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    Microfluidic electrophoresis chip having flow-retarding structure
    1.
    发明申请
    Microfluidic electrophoresis chip having flow-retarding structure 审中-公开
    具有阻流结构的微流控电泳芯片

    公开(公告)号：US20060042948A1

    公开(公告)日：2006-03-02

    申请号：US10932078

    申请日：2004-09-02

    申请人： Juan Santiago ,  Byoungsok Jung ,  Rajiv Bharadwaj

    发明人： Juan Santiago ,  Byoungsok Jung ,  Rajiv Bharadwaj

    IPC分类号： C07K1/26 ,  G01N27/447

    CPC分类号： G01N27/44791

    摘要： A capillary electrophoresis device and separation protocol uses a hydraulic resistance-providing structure (HRPS) in the main separation channel to separate the divide the main separate channel into an upstream portion and a downstream portion. The HRPS may take the form of a porous plug, or a solid plug provided with at least one shallow channel. A sample separates and migrates through the porous structure or the shallow channel, upon application of a voltage difference between the upstream and downstream sides. Among other things, the HRPS helps reduce electrokinetic flow in the presence of conductivity gradients and facilitates robust, high-gradient on-chip field amplified sample stacking. The HRPS also enables the use of a pressure-injection scheme for the introduction of a high conductivity gradient in a separation channel and thereby avoids flow instabilities associated with high conductivity gradient electrokinetics. The approach also allows for the suppression of electroosmotic flow (EOF) and benefits from the associated minimization of sample dispersion caused by non-uniform EOF mobilities. An injection procedure employing a single pressure-flow high-conductivity buffer injection step followed by standard high voltage control of electrophoretic fluxes of sample, may be employed.

    摘要翻译： 毛细管电泳装置和分离方案在主分离通道中使用液压阻力提供结构（HRPS），以将主分离通道分成上游部分和下游部分。 HRPS可以采用多孔插塞的形式，或者具有至少一个浅沟道的实心插头。 当上游侧和下游侧之间施加电压差时，样品分离并迁移通过多孔结构或浅沟道。 除了别的以外，HRPS有助于在电导率梯度的存在下减少电动流动，并且有助于稳健的高梯度片上场扩增样品堆叠。 HRPS还能够使用压力注入方案来在分离通道中引入高电导率梯度，从而避免与高电导率梯度电动力相关联的流动不稳定性。 该方法还允许抑制电渗流（EOF），并从由非均匀EOF迁移率引起的样品分散的相关最小化中获益。 可以采用使用单一压力 - 流动高电导率缓冲液注入步骤的注射程序，然后进行样品电泳通量的标准高压控制。

    LIQUID AND GEL ELECTRODES FOR TRANSVERSE FREE FLOW ELECTROPHORESIS
    2.
    发明申请
    LIQUID AND GEL ELECTRODES FOR TRANSVERSE FREE FLOW ELECTROPHORESIS 有权
    液体和凝胶电极用于横向自由流动电泳

    公开(公告)号：US20120228141A1

    公开(公告)日：2012-09-13

    申请号：US13413161

    申请日：2012-03-06

    申请人： Byoungsok Jung ,  Klint A. Rose ,  Maxim Shusteff ,  Alexandre Persat ,  Juan Santiago

    发明人： Byoungsok Jung ,  Klint A. Rose ,  Maxim Shusteff ,  Alexandre Persat ,  Juan Santiago

    IPC分类号： C25B9/00 ,  B01D43/00

    CPC分类号： B01D43/00 ,  B01D57/02 ,  G01N27/44769

    摘要： The present invention provides a mechanism for separating or isolating charged particles under the influence of an electric field without metal electrodes being in direct contact with the sample solution. The metal electrodes normally in contact with the sample are replaced with high conductivity fluid electrodes situated parallel and adjacent to the sample. When the fluid electrodes transmit the electric field across the sample, particles within the sample migrate according to their electrophoretic mobility.

    摘要翻译： 本发明提供了一种用于在没有金属电极与样品溶液直接接触的电场的影响下分离或分离带电粒子的机理。 通常与样品接触的金属电极被替换为与样品平行且相邻的高导电性流体电极。 当流体电极跨越样品传播电场时，样品内的颗粒根据其电泳迁移率而迁移。

    Micro-fabricated electrokinetic pump
    5.
    发明授权
    Micro-fabricated electrokinetic pump 有权
    微电动动力泵

    公开(公告)号：US07449122B2

    公开(公告)日：2008-11-11

    申请号：US10968376

    申请日：2004-10-18

    申请人： David Corbin ,  Kenneth Goodson ,  Thomas Kenny ,  Juan Santiago ,  Shulin Zeng

    发明人： David Corbin ,  Kenneth Goodson ,  Thomas Kenny ,  Juan Santiago ,  Shulin Zeng

    IPC分类号： F04B1/00

    CPC分类号： F04B17/00 ,  F04B19/006

    摘要： An electrokinetic pump for pumping a liquid includes a pumping body having a plurality of narrow, short and straight pore apertures for channeling the liquid through the body. A pair of electrodes for applying a voltage differential are formed on opposing surfaces of the pumping body at opposite ends of the pore apertures. The pumping body is formed on a support structure to maintain a mechanical integrity of the pumping body. The pump can be fabricated using conventional semiconductor processing steps. The pores are preferably formed using plasma etching. The structure is oxidized to insulate the structure and also narrow the pores. A support structure is formed by etching a substrate and removing an interface oxide layer. Electrodes are formed to apply a voltage potential across the pumping body. Another method of fabricating an electrokinetic pump includes providing etch stop alignment marks so that the etch step self-terminates.

    摘要翻译： 用于泵送液体的电动泵包括具有多个窄的，短的和直的孔隙的泵送体，用于将液体引导通过身体。 用于施加电压差的一对电极形成在孔隙的相对端处的泵体的相对表面上。 泵体形成在支撑结构上以保持泵体的机械完整性。 泵可以使用常规的半导体处理步骤制造。 优选使用等离子体蚀刻形成孔。 该结构被氧化以使结构绝缘并且还使孔变窄。 通过蚀刻衬底并除去界面氧化物层形成支撑结构。 形成电极以在泵体上施加电压电位。 制造电动泵的另一种方法包括提供蚀刻停止对准标记，使得蚀刻步骤自我终止。

    Heat and water management device and method in fuel cells
    6.
    发明申请
    Heat and water management device and method in fuel cells 有权
    燃料电池中的热水管理装置和方法

    公开(公告)号：US20080032169A1

    公开(公告)日：2008-02-07

    申请号：US11807228

    申请日：2007-05-24

    申请人： Tibor Fabian ,  Shawn Litster ,  Juan Santiago ,  Cullen Bule ,  Jun Sasahara ,  Tadahiro Kubota

    发明人： Tibor Fabian ,  Shawn Litster ,  Juan Santiago ,  Cullen Bule ,  Jun Sasahara ,  Tadahiro Kubota

    IPC分类号： H01M8/00 ,  B29C45/00

    CPC分类号： H01M8/023 ,  H01M8/0245 ,  H01M8/0258 ,  H01M8/0267 ,  H01M8/04074 ,  H01M8/04126 ,  H01M8/04171 ,  H01M8/04291 ,  H01M8/241 ,  Y10T29/49108

    摘要： A method and device for fuel cell heat and water management is provided. A thermally and electrically conductive hydrophilic heat and mass transport element is provided to the fuel cell spanning from inside to outside the cell. The transport element is deposited between current collector and gas diffusion layers, where heat is transported along the transport element from an interior portion of the element inside the cell to an exterior portion of the element outside the cell. Liquid water is transported along the element into or out of the cell, and heat is removed from the exterior portion by any combination of radiation, free convection and forced convection, and where the liquid water is removed from the exterior portion by any combination of convection driven evaporation and advection. The water is added to the cell from the exterior to the interior by any combination of advection and capillary wicking.

    摘要翻译： 提供了一种用于燃料电池热水管理的方法和装置。 向导电池内部和外部的燃料电池提供导热和导电的亲水热传质元件。 传输元件沉积在集流体和气体扩散层之间，其中热量沿着传输元件从电池内的元件的内部传送到电池单元外部的外部部分。 液体水沿着元件进入或离开电池，并且通过辐射，自由对流和强制对流的任何组合从外部部分去除热量，并且其中液体水通过对流的任何组合从外部部分去除 驱动蒸发和平流。 通过对流和毛细管芯吸的任何组合将水从外部添加到细胞中。

    Device and methods of detection of airborne agents
    8.
    发明授权
    Device and methods of detection of airborne agents 有权
    空气传播剂检测装置及方法

    公开(公告)号：US08247238B2

    公开(公告)日：2012-08-21

    申请号：US13217616

    申请日：2011-08-25

    申请人： Carl D. Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan Santiago

    发明人： Carl D. Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan Santiago

    IPC分类号： G01N21/75

    CPC分类号： G01N21/658 ,  G01N21/0332 ,  G01N21/05 ,  G01N33/0057 ,  G01N2021/0346 ,  G01N2201/06113 ,  G01N2201/1087 ,  Y10S977/902

    摘要： Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.

    摘要翻译： 提供了利用自由表面流体学和SERS用于具有高灵敏度和特异性的分析物检测的方法，装置和系统。 分子可以是空气传播剂，包括但不限于爆炸物，麻醉剂，危险化学品或其他化学物质。 自由表面流体结构使用开放的微通道产生，并且表现出大的表面与体积比。 自由表面流体界面可以过滤干扰分子，同时浓缩空气中的分析物。 微通道流动使SERS活性探针颗粒在流动中受控聚集，从而提高检测器的灵敏度。

    MICRO-FABRICATED ELECTROKINETIC PUMP
    9.
    发明申请
    MICRO-FABRICATED ELECTROKINETIC PUMP 有权
    微型电动泵

    公开(公告)号：US20050042110A1

    公开(公告)日：2005-02-24

    申请号：US10366121

    申请日：2003-02-12

    申请人： David Corbin ,  Kenneth Goodson ,  Thomas Kenny ,  Juan Santiago ,  Shulin Zeng

    发明人： David Corbin ,  Kenneth Goodson ,  Thomas Kenny ,  Juan Santiago ,  Shulin Zeng

    IPC分类号： F04B17/00 ,  F04B19/00 ,  F04F99/00 ,  F04F11/00 ,  F04B37/02

    CPC分类号： F04B17/00 ,  F04B19/006

    摘要： An electrokinetic pump for pumping a liquid includes a pumping body having a plurality of narrow, short and straight pore apertures for channeling the liquid through the body. A pair of electrodes for applying a voltage differential are formed on opposing surfaces of the pumping body at opposite ends of the pore apertures. The pumping body is formed on a support structure to maintain a mechanical integrity of the pumping body. The pump can be fabricated using conventional semiconductor processing steps. The pores are preferably formed using plasma etching. The structure is oxidized to insulate the structure and also narrow the pores. A support structure is formed by etching a substrate and removing an interface oxide layer. Electrodes are formed to apply a voltage potential across the pumping body. Another method of fabricating an electrokinetic pump includes providing etch stop alignment marks so that the etch step self-terminates.

    摘要翻译： 用于泵送液体的电动泵包括具有多个窄的，短的和直的孔隙的泵送体，用于将液体引导通过身体。 用于施加电压差的一对电极形成在孔隙的相对端处的泵体的相对表面上。 泵体形成在支撑结构上以保持泵体的机械完整性。 泵可以使用常规的半导体处理步骤制造。 优选使用等离子体蚀刻形成孔。 该结构被氧化以使结构绝缘并且还使孔变窄。 通过蚀刻衬底并除去界面氧化物层形成支撑结构。 形成电极以在泵体上施加电压电位。 制造电动泵的另一种方法包括提供蚀刻停止对准标记，使得蚀刻步骤自我终止。

    Electroosmotic micropumps with applications to fluid dispensing and field sampling
    10.
    发明申请
    Electroosmotic micropumps with applications to fluid dispensing and field sampling 失效
    电渗雾微乳液，适用于流体分配和现场取样

    公开(公告)号：US20050034842A1

    公开(公告)日：2005-02-17

    申请号：US10638732

    申请日：2003-08-11

    申请人： David Huber ,  Shuhuai Yao ,  Juan Santiago

    发明人： David Huber ,  Shuhuai Yao ,  Juan Santiago

    IPC分类号： B01L3/02 ,  C01B5/00 ,  F04B19/00 ,  F28F7/00

    CPC分类号： C01B5/00 ,  B01L3/0241 ,  B01L2200/143 ,  B01L2300/069 ,  B01L2400/0418 ,  F04B19/006

    摘要： Apparatus and methods according to the present invention preferably utilize electroosmotic pumps in fluid handling and field sampling applications. The electroosmotic pumps used in these applications are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. Having multiple small flow channels in parallel provides both a high flow rate and high pressure in liquid handling. These electroosmotic pumps are fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the fluid handling and field sampling devices through electrical control of the flow through the pump. Electroosmotic pumping enables precise dispensing of samples to form genetic, proteomic, or small molecule arrays. A fluid sensor which can be optical, capacitive or other type of electrical sensor is integrated with the electroosmotic pump for measuring liquid levels in liquid drawing and dispensing operations.

    摘要翻译： 根据本发明的设备和方法优选地在流体处理和现场取样应用中使用电渗泵。 在这些应用中使用的电渗泵能够在不移动机械部件的情况下产生高压力和流量，并且相关产生不可接受的电气和噪音噪声以及相关联的可靠性降低。 具有多个小流量通道并联提供液体处理中的高流速和高压力。 这些电渗泵由材料和结构制成，相对于目前可获得的微量泵，其材料和结构提高了性能，效率并降低了重量和制造成本。 这些电渗泵还允许重新捕获可能提供长期闭环操作的放出气体和沉积材料。 根据本发明的装置和方法还允许通过对通过泵的流的电控制来主动调节流体处理和现场取样装置。 电渗抽吸可以精确分配样品以形成遗传，蛋白质组或小分子阵列。 可以将光学，电容或其它类型的电传感器的流体传感器与电渗泵一体化，以测量液体抽取和分配操作中的液位。