摘要:
Methods for isothermal titration calorimetry analysis of the binding affinity of protease inhibitors to plasma proteins. A method that can quantitatively calculate free drug concentrations of protease inhibitors in human plasma, as well as a method to calculate therapeutic amounts and dosage regimens. Furthermore, the present invention provides a method that can calculate the effect of plasma proteins on the antiviral activity (EC50 values) of protease inhibitors from their binding affinities to plasma proteins. The present invention provides as well a method that can evaluate the in vivo anti-HIV efficacy of PIs in human plasma.
摘要:
Methods for isothermal titration calorimetry analysis of the binding affinity of protease inhibitors to plasma proteins. A method that can quantitatively calculate free drug concentrations of protease inhibitors in human plasma, as well as a method to calculate therapeutic amounts and dosage regimens. Furthermore, the present invention provides a method that can calculate the effect of plasma proteins on the antiviral activity (EC50 values) of protease inhibitors from their binding affinities to plasma proteins. The present invention provides as well a method that can evaluate the in vivo anti-HIV efficacy of PIs in human plasma.
摘要:
In general, the invention is directed to techniques for scheduling resource access within an intermediate network device. For example, as described herein, a device receives packets for a plurality of sessions that include application-layer data for the sessions. The device determines a weight for each of the plurality of sessions and, during periods of resource congestion, selects one or more sessions for additional resource allocation based on the respective weights of the sessions. The device allocates additional memory resources to selected sessions to enable further buffering of application-layer data such that the device may apply the service to multiple sessions concurrently despite the resource congestion.
摘要:
A magnetic tunneling junction (MTJ) in an MRAM array is disclosed with a composite free layer having a FL1/FL2/FL3 configuration where FL1 and FL2 are crystalline magnetic layers and FL3 is an amorphous NiFeX layer for improved bit switching performance. FL1 layer is CoFe which affords a high magnetoresistive (MR) ratio when forming an interface with a MgO tunnel barrier. FL2 is Fe to improve switching performance. NiFeX thickness where X is Hf is preferably between 20 to 40 Angstroms to substantially reduce bit line switching current and number of shorted bits. Annealing at 330° C. to 360° C. provides a high MR ratio of 190%. Furthermore, low Hc and Hk are simultaneously achieved with improved bit switching performance and fewer shorts without compromising other MTJ properties such as MR ratio. As a result of high MR ratio and lower bit-to-bit resistance variation, higher reading margin is realized.
摘要:
A method for establishment a pseudo wire (PW) is disclosed, including: receiving a first label mapping (LM) message, where the first LM message carries a PW ID, PW parameters, and label switching path (LSP) tunnel information that are selected by the sender of the first LM message; matching a local PW according to the PW ID; performing parameter negotiation of the local PW according to the PW parameters; matching a local tunnel according to the LSP tunnel information; binding the local tunnel and the local PW when the matching between the PW ID and the LSP tunnel information is successful; and establishing a PW when the parameter negotiation is successful. A device and system for establishing a PW are also disclosed. With the present invention, a PW service is associated with an LSP tunnel to improve the reliability of the information transmission process.
摘要:
A method for obtaining link aggregation group (LAG) information, and a node and a system thereof are provided, which belong to the field of communication technologies. The method includes the following steps. An ingress node of a label switched path (LSP) sends an echo request message to another node on the LSP, in which the message carries identification information, and the identification information is for identifying that the LAG information on the LSP needs to be obtained. The ingress node receives an echo reply message returned by said another node, in which the message carries LAG information between said another node and a next hop node on the LSP. The present invention implements the obtaining of LAG information on the LSP and brings great convenience to OAM of MPLS network, and has the advantages of being simple, convenient, and easy to implement and having strong practicality.
摘要:
A non-oriented electrical steel sheet without corrugated defect and a manufacturing method thereof is provided, the weight percentage of the chemical composition of the non-oriented electrical steel sheet is that C is no more than 0.005%, Si is 1.2-2.2%, Mn is 0.2-0.4%, P is no more than 0.2%, S is no more than 0.005%, Al is 0.2-0.6%, N is no more than 0.005%, O is no more than 0.005%, and a balance substantially being Fe, a slab can be obtained by hot metal preprocessing, smelting with converter, RH refining, and continuous casting and pouring, wherein a secondary cooling water amount is controlled, the water flowrate of cooling water is controlled to 100-190 l/min, the average superheat of liquid steel in the continuous casting process is controlled to 10-45° C., the slab is heated and hot rolled; wherein the furnace tap temperature of the slab is 1050-1150 ° C., the temperature difference between random two points in the length direction when the slab is heated, is lower than 25° C., the hot rolling process includes a rough rolling process and a planishing process, the entry temperature in the planishing process is no lower than 970° C.; the finished non-oriented electrical steel sheet is obtained by acid pickling, cold rolling, annealing and coating. No corrugated defect can be accomplished by controlling the cooling speed of the slab in continuous casting and pouring process, the temperature difference in the length direction of the slab in the heating furnace, and by controlling the temperature drop before planishing the slab.
摘要翻译:本发明提供一种无波纹状缺陷的无取向电工钢板及其制造方法,其中,所述无方向性电工钢板的化学成分的重量百分比为C为0.005%以下,Si为1.2〜2.2% Mn为0.2〜0.4%,P为0.2%以下,S为0.005%以下,Al为0.2〜0.6%,N为0.005%以下,O为0.005以下,余量基本上为 是Fe,可以通过热金属预处理,转炉熔炼,RH精炼以及连续铸造和浇注获得板坯,其中控制二次冷却水量,将冷却水的水流量控制在100-190l / min ,连铸过程中液态钢的平均过热度控制在10-45℃,将板坯加热和热轧; 其特征在于,板坯的炉膛温度为1050〜1150℃,板坯加热时长度方向随机两点之间的温差低于25℃,热轧工序包括粗轧工序 和平整过程中,平整过程中的入口温度不低于970℃; 通过酸洗,冷轧,退火和涂布获得成品的无取向电工钢板。 通过在连续铸造和浇注过程中控制板坯的冷却速度,加热炉中板坯的长度方向的温差,以及通过控制板坯平整之前的温度下降来控制温度下降,可以不产生瓦楞缺陷。
摘要:
Reading margin is improved in a MTJ designed for MRAM applications by employing a pinned layer with an AP2/Ru/AP1 configuration wherein the AP1 layer is a CoFeB/CoFe composite and by forming a MgO tunnel barrier adjacent to the CoFe AP1 layer by a sequence that involves depositing and oxidizing a first Mg layer with a radical oxidation (ROX) process, depositing and oxidizing a second Mg layer with a ROX method, and depositing a third Mg layer on the oxidized second Mg layer. The third Mg layer becomes oxidized during a subsequent anneal. MTJ performance may be further improved by selecting a composite free layer having a Fe/NiFeHf or CoFe/Fe/NiFeHf configuration where the NiFeHf layer adjoins a capping layer in a bottom spin valve configuration. As a result, read margin is optimized simultaneously with improved MR ratio, a reduction in bit line switching current, and a lower number of shorted bits.
摘要:
The present invention relates to communications technologies and discloses a method, a system, and a label switching router for setting up a Label Switching Path (LSP). The method includes: an ingress edge node sends a label request packet to a downstream node, where the label request packet carries an Equal Cost Multi-Path (ECMP) property flag of a Forwarding Equivalence Class (FEC); the downstream node that receives the label request packet sends the label request packet to a next-hop node according to the property flag; and the node that receives the label request packet performs label mapping according to a path of the label request packet, binds a label to the FEC, and sets up an LSP. An ECMP property flag indicating setting up an ECMP route is permitted is introduced in the process of setting up an LSP. Therefore, setup of an ECMP route is prevented for the FEC that imposes special requirements, and management and maintenance of the network are facilitated.
摘要:
A method and an apparatus for failure notification are provided. The method includes: sending, when it is detected that a failure occurs in a multicast label switch path, failure information to a downstream node of a multicast tree where a failed point locates, where the multicast label switch path is established based on a multicast label distribution protocol; and forwarding the failure information through the downstream node, where the failure information arrives at a leaf node of the multicast tree where the failed point locates. According to the method and the apparatus for failure notification of the present invention, finally, the failure information is transmitted to a leaf node. After the failure information is obtained, the leaf node may take appropriate measure to ensure the normal service and improve the reliability of the network.