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公开(公告)号：US5497772A
公开(公告)日：1996-03-12
申请号：US155737
申请日：1993-11-19
申请人： Joseph H. Schulman , Orville R. Rule, III , David I. Whitmoyer , Ronald J. Lebel , Joseph Y. Lucisano , Alfred E. Mann
发明人： Joseph H. Schulman , Orville R. Rule, III , David I. Whitmoyer , Ronald J. Lebel , Joseph Y. Lucisano , Alfred E. Mann
CPC分类号： A61B5/14865 , A61B5/1495 , A61B5/6849 , A61B2562/08 , A61B5/742
摘要： A glucose monitoring system continuously measures the glucose concentration in a patient's blood, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset limits. If not, an audible and/or visual alarm signal is generated. The glucose monitoring system includes a glucose sensor adapted to be inserted into the venous system of the patient, where it responds to blood glucose and produces sensor signals related to the glucose concentration. The sensor signals are delivered through a suitable interconnect cable to a glucose monitor. In one embodiment, the interconnect cable includes a contactless connector that electrically isolates the glucose sensor from the monitor, and reduces the number of conductors required to interface with a plurality of sensors. The glucose monitor interprets the sensor signals by applying a previously determined calibration to quantitatively determine the blood glucose value. The blood glucose value thus determined is then processed in order to determine the rate of change, is stored (to create a history or record), and may also be displayed in large, easy-to-read numerals. Rate of change information (trend) may also be numerically or graphically displayed.
摘要翻译： 葡萄糖监测系统连续测量患者血液中的葡萄糖浓度，提供这种浓度变化率的指示，并确定测量的浓度和变化率是否在某些预设限度内。 如果没有，则产生声音和/或视觉报警信号。 葡萄糖监测系统包括适于插入患者静脉系统中的葡萄糖传感器，其响应于血糖并产生与葡萄糖浓度相关的传感器信号。 传感器信号通过合适的互连电缆传送到葡萄糖监测器。 在一个实施例中，互连电缆包括非接触式连接器，其将葡萄糖传感器与监视器电隔离，并且减少与多个传感器接合所需的导体的数量。 葡萄糖监测器通过应用预先确定的校准来定量地确定血糖值来解释传感器信号。 然后处理如此确定的血糖值以确定变化率，存储（创建历史或记录），并且还可以以大的易于阅读的数字显示。 变化率信息（趋势）也可以数字或图形显示。
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公开(公告)号：US5660163A
公开(公告)日：1997-08-26
申请号：US444300
申请日：1995-05-18
申请人： Joseph H. Schulman , Orville Rey Rule, III , David I. Whitmoyer , Ronald J. Lebel , Joseph Y. Lucisano , Alfred E. Mann
发明人： Joseph H. Schulman , Orville Rey Rule, III , David I. Whitmoyer , Ronald J. Lebel , Joseph Y. Lucisano , Alfred E. Mann
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/1495 , A61B5/6849 , A61B2562/08 , A61B5/742
摘要： A glucose monitoring system continuously measures the glucose concentration in a patient's blood, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset limits. If not, an audible and/or visual alarm signal is generated. The glucose monitoring system includes a glucose sensor adapted to be inserted into the venous system of the patient, where it responds to blood glucose and produces sensor signals related to the glucose concentration. The sensor signals are delivered through a suitable interconnect cable to a glucose monitor. In one embodiment, the interconnect cable includes a contactless connector that electrically isolates the glucose sensor from the monitor, and reduces the number of conductors required to interface with a plurality of sensors. The glucose monitor interprets the sensor signals by applying a previously determined calibration to quantitatively determine the blood glucose value. The blood glucose value thus determined is then processed in order to determine the rate of change, is stored (to create a history or record), and may also be displayed in large, easy-to-read numerals. Rate of change information (trend) may also be numerically or graphically displayed.
摘要翻译： 葡萄糖监测系统连续测量患者血液中的葡萄糖浓度，提供这种浓度变化率的指示，并确定测量的浓度和变化率是否在某些预设限度内。 如果没有，则产生声音和/或视觉报警信号。 葡萄糖监测系统包括适于插入患者静脉系统中的葡萄糖传感器，其响应于血糖并产生与葡萄糖浓度相关的传感器信号。 传感器信号通过合适的互连电缆传送到葡萄糖监测器。 在一个实施例中，互连电缆包括非接触式连接器，其将葡萄糖传感器与监视器电隔离，并且减少与多个传感器接合所需的导体的数量。 葡萄糖监测器通过应用预先确定的校准来定量地确定血糖值来解释传感器信号。 然后处理如此确定的血糖值以确定变化率，存储（创建历史或记录），并且还可以以大的易于阅读的数字显示。 变化率信息（趋势）也可以数字或图形显示。
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公开(公告)号：US5791344A
公开(公告)日：1998-08-11
申请号：US582756
申请日：1996-01-04
申请人： Joseph H. Schulman , Ronald J. Lebel , Joseph Y. Lucisano , Alfred E. Mann , Orville Rey Rule, III , David I. Whitmoyer
发明人： Joseph H. Schulman , Ronald J. Lebel , Joseph Y. Lucisano , Alfred E. Mann , Orville Rey Rule, III , David I. Whitmoyer
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14865 , A61B5/6849 , A61B2562/08 , A61B5/742
摘要： A patient monitoring system measures the concentration of a particular substance in a patient's tissue, blood, or other bodily fluids, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset limits. If not, an audible and/or visual alarm signal is generated. The patient monitoring system includes at least one enzymatic sensor adapted to be inserted into the patient, where it produces sensor signals related to the concentration of the substance being measured. The sensor signals are delivered through a suitable interconnect cable to a monitor. In one embodiment, the interconnect cable includes a contactless connector that electrically isolates the enzymatic sensor from the monitor, and reduces the number of conductors required to interface with a plurality of sensors. The monitor interprets the sensor signals by applying a previously determined calibration to quantitatively determine the substance concentration value. The substance concentration value thus determined is then processed in order to determine the rate of change, is stored (to create a history or record), and may also be displayed in large, easy-to-read numerals. Rate of change information (trend) may also be numerically or graphically displayed.
摘要翻译： 患者监测系统测量患者组织，血液或其他体液中特定物质的浓度，提供这种浓度变化率的指示，并确定测量的浓度和变化率是否在某些预设限度内 。 如果没有，则产生声音和/或视觉报警信号。 患者监测系统包括适于插入到患者体内的至少一个酶传感器，其中它产生与所测量物质的浓度相关的传感器信号。 传感器信号通过合适的互连电缆传输到监视器。 在一个实施例中，互连电缆包括非接触式连接器，其将酶传感器与监视器电隔离，并且减少与多个传感器接合所需的导体的数量。 监视器通过应用先前确定的校准来定量地确定物质浓度值来解释传感器信号。 然后处理如此确定的物质浓度值以确定变化率，存储（以创建历史或记录），并且还可以以大的易于阅读的数字显示。 变化率信息（趋势）也可以数字或图形显示。
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4.发明授权Implantable stimulator that prevents DC current flow without the use of discrete output coupling capacitors 失效可植入式刺激器，可防止直流电流流动而不使用离散输出耦合电容
公开(公告)号：US06035237A
公开(公告)日：2000-03-07
申请号：US447455
申请日：1995-05-23
CPC分类号： A61N1/36142 , A61N1/36125
摘要： An implantable living tissue stimulator avoids the use of conventional coupling capacitors in its output stage, yet still prevents an average dc current flow from flowing through living tissue in electrical contact with the stimulator. The output stage generates and applies a biphasic stimulating current pulse to selected paired output terminals. The terminals, in turn, are electrically connected to respective electrodes which are positioned so as to contact the living tissue to be stimulated. In one embodiment, special circuitry is employed within the output stage to block dc current flow through the living tissue and to balance the electrical charge that is delivered to the living tissue. In another embodiment, the electrodes themselves are made from a material that allows them to function as a capacitor. In yet an additional embodiment, the coupling capacitors are integrated into the leads that connect the output terminals of the output stage with the electrodes.
摘要翻译： 植入式生物组织刺激器避免了在其输出阶段使用传统的耦合电容器，但仍然阻止平均直流电流流过活组织与刺激器电接触。 输出级产生并将双相刺激电流脉冲施加到选定的配对输出端子。 这些端子又电连接到相应的电极，这些电极定位成接触待刺激的生物体组织。 在一个实施例中，在输出级内采用特殊电路来阻止直流电流流过活组织并平衡输送到生物体组织的电荷。 在另一个实施例中，电极本身由允许它们用作电容器的材料制成。 在又一个实施例中，耦合电容器集成到将输出级的输出端与电极连接的引线中。
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公开(公告)号：US5531679A
公开(公告)日：1996-07-02
申请号：US212226
申请日：1994-03-14
CPC分类号： A61M25/003 , A61M25/0068 , A61M25/0082 , A61N1/0568 , A61M2025/004 , A61M25/007 , A61M25/0075 , Y10S128/12
摘要： A fluidic infusion system introduces a select liquid chemical into the environment surrounding the functional end of an in vivo catheter or probe. The catheter/probe typically has a-sensor or electrode positioned near or at its closed distal end. A plurality of spaced radial openings are formed in an appropriate pattern adjacent to the end of the catheter/probe for introducing the select liquid chemical into the appropriate environment. The catheter/probe has at least one lumen extending through its length for directing the liquid chemical from a controlled pump to the radial openings. The openings are positioned within the catheter/probe so that when the catheter/probe is inserted into the appropriate environment, e.g., within a blood stream inside an artery or vein, the openings are upstream from the sensor or electrode relative to the flow of blood within such environment, thereby allowing the natural flow of blood to carry the liquid chemical from the radial openings to the sensor or probe area, where it can perform its intended function. The openings allow fluid flow therethrough only in one direction--from the lumen to the environment surrounding the catheter/probe. The catheter/probe may include a plurality of lumens for transporting differing liquid chemicals to the concerned environment.
摘要翻译： 流体输注系统将选择的液体化学品引入围绕体内导管或探针的功能端的环境中。 导管/探针通常具有位于其封闭远端附近或位于其封闭远端的传感器或电极。 多个间隔开的径向开口形成为与导管/探针的端部相邻的适当图案，用于将选择的液体化学品引入适当的环境中。 导管/探针具有延伸穿过其长度的至少一个腔，用于将液体化学物质从受控泵引导到径向开口。 开口定位在导管/探针内，使得当导管/探针插入适当的环境中时，例如在动脉或静脉内的血液内，开口在传感器或电极的上游相对于血流 在这种环境中，从而允许血液的自然流动将液体化学品从径向开口运送到传感器或探针区域，在那里它可以执行其预期的功能。 这些开口允许流体仅从一个方向 - 从内腔到围绕导管/探针的环境流动。 导管/探针可以包括用于将不同液体化学物质输送到相关环境的多个内腔。
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6.发明授权Alumina insulation for coating implantable components and other microminiature devices 有权用于涂层可植入组件和其他微型设备的氧化铝绝缘公开(公告)号：US06844023B2
公开(公告)日：2005-01-18
申请号：US10251633
申请日：2002-09-20
IPC分类号： A61L2/00 , A61N1/02 , B05D3/00 , B32B9/00 , C23C14/00 , C23C14/04 , G03F1/00 , G03F7/20 , H01L21/308 , H01L23/29 , H05K3/28
CPC分类号： G03F7/70641 , A61N1/02 , A61N1/375 , C23C14/042 , H01L21/308 , H01L23/291 , H01L2924/0002 , H05K3/284 , Y10T29/49144 , Y10T428/24802 , Y10T428/24917 , Y10T428/24926 , Y10T428/265 , H01L2924/00
摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zirconia or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.
摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括厚度小于25微米，例如5-10微米厚的氧化铝，氧化锆或其它陶瓷的薄层或多层。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳×25密耳面积的面积上表现出小于10pA的漏电流，同时在高达80℃的温度下浸入盐水溶液中 一个三个月的时间。
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7.发明授权Alumina insulation for coating implantable components and other microminiature devices 失效用于涂层可植入组件和其他微型设备的氧化铝绝缘
公开(公告)号：US6043437A
公开(公告)日：2000-03-28
申请号：US994515
申请日：1997-12-19
IPC分类号： A61L2/00 , A61N1/02 , B05D3/00 , B32B9/00 , C23C14/00 , C23C14/04 , G03F1/00 , G03F7/20 , H01L21/308 , H01L23/29 , H05K3/28 , H05K1/03
CPC分类号： G03F7/70641 , C23C14/042 , H01L21/308 , H01L23/291 , H05K3/284 , A61N1/02 , A61N1/375 , H01L2924/0002 , Y10T29/49144 , Y10T428/24802 , Y10T428/24917 , Y10T428/24926 , Y10T428/265
摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material includes a thin layer or layers of alumina, zirconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils while soaking in a saline solution at temperatures up to 80.degree. C. over a three month period.
摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括小于25微米厚，例如5-10微米厚的氧化铝，氧化锆或其它陶瓷的薄层或多层。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳×25密耳的区域上表现出低于10pA的漏电流，同时在温度高达80℃的盐水溶液中浸泡 三个月的时间。
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8.发明授权Alumina insulation for coating implantable components and other microminiature devices 有权用于涂层可植入组件和其他微型设备的氧化铝绝缘公开(公告)号：US07235350B2
公开(公告)日：2007-06-26
申请号：US10969758
申请日：2004-10-20
CPC分类号： G03F7/70641 , A61N1/02 , A61N1/375 , C23C14/042 , H01L21/308 , H01L23/291 , H01L2924/0002 , H05K3/284 , Y10T29/49144 , Y10T428/24802 , Y10T428/24917 , Y10T428/24926 , Y10T428/265 , H01L2924/00
摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zirconia or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at a relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.
摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括厚度小于25微米，例如5-10微米厚的氧化铝，氧化锆或其它陶瓷的薄层或多层。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳25密耳面积的面积上表现出低于10pA的漏电流，同时在高达80℃的温度下浸入盐水溶液中 一个三个月的时间。
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9.发明授权Alumina insulation for coating implantable components and other microminiature devices 有权用于涂层可植入组件和其他微型设备的氧化铝绝缘公开(公告)号：US07160672B2
公开(公告)日：2007-01-09
申请号：US11150547
申请日：2005-06-10
CPC分类号： G03F7/70641 , A61N1/02 , A61N1/375 , C23C14/042 , H01L21/308 , H01L23/291 , H01L2924/0002 , H05K3/284 , Y10T29/49144 , Y10T428/24802 , Y10T428/24917 , Y10T428/24926 , Y10T428/265 , H01L2924/00
摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5–10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.
摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括薄层或多层氧化铝，稀土或其它小于25微米厚，例如5-10微米厚的陶瓷。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳25密耳面积的面积上表现出低于10pA的漏电流，同时在高达80℃的温度下浸入盐水溶液中 一个三个月的时间。
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10.发明授权公开(公告)号：US06472122B1
公开(公告)日：2002-10-29
申请号：US09393438
申请日：1999-09-09
IPC分类号： G03F716
CPC分类号： G03F7/70641 , A61N1/02 , A61N1/375 , C23C14/042 , H01L21/308 , H01L23/291 , H01L2924/0002 , H05K3/284 , Y10T29/49144 , Y10T428/24802 , Y10T428/24917 , Y10T428/24926 , Y10T428/265 , H01L2924/00
摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.
摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括薄层或多层氧化铝，稀土或其它小于25微米厚，例如5-10微米厚的陶瓷。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳25密耳面积的面积上表现出低于10pA的泄漏电流，同时在高达80℃的温度下浸入盐水溶液中 一个三个月的时间。
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