摘要:
Methods are provided for the construction of unsymmetrical biaryl compounds and alkylated aromatic compounds from arylnitriles using a nickel or palladium catalyzed coupling in which the catalyst has at least one phosphine or phosphite ligand.
摘要:
A novel migratory insertion reaction is disclosed utilizing organoaluminum compounds. An intramolecular transfer of a carbon group from the aluminum complex E-1-halo-1-alkenyl)trialkylalanate occurs to produce an E-alkenyl(alkoxy)dialkylalanate or an E-dialkylalkenylalane or an (E,E)-3-alkyl-2-dialkylalumino-1,3-diene depending on process conditions. Novel organic aluminates are also disclosed.
摘要:
Mono- and disubstituted aryl or heterocyclic acetylenes are produced by a process comprising reacting an aryl nitrile with an alkynylzinc compound, a bis-alkynylzinc compound, or an alkynylmagnesium compound, in the presence of a nickel/phosphine catalyst.
摘要:
The present invention involves compounds having the structure: ##STR1## (a) --A-- is selected from the group consisting of ##STR2## (b) --Y is selected from certain low molecular weight moieties which terminate in specific functional groups: --C.tbd.CH, ##STR3## and aldehydes in the form of their acetals; pharmaceutical compositions comprising such compounds; and methods for treating inflammation by administering such compounds.
摘要:
A modular prosthetic foot characterized by an ankle component; a forefoot component having a circular part with a rounded top surface and at least one flat side surface, said circular part being connected to a rear part of the forefoot component; a forefoot cushion bumper positioned around the circular part; and a heel component.
摘要:
Methods are provided for the construction of unsymmetrical biaryl compounds and alkylated aromatic compounds from arylnitriles using a nickel or palladium catalyzed coupling in which the catalyst has at least one phosphine or phosphite ligand.
摘要:
An adapter for receiving a vessel of one size and configured for retaining placement of the one size vessel in a receptacle cavity dimensioned to hold a different size vessel. The adapter comprises a pair of similarly configured segments each having a flat lower portion of a width sized for placement transversely within the receptacle cavity integral with and depending below an upper portion having a plurality of upwardly extending arms separated a distance as accommodates placement of the one size vessel between the arms. The respective adapter segments each have similarly dimensioned slots midway of and extending longitudinally approximately one-half the height of the flat lower portion, the slot in one adapter segment of the pair extending upwardly from the bottom edge of the one segment and the slot in the other adapter segment of the pair extending downwardly from the top edge of the other segment. The adapter segments form a unitary adapter device with the respective adapter segments in nesting engagement transversely of each other upon arranging the respective segments such that the slots of each segment of the pair closely straddles approximately one-half of the lower portion of the other of the pair of segments.
摘要:
The subject invention relates to compounds having the structure: ##STR1## wherein (a) X is selected from hydroxy, C.sub.1 to about C.sub.2 alkanoxy, thiol, C.sub.1 to about C.sub.2 alkanylthiol, and halo;(b) R and R' are each independently selected from C.sub.1 to about C.sub.3 straight or branched alkanyl, and C.sub.3 to about C.sub.4 cyclic alkanyl; or R and R' are bonded together to form a C.sub.3 to about C.sub.6 cyclic alkanyl ring, or a C.sub.3 to about C.sub.5 cyclic heteroalkanyl ring having one oxygen or sulfur atom in the ring, the heteroatom not being bonded to the carbon to which X is bonded; and R and R', or the ring formed by them when bonded together, are each, independently, unsubstituted or monosubstituted with a substituent selected from halo, hydroxy, thiol, C.sub.1 to about C.sub.2 alkanoxy, and C.sub.1 to about C.sub.2 alkanylthiol.The subject invention also relates to the pharmaceutical compositions comprising the above compounds, and methods of treating inflammation using the compounds.
摘要:
Convenience fishing rod attachments enable a fisherman to leave multiple fishing rods unattended without concern that the rods may be pulled into the water by fish strikes, and subsequently lost or damaged. The attachments permit such unattended use of a fishing rod in a boat or on a bank or shore of a body of water. One of the attachments provides a system by which a hook is automatically set in the mouth tissue of a striking fish.