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公开(公告)号：US07597897B2
公开(公告)日：2009-10-06
申请号：US10596836
申请日：2004-12-10
CPC分类号： A61K9/008 , A61K9/08 , A61K9/10 , A61K9/1647 , A61K47/34 , A61K47/593 , C08G63/912
摘要： Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula —[O—R1—C(O)]n— wherein: “R1” is a linear, branched, or cyclic organic group, “n” is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.
摘要翻译： 描述了药物组合物的制造方法。 制备根据本发明的药用组合物的方法包括：（a）提供通式为[O-R 1 -C（O）] n - 的生物相容性聚合物，其中：“R 1”为直链，支链， 或环状有机基团，“n”为至少三个，（b）酰化生物相容性聚合物以提供酰化生物相容性聚合物和混合酸酐; （c）用亲核试剂反应混合酸酐以提供酰化的生物相容性聚合物，其具有能够在不存在水的情况下化学转化为酸的末端羧酸衍生物; （d）将末端羧酸衍生物与末端羧酸转化成酰化生物相容性聚合物; 和（e）将酰化的生物相容性聚合物与药物组合以提供药物组合物。
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公开(公告)号：US20080112894A1
公开(公告)日：2008-05-15
申请号：US11816883
申请日：2006-03-14
申请人： John T. Capecchi , James S. Stefely
发明人： John T. Capecchi , James S. Stefely
CPC分类号： A61K31/517 , A61K9/0075 , A61K9/008 , A61K47/34
摘要： Stability of biocompatible polymers of the formula: wherein Z is —C(O)R1; each R1 is independently selected from a linear, branched, or cyclic alkyl, alkoxy, or aryl with 1 to 18 carbon atoms optionally substituted by carbonyl, oxy, thio, and/or nitrogen; each R2 is independently selected from hydrogen or a linear or branched hydrocarbon with 1 to 4 carbon atoms; X is selected from the group consisting of —OR1, —SR1, —N(R1)2 and divalent or trivalent headgroups terminated in oxygen, nitrogen, or sulfur; y is greater than or equal to 1 and less than or equal to 3; is enhanced by providing compositions where there is a low level of —OH end group impurity, i.e., where Z is —H instead of —C(O)R1 and/or X is —OH instead of —OR1, —SR1, —N(R1)2 or divalent or trivalent headgroups terminated in —O—, —N—, or —S—, such that there are no more than 10 of these —OH end groups for every 100 intended biocompatible polymer molecules.
摘要翻译： 下式的生物相容性聚合物的稳定性：其中Z为-C（O）R 1; 每个R 1独立地选自具有任选被羰基，氧基，硫基和/或氮取代的具有1至18个碳原子的直链，支链或环状烷基，烷氧基或芳基; 每个R 2独立地选自氢或具有1至4个碳原子的直链或支链烃; X选自-OR 1，-SR 1 N， - N（R 1）2， - SUB >和二价或三价头基终止于氧，氮或硫; y大于或等于1且小于或等于3; 通过提供其中存在低水平的-OH端基杂质的组合来增强，即其中Z是-H而不是-C（O）R 1和/或X是-OH而不是 -OR 1，-SR 1，-N（R 1）2，或二价或三价头基终止于 -O-，-N-或-S-，使得每100个预期的生物相容性聚合物分子中不超过10个这些-OH端基。
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公开(公告)号：US20080267885A1
公开(公告)日：2008-10-30
申请号：US10596836
申请日：2004-12-10
CPC分类号： A61K9/008 , A61K9/08 , A61K9/10 , A61K9/1647 , A61K47/34 , A61K47/593 , C08G63/912
摘要： Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula —[O—R1—C(O)]n— wherein: “R1” is a linear, branched, or cyclic organic group, “n” is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.
摘要翻译： 描述了药物组合物的制造方法。 制备根据本发明的药物组合物的方法包括：（a）提供具有通式的生物相容性聚合物 - [OR 1 -C 2 -C（O）] n 其中：“R 1”是直链，支链或环状有机基团，“n”为至少三个，（b）酰化生物相容性聚合物以提供酰化生物相容性聚合物和混合 酐; （c）用亲核试剂反应混合酸酐以提供酰化的生物相容性聚合物，其具有能够在不存在水的情况下化学转化为酸的末端羧酸衍生物; （d）将末端羧酸衍生物与末端羧酸转化成酰化生物相容性聚合物; 和（e）将酰化的生物相容性聚合物与药物组合以提供药物组合物。
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公开(公告)号：US20090123391A1
公开(公告)日：2009-05-14
申请号：US12293205
申请日：2007-03-21
申请人： John T. Capecchi , James S. Stefely
发明人： John T. Capecchi , James S. Stefely
CPC分类号： A61K9/008
摘要： A pharmaceutical aerosol formulation includes a therapeutically effective amount of particulate medicament of formula (I) or a solvate thereof, a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoro-n-propane or mixtures thereof, and a biocompatible polymer comprising one or more compounds of formula (II)
摘要翻译： 药物气溶胶制剂包括治疗有效量的式（I）的颗粒药物或其溶剂合物，推荐剂选自1,1,1,2-四氟乙烷，1,1,1,2,3， 3,3-七氟正丙烷或其混合物，以及包含一种或多种式（II）化合物的生物相容性聚合物，
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公开(公告)号：US5489300A
公开(公告)日：1996-02-06
申请号：US82261
申请日：1993-06-24
申请人： John T. Capecchi , Carl Franzblau , Donald F. Gibbons , William B. Isaacson , Manley R. Johnston , Randall L. Knoll , Howard M. Leibowitz , Vickery Trinkaus-Randall
发明人： John T. Capecchi , Carl Franzblau , Donald F. Gibbons , William B. Isaacson , Manley R. Johnston , Randall L. Knoll , Howard M. Leibowitz , Vickery Trinkaus-Randall
CPC分类号： A61F2/142 , A61L27/14 , A61L27/16 , A61L2430/16 , Y10S623/906
摘要： A corneal prosthesis including an optical element having an optically transparent central portion and an anterior surface capable of supporting a layer of epithelial cells, the optical element being made of optical material having water content between 50% and 90% and a tensile strength greater than 20 kg/cm.sup.2, and a porous outer skirt secured to the periphery of said element, said skirt being sufficiently porous to permit cell ingrowth and tissue attachment. Also disclosed are methods of making, seeding and using corneal implants having epithelial layers thereon and porous implant material of a coherent mass of randomly oriented fibers having an interconnected network of pores.
摘要翻译： 一种角膜假体，其包括具有光学透明中心部分和能够支撑一层上皮细胞的前表面的光学元件，所述光学元件由水含量为50％至90％且抗拉强度大于20的光学材料制成 kg / cm 2，以及固定到所述元件的周边的多孔外裙，所述裙部足够多孔以允许细胞向内生长和组织附着。 还公开了制造，接种和使用其上具有上皮层的角膜植入物的方法，以及具有互连的孔网络的随机取向纤维的相干团块的多孔植入材料。
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公开(公告)号：US08512723B2
公开(公告)日：2013-08-20
申请号：US10937059
申请日：2004-09-08
CPC分类号： A61K31/23 , A61K9/0014 , A61K9/0043 , A61K9/0046 , A61K9/0053 , A61K9/007 , A61K31/19 , A61K31/231 , A61K31/25 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/44 , Y02A50/473 , A61K2300/00
摘要： Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including, in particular, an antimicrobial lipid component, such as a fatty acid ester, fatty ether, or alkoxide derivative thereof. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).
摘要翻译： 抗微生物组合物，特别是当局部施用时特别是对粘膜组织（即粘膜）有用的组合物，特别包括抗微生物脂质组分如脂肪酸酯，脂肪醚或其醇盐衍生物。 组合物还可以包括增强剂组分，表面活性剂，疏水组分和/或亲水组分。 这样的组合物提供有效的局部抗微生物活性，因此可用于治疗和/或预防由微生物（包括病毒）引起或加剧的病症。
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公开(公告)号：US5032131A
公开(公告)日：1991-07-16
申请号：US163515
申请日：1988-03-02
申请人： James E. Aysta , John T. Capecchi , Carl Franzblau , Donald F. Gibbons , Randall L. Knoll , Howard M. Leibowitz , Vickery Trinkaus-Randall
发明人： James E. Aysta , John T. Capecchi , Carl Franzblau , Donald F. Gibbons , Randall L. Knoll , Howard M. Leibowitz , Vickery Trinkaus-Randall
CPC分类号： A61F2/14 , A61F2/0095 , Y10S623/92
摘要： A holding device for seeding cells on a surface of a prosthesis including chamber means for partially defining a first chamber with the first surface, and sealing means for providing a seal between the chamber means and the prosthesis so as to isolate the seeding surface from another portion of the prosthesis.
摘要翻译： 一种用于在假体的表面上接种细胞的保持装置，包括用于部分地限定具有第一表面的第一腔室的腔室装置，以及用于在腔室装置和假体之间提供密封的密封装置，以便将接种表面与另一部分 的假体。
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公开(公告)号：US5849325A
公开(公告)日：1998-12-15
申请号：US726510
申请日：1996-10-07
IPC分类号： A61F13/02 , A61L15/16 , C08F220/18 , A61F13/00
CPC分类号： A61F13/023
摘要： An adhesive dressing includes an adhesive composition in the form of a substantially continuous layer on at least a portion of a conformable backing in which the adhesive composition and the backing are selected such that the adhesive dressing has an Inverted Buffered Saline Moisture Vapor Transmission Rate of at least about 9000 g/m.sup.2 /24 hrs.
摘要翻译： 粘合剂敷料包括在适形背衬的至少一部分上具有基本上连续的层的形式的粘合剂组合物，其中粘合剂组合物和背衬被选择为使得粘合剂敷料具有反向缓冲的盐水湿气透过率 至少约9000 g / m2 / 24小时。
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公开(公告)号：US6129971A
公开(公告)日：2000-10-10
申请号：US39103
申请日：1998-03-13
CPC分类号： C09J7/0232 , A61L15/26 , A61L15/58 , C09J2477/005 , Y10S428/913 , Y10T428/1476 , Y10T428/149 , Y10T428/1495 , Y10T428/24355 , Y10T428/2839 , Y10T428/2896
摘要： An article comprising a substrate, and a textured, matte-finish, low adhesion backsize coating on one surface of the substrate, wherein the coating comprises polyvinyl carbamate having nitrogen-bonded hydrocarbon side chains which provide terminal alkyl groups more than five carbons in length.
摘要翻译： 一种制品，其包含基材和在基材的一个表面上的有纹理，无光泽的低粘度背景涂料的制品，其中该涂料包含具有氮键合的烃侧链的聚氨基甲酸酯，其提供长度超过五个碳原子的末端烷基。
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10.发明授权Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof 失效吖内酯功能底物，角膜假体，及其制造和使用
公开(公告)号：US5292514A
公开(公告)日：1994-03-08
申请号：US903367
申请日：1992-06-24
IPC分类号： A61L27/00 , A61L27/28 , A61L27/34 , A61L27/50 , C07C45/71 , C07C49/84 , C08F8/30 , A61F2/14 , C08K5/15
摘要： Azlactone-functional substrates, (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalently couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reaction, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth.
摘要翻译： 公开了吖内酯功能底物（特别是水凝胶），哺乳动物体植入物及其制备和使用方法。 吖内酯功能底物是具有吖内酯反应性亲核表面的底物和具有至少两个吖内酯部分的多功能吖内酯组合物的反应产物，其中至少一个部分共价连接到吖内酯反应性亲核表面和至少一个部分 仍然可用于进一步的亲核反应，例如用生物活性物质。 吖内酯功能水凝胶的优选用途是作为增强上皮细胞生长的角膜假体的光学元件。
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