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39 条记录 (耗时 0.109 秒)

    Novel adenosine deaminase homolog
    2.
    发明申请
    Novel adenosine deaminase homolog 审中-公开

    公开(公告)号：US20060160128A1

    公开(公告)日：2006-07-20

    申请号：US11386902

    申请日：2006-03-22

    申请人： John Feder ,  Chandra Ramanathan ,  Gabe Mintier

    发明人： John Feder ,  Chandra Ramanathan ,  Gabe Mintier

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/88

    CPC分类号： C12Q1/6883 ,  C12N9/78 ,  C12Q2600/158

    摘要： This invention provides a novel isolated polynucleotide sequence, called ADARP1 (adenosine deaminase related protein 1), that displays significant homology to the adenosine deaminase (ADA) gene. Also provided is the amino acid sequence of the ADARP1 polypeptide encoded by the polynucleotide of the invention. The RNA for this novel gene is found in variety of tissues, with higher levels observed in the heart, testes, and skeletal muscle compared with others tested. Based on amino acid sequence homology, the ADARP1 protein will likely display the catalytic activity characteristic of ADA. This newly found ADARP1 gene and its encoded product may be useful in the treatment of immunodeficiencies, including severe combined immunodeficiency disease (SCID) and other ADA deficiencies, treatment of male reproductive disorders, testicular disorders and musclo-skeletal disorders.

    Novel human leucine-rich repeat domain containing protein HLLRCR-1
    5.
    发明申请
    Novel human leucine-rich repeat domain containing protein HLLRCR-1 有权
    含有蛋白质HLLRCR-1的新型富含亮氨酸的重复结构域

    公开(公告)号：US20060292625A1

    公开(公告)日：2006-12-28

    申请号：US11511141

    申请日：2006-08-28

    申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier

    发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly nervous system diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码HLLRCR-1多肽的新型多核苷酸，其片段和同源物。还提供了用于产生所述多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型HLLRCR-1多肽应用于诊断，治疗和/或预防与这些多肽，特别是神经系统疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel human G-protein coupled receptor variant of the relaxin receptor HGPRBMY5v1, and variants thereof
    6.
    发明申请
    Polynucleotide encoding a novel human G-protein coupled receptor variant of the relaxin receptor HGPRBMY5v1, and variants thereof 有权
    编码松质素受体HGPRBMY5v1的新型人G蛋白偶联受体变体的多核苷酸及其变体

    公开(公告)号：US20060257918A1

    公开(公告)日：2006-11-16

    申请号：US11486332

    申请日：2006-07-13

    申请人： Chandra Ramanathan ,  John Feder ,  Gabriel Mintier

    发明人： Chandra Ramanathan ,  John Feder ,  Gabriel Mintier

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K14/723

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY5v1 and HGPRBMY5v2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY5v1 and HGPRBMY5v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码HGPRBMY5v1和HGPRBMY5v2多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY5v1和HGPRBMY5v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74
    7.
    发明申请
    Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74 有权

    公开(公告)号：US20060177903A1

    公开(公告)日：2006-08-10

    申请号：US11377517

    申请日：2006-03-16

    申请人： Chandra Ramanathan ,  John Feder

    发明人： Chandra Ramanathan ,  John Feder

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY74 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY74 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    Polynucleotide encoding a novel human G-protein coupled receptor, HGPRBMY39
    8.
    发明申请
    Polynucleotide encoding a novel human G-protein coupled receptor, HGPRBMY39 有权
    编码新型人G蛋白偶联受体的多核苷酸HGPRBMY39

    公开(公告)号：US20060084140A1

    公开(公告)日：2006-04-20

    申请号：US10237813

    申请日：2002-09-06

    申请人： Chandra Ramanathan ,  Shuba Gopal ,  Gabriel Mintier ,  John Feder

    发明人： Chandra Ramanathan ,  Shuba Gopal ,  Gabriel Mintier ,  John Feder

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/723 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY39 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY39 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码HGPRBMY39多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY39多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof
    9.
    发明申请
    Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof 有权
    编码两种新型人G蛋白偶联受体的多核苷酸HGPRBMY28和HGPRBMY29及其剪接变体

    公开(公告)号：US20080064094A1

    公开(公告)日：2008-03-13

    申请号：US11890963

    申请日：2007-08-08

    申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

    发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

    IPC分类号： C12N5/00 ,  C07K1/00 ,  C07K16/00

    CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1
    10.
    发明申请
    Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1 有权
    人类含有亮氨酸的重复含有蛋白质主要在骨髓HLRRBM1中表达

    公开(公告)号：US20050203048A1

    公开(公告)日：2005-09-15

    申请号：US11107572

    申请日：2005-04-15

    申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

    发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  A61K48/00 ,  C07H21/04 ,  C07K14/82 ,  G01N33/574

    CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K2039/53 ,  C07K14/47

    摘要： The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码HLRRBM1多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HLRRBM1多肽应用于诊断，治疗和/或预防与这些多肽，特别是免疫疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。