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    Medical imaging systems
    1.
    发明申请
    Medical imaging systems 有权
    医学影像系统

    公开(公告)号：US20050182321A1

    公开(公告)日：2005-08-18

    申请号：US10507253

    申请日：2003-03-11

    申请人： John Frangioni

    发明人： John Frangioni

    IPC分类号： A61B5/00 ,  A61B6/00

    CPC分类号： B82Y5/00 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/045 ,  A61B1/0638 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0086 ,  B82Y10/00

    摘要： A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remains in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may also employ dyes or other fluorescent substances associated with antibodies, antibody fragments, or ligands that accumulate within a region of diagnostic significance. In one embodiment, the system provides an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide that is used to capture images. In another embodiment, the system is configured for use in open surgical procedures by providing an operating area that is closed to ambient light. More broadly, the systems described herein may be used in imaging applications where a visible light image may be usefully supplemented by an image formed from fluorescent emissions from a fluorescent substance that marks areas of functional interest.

    摘要翻译： 医学成像系统提供可见光和荧光图像的同时呈现。 该系统可以使用保留在受试者的血液中几分钟的小分子形式的染料，允许对象的循环系统的叠加在受试者的常规可见光图像上的实时成像。 该系统还可以使用与诊断意义的区域内积累的抗体，抗体片段或配体相关联的染料或其它荧光物质。 在一个实施例中，系统提供激发光源以激发用于捕获图像的相同光导中的荧光物质和用于一般照明的可见光源。 在另一个实施例中，该系统被配置为通过提供与环境光相近的操作区域在开放式外科手术中使用。 更广泛地说，本文描述的系统可以用于成像应用，其中可见光图像可以有用地由通过标记功能感兴趣的区域的荧光物质的荧光发射形成的图像补充。

    Systems and methods for multi-modal imaging
    2.
    发明申请
    Systems and methods for multi-modal imaging 有权
    多模态成像的系统和方法

    公开(公告)号：US20060108509A1

    公开(公告)日：2006-05-25

    申请号：US11222864

    申请日：2005-09-09

    申请人： John Frangioni ,  Roberto Accorsi ,  Richard Lanza ,  John Idoine

    发明人： John Frangioni ,  Roberto Accorsi ,  Richard Lanza ,  John Idoine

    IPC分类号： H01L27/00

    CPC分类号： A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  A61B6/00 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01T1/1603 ,  G01T1/295 ,  G06F19/00

    摘要： The invention relates to imaging systems that include a coded aperture detection system and an optical detection system. The coded aperture detection system is configured to detect radiation emitted by a radionuclide present within an object and to provide a first detector signal from the detected radiation. The optical detection system is configured to detect optical radiation from the object and to provide a second detector signal from the detected optical radiation. The system also includes a processor configured to prepare first image data from the first detector signal, second image data from the second detector signal, and registered data indicative of a spatial relationship in at least one dimension between the first and second image data. The invention also includes methods of using the new systems, e.g., for sentinel lymph node mapping and tissue resection.

    摘要翻译： 本发明涉及包括编码孔径检测系统和光学检测系统的成像系统。 编码孔径检测系统被配置为检测存在于物体内的放射性核素发射的辐射并且从所检测的辐射提供第一检测器信号。 光学检测系统被配置为检测来自物体的光辐射并且从检测到的光辐射提供第二检测器信号。 该系统还包括配置成从第一检测器信号准备第一图像数据，来自第二检测器信号的第二图像数据和指示第一和第二图像数据之间的至少一维中的空间关系的登记数据的处理器。 本发明还包括使用新系统的方法，例如用于前哨淋巴结作图和组织切除术。

    Medical Imaging Systems
    3.
    发明申请
    Medical Imaging Systems 有权
    医学影像系统

    公开(公告)号：US20070203413A1

    公开(公告)日：2007-08-30

    申请号：US10572169

    申请日：2003-09-15

    申请人： John Frangioni

    发明人： John Frangioni

    IPC分类号： A61B5/05

    CPC分类号： A61B5/418 ,  A61B1/042 ,  A61B1/043 ,  A61B1/3132 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/415 ,  G06T19/20 ,  G06T2210/41 ,  G06T2219/028 ,  G06T2219/2012

    摘要： A medical imaging system provides simultaneous rendering of visible light and diagnostic or functional images. The system may be portable, and may include adapters for connecting various light sources and cameras in open surgical environments or laparascopic or endoscopic environments. A user interface provides control over the functionality of the integrated imaging system. In one embodiment, the system provides a tool for surgical pathology.

    摘要翻译： 医学成像系统提供可见光和诊断或功能图像的同时呈现。 该系统可以是便携式的，并且可以包括用于在开放式手术环境或laparoascopic或内窥镜环境中连接各种光源和照相机的适配器。 用户界面提供对集成成像系统的功能的控制。 在一个实施例中，该系统提供用于手术病理学的工具。

    Device for wavelength-selective imaging
    5.
    发明申请
    Device for wavelength-selective imaging 失效
    波长选择成像装置

    公开(公告)号：US20050285038A1

    公开(公告)日：2005-12-29

    申请号：US10517280

    申请日：2003-05-22

    申请人： John Frangioni

    发明人： John Frangioni

    IPC分类号： A61B5/00 ,  G01J3/36 ,  G01N21/64 ,  G02B5/20 ,  G02B23/12 ,  G02F1/01 ,  H01L27/146 ,  H01L27/148 ,  H01L31/00 ,  H01L31/101 ,  H01L31/111

    CPC分类号： H01L31/111 ,  A61B5/0059 ,  A61B5/7425 ,  G01J3/36 ,  G01N21/6428 ,  G01N21/6456 ,  G02B5/201 ,  G02B23/12 ,  H01L27/14621 ,  H01L27/14625 ,  H01L27/14647 ,  H01L27/14806 ,  H01L27/14837 ,  H01L27/14843 ,  H01L27/14868 ,  H01L31/101

    摘要： An imaging device captures both a visible light image and a diagnostic image, the diagnostic image corresponding to emissions from an imaging medium within the object. The visible light image (which may be color or grayscale) and the diagnostic image may be superimposed to display regions of diagnostic significance within a visible light image. A number of imaging media may be used according to an intended application for the imaging device, and an imaging medium may have wavelengths above, below, or within the visible light spectrum. The devices described herein may be advantageously packaged within a single integrated device or other solid state device, and/or employed in an integrated, single-camera medical imaging system, as well as many non-medical imaging systems that would benefit from simultaneous capture of visible-light wavelength images along with images at other wavelengths.

    摘要翻译： 成像装置捕获可见光图像和诊断图像，诊断图像对应于来自对象内的成像介质的发射。 可见光图像（其可以是彩色或灰度）和诊断图像可以叠加以在可见光图像内显示具有诊断意义的区域。 可以根据成像装置的预期应用使用多个成像介质，并且成像介质可以具有在可见光光谱之上，之下或之内的波长。 本文描述的装置可以有利地封装在单个集成装置或其他固态装置内，和/或用于集成的单相机医疗成像系统，以及许多非医学成像系统，其将受益于同时捕获 可见光波长图像以及其他波长的图像。

    Tissue-like phantoms
    9.
    发明申请
    Tissue-like phantoms 失效
    组织样幻影

    公开(公告)号：US20060056580A1

    公开(公告)日：2006-03-16

    申请号：US11222949

    申请日：2005-09-09

    申请人： John Frangioni ,  Alec De Grand

    发明人： John Frangioni ,  Alec De Grand

    IPC分类号： G01N23/00 ,  G01D18/00

    CPC分类号： G01N23/223 ,  G01N2223/076

    摘要： The invention is based, in part, on the discovery that by combining certain components one can generate a tissue-like phantom that mimics any desired tissue, is simple and inexpensive to prepare, and is stable over many weeks or months. In addition, new multi-modal imaging objects (e.g., beads) can be inserted into the phantoms to mimic tissue pathologies, such as cancer, or merely to serve as calibration standards. These objects can be imaged using one, two, or more (e.g., four) different imaging modalities (e.g., x-ray computed tomography (CT), positron emission tomography (PET), single photon emission computed tomography (SPECT), and near-infrared (NIR) fluorescence) simultaneously.

    摘要翻译： 本发明部分地基于通过组合某些组分的发现，可以产生模拟任何所需组织的组织样模型，其制备简单且便宜，并且在多个星期或数月内是稳定的。 此外，可以将新的多模态成像对象（例如珠）插入到模体中以模拟诸如癌症的组织病理学，或者仅用作校准标准。 这些物体可以使用一个，两个或更多（例如四个）不同的成像模式（例如，x射线计算机断层摄影（CT），正电子发射断层摄影（PET），单光子发射计算机断层摄影（SPECT）和近距离 - 红外（NIR）荧光）。