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    Non-invasive biochemical analysis
    1.
    发明申请
    Non-invasive biochemical analysis 有权
    非侵入性生化分析

    公开(公告)号：US20060276697A1

    公开(公告)日：2006-12-07

    申请号：US11146458

    申请日：2005-06-07

    申请人： Joseph Demuth ,  Patrick Treado ,  John Maier ,  Jeffrey Cohen

    发明人： Joseph Demuth ,  Patrick Treado ,  John Maier ,  Jeffrey Cohen

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/415 ,  A61B5/418

    摘要： The invention relates to methods and devices for assessing one or more blood components in an animal. The present invention permits non-invasive assessment of blood components in a body structure containing blood and other tissue types by assessing multiple regions of a tissue surface for an optical characteristic of blood and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood component for one or more regions that exhibit the optical characteristic of blood.

    摘要翻译： 本发明涉及用于评估动物体内一种或多种血液成分的方法和装置。 本发明通过评估血液的光学特性的组织表面的多个区域并分别评估一种或多种光学（例如，拉曼或NIR）特征，允许对包含血液和其它组织类型的体内结构中的血液成分进行非侵入性评估 的血液成分用于表现出血液光学特性的一个或多个区域。

    Method and apparatus for spectral modulation compensation
    4.
    发明申请
    Method and apparatus for spectral modulation compensation 有权
    光谱调制补偿的方法和装置

    公开(公告)号：US20060001867A1

    公开(公告)日：2006-01-05

    申请号：US10879632

    申请日：2004-06-30

    申请人： John Maier ,  Jason Neiss ,  Shona Stewart ,  Matthew Nelson ,  Joseph Demuth ,  Patrick Treado

    发明人： John Maier ,  Jason Neiss ,  Shona Stewart ,  Matthew Nelson ,  Joseph Demuth ,  Patrick Treado

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/65 ,  G01J3/0297 ,  G01J3/44 ,  G01N2021/656

    摘要： The embodiments disclosed herein generally relate to identifying and removing background noise in spectroscopic imaging of a sample. Because white-light has essentially constant intensity at every wavelength, background noise caused by white light can be identified and removed from spectroscopic measurements including Raman spectroscopy. Thus, once the Raman spectrum for a sample is obtained, it may be corrected to remove the white-light dispersive spectrum in accordance with the embodiments disclosed herein.

    摘要翻译： 本文公开的实施例通常涉及在样本的光谱成像中识别和去除背景噪声。 因为白光在每个波长处具有基本恒定的强度，所以可以从包括拉曼光谱的光谱测量中识别和去除由白光引起的背景噪声。 因此，一旦获得样品的拉曼光谱，就可以根据本文公开的实施方案来校正其去除白光色散谱。

    Method and applications to enhance and image optical signals from biological objects
    5.
    发明申请
    Method and applications to enhance and image optical signals from biological objects 审中-公开
    从生物对象增强和成像光信号的方法和应用

    公开(公告)号：US20060250613A1

    公开(公告)日：2006-11-09

    申请号：US11404964

    申请日：2006-04-14

    申请人： Joseph Demuth ,  Patrick Treado ,  John Maier ,  David Tuschel

    发明人： Joseph Demuth ,  Patrick Treado ,  John Maier ,  David Tuschel

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01J3/44 ,  G01J3/32 ,  G01N21/658

    摘要： A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. The surface includes a two dimensional area of at least 5×105 nm. The enhancing structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited on the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.

    摘要翻译： 一种用于成像生物体的方法和装置。 提供了具有均匀分布在表面上的增强结构的SERS表面。 该表面包括至少5×10 5 nm的二维区域。 增强结构可以在100nm至1000nm范围内的高度，宽度和长度的至少一个尺寸中具有尺寸。 生物材料沉积在SERS表面上。 使用产生拉曼散射光子的单色光源照射SERS表面上的生物材料。 使用可调滤波器将拉曼散射光子滤波成多个预定波长带。 二维阵列检测器以空间准确的方式检测经过滤波的拉曼散射光子。 滤波和检测步骤的结果被组合以产生生物材料的多个光谱分辨的拉曼图像。

    Digitizing biology
    7.
    发明申请
    Digitizing biology 审中-公开
    数字化生物学

    公开(公告)号：US20060253261A1

    公开(公告)日：2006-11-09

    申请号：US11484040

    申请日：2006-07-11

    申请人： John Maier ,  Patrick Treado ,  Jeffrey Cohen ,  Jason Neiss

    发明人： John Maier ,  Patrick Treado ,  Jeffrey Cohen ,  Jason Neiss

    IPC分类号： G06F19/00 ,  A61B5/00

    CPC分类号： G01N21/65

    摘要： A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.

    摘要翻译： 用于确定疾病进展的方法和装置。 确定矢量空间，其中矢量空间以多个时间间隔数学地描述波长分辨数据的参考集合。 用光照射含有至少一个电池的样品。 收集目标数据，其中目标数据对应于由样本发射或散射的光中的至少一种，并且包括多个空间上精确的波长分辨的光测量。 每个空间精确的波长分辨光测量，将目标数据转换成预定向量空间。 在多个预定向量空间中分析变换点的分布。 根据分析，对样本的疾病状况进行分类。

    System and method for cytological analysis by raman spectroscopic imaging
    8.
    发明申请
    System and method for cytological analysis by raman spectroscopic imaging 审中-公开
    通过拉曼光谱成像进行细胞学分析的系统和方法

    公开(公告)号：US20070178067A1

    公开(公告)日：2007-08-02

    申请号：US11598248

    申请日：2006-11-09

    申请人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Lindy McClelland ,  Shona Stewart

    发明人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Lindy McClelland ,  Shona Stewart

    IPC分类号： A61K48/00 ,  C12Q1/00 ,  G06F19/00

    CPC分类号： G01N33/5005 ,  G01N15/1459 ,  G01N21/65 ,  G01N33/574 ,  G01N33/57407 ,  G01N2021/656

    摘要： A method and system of differentially manipulating cells where the cells, suspended in a fluid, are irradiated with substantially monochromatic light. A Raman data set is obtained from the irradiated cells and where the data set is characteristic of a disease status. The data set is assessed to identify diseased cells. A Raman chemical image of the irradiated cells is also obtained. Based on the assessment and the Raman chemical image, the fluid in which the cells are suspended is differentially manipulated. The diseased cells are directed to a first location and other non-diseased cells are directed to a second location as part of the differential manipulation. The diseased cells may be treated with a physical stress, a chemical stress, and a biological stress and then returned to a patient from whom the diseased cells were obtained prior to the irradiation.

    摘要翻译： 一种差异操纵细胞的方法和系统，其中悬浮在流体中的细胞用基本上单色的光照射。 从照射的细胞获得拉曼数据集，其中数据集是疾病状态的特征。 评估数据集以鉴定患病细胞。 还获得了照射的细胞的拉曼化学图像。 基于评估和拉曼化学图像，细胞悬浮的流体被差异地操纵。 病变细胞被引导到第一位置，并且其他非病变细胞被引导到第二位置作为差异操纵的一部分。 患病细胞可以用物理应力，化学应力和生物应激治疗，然后返回到在照射之前从其获得患病细胞的患者。

    Cytological analysis by raman spectroscopic imaging
    9.
    发明申请
    Cytological analysis by raman spectroscopic imaging 有权
    通过拉曼光谱成像进行细胞学分析

    公开(公告)号：US20050277816A1

    公开(公告)日：2005-12-15

    申请号：US11000591

    申请日：2004-11-30

    申请人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Shona Stewart ,  Lindy McClelland

    发明人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Shona Stewart ,  Lindy McClelland

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B5/4519 ,  G01N21/65

    摘要： Raman molecular imaging is used to differentiate between normal and diseased cells or tissue. For instance benign and malignant lesions of bladder and other tissues can be distinguished, including epithelial tissues such as lung, prostate, kidney, breast, and colon, and non-epithelial tissues, such as bone marrow and brain. Raman scattering data relevant to the disease state of cells or tissue can be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view.

    摘要翻译： 拉曼分子成像用于区分正常和病变细胞或组织。 例如，可以区分膀胱和其他组织的良性和恶性病变，包括上皮组织如肺，前列腺，肾脏，乳腺和结肠，以及非上皮组织，如骨髓和脑。 可以将与细胞或组织的疾病状态相关的拉曼散射数据与视觉图像数据组合，以产生描绘细胞结构的放大视图和与视野中的各个细胞的疾病状态有关的信息的混合图像。

    Cytological analysis by raman spectroscopic imaging
    10.
    发明授权
    Cytological analysis by raman spectroscopic imaging 有权
    通过拉曼光谱成像进行细胞学分析

    公开(公告)号：US08553732B2

    公开(公告)日：2013-10-08

    申请号：US12755463

    申请日：2010-06-23

    申请人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Shona Stewart ,  Lindy McClelland

    发明人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Shona Stewart ,  Lindy McClelland

    IPC分类号： H01S3/00

    CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B5/4519 ,  G01N21/65

    摘要： A method for generating an image of a sample that is informative of the disease state of a cell in the sample. A sample including the cell is irradiated with monochromatic light. The Raman scattered light is assessed. A digital brightfield image of the Raman scattered light is generated and combined with the Raman scattered light emitted by the cell whereby the Raman scattered light is informative of the disease state of the cell in the sample. The method can also be used to determine the metabolic activity of the cell, the inflammatory status of the cell and/or the infected status of the cell in the sample.

    摘要翻译： 一种产生样品图像的方法，其用于提供样品中细胞的疾病状态。 用单色光照射包含电池的样品。 评估拉曼散射光。 产生拉曼散射光的数字明场图像，并与细胞发射的拉曼散射光组合，由此拉曼散射光提供样品中细胞的疾病状态。 该方法还可以用于确定细胞的代谢活性，细胞的炎性状态和/或样品中细胞的感染状态。