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1.发明申请IMMUNOSTIMULANT COMPOSITIONS COMPRISING A NUCLEOBASE AND A POLYSACCHARIDE OBTAINABLE FROM FUNGI, YEAST OR BACTERIA 有权含有核酸酶和从真菌，YEAST或BACTERIA获得的多糖的免疫组织化合物公开(公告)号：US20110213020A1
公开(公告)日：2011-09-01
申请号：US13121147
申请日：2009-09-08
申请人： Josep Escaich Ferrer , Daniel Martinez Puig , Carles Chetrit Russi , Elisabet Borda Casas , Ken-ichi Kosuna
发明人： Josep Escaich Ferrer , Daniel Martinez Puig , Carles Chetrit Russi , Elisabet Borda Casas , Ken-ichi Kosuna
IPC分类号： A61K31/716 , A61P37/04 , A61P31/04 , A61P39/00
CPC分类号： A61K45/06 , A61K31/198 , A61K31/7052 , A61K31/7105 , A61K31/711 , A61K31/716 , A61K36/06 , A61K2300/00
摘要： The present invention relates to compositions comprising nucleobases and/or sources of nucleobases and polysaccharides from extracts of fungi, yeasts or bacteria. Preferably, the compositions include Nucleoforce® or Nucleoforce® Dogs and AHCC®. Said compositions are useful in the treatment and prevention of immunosuppression, of the toxicity derived from chemotherapy or radiotherapy treatment, of diseases of the immune system, of cancer or an infection; and are also useful to stimulate the immune function in a mammal, including a human.
摘要翻译： 本发明涉及包含真核，酵母或细菌提取物的核碱基和/或核碱基和多糖来源的组合物。 优选地，组合物包括Nucleoforce或Nucleoforce Dogs和AHCC。 所述组合物可用于治疗和预防免疫抑制，来自化疗或放射治疗的毒性，免疫系统疾病，癌症或感染的毒性; 并且还可用于刺激包括人在内的哺乳动物的免疫功能。
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2.发明授权Immunostimulant compositions comprising a nucleobase and a polysaccharide obtainable from fungi, yeast or bacteria 有权包含可从真菌，酵母或细菌获得的核碱基和多糖的免疫刺激剂组合物公开(公告)号：US09161979B2
公开(公告)日：2015-10-20
申请号：US13121147
申请日：2009-09-08
申请人： Josep Escaich Ferrer , Daniel Martinez Puig , Carles Chetrit Russi , Elisabet Borda Casas , Ken-ichi Kosuna
发明人： Josep Escaich Ferrer , Daniel Martinez Puig , Carles Chetrit Russi , Elisabet Borda Casas , Ken-ichi Kosuna
IPC分类号： A61K36/07 , A61K31/716 , A61K45/06 , A61K31/198 , A61K31/7052 , A61K31/7105 , A61K31/711 , A61K36/06
CPC分类号： A61K45/06 , A61K31/198 , A61K31/7052 , A61K31/7105 , A61K31/711 , A61K31/716 , A61K36/06 , A61K2300/00
摘要： The present invention relates to compositions comprising nucleobases and/or sources of nucleobases and polysaccharides from extracts of fungi, yeasts or bacteria. Preferably, the compositions include Nucleoforce® or Nucleoforce® Dogs and AHCC®. Said compositions are useful in the treatment and prevention of immunosuppression, of the toxicity derived from chemotherapy or radiotherapy treatment, of diseases of the immune system, of cancer or an infection; and are also useful to stimulate the immune function in a mammal, including a human.
摘要翻译： 本发明涉及包含真核，酵母或细菌提取物的核碱基和/或核碱基和多糖来源的组合物。 优选地，组合物包括Nucleoforce或Nucleoforce Dogs和AHCC。 所述组合物可用于治疗和预防免疫抑制，来自化疗或放射治疗的毒性，免疫系统疾病，癌症或感染的毒性; 并且还可用于刺激包括人在内的哺乳动物的免疫功能。
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3.发明申请公开(公告)号：US20100129331A1
公开(公告)日：2010-05-27
申请号：US12664589
申请日：2008-05-15
IPC分类号： A61K35/12 , A61K31/715 , C07H1/00 , A61K31/7016
CPC分类号： A61K31/7016 , A61K31/728 , A61K31/737 , A61K35/32 , A61K38/30 , A61K2300/00
摘要： The present invention relates to the use of a series of disaccharides, as well as of compositions containing them, for the preparation of a medicament for the treatment or prevention of a tendon, ligament or bone disease, disorder or injury. The present invention also relates to the new compositions comprising a disaccharide in combination with inulin polysulphate, a glycosamino-glycan, a growth factor or cells. The glycosaminoglycan is preferably chondroitin sulphate or hyaluronic acid and the growth fact is IFG-1.
摘要翻译： 本发明涉及一系列二糖以及含有它们的组合物在制备用于治疗或预防腱，韧带或骨疾病，病症或损伤的药物中的用途。 本发明还涉及新的组合物，其包含与多聚磺酸菊糖苷，糖基氨基聚糖，生长因子或细胞组合的二糖。 糖胺聚糖优选为硫酸软骨素或透明质酸，生长事实为IFG-1。
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公开(公告)号：US08445462B2
公开(公告)日：2013-05-21
申请号：US12810775
申请日：2008-12-17
IPC分类号： A61K31/715 , A61K31/737 , A61P19/02 , A61P29/00
CPC分类号： A61K31/7008 , A61K31/737 , A61K2300/00
摘要： The present invention relates to compositions comprising chondroitin sulphate and mannosamine or a derivative thereof. The mannosamine derivative is preferably N-acetylmannosamine. The compositions may comprise glucosamine. Said compositions are useful in the treatment or prevention of degenerative joint diseases, preferably of osteoarthritis, in the treatment or prevention of tendon or ligament diseases, disorders or injuries and of immune system diseases, preferably of rheumatoid arthritis.
摘要翻译： 本发明涉及包含硫酸软骨素和甘露糖胺或其衍生物的组合物。 甘露糖胺衍生物优选为N-乙酰甘露糖胺。 组合物可以包含葡糖胺。 所述组合物可用于治疗或预防退行性关节疾病，优选骨关节炎，用于治疗或预防腱或韧带疾病，病症或损伤以及免疫系统疾病，优选类风湿性关节炎。
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公开(公告)号：US09347081B2
公开(公告)日：2016-05-24
申请号：US14112679
申请日：2012-04-16
申请人： Josep Escaich Ferrer , Pere Dalmau Castanares , Ana Maria Torrent Gibert , Ramon Ruhi Roura , Carlos Raul Alaez Verson
发明人： Josep Escaich Ferrer , Pere Dalmau Castanares , Ana Maria Torrent Gibert , Ramon Ruhi Roura , Carlos Raul Alaez Verson
IPC分类号： A61K31/726 , A61K38/00 , A61K38/01 , A61K38/18 , C12P21/06 , A61K35/32 , A61Q19/08 , A23L1/305 , A23J1/00 , A23J3/34 , A61K8/66 , A61K8/73 , A61K8/65 , A61K38/39 , A61Q19/00
CPC分类号： A61K38/1841 , A23J1/002 , A23J3/342 , A23L33/18 , A23V2002/00 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/73 , A61K8/735 , A61K31/728 , A61K31/737 , A61K35/32 , A61K38/39 , A61K2800/592 , A61K2800/5922 , A61K2800/80 , A61Q19/007 , A61Q19/08 , C12P21/06
摘要： The present invention relates to a method for preparing a cartilage product comprising a protein hydrolysate with a degree of hydrolysis comprised between 0.5% and 3.0%, at least one glycosaminoglycan and at least one growth factor. The present invention also relates to the cartilage product obtainable through said method. Said cartilage product is useful in the treatment or prevention of wounds, ulcers, burns, psoriasis, osteoarthritis, synovitis, osteoporosis, osteopenia, diseases of the tendons and ligaments, periodontal diseases, signs of skin aging, the harmful effects of ultraviolet radiation exposure or stretch marks.
摘要翻译： 本发明涉及一种制备软骨制品的方法，该软骨制品包含水解度为0.5％至3.0％的蛋白质水解产物，至少一种糖胺聚糖和至少一种生长因子。 本发明还涉及通过所述方法可获得的软骨产品。 所述软骨产品可用于治疗或预防伤口，溃疡，烧伤，牛皮癣，骨关节炎，滑膜炎，骨质疏松症，骨质减少，肌腱和韧带疾病，牙周病，皮肤老化迹象，紫外线辐射暴露的有害影响或 妊娠纹。
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公开(公告)号：US20140113861A1
公开(公告)日：2014-04-24
申请号：US14112679
申请日：2012-04-16
申请人： Josep Escaich Ferrer , Pere Dalmau Castanares , Ana Maria Torrent Gibert , Ramon Ruhi Roura , Carlos Raul Alaez Verson
发明人： Josep Escaich Ferrer , Pere Dalmau Castanares , Ana Maria Torrent Gibert , Ramon Ruhi Roura , Carlos Raul Alaez Verson
CPC分类号： A61K38/1841 , A23J1/002 , A23J3/342 , A23L33/18 , A23V2002/00 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/73 , A61K8/735 , A61K31/728 , A61K31/737 , A61K35/32 , A61K38/39 , A61K2800/592 , A61K2800/5922 , A61K2800/80 , A61Q19/007 , A61Q19/08 , C12P21/06
摘要： The present invention relates to a method for preparing a cartilage product comprising a protein hydrolysate with a degree of hydrolysis comprised between 0.5% and 3.0%, at least one glycosaminoglycan and at least one growth factor. The present invention also relates to the cartilage product obtainable through said method. Said cartilage product is useful in the treatment or prevention of wounds, ulcers, burns, psoriasis, osteoarthritis, synovitis, osteoporosis, osteopenia, diseases of the tendons and ligaments, periodontal diseases, signs of skin aging, the harmful effects of ultraviolet radiation exposure or stretch marks.
摘要翻译： 本发明涉及一种制备软骨制品的方法，该软骨制品包含水解度为0.5％至3.0％的蛋白质水解产物，至少一种糖胺聚糖和至少一种生长因子。 本发明还涉及通过所述方法可获得的软骨产品。 所述软骨产品可用于治疗或预防伤口，溃疡，烧伤，牛皮癣，骨关节炎，滑膜炎，骨质疏松症，骨质减少，肌腱和韧带疾病，牙周病，皮肤老化迹象，紫外线辐射暴露的有害影响或 妊娠纹。
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公开(公告)号：US08394781B2
公开(公告)日：2013-03-12
申请号：US12664589
申请日：2008-05-15
IPC分类号： A61K31/7016 , A61K31/715 , A61K31/737 , A61K31/70
CPC分类号： A61K31/7016 , A61K31/728 , A61K31/737 , A61K35/32 , A61K38/30 , A61K2300/00
摘要： Disaccharides for the treatment of tendons, ligaments and bones.The present invention relates to the use of a series of disaccharides, as well as of compositions containing them, for the preparation of a medicament for the treatment or prevention of a tendon, ligament or bone disease, disorder or injury. The present invention also relates to the new compositions comprising a disaccharide in combination with inulin polysulphate, a glycosaminoglycan, a growth factor or cells. The glycosaminoglycan is preferably chondroitin sulphate or hyaluronic acid and the growth factor is IFG-1.
摘要翻译： 二糖用于治疗肌腱，韧带和骨骼。 本发明涉及一系列二糖以及含有它们的组合物在制备用于治疗或预防腱，韧带或骨疾病，病症或损伤的药物中的用途。 本发明还涉及新的组合物，其包含与菊糖多硫酸盐，糖胺聚糖，生长因子或细胞组合的二糖。 糖胺聚糖优选为硫酸软骨素或透明质酸，生长因子为IFG-1。
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8.发明授权Sulphated disaccharides for the treatment of neurodegenerative and/or neurovascular diseases 失效用于治疗神经变性和/或神经血管疾病的硫酸二糖公开(公告)号：US08785416B2
公开(公告)日：2014-07-22
申请号：US13520069
申请日：2010-12-22
申请人： Josep Verges Milano , Antonio Garcia Garcia , Ramon Ruhi Roura , Eulalia Montell Bonaventura , Manuela Garcia Lopez , Carlos Raul Alaez Verson , Josep Escaich Ferrer , Javier Egea Maiquez , Pilar Negredo Madrigal , Silvia Lorrio Gonzalez
发明人： Josep Verges Milano , Antonio Garcia Garcia , Ramon Ruhi Roura , Eulalia Montell Bonaventura , Manuela Garcia Lopez , Carlos Raul Alaez Verson , Josep Escaich Ferrer , Javier Egea Maiquez , Pilar Negredo Madrigal , Silvia Lorrio Gonzalez
IPC分类号： A61K31/7016 , A61K31/715 , C07H3/04 , C07H5/06
CPC分类号： A61K31/7016
摘要： The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular disease, of a traumatic brain injury or of a traumatic spinal cord injury. The present invention also relates to the use of said sulphated disaccharides for the preparation of a neuroprotective medicament or of an antioxidant medicament. The neurodegenerative and/or neurovascular diseases are preferably: Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke.
摘要翻译： 本发明涉及一系列硫酸化二糖在制备用于治疗或预防神经变性和/或神经血管疾病，创伤性脑损伤或创伤性脊髓损伤的药物中的用途。 本发明还涉及所述硫酸化二糖用于制备神经保护药物或抗氧化剂药物的用途。 神经变性和/或神经血管疾病优选为：阿尔茨海默氏病，帕金森病，肌萎缩性侧索硬化和中风。
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9.发明申请SULPHATED DISACCHARIDES FOR THE TREATMENT OF NEURODEGENERATIVE AND/OR NEUROVASCULAR DISEASES 失效用于治疗神经损伤和/或神经性血管疾病的硫化物公开(公告)号：US20120309707A1
公开(公告)日：2012-12-06
申请号：US13520069
申请日：2010-12-22
申请人： Josep Verges Milano , Antonio Garcia Garcia , Ramon Ruhi Roura , Eulalia Montell Bonaventura , Manuela Garcia Lopez , Carlos Raul Alaez Verson , Josep Escaich Ferrer , Javier Egea Maiquez , Pilar Negredo Madrigal , Silvia Lorrio Gonzalez
发明人： Josep Verges Milano , Antonio Garcia Garcia , Ramon Ruhi Roura , Eulalia Montell Bonaventura , Manuela Garcia Lopez , Carlos Raul Alaez Verson , Josep Escaich Ferrer , Javier Egea Maiquez , Pilar Negredo Madrigal , Silvia Lorrio Gonzalez
IPC分类号： A61K31/7016 , A61P25/16 , C07H5/04 , A61P25/28 , A61P25/00
CPC分类号： A61K31/7016
摘要： The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular disease, of a traumatic brain injury or of a traumatic spinal cord injury. The present invention also relates to the use of said sulphated disaccharides for the preparation of a neuroprotective medicament or of an antioxidant medicament. The neurodegenerative and/or neurovascular diseases are preferably: Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke.
摘要翻译： 本发明涉及一系列硫酸化二糖在制备用于治疗或预防神经变性和/或神经血管疾病，创伤性脑损伤或创伤性脊髓损伤的药物中的用途。 本发明还涉及所述硫酸化二糖用于制备神经保护药物或抗氧化剂药物的用途。 神经变性和/或神经血管疾病优选为：阿尔茨海默氏病，帕金森病，肌萎缩性侧索硬化和中风。
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公开(公告)号：US07943598B2
公开(公告)日：2011-05-17
申请号：US11659504
申请日：2005-06-23
CPC分类号： A61K31/7008
摘要： The present invention relates to the use of an organic glucosamine salt selected from glucosamine glucuronate, glucosamine ascorbate, glucosamine malate, glucosamine hydrogen malate, glucosamine citrate, glucosamine hydrogen citrate, and glucosamine dihydrogen citrate for the preparation of a medicament for the treatment of arthrosis and inflammation and pain associated with arthrosis. The present invention also relates to the use of an organic glucosamine salt, selected from the ones mentioned above, for the preparation of a nutritional supplement acting as a chondroprotector, to nourish the cartilage, protect the joints, prevent water deficit in the tissues that form the joint, improve the joints' functional capacity, elasticity, and flexibility, and prevent and revert the physical overexertion syndrome in athletes, and the effects associated therewith.
摘要翻译： 本发明涉及选自葡糖醛糖葡糖胺，苹果酸葡萄糖胺，苹果酸葡糖胺，柠檬酸葡糖胺，柠檬酸葡糖胺，柠檬酸葡糖胺二柠檬酸等有机葡糖胺盐在制备用于治疗关节病的药物中的应用， 与关节炎相关的炎症和疼痛。 本发明还涉及选自上述有机葡糖胺盐的用途，用于制备作为软骨转运蛋白的营养补充剂，滋养软骨，保护关节，防止形成的组织中的水分亏缺 联合，提高关节功能，弹性和弹性，防止和恢复运动员身体过度疲劳综合征及其相关影响。
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