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公开(公告)号：US07192740B2
公开(公告)日：2007-03-20
申请号：US10280725
申请日：2002-10-24
申请人： Jonathan Donson , William O. Dawson , George L. Grantham , Thomas H. Turpen , Ann Myers Turpen , Stephen J. Garger, Jr. , Laurence K. Grill
发明人： Jonathan Donson , William O. Dawson , George L. Grantham , Thomas H. Turpen , Ann Myers Turpen , Stephen J. Garger, Jr. , Laurence K. Grill
CPC分类号： C07K14/005 , C07K14/415 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12N15/1137 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00022 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32722 , C12N2770/32743 , C12N2770/32762 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2810/609 , C12N2830/00 , C12N2830/60 , C12P41/003 , C12Y114/18001 , C12Y302/01031 , C12Y304/21069
摘要： The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular advantage that it systemically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants. The present invention also relates to viruses containing the viral vectors which are infective, production cells which are capable of producing the viruses or parts thereof, a host infected by the viruses of the invention, the gene products produced by expression of the viral nucleic acids and a process for the production of a desired product by growing the infected hosts.
摘要翻译： 本发明涉及选自具有编码第一病毒亚基因组启动子的天然亚基因启动子的（+）有义单链RNA病毒的重组病毒核酸，编码转录调节的病毒外壳蛋白的核酸序列 通过第一病毒亚基因组启动子，第二病毒亚基因组启动子和其转录受第二病毒亚基因组启动子调控的第二核酸序列。 重组病毒核酸的第一和第二病毒亚基因组启动子相对于彼此不具有同源序列。 重组病毒核酸提供其系统地转录宿主中的第二核酸的特别优点。 本发明包括的宿主生物包括原核生物和真核生物，特别是动物和植物。 本发明还涉及含有感染性病毒载体的病毒，能够产生病毒或其部分的生产细胞，被本发明的病毒感染的宿主，通过表达病毒核酸产生的基因产物和 通过生长受感染的宿主来生产所需产品的方法。
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公开(公告)号：US5889190A
公开(公告)日：1999-03-30
申请号：US480432
申请日：1995-06-07
申请人： Jon Donson , William O. Dawson , George L. Grantham , Thomas H. Turpen , Ann Myers Turpen , Stephen J. Garger , Laurence K. Grill
发明人： Jon Donson , William O. Dawson , George L. Grantham , Thomas H. Turpen , Ann Myers Turpen , Stephen J. Garger , Laurence K. Grill
IPC分类号： C07K14/08 , C07K14/095 , C07K14/415 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/24 , C12N9/72 , C12N9/78 , C12N9/84 , C12N15/113 , C12N15/12 , C12N15/33 , C12N15/40 , C12N15/82 , C12N15/83 , C12N15/86 , C12P41/00 , A01H5/00
CPC分类号： C12Y114/18001 , C07K14/005 , C07K14/415 , C12N15/1137 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12P41/003 , C12Y302/01031 , C12Y304/21069 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00022 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32722 , C12N2770/32743 , C12N2770/32762 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2810/609
摘要： The present invention is directed to recombinant plant viral nucleic acids and to hosts infected thereby. The recombinant plant viral nucleic acids comprise a native plant viral subgenomic promoter, at least one non-native plant viral subgenomic promoter, a plant viral coat protein coding sequence, and optionally, at least one non-native nucleic acid sequence to be transcribed or expressed in the infected host plant. The recombinant plant viral nucleic acids are stable, capable of systemic infection and capable of stable transcription or expression in the plant host of the non-native nucleic acid sequences.
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公开(公告)号：US6054566A
公开(公告)日：2000-04-25
申请号：US484341
申请日：1995-06-07
申请人： Jon Donson , William O. Dawson , George L. Granthan , Thomas H. Turpen , Ann Myers Turpen , Stephen J. Garger , Laurence K. Grill
发明人： Jon Donson , William O. Dawson , George L. Granthan , Thomas H. Turpen , Ann Myers Turpen , Stephen J. Garger , Laurence K. Grill
IPC分类号： C07K14/08 , C07K14/095 , C07K14/415 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/24 , C12N9/72 , C12N9/78 , C12N9/84 , C12N15/113 , C12N15/12 , C12N15/33 , C12N15/40 , C12N15/82 , C12N15/83 , C12N15/86 , C12P41/00 , C07H21/02 , C12N15/63
CPC分类号： C07K14/005 , C07K14/415 , C12N15/1137 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12P41/003 , C12Y114/18001 , C12Y302/01031 , C12Y304/21069 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00022 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32722 , C12N2770/32743 , C12N2770/32762 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2810/609 , C12N2830/00 , C12N2830/60
摘要： The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular adivantage that it systemically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants.The present invention also relates to viruses containing the viral vectors which are infective, production cells which are capable of producing the viruses or parts thereof, a host infected by the viruses of the invention, the gene products produced by expression of the viral nucleic acids and a process for the production of a desired product by growing the infected hosts.
摘要翻译： 本发明涉及选自具有编码第一病毒亚基因组启动子的天然亚基因启动子的（+）有义单链RNA病毒的重组病毒核酸，编码转录调节的病毒外壳蛋白的核酸序列 通过第一病毒亚基因组启动子，第二病毒亚基因组启动子和其转录受第二病毒亚基因组启动子调控的第二核酸序列。 重组病毒核酸的第一和第二病毒亚基因组启动子相对于彼此不具有同源序列。 重组病毒核酸提供其系统地转录宿主中的第二核酸的特别优点。 本发明包括的宿主生物包括原核生物和真核生物，特别是动物和植物。 本发明还涉及含有感染性病毒载体的病毒，能够产生病毒或其部分的生产细胞，被本发明的病毒感染的宿主，通过表达病毒核酸产生的基因产物和 通过生长受感染的宿主来生产所需产品的方法。
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公开(公告)号：US5866785A
公开(公告)日：1999-02-02
申请号：US482920
申请日：1995-06-07
申请人： Jon Donson , William O. Dawson , George L. Granthan , Thomas H. Turpen , Ann Myers Turpen , Stephen J. Garger , Laurence K. Grill
发明人： Jon Donson , William O. Dawson , George L. Granthan , Thomas H. Turpen , Ann Myers Turpen , Stephen J. Garger , Laurence K. Grill
IPC分类号： C07K14/08 , C07K14/095 , C07K14/415 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/24 , C12N9/72 , C12N9/78 , C12N9/84 , C12N15/113 , C12N15/12 , C12N15/33 , C12N15/40 , C12N15/82 , C12N15/83 , C12N15/86 , C12P41/00 , A01H5/00
CPC分类号： C12Y114/18001 , C07K14/005 , C07K14/415 , C12N15/1137 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12P41/003 , C12Y302/01031 , C12Y304/21069 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00022 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32722 , C12N2770/32743 , C12N2770/32762 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2810/609
摘要： The present invention is directed to recombinant plant viral nucleic acids and to hosts infected thereby. The recombinant plant viral nucleic acids comprise a native plant viral subgenomic promoter, at least one non-native plant viral subgenomic promoter, a plant viral coat protein coding sequence, and optionally, at least one non-native nucleic acid sequence to be transcribed or expressed in the infected host plant. The recombinant plant viral nucleic acids are stable, capable of systemic infection and capable of stable transcription or expression in the plant host of the non-native nucleic acid sequences.
摘要翻译： 本发明涉及重组植物病毒核酸和由此感染的宿主。 重组植物病毒核酸包含天然植物病毒亚基因组启动子，至少一种非天然植物病毒亚基因组启动子，植物病毒外壳蛋白编码序列和任选的至少一个待转录或表达的非天然核酸序列 在被感染的宿主植物中。 重组植物病毒核酸是稳定的，能够全身感染并且能够在非天然核酸序列的植物宿主中稳定转录或表达。
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公开(公告)号：US06448046B1
公开(公告)日：2002-09-10
申请号：US09726651
申请日：2000-11-28
申请人： Jon Donson , William O. Dawson , George L. Grantham , Thomas H. Turpen , Ann M. Turpen , Stephen J. Garger , Laurence K. Grill
发明人： Jon Donson , William O. Dawson , George L. Grantham , Thomas H. Turpen , Ann M. Turpen , Stephen J. Garger , Laurence K. Grill
IPC分类号： C12N1511
CPC分类号： C12Y114/18001 , C07K14/005 , C07K14/415 , C12N9/0059 , C12N9/0071 , C12N9/1033 , C12N9/1074 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12N15/8203 , C12N15/8289 , C12N15/86 , C12N2770/36122 , C12N2830/00 , C12N2830/60 , C12P41/003 , C12Y203/01028 , C12Y302/01031 , C12Y304/21069
摘要： The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular advantage that it systemically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants. The present invention also relates to viruses containing the viral vectors which are infective, production cells which are capable of producing the viruses or parts thereof, a host infected by the viruses of the invention, the gene products produced by expression of the viral nucleic acids and a process for the production of a desired product by growing the infected hosts.
摘要翻译： 本发明涉及选自具有编码第一病毒亚基因组启动子的天然亚基因启动子的（+）有义单链RNA病毒的重组病毒核酸，编码转录调节的病毒外壳蛋白的核酸序列 通过第一病毒亚基因组启动子，第二病毒亚基因组启动子和其转录受第二病毒亚基因组启动子调控的第二核酸序列。 重组病毒核酸的第一和第二病毒亚基因组启动子相对于彼此不具有同源序列。 重组病毒核酸提供其系统地转录宿主中的第二核酸的特别优点。 本发明包括的宿主生物包括原核生物和真核生物，特别是动物和植物。 本发明还涉及含有感染性病毒载体的病毒，能够产生病毒或其部分的生产细胞，被本发明的病毒感染的宿主，通过表达病毒核酸产生的基因产物和 通过生长受感染的宿主来生产所需产品的方法。
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公开(公告)号：US06284492B1
公开(公告)日：2001-09-04
申请号：US08483502
申请日：1995-06-07
申请人： Jon Donson , William O. Dawson , George L. Grantham , Thomas H. Turpen , Ann M. Turpen , Stephen J. Garger , Laurence K. Grill
发明人： Jon Donson , William O. Dawson , George L. Grantham , Thomas H. Turpen , Ann M. Turpen , Stephen J. Garger , Laurence K. Grill
IPC分类号： C12N1511
CPC分类号： C07K14/005 , C07K14/415 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12N15/1137 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32743 , C12N2770/32762 , C12N2770/36143 , C12N2770/36162 , C12N2810/609 , C12P41/003 , C12Y114/18001 , C12Y204/01019 , C12Y302/01031 , C12Y304/21069
摘要： The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular advantage that it systemically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants. The present invention also relates to viruses containing the viral vectors which are infective, production cells which are capable of producing the viruses or parts thereof, a host infected by the viruses of the invention, the gene products produced by expression of the viral nucleic acids and a process for the production of a desired product by growing the infected hosts.
摘要翻译： 本发明涉及选自具有编码第一病毒亚基因组启动子的天然亚基因启动子的（+）有义单链RNA病毒的重组病毒核酸，编码转录调节的病毒外壳蛋白的核酸序列 通过第一病毒亚基因组启动子，第二病毒亚基因组启动子和其转录受第二病毒亚基因组启动子调控的第二核酸序列。 重组病毒核酸的第一和第二病毒亚基因组启动子相对于彼此没有同源序列。 重组病毒核酸提供其系统地转录宿主中的第二核酸的特别优点。 本发明包括的宿主生物包括原核生物和真核生物，特别是动物和植物。本发明还涉及含有感染性病毒载体的病毒，能够产生病毒或其部分的生产细胞，被 本发明的病毒，通过表达病毒核酸产生的基因产物和通过生长受感染宿主生产所需产物的方法。
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公开(公告)号：US5814495A
公开(公告)日：1998-09-29
申请号：US404384
申请日：1995-03-14
申请人： Guy della-Cioppa , Stephen J. Garger, Jr. , Genadie G. Sverlow , Thomas H. Turpen , Laurence K. Grill , Miles R. Chedekal
发明人： Guy della-Cioppa , Stephen J. Garger, Jr. , Genadie G. Sverlow , Thomas H. Turpen , Laurence K. Grill , Miles R. Chedekal
CPC分类号： C12N9/0059 , C07K14/36 , C12N9/0071 , C12P17/00 , C12Y110/03001 , C12Y114/18001
摘要： The present invention is directed to a process for producing melanins, their precursors and their analoges, hereinafter referred to generically as melanins. According to the invention, melanins are produced in amounts greater than about 3.3 grams wet weight per liter of growth medium. The enhanced production of melanin can be achieved by manipulating the constituents of the growth medium, and/or attenuating fermentations conditions, and/or by genetically engineering microorganisms to produce melanins, and/or mutating the microorganisms.
摘要翻译： 本发明涉及一种生产黑色素及其前体及其类似物的方法，以下通常称为黑色素。 根据本发明，以每升生长培养基大于约3.3克湿重的量生产黑色素。 可以通过操纵生长培养基的成分和/或减弱发酵条件和/或通过遗传工程微生物产生黑色素和/或使微生物变异来实现黑色素的增强生产。
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公开(公告)号：US5631151A
公开(公告)日：1997-05-20
申请号：US857602
申请日：1992-03-20
申请人： Guy della-Cioppa , Stephen J. Garger, Jr. , Genadie G. Sverlow , Thomas H. Turpen , Laurence K. Grill , Miles R. Chedekel , Monto H. Kumagai
发明人： Guy della-Cioppa , Stephen J. Garger, Jr. , Genadie G. Sverlow , Thomas H. Turpen , Laurence K. Grill , Miles R. Chedekel , Monto H. Kumagai
CPC分类号： C12N9/0059 , C07K14/36 , C12N9/0071 , C12P17/00 , C12Y110/03001 , C12Y114/18001
摘要： The present invention is directed to a process for producing melanins, their precursors and their analogues, hereinafter referred to generically as melanins. According to the invention, melanins are produced in amounts greater than about 3.3 grams wet weight per liter of growth medium. The enhanced production of melanin can be achieved by manipulating the constituents of the growth medium, and/or attenuating fermentations conditions, and/or by genetically engineering microorganisms to produce melanins, and/or mutating the microorganisms.
摘要翻译： 本发明涉及一种生产黑色素，其前体及其类似物的方法，以下一般称为黑色素。 根据本发明，以每升生长培养基大于约3.3克湿重的量生产黑色素。 可以通过操纵生长培养基的成分和/或减弱发酵条件和/或通过遗传工程微生物产生黑色素和/或使微生物变异来实现黑色素的增强生产。
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公开(公告)号：US5837505A
公开(公告)日：1998-11-17
申请号：US401746
申请日：1995-03-09
申请人： Guy della-Cioppa , Stephen J. Garger, Jr. , Genadie G. Sverlow , Thomas H. Turpen , Laurence K. Grill , Miles R. Chedekal
发明人： Guy della-Cioppa , Stephen J. Garger, Jr. , Genadie G. Sverlow , Thomas H. Turpen , Laurence K. Grill , Miles R. Chedekal
CPC分类号： C12N9/0059 , C07K14/36 , C12N9/0071 , C12P17/00 , C12Y110/03001 , C12Y114/18001
摘要： The present invention is directed to a process for producing melanins, their precursors and their analoges, hereinafter referred to generically as melanins. According to the invention, melanins are produced in amounts greater than about 3.3 grams wet weight per liter of growth medium. The enhanced production of melanin can be achieved by manipulating the constituents of the growth medium, and/or attenuating fermentations conditions, and/or by genetically engineering microorganisms to produce melanins, and/or mutating the microorganisms.
摘要翻译： 本发明涉及一种生产黑色素及其前体及其类似物的方法，以下通常称为黑色素。 根据本发明，以每升生长培养基大于约3.3克湿重的量生产黑色素。 可以通过操纵生长培养基的成分和/或减弱发酵条件和/或通过遗传工程微生物产生黑色素和/或使微生物变异来实现黑色素的增强生产。
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公开(公告)号：US5589367A
公开(公告)日：1996-12-31
申请号：US184237
申请日：1994-01-19
申请人： Jon Donson , William O. Dawson , George L. Granthan , Thomas H. Turpen , Ann M. Turpen , Stephen J. Garger , Laurence K. Grill
发明人： Jon Donson , William O. Dawson , George L. Granthan , Thomas H. Turpen , Ann M. Turpen , Stephen J. Garger , Laurence K. Grill
IPC分类号： C07K14/08 , C07K14/095 , C07K14/415 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/24 , C12N9/72 , C12N9/78 , C12N9/84 , C12N15/113 , C12N15/12 , C12N15/33 , C12N15/40 , C12N15/82 , C12N15/83 , C12N15/86 , C12P41/00 , C12N15/68
CPC分类号： C12Y114/18001 , C07K14/005 , C07K14/415 , C12N15/1137 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12P41/003 , C12Y302/01031 , C12Y304/21069 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00022 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32722 , C12N2770/32743 , C12N2770/32762 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2810/609
摘要： The present invention is directed to recombinant plant viral nucleic acids and to hosts infected thereby. The recombinant plant viral nucleic acids comprise a native plant viral subgenomic promoter, at least one non-native plant viral subgenomic promoter, a plant viral coat protein coding sequence, and optionally, at least one non-native nucleic acid sequence to be transcribed or expressed in the infected host plant. The recombinant plant viral nucleic acids are stable, capable of systemic infection and capable of stable transcription or expression in the plant host of the non-native nucleic acid sequences.
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