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117 条记录 (耗时 0.032 秒)

    Anti-fusion assay
    1.
    发明申请
    Anti-fusion assay 审中-公开
    抗融合测定

    公开(公告)号：US20050208678A1

    公开(公告)日：2005-09-22

    申请号：US10490716

    申请日：2002-09-27

    申请人： Dong Xie ,  John Erickson ,  Paul Grulich

    发明人： Dong Xie ,  John Erickson ,  Paul Grulich

    IPC分类号： A61K45/00 ,  A61P31/18 ,  C07K7/00 ,  C07K14/47 ,  G01N27/447 ,  G01N33/15 ,  G01N33/48 ,  G01N33/50 ,  G01N33/561 ,  G01N33/569 ,  G01N33/68 ,  G06F19/00

    CPC分类号： G01N33/56988 ,  G01N33/6803 ,  G01N2333/162 ,  G01N2500/02

    摘要： Methods of identifying a fusion inhibitor and inhibitors of gp41-mediated membrane fusion are disclosed. The methods comprise, for example, providing a first helical polypeptide comprising a sequence of IQN17 (SEQ ID NO: 1); providing a second helical polypeptide of 34 or less than 34 amino acids comprising the amino acid sequence W-X1-X2-W-X3-X4-X5-I, wherein X1, X2, X3, X4, and X5 are each independently chosen from any amino acid except proline; measuring, by capillary zone electrophoresis, the degree of complex formation between these peptides; and comparing the measured degree of complex formation to the degree in the presence of a test composition.

    摘要翻译： 公开了鉴定融合抑制剂和gp41介导的膜融合抑制剂的方法。 所述方法包括例如提供包含IQN17（SEQ ID NO：1）序列的第一螺旋多肽; 提供包含氨基酸序列W-X1-X2-W-X3-X4-X5-I的34个或小于34个氨基酸的第二螺旋多肽，其中X1，X2，X3，X4和X5各自独立地选自 除脯氨酸以外的任何氨基酸; 通过毛细管区带电泳测量这些肽之间的复合物形成程度; 并将测量的复合物形成程度与存在测试组合物的程度进行比较。

    METHOD OF FORMING A LEAD
    5.
    发明申请
    METHOD OF FORMING A LEAD 有权
    形成铅的方法

    公开(公告)号：US20130167372A1

    公开(公告)日：2013-07-04

    申请号：US13617187

    申请日：2012-09-14

    申请人： Damon Ray Black ,  Terry Daglow ,  John Erickson ,  Robert Earl Jones ,  B. Reno Lauro

    发明人： Damon Ray Black ,  Terry Daglow ,  John Erickson ,  Robert Earl Jones ,  B. Reno Lauro

    IPC分类号： H01R43/00

    CPC分类号： H01R43/00 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/056

    摘要： An implantable, substantially isodiametric, low resistance implantable lead having at least one electrode positioned in a stimulation/sensing portion of the lead as well as a method of manufacturing the same. At least the stimulation/sensing portion is unitized through partially surrounding and supporting insulation and conductive element(s) of the stimulation/sensing portion with a fused matrix of material having mechanical properties consistent with a body of the lead.

    摘要翻译： 具有至少一个电极位于引线的刺激/感测部分中的可植入的，基本上等径的低电阻可植入引线以及其制造方法。 至少刺激/感测部分通过部分地围绕和支撑刺激/感测部分的绝缘和导电元件而被整合，所述绝缘和导电元件具有与导体主体一致的机械特性的材料的熔融基质。

    System and method for electrical stimulation of the intervertebral disc
    6.
    发明授权
    System and method for electrical stimulation of the intervertebral disc 有权
    用于电刺激椎间盘的系统和方法

    公开(公告)号：US08359101B2

    公开(公告)日：2013-01-22

    申请号：US13336593

    申请日：2011-12-23

    申请人： Philip M. Finch ,  Scott F. Drees ,  John Erickson

    发明人： Philip M. Finch ,  Scott F. Drees ,  John Erickson

    IPC分类号： A61N1/39 ,  A61N1/00

    CPC分类号： A61N1/36021 ,  A61N1/0558 ,  A61N1/36017 ,  A61N1/36071

    摘要： In one embodiment, a method electrically stimulates an area in a spinal disc. The method comprises: implanting at least one steerable lead at a placement site for stimulating a spinal disc such that the lead is disposed exterior and immediately adjacent to and circumferentially along an annulus of the spinal disc, the at least one lead including a plurality of electrodes distributed along a majority of a circumference of the annulus; connecting the lead to a signal generator; and generating electrical stimulation pulses using the generator to stimulate targeted portions of the spinal disc, wherein the stimulation of the targeted portion of the spinal disc sufficiently stimulates nerve tissue within the spinal disc to prevent communication of pain signals originating in the spinal disc without damaging tissue of the spinal disc.

    摘要翻译： 在一个实施例中，一种电刺激脊椎盘中的区域的方法。 该方法包括：在放置位置处植入至少一个可操纵的引线，用于刺激脊椎盘，使得引线设置在脊椎盘的环形的外侧并且沿着脊椎盘的环形区域周向地设置，所述至少一个引线包括多个电极 沿着圆环的大部分圆周分布; 将引线连接到信号发生器; 以及使用所述发生器产生电刺激脉冲以刺激所述脊椎盘的目标部分，其中所述脊髓盘的目标部分的刺激充分地刺激所述脊椎盘内的神经组织，以防止源自所述脊髓盘的疼痛信号的通信而不损伤组织 的脊椎盘。

    DATA COLLISIONS IN CONCURRENT PROGRAMS
    9.
    发明申请
    DATA COLLISIONS IN CONCURRENT PROGRAMS 有权
    相关程序中的数据冲突

    公开(公告)号：US20110314338A1

    公开(公告)日：2011-12-22

    申请号：US12819069

    申请日：2010-06-18

    申请人： John Erickson ,  Madan Musuvathi

    发明人： John Erickson ,  Madan Musuvathi

    IPC分类号： G06F11/26 ,  G06F12/00

    CPC分类号： G06F11/3636 ,  G06F11/3632 ,  G06F11/3644 ,  G06F11/366

    摘要： Described are techniques for detecting data collisions between a first portion and a second portion of an application executing on a computer, the first portion and the second portions executing concurrently with respect to each other. While the first portion and second portion are executing, before the first portion accesses a memory location shared by the first portion and the second portion, a value stored in the memory location is captured and the first portion is delayed. While the second portion continues to execute the first portion is delayed. After a period of the first portion having been paused or slowed, the current content of the memory location is compared with the captured content to determine if there is a data collision. The first and second portions may be threads, and the capturing, delaying, and determining may be performed by code inserted to the application after it has been compiled.

    摘要翻译： 描述了用于检测在计算机上执行的应用的第一部分和第二部分之间的数据冲突的技术，第一部分和第二部分相对于彼此并行执行。 当第一部分和第二部分正在执行时，在第一部分访问由第一部分和第二部分共享的存储位置之前，捕获存储在存储器位置中的值，并且第一部分被延迟。 而第二部分继续执行第一部分被延迟。 在暂停或减慢第一部分的时段之后，将存储器位置的当前内容与捕获的内容进行比较以确定是否存在数据冲突。 第一和第二部分可以是线程，并且捕获，延迟和确定可以在编译之后插入应用程序的代码执行。

    SYSTEM AND METHOD FOR ELECTRICAL STIMULATION OF THE INTERVERTEBRAL DISC
    10.
    发明申请
    SYSTEM AND METHOD FOR ELECTRICAL STIMULATION OF THE INTERVERTEBRAL DISC 有权
    用于电刺激椎间盘的系统和方法

    公开(公告)号：US20110046695A1

    公开(公告)日：2011-02-24

    申请号：US12917827

    申请日：2010-11-02

    申请人： Philip M. Finch ,  Scott F. Drees ,  John Erickson

    发明人： Philip M. Finch ,  Scott F. Drees ,  John Erickson

    IPC分类号： A61N1/34

    CPC分类号： A61N1/36021 ,  A61N1/0558 ,  A61N1/36017 ,  A61N1/36071

    摘要： In one embodiment, a method electrically stimulates an area in a spinal disc. The method comprises: implanting at least one steerable lead at a placement site for stimulating a spinal disc such that the lead is disposed exterior and immediately adjacent to and circumferentially along an annulus of the spinal disc, the at least one lead including a plurality of electrodes distributed along a majority of a circumference of the annulus; connecting the lead to a signal generator; and generating electrical stimulation pulses using the generator to stimulate targeted portions of the spinal disc, wherein the stimulation of the targeted portion of the spinal disc sufficiently stimulates nerve tissue within the spinal disc to prevent communication of pain signals originating in the spinal disc without damaging tissue of the spinal disc.

    摘要翻译： 在一个实施例中，一种电刺激脊椎盘中的区域的方法。 该方法包括：在放置位置处植入至少一个可操纵的引线，用于刺激脊椎盘，使得引线设置在脊椎盘的环形的外侧并且沿着脊椎盘的环形区域周向地设置，所述至少一个引线包括多个电极 沿着圆环的大部分圆周分布; 将引线连接到信号发生器; 以及使用所述发生器产生电刺激脉冲以刺激所述脊椎盘的目标部分，其中所述脊髓盘的目标部分的刺激充分地刺激所述脊椎盘内的神经组织，以防止源自所述脊髓盘的疼痛信号的通信而不损伤组织 的脊椎盘。