels, a reaction chamber, and an overflow chamber. The liquid sample to be analyzed is applied to the sample application port which gives the liquid entry to a capillary channel leading to the reaction chamber which contains a material capable of detecting the component of interest in the liquid. When the reaction chamber is filled, the remaining liquid will flow through another capillary channel to an overflow chamber. The capillary channel leading to the overflow chamber is controlled so that liquid cannot flow back into the reaction chamber.

摘要翻译： 一种用于控制流过反应表面的液体体积的方法，其包括样品施加口，两个毛细通道系统，反应室和溢流室。 要分析的液体样品被施加到样品施加口，其使得液体进入通向反应室的毛细通道，该反应室含有能够检测液体中感兴趣组分的材料。 当反应室被填充时，剩余的液体将通过另一个毛细通道流到溢流室。 控制通向溢流室的毛细通道，使得液体不能流回反应室。

公开(公告)号：US07550104B2

公开(公告)日：2009-06-23

申请号：US10984504

申请日：2004-11-09

申请人： Allen J. Brenneman ,  Frank W. Wogoman

发明人： Allen J. Brenneman ,  Frank W. Wogoman

IPC分类号： B29C39/02

CPC分类号： B01L3/502707 ,  B01L3/5027 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2300/0825 ,  B01L2400/0406 ,  B29C45/14 ,  B29C45/14065 ,  B29C45/14639 ,  B29C45/14754 ,  B29C2045/1477 ,  G01N21/03 ,  G01N27/4473 ,  G01N2021/0346

摘要： An optical reagent format with a precise capillary channel is made by molding a format on a carrier of a precise predetermined thickness. The carrier includes an insert at least a portion of which is molded in the format. Once the format is made, the insert is detached from the carrier and removed from the format leaving a precisely dimensioned capillary channel with an inlet and vent. A reagent may be applied in the capillary channel and the format used to measure the analyte in a fluid such as blood.An electrochemical sensor with a capillary channel is formed by placing a sacrificial insert and electrodes on a sensor base and applying plastic material. After the plastic material is cured, the sacrificial is removed leaving a capillary channel in the sensor. The inserts may be removed by a tool including a clamp for clamping and holding each insert stationary and a sliding block to which the sensor is secured.

公开(公告)号：US07122102B2

公开(公告)日：2006-10-17

申请号：US10156572

申请日：2002-05-29

申请人： Frank W. Wogoman

发明人： Frank W. Wogoman

IPC分类号： G01N27/403 ,  G01N27/333 ,  G01N27/327

CPC分类号： G01N27/3272

摘要： An electrochemical sensor with a capillary channel is formed by placing a sacrificial insert on a sensor base and applying casting material. After the casting material is cured, the sacrificial is removed leaving a capillary channel in the sensor. The insert may be removed by a tool including a clamp for clamping and holding the insert stationary and a sliding block to which the sensor is secured.

摘要翻译： 具有毛细通道的电化学传感器通过将牺牲插件放置在传感器基座上并施加铸造材料而形成。 在铸造材料固化之后，去除牺牲物，留下传感器中的毛细通道。 可以通过包括用于夹紧和保持插入件固定的夹具的工具以及固定有传感器的滑块来移除插入件。

公开(公告)号：US5630986A

公开(公告)日：1997-05-20

申请号：US404303

申请日：1995-03-14

申请人： Steven C. Charlton ,  Anne T. Miller ,  Joseph L. Moulton ,  Matthew A. Schumann ,  Dennis Slomski ,  Frank W. Wogoman

发明人： Steven C. Charlton ,  Anne T. Miller ,  Joseph L. Moulton ,  Matthew A. Schumann ,  Dennis Slomski ,  Frank W. Wogoman

IPC分类号： G01N33/66 ,  B01L99/00 ,  G01N27/28 ,  G01N27/327 ,  G01N33/487 ,  G01N35/00 ,  G01N37/00

CPC分类号： G01N33/4875 ,  B01L99/00 ,  G01N2035/00089 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/112499

摘要： A sensor dispensing instrument is adapted to receive a generally circular sensor pack containing a plurality of blood glucose sensors. Each of the sensors are disposed in sensor cavities, each of which is in fluid communication with a corresponding desiccant cavity and has a support wall that assists in directing the sensor as its being ejected from the cavity. The sensor pack is loaded on an indexing disk in the instrument such that when a slide actuator on the instrument is moved toward a testing position, a feed mechanism engaged by the slide actuator moves a knife blade thereon toward one of the sensor cavities. The knife blade pierces a portion of a foil covering the sensor cavity and engages the sensor disposed in the cavity to thereby eject the sensor from the sensor cavity. The continued sliding of the slide actuator toward its testing position results in the sensor being completely ejected from the sensor cavity and disposed in a testing position with a testing end of the sensor projecting from the instrument. Once the blood analyzing test is completed, the slide actuator is moved in the opposite direction towards its standby position. As the slide actuator is moved away from its testing position, the indexing disk with the sensor pack thereon is rotated so that the next one of sensor cavities is positioned so that the sensor therein can be used for the next blood glucose test that is to be performed. The instrument includes circuitry to obtain test data from the sensor pack and to display testing data.

摘要翻译： 传感器分配仪器适于接收包含多个血糖传感器的大体上圆形的传感器组件。 每个传感器设置在传感器腔中，每个传感器腔与相应的干燥剂腔流体连通，并且具有支撑壁，该支撑壁有助于将传感器从空腔喷射出来。 传感器组件被装载在仪器中的分度盘上，使得当仪器上的滑块致动器朝向测试位置移动时，由滑动致动器接合的进给机构将其上的刀片向着其中一个传感器腔移动。 刀片刺穿覆盖传感器腔的箔片的一部分，并接合设置在空腔中的传感器，从而将传感器从传感器腔排出。 滑动致动器朝向其测试位置的持续滑动导致传感器从传感器腔完全弹出并且设置在测试位置，传感器的测试端从仪器突出。 一旦血液分析测试完成，滑动致动器就朝向其待机位置的相反方向移动。 当滑块致动器从其测试位置移开时，其上具有传感器组件的分度盘被旋转，使得下一个传感器腔被定位成使得其中的传感器可用于下一次血糖测试 执行。 仪器包括从传感器组件获取测试数据并显示测试数据的电路。

公开(公告)号：US5055261A

公开(公告)日：1991-10-08

申请号：US270849

申请日：1988-11-14

申请人： Mirza A. Khoja ,  Frank W. Wogoman

发明人： Mirza A. Khoja ,  Frank W. Wogoman

IPC分类号： B65G25/02 ,  G01N1/28 ,  G01N35/00

CPC分类号： B65G25/02 ,  G01N21/8483 ,  G01N35/00029 ,  G01N1/2813 ,  G01N2035/00039 ,  G01N2035/00118

摘要： A multiple reagent test strip-reading instrument having rails extending from a loading area to one or more reading station platforms and then to a waste receptacle, a reciprocating blotter arm which contacts individual reagent strips sequentially placed transversely on the rails in the loading area, moving individual strips along the rails to an indexing strip advancing mechanism which intermittently advances the strips along the rails in spaced parallel relation, and after each advance, allows the strips to dwell for a predetermined time period; individual test strips being thereby sequentially delivered to reading position on the reading station platform where, during the dwell period, they are read by reflectance photometry. After reading, the strips are moved to the waste receptacle. Means is provided for insuring that each test strip is delivered to reading position in registration with the read head of the photometer, and means is also provided for pressing each test strip flat against the reading station platform. The indexing mechanism employs a strip advancing member provided with parallel rows of equally spaced upstanding pegs or fingers, there being guiding and drive means for imparting movement to said member along a vertical orbital path having a generally circular extent and also having a rectilinear extent parallel with the rails, said pegs intersecting the plane of the reagent strips on the rails when said member moves forwardly along said rectilinear extent and being withdrawn from said plane when said member moves rearwardly along said circular extent.

摘要翻译： 一种多试剂测试条读取仪器，具有从装载区域延伸到一个或多个阅读站平台，然后到废物容器的轨道，一个往复式吸墨纸臂，其接触各个试剂条，其横向地放置在装载区域中的轨道上，移动 沿着轨道的单独条带到分段条带前进机构，其间隔地沿着轨道以间隔开的平行关系推进条带，并且在每个前进之后允许条带停留预定时间段; 单独的测试条由此顺序地传送到阅读台平台上的读取位置，在停留时段期间，它们通过反射光度测量被读取。 阅读后，将条移动到废物容器。 提供了用于确保每个测试条被传送到与光度计的读取头对准的读取位置的装置，并且还提供用于将每个测试条平放在读取台平台上的装置。 分度机构采用设置有平行的等间距直立的钉或手指的条带推进构件，存在引导和驱动装置，用于沿着具有大致圆形范围的垂直轨道路径向所述构件施加运动，并且还具有与 所述轨道，当所述构件沿着所述直线范围向前移动时，所述栓与试剂条的平面相交，并且当所述构件沿着所述圆形范围向后移动时从所述平面撤回。

公开(公告)号：US5738244A

公开(公告)日：1998-04-14

申请号：US660874

申请日：1996-06-10

申请人： Steven C. Charlton ,  Anne T. Miller ,  Joseph L. Moulton ,  Matthew A. Schumann ,  Dennis Slomski ,  Frank W. Wogoman

发明人： Steven C. Charlton ,  Anne T. Miller ,  Joseph L. Moulton ,  Matthew A. Schumann ,  Dennis Slomski ,  Frank W. Wogoman

IPC分类号： B01L99/00 ,  G01N33/487 ,  G01N35/00 ,  G01N37/00 ,  B65H3/58

CPC分类号： G01N33/4875 ,  B01L99/00 ,  G01N2035/00089 ,  Y10S206/828

摘要： A sensor dispensing instrument is adapted to receive a generally circular sensor pack containing a plurality of blood glucose sensors. Each of the sensors are disposed in sensor cavities, each of which is in fluid communication with a corresponding desiccant cavity and has a support wall that assists in directing the sensor as its being ejected from the cavity. The sensor pack is loaded on an indexing disk in the instrument such that when a slide actuator on the instrument is moved toward a testing position, a feed mechanism engaged by the slide actuator moves a knife blade thereon toward one of the sensor cavities. The knife blade pierces a portion of a foil covering the sensor cavity and engages the sensor disposed in the cavity to thereby eject the sensor from the sensor cavity. The continued sliding of the slide actuator toward its testing position results in the sensor being completely ejected from the sensor cavity and disposed in a testing position with a testing end of the sensor projecting from the instrument. Once the blood analyzing test is completed, the slide actuator is moved in the opposite direction towards its standby position. As the slide actuator is moved away from its testing position, the indexing disk with the sensor pack thereon is rotated so that the next one of sensor cavities is positioned so that the sensor therein can be used for the next blood glucose test that is to be performed. The instrument includes circuitry to obtain test data from the sensor pack and to display testing data.

公开(公告)号：US5632410A

公开(公告)日：1997-05-27

申请号：US638971

申请日：1996-07-12

申请人： Joseph L. Moulton ,  Frank W. Wogoman

发明人： Joseph L. Moulton ,  Frank W. Wogoman

IPC分类号： G01N33/66 ,  B01L99/00 ,  G01N27/28 ,  G01N27/327 ,  G01N33/487 ,  G01N35/04 ,  G07F11/00

CPC分类号： B01L99/00 ,  G01N33/4875 ,  G01N33/66

摘要： A sensor dispensing instrument (20) includes a sensor magazine (26) that contains a plurality of blood glucose sensors (38) disposed in sensor slots (30A-J). Each of the sensor slots (30A-J) is in fluid communication with a desiccant cavity (50A-J) in which desiccant material is disposed. The front and rear walls (34, 32) of the sensor magazine (26) are sealed with burst foils (40, 42) so as to seal the sensor slots (30A-J) and the desiccant cavities (36A-J). The sensor instrument (20) has an outer housing (22) with a laterally extending magazine opening (24) adapted to receive the sensor magazine (26). A pivot rod (28) is moved through the magazine (26) and is locked into an operating position. The magazine (26) is rotated on the pivot rod (28) until a detent arm (48) on the instrument housing (22) engages a detent groove (50A-J) on the magazine (26) to position the magazine (26) in a sensor feeding position. Once so positioned, a sensor push rod (54) is pushed forward resulting in the push rod (54) piercing the rear burst foil (42) and engaging a sensor (38) in one of the sensor slots (30A-J) to thereby push the sensor (38) out through the front burst foil (40) and into a testing position. While in this testing position, the sensor (38) can be placed in a blood sample that needs to be analyzed. Once the test is completed, the push rod (54) is advanced forward further to thereby eject the used sensor (38) from the sensor handling instrument (20). The push rod (54) then is retracted to a standby position and the sensor magazine (26) is rotated until the detent arm (48) engages another detent groove (50A-J) so that another sensor slot (30A-J) is in alignment with the push rod (54).

摘要翻译： 传感器分配仪器（20）包括传感器盒（26），其包含设置在传感器槽（30A-J）中的多个血糖传感器（38）。 每个传感器槽（30A-J）与其中设置干燥剂材料的干燥剂腔（50A-J）流体连通。 传感器盒（26）的前壁和后壁（34,32）用爆裂箔（40,42）密封，以密封传感器槽（30A-J）和干燥剂腔（36A-J）。 传感器仪器（20）具有外壳（22），其具有适于容纳传感器盒（26）的横向延伸的盒式开口（24）。 枢轴杆（28）移动通过料仓（26）并被锁定到操作位置。 刀库（26）在枢轴杆（28）上旋转，直到仪器壳体（22）上的止动臂（48）接合在刀库（26）上的止动槽（50A-J） 在传感器进给位置。 一旦这样定位，传感器推杆（54）被向前推动，导致推杆（54）刺穿后爆裂箔片（42）并将传感器（38）接合在传感器插槽（30A-J）之一中，从而 将传感器（38）推出前部爆破箔（40）并进入测试位置。 在该测试位置，传感器（38）可以被放置在需要分析的血样中。 一旦测试完成，推杆（54）进一步前进，从而从传感器处理仪器（20）弹出使用的传感器（38）。 推杆（54）然后被缩回到备用位置，并且传感器仓（26）旋转直到定位臂（48）接合另一个制动槽（50A-J），使得另一个传感器槽（30A-J）处于 与推杆（54）对准。

公开(公告)号：US4820491A

公开(公告)日：1989-04-11

申请号：US32607

申请日：1987-04-01

申请人： Mirza A. Khoja ,  Frank W. Wogoman

发明人： Mirza A. Khoja ,  Frank W. Wogoman

IPC分类号： G01N33/52 ,  B65G25/02 ,  G01N1/28 ,  G01N21/75 ,  G01N21/78 ,  G01N35/00

CPC分类号： G01N35/00029 ,  B65G25/02 ,  G01N21/8483 ,  G01N1/2813 ,  G01N2035/00039 ,  G01N2035/00118 ,  Y10T436/112499 ,  Y10T436/113332

摘要： A multiple reagent test strip-reading instrument having rails extending from a loading area to one or more reading station platforms and then to a waste receptacle, a reciprocating blotter arm which contacts individual reagent strips sequentially placed transversely on the rails in the loading area, moving individual strips along the rails to an indexing strip advancing mechanism which intermittently advances the strips along the rails in spaced parallel relation, and after each advance, allows the strips to dwell for a predetermined time period; individual test strips being thereby sequentially delivered to reading position on the reading station platform where, during the dwell period, they are read by reflectance photometry. After reading, the strips are moved to the waste receptacle. Means is provided for insuring that each test strip is delivered to reading position in registration with the read head of the photometer, and means is also provided for pressing each test strip flat against the reading station platform. The indexing mechanism employs a strip advancing member provided with parallel rows of equally spaced upstanding pegs or fingers, there being guiding and drive means for imparting movement to said member along a vertical orbital path having a generally circular extent and also having a rectilinear extent parallel with the rails, said pegs intersecting the plane of the reagent strips on the rails when said member moves forwardly along said rectilinear extent and being withdrawn from said plane when said member moves rearwardly along said circular extent.

摘要翻译： 一种多试剂测试条读取仪器，具有从装载区域延伸到一个或多个阅读站平台，然后到废物容器的轨道，一个往复式吸墨纸臂，其接触各个试剂条，其横向地放置在装载区域中的轨道上，移动 沿着轨道的单独条带到分段条带前进机构，其间隔地沿着轨道以间隔开的平行关系推进条带，并且在每个前进之后允许条带停留预定时间段; 单独的测试条由此顺序地传送到阅读台平台上的读取位置，在停留时段期间，它们通过反射光度测量被读取。 阅读后，将条移动到废物容器。 提供了用于确保每个测试条被传送到与光度计的读取头对准的读取位置的装置，并且还提供用于将每个测试条平放在读取台平台上的装置。 分度机构采用设置有平行的等间距直立的钉或手指的条带推进构件，存在引导和驱动装置，用于沿着具有大致圆形范围的垂直轨道路径向所述构件施加运动，并且还具有与 所述轨道，当所述构件沿着所述直线范围向前移动时，所述栓与试剂条的平面相交，并且当所述构件沿着所述圆形范围向后移动时从所述平面撤回。

公开(公告)号：US4689202A

公开(公告)日：1987-08-25

申请号：US649363

申请日：1984-09-11

申请人： Mirza A. Khoja ,  Frank W. Wogoman

发明人： Mirza A. Khoja ,  Frank W. Wogoman

IPC分类号： G01N33/52 ,  B65G25/02 ,  G01N1/28 ,  G01N21/75 ,  G01N21/78 ,  G01N35/00 ,  G01N21/13 ,  G01N35/04

CPC分类号： G01N35/00029 ,  B65G25/02 ,  G01N21/8483 ,  G01N1/2813 ,  G01N2035/00039 ,  G01N2035/00118 ,  Y10T436/112499 ,  Y10T436/113332

摘要： A multiple reagent test strip-reading instrument having rails extending from a loading area to one or more reading station platforms and then to a waste receptacle, a reciprocating blotter arm which contacts individual reagent strips sequentially placed transversely on the rails in the loading area, moving individual strips along the rails to an indexing strip advancing mechanism which intermittently advances the strips along the rails in spaced parallel relation, and after each advance, allows the strips to dwell for a predetermined time period; individual test strips being thereby sequentially delivered to reading position on the reading station platform where, during the dwell period, they are read by reflectance photometry. After reading, the strips are moved to the waste receptacle. Means is provided for insuring that each test strip is delivered to reading position in registration with the read head of the photometer, and means is also provided for pressing each test strip flat against the reading station platform. The indexing mechanism employs a strip advancing member provided with parallel rows of equally spaced upstanding pegs or fingers, there being guiding and drive means for imparting movement to said member along a vertical orbital path having a generally circular extent and also having a rectilinear extent parallel with the rails, said pegs intersecting the plane of the reagent strips on the rails when said member moves forwardly along said rectilinear extent and being withdrawn from said plane when said member moves rearwardly along said circular extent.

公开(公告)号：USD452564S1

公开(公告)日：2001-12-25

申请号：US29123774

申请日：2000-05-24

申请人： Russell J. Micinski ,  Eric W. Miller ,  Frank W. Wogoman

设计人： Russell J. Micinski ,  Eric W. Miller ,  Frank W. Wogoman