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公开(公告)号：US20070135431A1
公开(公告)日：2007-06-14
申请号：US11608726
申请日：2006-12-08
申请人： Nicholas Smith , Celine Bonnefous , Joseph Payne , Timothy Hoffman , Paul Wash , Christian Hassig , Shawn Scranton
发明人： Nicholas Smith , Celine Bonnefous , Joseph Payne , Timothy Hoffman , Paul Wash , Christian Hassig , Shawn Scranton
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4439 , C07D413/14 , C07D401/14
CPC分类号： C07D401/12 , C07C327/30 , C07D211/46 , C07D213/30 , C07D213/38 , C07D213/76 , C07D295/096 , C07D295/26 , C07D413/12
摘要： Disclosed herein are carbonyl compounds of having the structural formula: or a salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译： 本文公开了具有以下结构式的羰基化合物：或其盐，酯或前药。公开了用于治疗疾病状态的方法和组合物，包括但不限于癌症，自身免疫疾病，组织损伤，中枢神经系统疾病，神经变性 使用本发明的化合物，疾病，纤维化，骨病，聚谷氨酰胺重复病症，贫血，地热病，炎性病症，心血管病症和血管发生在发病机理中发挥作用的病症。 此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。
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2.发明申请Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease 审中-公开多环磺酰胺化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病公开(公告)号：US20070027184A1
公开(公告)日：2007-02-01
申请号：US11496784
申请日：2006-07-27
申请人： James Malecha , Stewart Noble , Brandon Wiley , Timothy Hoffman , Celine Bonnefous , Michael Sertic , Paul Wash , Nicholas Smith , Christian Hassig , Shawn Scranton , Joseph Payne , Jeffery Hager
发明人： James Malecha , Stewart Noble , Brandon Wiley , Timothy Hoffman , Celine Bonnefous , Michael Sertic , Paul Wash , Nicholas Smith , Christian Hassig , Shawn Scranton , Joseph Payne , Jeffery Hager
IPC分类号： A61K31/47 , C07D215/12 , C07D319/14 , A61K31/36
CPC分类号： C07D405/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12
摘要： Disclosed herein are sulfonamide compounds of Formula VII as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译： 本文公开的是本文所述的式VII的磺酰胺化合物。 公开了用于治疗疾病状态的方法和组合，包括但不限于癌症，自身免疫性疾病，组织损伤，中枢神经系统疾病，神经变性疾病，纤维化，骨病，聚谷氨酰胺 - 重复病症，贫血，地中海贫血，炎性病症，心血管疾病 以及使用本发明化合物的血管发生在发病机理中起作用的病症。 此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。
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公开(公告)号：US20070135438A1
公开(公告)日：2007-06-14
申请号：US11608736
申请日：2006-12-08
申请人： Joseph Payne , Nicholas Smith , Shawn Scranton , Christian Hassig
发明人： Joseph Payne , Nicholas Smith , Shawn Scranton , Christian Hassig
IPC分类号： A61K31/53 , A61K31/4965 , C07D253/08 , A61K31/505
CPC分类号： C07D213/76 , C07D405/12
摘要： Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译： 本文公开了具有以下结构式的羰基化合物：或其药学上可接受的盐，酯或前药。公开了用于治疗疾病状态的方法和组合物，包括但不限于癌症，自身免疫疾病，组织损伤，中枢神经系统疾病 使用本发明的化合物，神经变性疾病，纤维化，骨病，聚谷氨酰胺重复病症，贫血，地热病，炎性病症，心血管病症和血管生成在发病机理中发挥作用的病症。 此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。
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4.发明申请公开(公告)号：US20080194681A1
公开(公告)日：2008-08-14
申请号：US11792624
申请日：2005-12-09
申请人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman , Celine Bonnefous , NIcholas Smith
发明人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman , Celine Bonnefous , NIcholas Smith
IPC分类号： A61K31/265 , C07C327/32 , A61P9/00 , A61P7/06 , A61P35/00 , A61P35/04
CPC分类号： C07D213/74 , C07C327/22 , C07C327/28 , C07C327/30 , C07C327/32 , C07D213/32 , C07D213/70 , C07D215/36 , C07D215/38 , C07D231/38 , C07D241/44 , C07D295/192 , C07D295/26 , C07D319/18
摘要： Disclosed herein are carbonyl compounds of Formula: (I) as described herein. Compounds as modulators of his-tone deacetylase (HDAC), pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 本文公开的是如本文所述的式（I）的羰基化合物。 公开了作为其脱色酶脱乙酰酶（HDAC）调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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5.发明授权Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease 失效羰基化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病公开(公告)号：US07271195B2
公开(公告)日：2007-09-18
申请号：US10865743
申请日：2004-06-10
IPC分类号： A61K31/18 , C07C303/00
CPC分类号： C07D295/112 , C07C323/49 , C07C323/67 , C07C327/30 , C07D277/16 , C07D277/36 , C07D319/18 , C07D417/12
摘要： Disclosed herein are carbonyl compounds of Formula I, II, or III, and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, autoimmune diseases and cardiovascular conditions, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译： 本文公开的是式I，II或III的羰基化合物和本文所述的其它。 还公开了使用本发明的化合物治疗诸如癌症的疾病，包括多聚谷氨酰胺重复病症，贫血，地贫，炎性病症，自身免疫性疾病和心血管疾病的疾病的方法。 此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。
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公开(公告)号：US20070093413A1
公开(公告)日：2007-04-26
申请号：US10919217
申请日：2004-08-16
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
摘要翻译： 本发明涉及由一系列基因（称为HDx相关基因）编码的蛋白质的发现，其涉及染色质结构的控制，因此涉及转录和翻译。 本发明提供可用于例如在体外和体内控制细胞增殖和分化的组合物和方法。
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7.发明申请Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease 失效新型磺酰胺作为组蛋白脱乙酰酶的抑制剂用于治疗疾病公开(公告)号：US20060030554A1
公开(公告)日：2006-02-09
申请号：US11150783
申请日：2005-06-09
申请人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman
发明人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman
IPC分类号： A61K31/675 , A61K31/55 , A61K31/21 , C07C237/30
CPC分类号： C07C323/49 , C07C323/67 , C07C327/30 , C07D277/16 , C07D277/36 , C07D295/112 , C07D319/18 , C07D417/12
摘要： Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译： 本文公开了具有以下结构式的羰基化合物：或其药学上可接受的盐，酰胺，酯或前药。公开了用于治疗疾病状态的方法和组合物，包括但不限于癌症，自身免疫性疾病，组织损伤，中枢神经 使用本发明的化合物，系统疾病，神经变性疾病，纤维化，骨病，聚谷氨酰胺 - 重复病症，贫血，地热病，炎性病症，心血管病症和血管发生在发病机理中起作用的病症。 此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。
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公开(公告)号：US20060116515A1
公开(公告)日：2006-06-01
申请号：US11288888
申请日：2005-11-28
申请人： Timothy Gahman , Hengyuan Lang , Mark Herbert , Angelina Thayer , Christian Hassig , Stewart Noble , Russell Cousins , Hui Zhuang , Christopher Santos , Xiaohong Chen
发明人： Timothy Gahman , Hengyuan Lang , Mark Herbert , Angelina Thayer , Christian Hassig , Stewart Noble , Russell Cousins , Hui Zhuang , Christopher Santos , Xiaohong Chen
IPC分类号： C07D403/14
CPC分类号： C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to compounds and methods useful as inhibitors of nitric oxide synthase. Certain compounds of the subject invention have the following structural formula: wherein T, X, and Y are independently selected from the group consisting of CR4, N, NR4, S, and O; U is selected from the group consisting of CR10 and N; V is selected from the group consisting of CR4 and N; W and W′ are independently selected from the group consisting of CH2, CR7R8, NR9, O, N(O), S(O)q and C(O); n, m and p are independently an integer from 0 to 5; q is 0, 1, or 2; and other substituents are as defined herein. Other compounds of the subject invention have structural formulas as defined herein. Also disclosed herein are pharmaceutical compositions comprising the compounds of the subject invention.
摘要翻译： 本发明涉及可用作一氧化氮合酶抑制剂的化合物和方法。 本发明的某些化合物具有以下结构式：其中T，X和Y独立地选自CR 4，N，NR 4，S ，和O; U选自CR 10和N; V选自CR 4和N; W和W'独立地选自CH 2，CR 7，R 8，NR 9， ，O，N（O），S（O）q和C（O）; n，m和p独立地为0至5的整数; q是0,1或2; 和其它取代基如本文所定义。 本发明的其它化合物具有本文定义的结构式。 本文还公开了包含本发明化合物的药物组合物。
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9.发明申请Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease 失效多环磺酰胺化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病公开(公告)号：US20060030543A1
公开(公告)日：2006-02-09
申请号：US11150500
申请日：2005-06-09
申请人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman
发明人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman
IPC分类号： A61K31/675 , A61K31/55 , A61K31/519 , A61K31/4745 , A61K31/4743 , A61K31/47 , A61K31/404
CPC分类号： C07D221/04 , C07C323/49 , C07C327/30 , C07D209/08 , C07D209/16 , C07D215/36 , C07D217/06 , C07D241/42 , C07D307/82 , C07D317/62 , C07D319/18 , C07D333/54 , C07D333/62 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07F9/1653
摘要： Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译： 本文公开的是本文所述的式I的羰基化合物。 公开了用于治疗疾病状态的方法和组合，包括但不限于癌症，自身免疫性疾病，组织损伤，中枢神经系统疾病，神经变性疾病，纤维化，骨病，聚谷氨酰胺 - 重复病症，贫血，地中海贫血，炎性病症，心血管疾病 以及使用本发明化合物的血管发生在发病机理中起作用的病症。 此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。
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10.发明申请Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease 失效羰基化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病公开(公告)号：US20050026907A1
公开(公告)日：2005-02-03
申请号：US10865743
申请日：2004-06-10
申请人： Paul Wash , Brandon Wiley , Christian Hassig , James Malecha , Stewart Noble
发明人： Paul Wash , Brandon Wiley , Christian Hassig , James Malecha , Stewart Noble
IPC分类号： C07C323/49 , C07C323/67 , C07C327/30 , C07D277/16 , C07D277/36 , C07D295/112 , C07D319/18 , C07D417/12 , A61K31/55 , A61K31/19 , A61K31/401 , A61K31/445
CPC分类号： C07D295/112 , C07C323/49 , C07C323/67 , C07C327/30 , C07D277/16 , C07D277/36 , C07D319/18 , C07D417/12
摘要： Disclosed herein are carbonyl compounds of Formula I, II, or III, and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, autoimmune diseases and cardiovascular conditions, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译： 本文公开的是式I，II或III的羰基化合物和本文所述的其它。 还公开了使用本发明的化合物治疗诸如癌症的疾病，包括多聚谷氨酰胺 - 重复病症，贫血，地贫，炎性病症，自身免疫性疾病和心血管疾病的疾病的方法。 此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。
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