公开(公告)号：US20070092445A1

公开(公告)日：2007-04-26

申请号：US11530718

申请日：2006-09-11

申请人： John Coley ,  Fernando Miro ,  Jayne Ellis ,  Paul Henry Mundill

发明人： John Coley ,  Fernando Miro ,  Jayne Ellis ,  Paul Henry Mundill

IPC分类号： A61K49/00 ,  G01N33/567

CPC分类号： G01N33/76

摘要： Methods for assessing the ovarian reserve of a female subject may include (a) testing the concentration of follicle stimulating hormone (FSH) in urine samples obtained from the subject, the samples being obtained on at least two different days during a first menstrual cycle in the subject; (b) testing the concentration of FSH in further urine samples, the further samples being obtained on at least two different days during one or more subsequent menstrual cycles in the subject, which days may be the same as, or different from, the days on which samples are obtained in step (a); (c) comparing the FSH test results obtained from the subject with a reference value calculated from a menopausal or non-menopausal control population; and, (d) based at least partly on the comparison, making an assessment of the subject's ovarian reserve

摘要翻译： 用于评估女性受试者卵巢储备的方法可以包括（a）在从受试者获得的尿液样本中测试促卵泡激素（FSH）的浓度，所述样品在第一次月经周期中在至少两个不同的日期获得 学科; （b）测试其他尿液样本中的FSH浓度，另外的样品是在受试者的一个或多个随后的月经周期中至少两个不同的日期获得的，这些天可以与天数相同或不同 在步骤（a）中获得样品; （c）将从受试者获得的FSH测试结果与从绝经或非绝经对照组计算的参考值进行比较; 和（d）至少部分地基于比较，对主体的卵巢储备进行评估

公开(公告)号：US20050130311A1

公开(公告)日：2005-06-16

申请号：US10489908

申请日：2002-09-18

申请人： John Coley ,  Fernando Miro ,  Laurence Aspinall ,  Peter Murray ,  Anthony Dadd ,  Zhi Zhang ,  Paul Mundill

发明人： John Coley ,  Fernando Miro ,  Laurence Aspinall ,  Peter Murray ,  Anthony Dadd ,  Zhi Zhang ,  Paul Mundill

IPC分类号： G01N33/74 ,  G01N33/76 ,  G01N33/00

CPC分类号： G01N33/74 ,  G01N33/76

摘要： Disclosed is a method of detecting a retarded cycle in a human female subject experiencing same, the method comprising the steps of obtaining a sample of body fluid from the subject on each of a plurality of, but not less than three, days; testing each of the plurality of samples to determine the concentration therein of at least one analyte of significance in the ovulatory cycle; comparing a result determined from said testing with a predetermined threshold value; and, if said determined result is different from the threshold value; declaring the cycle, during which the samples were taken, to be a retarded cycle.

摘要翻译： 本发明公开了一种在经历其的人类女性受试者中检测延迟循环的方法，所述方法包括以下步骤：从多个但不少于三天的每一天获得受试者的体液样品; 测试所述多个样品中的每一个以确定在排卵周期中至少一种有意义的分析物的浓度; 将从所述测试确定的结果与预定阈值进行比较; 并且如果所述确定结果不同于所述阈值; 宣布将采样的周期作为延迟周期。

公开(公告)号：US06454726B1

公开(公告)日：2002-09-24

申请号：US08728191

申请日：1996-10-10

申请人： Michael Catt ,  John Coley ,  Paul J Davis

发明人： Michael Catt ,  John Coley ,  Paul J Davis

IPC分类号： A61B500

CPC分类号： A61B10/0012 ,  G01N33/743 ,  G01N33/76

摘要： A method of monitoring the status of a current ovulation cycle of an individual human female subject, involving testing of the body fluid concentration of an analyte of significance in relation to the status of the ovulation cycle, such as urinary E3G, during at least part of the pre-ovulation phase of the current ovulation cycle of the individual subject, and identification from the results of such testing an analyte concentration change indicative of imminent ovulation, relative to an analyte concentration reference value that has been adapted to the individual human subject on the basis of analyte concentration test data obtained from the individual human subject during one or more previous ovulation cycles.

摘要翻译： 一种监测个体人类女性受试者当前排卵周期状态的方法，包括在至少部分时间内测量相对于排卵周期状态（例如尿E3G）的有意义的分析物的体液浓度 个体受试者当前排卵周期的排卵前阶段以及相对于已经适应于个体受试者的分析物浓度参考值的来自这种测试结果的指示即将排卵的分析物浓度变化的鉴定 在一个或多个以前的排卵周期中从个体人受试者获得的分析物浓度测试数据的基础。

公开(公告)号：US4980298A

公开(公告)日：1990-12-25

申请号：US370168

申请日：1989-06-20

申请人： Anthony Blake ,  John Coley ,  Ronald Smith

发明人： Anthony Blake ,  John Coley ,  Ronald Smith

IPC分类号： G01N33/493 ,  B01L3/00 ,  C12M1/34 ,  G01N33/48 ,  G01N33/53 ,  G01N33/543

CPC分类号： B01L3/502 ,  G01N33/5302 ,  G01N33/54366 ,  Y10S436/807 ,  Y10S436/81 ,  Y10S436/818

摘要： A device for carrying out chemical or clinical testing of a liquid sample, for example a urine sample, by a specific binding assay, said device comprising a test compoenent (2) which has a sensitised solid surface (2a) carrying an immobilized component of a specific binding pair relevant to the essay, and a handling piece (1), and characterized in that the test component (2) bearing the sensitized surface (2a) is removably mounted in spaced relationship with a removably mounted accessory component (4) carrying an accessory solid surface (5), and in that there is a space (4a) between the sensitized surface (2a) and the removable accessory component (4) to act as a container for sample liquid, so that when the device is contacted with a sample liquid source or immersed in liquid which is to provide the test sample, liquid of the sample can enter the space (4a) to contact the sensitized surface (2a), and the accessory surface (5) acts to retain and contain sample liquid in contact with the sensitized surface (2a) even after removal of the device from further contact with or immersion in the source of sample liquid, and in that the test component (2) is so formed that after removal of the removable accessory component (4) the sensitized surface (2a) is left exposed and accessible to further treatment liquid such as washing liquid and/or reagents.

公开(公告)号：US20080248494A1

公开(公告)日：2008-10-09

申请号：US12036489

申请日：2008-02-25

申请人： Lorraine D. Butlin ,  John Coley ,  Stephen J. Eida ,  Mohamed M. Gani

发明人： Lorraine D. Butlin ,  John Coley ,  Stephen J. Eida ,  Mohamed M. Gani

IPC分类号： G01N33/53 ,  C12M1/34 ,  C07K16/26

CPC分类号： G01N33/76 ,  C07K16/26

摘要： A method and test device for differentiating between states of an analyte that can exist in different forms, such as follicle stimulating hormone (FSH). The method or test device uses two contemporaneous assays, the first of which does not differentiate between the two analyte states and the second of which does, and the assay results are compared. A novel pair of anti-FSH monoclonal antibodies that can be used together in a sandwich-format assay to differentiate pre-menopausal and post-menopausal FSH samples is disclosed.

摘要翻译： 用于区分可以不同形式存在的分析物的状态的方法和测试装置，例如促卵泡激素（FSH）。 该方法或测试装置使用两个同时进行的测定，其中第一个测定不区分两个分析物状态，其中第二个测定结果与测定结果进行比较。 公开了一种新颖的抗FSH单克隆抗体，其可以以夹心形式测定一起使用以区分绝经前和绝经后FSH样品。

公开(公告)号：US07410768B2

公开(公告)日：2008-08-12

申请号：US09824587

申请日：2001-04-03

申请人： Lorraine D. Butlin ,  John Coley ,  Stephen J. Eida ,  Mohamed M. Gani

发明人： Lorraine D. Butlin ,  John Coley ,  Stephen J. Eida ,  Mohamed M. Gani

IPC分类号： G01N33/53

CPC分类号： C07K16/26 ,  G01N33/54306 ,  G01N33/76 ,  Y10S435/96 ,  Y10S436/806 ,  Y10S436/814 ,  Y10S436/815 ,  Y10S436/817 ,  Y10S436/818

摘要： A method and test device for differentiating between states of an analyte that can exist in different forms, such as follicle stimulating hormone (FSH). The method or test device uses a pair of specific binding agents, especially monoclonal antibodies, in two assays for the same analyte. The assays, applied to contemporaneous samples, differ from one another in format, one being a two step assay and the other being one step. A novel pair of anti-FSH monoclonal antibodies that can be used together in two such assays to differentiate pre-menopausal and post-menopausal FSH samples is disclosed.

摘要翻译： 用于区分可以不同形式存在的分析物的状态的方法和测试装置，例如促卵泡激素（FSH）。 该方法或测试装置在相同分析物的两个测定中使用一对特异性结合剂，特别是单克隆抗体。 应用于同期样品的测定法在格式上彼此不同，一种是两步测定，另一步是一步。 公开了一种新的一对抗FSH单克隆抗体，其可以在两种这样的测定中一起使用以区分绝经前和绝经后FSH样品。

公开(公告)号：US07464753B2

公开(公告)日：2008-12-16

申请号：US11396533

申请日：2006-04-03

申请人： Arthur F. White ,  John Coley

发明人： Arthur F. White ,  John Coley

IPC分类号： E21B43/12

CPC分类号： E21B43/121

摘要： A microcontroller system for oil and gas wells using a plunger lift device, which responds to the variations in well production and operation. The system requires minimal operator input, and is able to calculate the operational cycles and adjustments to maximize well production and maintain environmental safety using non-linear artificial intelligence processes.

摘要翻译： 使用柱塞提升装置的油气井微控制器系统，其响应井的生产和运行的变化。 该系统需要最少的操作员输入，并能够计算运行周期和调整，以最大限度地提高生产效率，并使用非线性人工智能过程来维护环境安全。

公开(公告)号：US5467778A

公开(公告)日：1995-11-21

申请号：US109503

申请日：1993-08-20

申请人： Michael Catt ,  John Coley ,  Paul J. Davis

发明人： Michael Catt ,  John Coley ,  Paul J. Davis

IPC分类号： G01N33/493 ,  A61B10/00 ,  G01N20060101 ,  G01N33/50 ,  G01N33/52 ,  G01N33/68 ,  G01N33/74 ,  G01N33/76

CPC分类号： G01N33/689 ,  A61B10/0012 ,  G01N33/743 ,  G01N33/76 ,  G01N2800/36

摘要： A method of monitoring the status of a current ovulation cycle of an individual human female subject, involving testing of the body fluid concentration of an analyte of significance in relation to the status of the ovulation cycle, such as urinary E3G, during at least part of the pre-ovulation phase of the current ovulation cycle of the individual subject, and identification from the results of such testing an analyte concentration change indicative of imminent ovulation, relative to an analyte concentration reference value that has been adapted to the individual human subject on the basis of analyte concentration test data obtained from the individual human subject during one or more previous ovulation cycles. Preferably testing for said analyte concentration during the current ovulation cycle is commenced a plurality of days (preferably at least 5) following the onset of menses but at least 2 numerical days in advance of the earliest numerical day on which actual ovulation has occurred in one or more previous ovulation cycles in the same individual subject.

摘要翻译： 一种监测个体人类女性受试者当前排卵周期状态的方法，包括在至少部分时间内测量相对于排卵周期状态（例如尿E3G）的有意义的分析物的体液浓度 个体受试者当前排卵周期的排卵前阶段以及相对于已经适应于个体受试者的分析物浓度参考值的来自这种测试结果的指示即将排卵的分析物浓度变化的鉴定 在一个或多个以前的排卵周期中从个体人受试者获得的分析物浓度测试数据的基础。 优选地，在当前排卵周期期间对所述分析物浓度的测试在月经开始之后开始多天（优选至少5天），但是在实际排卵发生在一个或多个之前的最早数字日之前的至少2个数天 在同一个体科目中更多的排卵周期。

公开(公告)号：US4742011A

公开(公告)日：1988-05-03

申请号：US740918

申请日：1985-05-30

申请人： Anthony Blake ,  John Coley ,  Ronald Smith

发明人： Anthony Blake ,  John Coley ,  Ronald Smith

IPC分类号： G01N33/493 ,  B01L3/00 ,  C12M1/34 ,  G01N33/48 ,  G01N33/53 ,  G01N33/543 ,  B01L9/00 ,  G01N33/76

CPC分类号： B01L3/502 ,  G01N33/5302 ,  G01N33/54366 ,  Y10S436/807 ,  Y10S436/81 ,  Y10S436/818

摘要： A device for carrying out chemical or clinical testing of a liquid sample, for example a urine sample, by a specific binding assay, said device comprising a test component (2) which has a sensitized solid surface (2a) carrying an immobilized component of a specific binding pair relevant to the assay, and a handling piece (1), and characterized in that the test component (2) bearing the sensitized surface (2a) is removably mounted in spaced relationship with a removably mounted accessory component (4) carrying an accessory solid surface (5), and in that there is a space (4a) between the sensitized surface (2a) and the removable accessory component (4) to act as a container for sample liquid, so that when the device is contacted with a sample liquid source or immersed in liquid which is to provide the test sample, liquid of the sample can enter the space (4a) to contact the sensitized surface (2a), and the accessory surface (5) acts to retain and contain sample liquid in contact with the sensitized surface (2a) even after removal of the device from further contact with or immersion in the source of sample liquid, and in that the test component (2) is so formed that after removal of the removable accessory component (4) the sensitized surface (2a) is left exposed and accessible to further treatment liquid such as washing liquid and/or reagents.

摘要翻译： PCT No.PCT / GB85 / 00102 Sec。 371日期1985年5月30日第 102（e）日期1985年5月30日PCT提交1985年3月15日PCT公布。 公开号WO85 / 04255 1985年9月26日，一种用于通过特异性结合测定对液体样品例如尿样进行化学或临床测试的装置，所述装置包括具有敏化固体表面（2a）的测试组分（2） ）和操作件（1），其特征在于，承载感光表面（2a）的测试部件（2）可拆卸地安装成与可拆卸地安装在一起的间隔开的关系 附着固体表面（5）的辅助部件（4），并且在致敏表面（2a）和可拆卸附件（4）之间存在空间（4a），以用作样品液体的容器，使得 当设备与样品液体源接触或浸入要提供测试样品的液体中时，样品的液体可以进入空间（4a）以接触致敏表面（2a），并且附件表面（5）起作用 保留并容纳样品液体 即使在将装置从样品液体进一步接触或浸没在样品液体源中之后，也与致敏表面（2a）接触，并且测试部件（2）被形成为在去除可移除的附件部件（4）之后 ）致敏表面（2a）被暴露并可进一步处理液体如洗涤液体和/或试剂。

公开(公告)号：US20080168749A1

公开(公告)日：2008-07-17

申请号：US11624019

申请日：2007-01-17

申请人： Joseph Regelski ,  Michael Anderson ,  Mark Strozensky ,  Craig Galloway ,  John Coley ,  Gregg Greg Jackson

发明人： Joseph Regelski ,  Michael Anderson ,  Mark Strozensky ,  Craig Galloway ,  John Coley ,  Gregg Greg Jackson

IPC分类号： B65B35/50

CPC分类号： B65B35/50 ,  B65B5/106 ,  B65G11/086 ,  B65G69/16

摘要： An apparatus for sorting and packaging vinyl siding panels. The apparatus comprises a panel receiving section for positioning in line with a panel extrusion line, pins for inverting and stacking the panels atop each other with the pins being coupled to a frame supporting the panel receiving section and situated below the panel receiving section, a panel accumulation section situated below the panel receiving section and the pins, and a mechanism means, preferably a ram mechanism, situated at a first end of the panel accumulation section for pushing the panels from the panel accumulation section and into a container, such as a pre-made carton, situated at a second end of the panel accumulation section that is opposite the first end. The apparatus substantially reduces ergonomic issues associated with the current apparatus for packaging vinyl siding panels and substantially increases the vinyl siding panel extrusion rate. A method is also disclosed.

摘要翻译： 一种用于分类和包装乙烯基壁板的设备。 该装置包括用于与面板挤出生产线一致地定位的面板接收部分，用于将面板彼此顶起反转和堆叠的销，销被联接到支撑面板接收部分并位于面板接收部分下方的框架，面板 位于板接收部分和销下方的蓄积部分，以及位于板聚集部分的第一端处的优选地冲压机构的机构装置，用于将板从面板积聚部分推入容器中，例如预先 制成的纸箱，位于与第一端相对的面板累积部分的第二端。 该设备基本上减少了与当前的用于包装乙烯基壁板的设备相关的人机工程学问题，并且基本上增加了乙烯基壁板挤出速度。 还公开了一种方法。