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公开(公告)号：US20070203205A1
公开(公告)日：2007-08-30
申请号：US11796389
申请日：2007-04-27
申请人： Jose Castro Pineiro , Laura Cooper , Myra Gilligan , Alexander Humphries , Peter Hunt , Tamara Ladduwahetty , Angus MacLeod , Kevin Merchant , Monique Van Niel , Kevin Wilson
发明人： Jose Castro Pineiro , Laura Cooper , Myra Gilligan , Alexander Humphries , Peter Hunt , Tamara Ladduwahetty , Angus MacLeod , Kevin Merchant , Monique Van Niel , Kevin Wilson
IPC分类号： A61K31/4245 , A61K31/4164 , A61K31/235 , A61K31/10
CPC分类号： C07C317/28 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/36 , C07C317/42 , C07C317/44 , C07D205/04 , C07D207/10 , C07D211/38 , C07D211/72 , C07D213/34 , C07D213/71 , C07D217/24 , C07D231/12 , C07D233/64 , C07D241/08 , C07D249/08 , C07D261/08 , C07D271/10 , C07D277/26 , C07D295/096 , C07D317/62 , C07D319/18
摘要： Compounds of formula I: are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS.
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公开(公告)号：US20060052445A1
公开(公告)日：2006-03-09
申请号：US11212789
申请日：2005-08-26
申请人： Jose Castro Pineiro , Laura Cooper , Myra Gilligan , Alexander Humphries , Peter Hunt , Tamara Ladduwahetty , Angus MacLeod , Kevin Merchant , Monique Van Niel , Kevin Wilson
发明人： Jose Castro Pineiro , Laura Cooper , Myra Gilligan , Alexander Humphries , Peter Hunt , Tamara Ladduwahetty , Angus MacLeod , Kevin Merchant , Monique Van Niel , Kevin Wilson
IPC分类号： A61K31/235 , A61K31/10 , C07C317/44 , C07C317/42
CPC分类号： C07C317/28 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/36 , C07C317/42 , C07C317/44 , C07D205/04 , C07D207/10 , C07D211/38 , C07D211/72 , C07D213/34 , C07D213/71 , C07D217/24 , C07D231/12 , C07D233/64 , C07D241/08 , C07D249/08 , C07D261/08 , C07D271/10 , C07D277/26 , C07D295/096 , C07D317/62 , C07D319/18
摘要： Compounds of formula I: are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS.
摘要翻译： 式I化合物：
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公开(公告)号：US20070281952A1
公开(公告)日：2007-12-06
申请号：US11791195
申请日：2005-11-28
申请人： Mark Chambers , Neil Curtis , Emanuela Gancia , Myra Gilligan , Alexander Humphries , Tamara Ladduwahetty , Robert Maxey , Kevin Merchant
发明人： Mark Chambers , Neil Curtis , Emanuela Gancia , Myra Gilligan , Alexander Humphries , Tamara Ladduwahetty , Robert Maxey , Kevin Merchant
IPC分类号： A61K31/495 , A61K31/41 , A61K31/415 , A61K31/52 , A61P25/20 , A61P25/24 , A61P27/06 , C07D213/02 , C07D231/10 , C07D473/00 , C07D239/02 , C07D233/00 , C07D221/02 , C07C317/00 , A61P25/30 , A61P25/22 , A61P25/18 , A61K31/435 , A61K31/4353
CPC分类号： C07D401/12 , C07C311/08 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/42 , C07C317/44 , C07C323/65 , C07C2601/04 , C07D213/61 , C07D213/64 , C07D213/70 , C07D215/36 , C07D215/60 , C07D233/64 , C07D241/12 , C07D249/06 , C07D249/08 , C07D249/18 , C07D261/08 , C07D271/10 , C07D277/26 , C07D333/34 , C07D471/04 , C07D473/38
摘要： Compounds of formula (I) are potent and selective 5-HT2A antagonists, useful in treatment of a variety of adverse conditions of the CNS.
摘要翻译： 式（I）化合物是有效和选择性的5-HT 2AA拮抗剂，可用于治疗CNS的多种不利条件。
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4.发明申请8-Fluoroimidazo 1,2-a pyridine derivatives as ligands for gaba receptors 失效8-氟咪唑并[1,2-a]吡啶衍生物作为gaba受体的配体公开(公告)号：US20060052385A1
公开(公告)日：2006-03-09
申请号：US10515165
申请日：2003-05-25
申请人： Wesley Blackaby , Jose Castro Pineiro , Simon Goodacre , David Hallett , Alexander Humphries , Philip Jones , Kevin Merchant , Michael Reader
发明人： Wesley Blackaby , Jose Castro Pineiro , Simon Goodacre , David Hallett , Alexander Humphries , Philip Jones , Kevin Merchant , Michael Reader
IPC分类号： A61K31/506 , A61K31/502 , A61K31/497 , C07D471/02
CPC分类号： C07D471/04
摘要： A class of 8-fluoroimidazo[1,2-α]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
摘要翻译： 一类由任选取代的五元或六元杂芳环在3-位被取代的8-氟咪唑并[1,2-α]吡啶衍生物，是GABA A A受体的选择性配体 特别是对α2和/或α3和/或α5亚基具有高亲和力，因此有益于治疗和/或预防中枢神经系统的不利条件，包括焦虑，抽搐和认知障碍。
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公开(公告)号：US20090012134A1
公开(公告)日：2009-01-08
申请号：US11885925
申请日：2006-03-10
申请人： Neil Roy Curtis , Emanuela Garcia , Tamara Ladduwahetty , Robert Maxey , Kevin Merchant , Andrew Mitchinson
发明人： Neil Roy Curtis , Emanuela Garcia , Tamara Ladduwahetty , Robert Maxey , Kevin Merchant , Andrew Mitchinson
IPC分类号： A61K31/428 , C07D209/04 , C07D277/62 , A61K31/404 , A61K31/4184 , C07D235/04
CPC分类号： C07D307/79 , C07D209/08 , C07D209/10 , C07D209/42 , C07D231/56 , C07D277/66 , C07D333/54
摘要： Compounds of formula (I): are potent and selective antagonists of the 5-HT2A receptor, and hence are useful in treatment of various CNS disorders.
摘要翻译： 式（I）化合物是5-HT 2A受体的有效和选择性拮抗剂，因此可用于治疗各种CNS疾病。
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公开(公告)号：US20060189666A1
公开(公告)日：2006-08-24
申请号：US10566486
申请日：2004-07-29
申请人： Michela Bettati , Amanda Boase , Ian Churcher , Tamara Ladduwahetty , Kevin Merchant , Abdul Quddus
发明人： Michela Bettati , Amanda Boase , Ian Churcher , Tamara Ladduwahetty , Kevin Merchant , Abdul Quddus
IPC分类号： A61K31/433 , C07D498/12
CPC分类号： C07D231/12 , C07D417/06
摘要： Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
摘要翻译： 式（I）的化合物：通过γ-分泌酶抑制APP的加工，因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号：US09290456B2
公开(公告)日：2016-03-22
申请号：US14240045
申请日：2012-08-21
申请人： William Farnaby , Charlotte Fieldhouse , Katherine Hazel , Catrina Kerr , Natasha Kinsella , David Livermore , Kevin Merchant , David Miller
发明人： William Farnaby , Charlotte Fieldhouse , Katherine Hazel , Catrina Kerr , Natasha Kinsella , David Livermore , Kevin Merchant , David Miller
IPC分类号： C07D237/16 , C07D401/06 , A61K31/50 , A61K31/501 , C07D401/10 , C07D407/10 , A61K45/06 , C07D237/18 , C07D237/22 , C07D405/06 , C07F7/08
CPC分类号： A61K31/50 , A61K31/501 , A61K45/06 , C07D237/16 , C07D237/18 , C07D237/22 , C07D401/06 , C07D401/10 , C07D405/06 , C07D407/10 , C07F7/0812
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，其中R1和R2如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20150030704A1
公开(公告)日：2015-01-29
申请号：US14240045
申请日：2012-08-21
申请人： William Farnaby , Charlotte Fieldhouse , Katherine Hazel , Catrina Kerr , Natasha Kinsella , David Livermore , Kevin Merchant , David Miller
发明人： William Farnaby , Charlotte Fieldhouse , Katherine Hazel , Catrina Kerr , Natasha Kinsella , David Livermore , Kevin Merchant , David Miller
IPC分类号： C07D237/16 , C07D401/06 , A61K45/06 , C07D237/18 , C07D237/22 , C07D405/06 , A61K31/50 , A61K31/501
CPC分类号： A61K31/50 , A61K31/501 , A61K45/06 , C07D237/16 , C07D237/18 , C07D237/22 , C07D401/06 , C07D401/10 , C07D405/06 , C07D407/10 , C07F7/0812
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，其中R1和R2如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20140248378A1
公开(公告)日：2014-09-04
申请号：US14131337
申请日：2012-07-05
IPC分类号： A61K31/513 , C07D239/22 , C07D403/12 , C07D401/12 , A61K45/06 , C07D471/04 , C07D413/12 , C07D405/12
CPC分类号： A61K31/513 , A61K45/06 , C07D239/22 , C07D239/54 , C07D239/60 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： The present invention provides compounds of formula (1) and pharmaceutically acceptable salts thereof, wherein R1, R2, Y and Z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（1）化合物及其药学上可接受的盐，其中R1，R2，Y和Z如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US10085986B2
公开(公告)日：2018-10-02
申请号：US14131337
申请日：2012-07-05
IPC分类号： C07F9/02 , A61K31/513 , C07D239/54 , C07D239/60 , A61K45/06 , C07D239/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： The present invention provides compounds of formula (1) and pharmaceutically acceptable salts thereof, wherein R1, R2, Y and Z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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