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公开(公告)号：US20130282136A1
公开(公告)日：2013-10-24
申请号：US13922787
申请日：2013-06-20
申请人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
发明人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
IPC分类号： A61L27/54
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2310/00359 , A61F2310/00976 , A61L27/3608 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： A method of preparing a preformed bone shape for implantation provides irradiating at least a portion of a preformed bone shape by a Neutral Beam derived from a GCIB, and the preformed bone shape so irradiated.
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公开(公告)号：US09808344B2
公开(公告)日：2017-11-07
申请号：US14833402
申请日：2015-08-24
申请人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
发明人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2310/00359 , A61F2310/00976 , A61L27/3608 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： A method of preparing a preformed bone shape for implantation provides irradiating at least a portion of a preformed bone shape by a Neutral Beam derived from a GCIB, and the preformed bone shape so irradiated.
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3.发明申请公开(公告)号：US20150359636A1
公开(公告)日：2015-12-17
申请号：US14833402
申请日：2015-08-24
申请人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
发明人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2310/00359 , A61F2310/00976 , A61L27/3608 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： A method of preparing a preformed bone shape for implantation provides irradiating at least a portion of a preformed bone shape by a Neutral Beam derived from a GCIB, and the preformed bone shape so irradiated.
摘要翻译： 制备用于植入的预成型骨形状的方法通过由GCIB得到的中性束和照射预先形成的骨形状，照射预先形成的骨形状的至少一部分。
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4.发明授权公开(公告)号：US09114195B2
公开(公告)日：2015-08-25
申请号：US13922787
申请日：2013-06-20
申请人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
发明人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2310/00359 , A61F2310/00976 , A61L27/3608 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： A method of preparing a preformed bone shape for implantation provides irradiating at least a portion of a preformed bone shape by a Neutral Beam derived from a GCIB, and the preformed bone shape so irradiated.
摘要翻译： 制备用于植入的预成型骨形状的方法通过由GCIB得到的中性束和照射预先形成的骨形状，照射预先形成的骨形状的至少一部分。
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5.发明申请METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY 有权改善表面表面和物体的生物活性特征的方法改进的表面公开(公告)号：US20140315271A1
公开(公告)日：2014-10-23
申请号：US14238774
申请日：2012-08-22
IPC分类号： C12N13/00
CPC分类号： A61L27/38 , A61L27/06 , A61L27/16 , A61L27/18 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N13/00 , C08L27/18
摘要： A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam.
摘要翻译： 包括二氧化钛，钛，钛合金和/或聚四氟乙烯（PTFE）的可植入物体的表面的生物活性的改善方法和由此制备的可植入物体形成加速的中性束，其由加速的气体 - 团簇离子束 （GCIB）在减压室中，将可植入物体引入减压室中，以及用GCIB衍生的中性光束照射所述可植入物体的表面的至少第一部分。
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6.发明申请METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY 有权改善表面表面和物体的生物活性特征的方法改进的表面公开(公告)号：US20160228609A1
公开(公告)日：2016-08-11
申请号：US15130354
申请日：2016-04-15
CPC分类号： A61L27/38 , A61L27/06 , A61L27/16 , A61L27/18 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N13/00 , C08L27/18
摘要： A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam.
摘要翻译： 包括二氧化钛，钛，钛合金和/或聚四氟乙烯（PTFE）的可植入物体的表面的生物活性的改善方法和由此制备的可植入物体形成加速的中性束，其由加速的气体 - 团簇离子束 （GCIB）在减压室中，将可植入物体引入减压室中，以及用GCIB衍生的中性光束照射所述可植入物体的表面的至少第一部分。
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7.发明授权公开(公告)号：US09315798B2
公开(公告)日：2016-04-19
申请号：US14238774
申请日：2012-08-22
IPC分类号： A61F2/02 , H01J37/317 , H01J37/05 , A61L27/14 , C12N13/00 , A61L27/06 , A61L27/16 , A61L27/38 , A61L27/50
CPC分类号： A61L27/38 , A61L27/06 , A61L27/16 , A61L27/18 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N13/00 , C08L27/18
摘要： A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam.
摘要翻译： 包括二氧化钛，钛，钛合金和/或聚四氟乙烯（PTFE）的可植入物体的表面的生物活性的改善方法和由此制备的可植入物体形成加速的中性束，其由加速的气体 - 团簇离子束 （GCIB）在减压室中，将可植入物体引入减压室中，以及用GCIB衍生的中性光束照射所述可植入物体的表面的至少第一部分。
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8.发明申请METHOD FOR MODIFYING BIOCOMPATIBILITY CHARACTERISTICS OF A SURFACE OF A BIOLOGICAL MATERIAL WITH GAS CLUSTER ION BEAM 审中-公开生物材料与气体离子束表面生物化学特性的改进方法公开(公告)号：US20140236295A1
公开(公告)日：2014-08-21
申请号：US14238752
申请日：2012-08-21
CPC分类号： H05H3/00 , A61F2/0077 , A61F2/08 , A61F2/28 , A61F2250/0056 , C12N5/0068 , H05H3/02
摘要： A method for preparing a biological material for implanting provides irradiating at least a portion of the surface of the material with an accelerated Neutral Beam.
摘要翻译： 用于制备用于植入的生物材料的方法提供用加速的中性束照射材料的表面的至少一部分。
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9.发明授权Method for modifying the wettability and/or other biocompatibility characteristics of a surface of a biological material by the application of gas cluster ion beam technology and biological materials made thereby 有权通过应用气体簇离子束技术和由此制备的生物材料来改变生物材料表面的润湿性和/或其它生物相容性特征的方法公开(公告)号：US08367092B2
公开(公告)日：2013-02-05
申请号：US12722126
申请日：2010-03-11
IPC分类号： A61K25/12
CPC分类号： A61F2/30771 , A61B2017/00969 , A61F2/0077 , A61F2/08 , A61F2/30767 , A61F2/4644 , A61L27/3604 , A61L27/3691 , A61L27/38 , A61L2430/10 , A61L2430/40 , H01J2237/0812 , H01J2237/20207 , H01J2237/20214
摘要： The invention provides methods for surgical grafting of a tissue. The method comprises the steps of explanting a graft tissue from a donor, irradiating at least a first portion of the graft tissue with an ion beam, and surgically grafting the graft tissue into a recipient.
摘要翻译： 本发明提供了用于组织外科移植的方法。 该方法包括以下步骤：从供体移出移植物组织，用离子束照射移植组织的至少第一部分，以及将移植物组织手术移植到受体中。
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10.发明申请METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY 审中-公开改善表面表面和物体的生物活性特征的方法改进的表面公开(公告)号：US20140336125A1
公开(公告)日：2014-11-13
申请号：US14368972
申请日：2012-12-18
申请人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Kshama J. Doshi
发明人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Kshama J. Doshi
摘要： A method for improving bioactivity and/or biodegradation time of a collagen surgical implant and collagen surgical implants having such improved properties. A gas-cluster ion-beam (GCIB) is formed in a reduced-pressure chamber, a collagen surgical implant is introduced into the reduced-pressure chamber, and at least a first portion of the surface of said collagen surgical implant is irradiated with a GCIB-derived beam.
摘要翻译： 一种用于改善具有这种改善的性质的胶原手术植入物和胶原外科植入物的生物活性和/或生物降解时间的方法。 在减压室中形成气体簇离子束（GCIB），将胶原外科植入物引入减压室中，并且将所述胶原外科植入物的表面的至少第一部分用 GCIB衍生光束。
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