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    REDUCING BLOCKAGES OF A PLAQUE DETECTION STREAM PROBE
    1.
    发明申请
    REDUCING BLOCKAGES OF A PLAQUE DETECTION STREAM PROBE 审中-公开
    减少一个解决方案探测流程的障碍

    公开(公告)号：US20160338635A1

    公开(公告)日：2016-11-24

    申请号：US15114558

    申请日：2015-01-21

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： MARK THOMAS JOHNSON ,  JOHANNES HENDRIKUS MARIA SPRUIT ,  MENNO WILLEM JOSE PRINS ,  STEVEN CHARLES DEANE ,  PIETER HORSTMAN ,  EDGAR MARTINUS VAN GOOL ,  OKKE OUWELTJES

    IPC: A61B5/00 ,  A61C17/22 ,  A61C17/20 ,  A61C17/02 ,  A61C1/00

    CPC classification number: A61B5/4547 ,  A61C1/0015 ,  A61C17/0202 ,  A61C17/20 ,  A61C17/221

    Abstract: A proximal body portion (210) of a detection apparatus for detecting the presence of a substance on a surface includes pump portion (124, 142) and a proximal probe portion (111, 120) in fluid communication with one another. A controller (225) processes signal readings sensed by the parameter sensor (P, P1 or P2) and determines whether the signal readings are indicative of a substance (116) obstructing the passage of fluid (130) through the open port of the distal tip (112, 112′) of a distal probe portion (110) of the detection apparatus (100, 100′, 100″, 100″a, 100″b, 100″c, 100″d, 100c). The controller (225) transmits a signal that changes dynamic pressure at the distal tip (112, 112′) upon determining that the signal readings are indicative of a substance (116) obstructing the passage of fluid (130) through the open port of the distal tip (112, 112′).

    Abstract translation: 用于检测表面上物质的存在的检测装置的近端主体部分（210）包括彼此流体连通的泵部分（124,142）和近侧探针部分（111,120）。 控制器（225）处理由参数传感器（P，P1或P2）感测的信号读数，并且确定信号读数是否指示阻止流体（130）通过远端的开口的物质（116） （100,100'，100“，100”a，100“b，100”c，100“d，100c）的远端探针部分（110）的距离（112,112'）。 控制器（225）在确定信号读数指示物质（116）阻止流体（130）通过通过开口的物体（116）时，传递改变远端顶端（112,112'）处的动态压力的信号 远端尖端（112,112'）。

    PLAQUE DETECTION USING A STREAM PROBE
    2.
    发明申请
    PLAQUE DETECTION USING A STREAM PROBE 有权
    使用流行探测器进行岩屑检测

    公开(公告)号：US20150327966A1

    公开(公告)日：2015-11-19

    申请号：US14650882

    申请日：2013-12-20

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： JOHANNES HENDRIKUS MARIA SPRUIT ,  MARK THOMAS JOHNSON ,  MENNO WILLEM JOSE PRINS ,  OKKE OUWELTJES ,  STEVEN CHARLES DEANE ,  EDGAR MARTINUS VAN GOOL

    IPC: A61C19/04 ,  A61C17/22

    CPC classification number: A61C19/04 ,  A46B15/0036 ,  A61B5/0013 ,  A61B5/0088 ,  A61B5/4547 ,  A61B5/4552 ,  A61B5/6891 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/746 ,  A61B2562/0233 ,  A61B2562/0247 ,  A61B2562/0261 ,  A61B2576/02 ,  A61C17/22 ,  A61C17/227 ,  G01N7/00

    Abstract: An apparatus (100, 100′) is configured such that passage of a fluid (30) through an open port (136, 2604) of a distal probe tip (112, 112′) enables detection of a substance (116) that may be present on a surface (31, 33), e.g., a surface of a tooth, based on measurement of a signal correlating to a substance at least partially obstructing the passage of fluid (30) through the open port (136, 2604). The apparatus (100, 100′) includes a proximal pump portion (124) and at least one distal probe portion (110) configured to be immersed in another fluid (11), e.g., water in toothpaste foam. A corresponding system (3000) includes one or two such apparatuses (3100, 3200). A method of detecting the presence of a substance on a surface includes probing an interaction zone (17) for at least partial obstruction of flow of the fluid (30) through the distal probe tip (112, 112′). The distal probe tip (112, 112′) may have a structural configuration for preventing blocking of the open port (136, 2604). The distal probe tip (112, 112′) may also have a non-uniform wear profile. The at least one distal probe portion (110) may include two or multiple components to improve performance and reliability.

    Abstract translation: 一种装置（100,100'）构造成使得流体（30）通过远端探针尖端（112,112'）的开放端口（136,2604）的通过能够检测物质（116），其可以是 基于与至少部分地阻碍流体（30）通过开放端口（136,2604）的通道的物质相关联的信号的测量，存在于表面（31,33）上，例如牙齿的表面。 该装置（100,100'）包括近端泵部分（124）和至少一个远端探针部分（110），该至少一个远端探针部分（110）被配置为浸没在另一种流体（11）中，例如牙膏泡沫中的水。 相应的系统（3000）包括一个或两个这样的设备（3100,3200）。 一种检测物质在表面上的存在的方法包括：探测通过远端探针尖端（112,112'）至少部分阻塞流体（30）流动的相互作用区域（17）。 远端探针尖端（112,112'）可以具有用于防止开放端口（136,2604）的阻塞的结构构造。 远端探针尖端（112,112'）也可具有不均匀的磨损轮廓。 至少一个远端探针部分（110）可以包括两个或多个部件以改善性能和可靠性。

    MICROFLUIDIC DEVICE, SYSTEM, AND METHOD
    4.
    发明申请
    MICROFLUIDIC DEVICE, SYSTEM, AND METHOD 审中-公开
    微流体装置，系统和方法

    公开(公告)号：US20170001194A1

    公开(公告)日：2017-01-05

    申请号：US15106623

    申请日：2014-12-16

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： WILLEM-JAN AREND DE WIJS ,  MENNO WILLEM JOSE PRINS

    IPC: B01L3/00 ,  C12N15/10

    CPC classification number: B01L3/50273 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2400/043 ,  C12N15/1013

    Abstract: The present invention relates to a micro-fluidic device for use in a micro-fluidic system. A rigid base structure is provided with a flexible membrane. An external magnetic driver moves from a first position to a second position underneath the micro-fluidic device whilst applying a magnetic field. A droplet containing magnetic particles will be attracted to the external magnetic driver. The flexible membrane is thin, and therefore the micro-fluidic device can be brought closer to the external magnetic driver, thus increasing the magnetic force incident on the fluid drop. A force will be exerted on the flexible membrane, so deflecting the flexible membrane, thus bringing the droplet containing magnetic particles closer to the external magnetic driver. The effect of the increased magnetic field is to increase the packing density of the magnetic droplet. Therefore, a droplet with higher integrity, and less susceptible to splitting, may be moved through the micro-fluidic device.

    Abstract translation: 本发明涉及用于微流体系统的微流体装置。 刚性基体结构设置有柔性膜。 外部磁驱动器在施加磁场的同时从微流体装置下方的第一位置移动到第二位置。 含有磁性颗粒的液滴将被吸引到外部磁性驱动器。 柔性膜薄，因此微流体装置可以靠近外部磁驱动器，从而增加入射到液滴上的磁力。 力将施加在柔性膜上，从而使柔性膜偏转，从而使含有磁性颗粒的液滴更接近外部磁性驱动器。 增加磁场的效果是增加磁滴的堆积密度。 因此，具有更高完整性并且较不易于分裂的液滴可以移动通过微流体装置。

    CARTRIDGE AND APPARATUS FOR PREPARING A BIOLOGICAL SAMPLE
    5.
    发明申请
    CARTRIDGE AND APPARATUS FOR PREPARING A BIOLOGICAL SAMPLE 审中-公开
    用于制备生物样品的盒子和装置

    公开(公告)号：US20150316454A1

    公开(公告)日：2015-11-05

    申请号：US14651859

    申请日：2013-09-24

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： REINHOLD WIMBERGER-FRIEDL ,  FREEK VAN HEMERT ,  ANJA VAN DE STOLPE ,  MENNO WILLEM JOSE PRINS ,  JOHANNES ADRIANUS VAN TOOREN

    IPC: G01N1/31 ,  B01L3/00

    CPC classification number: G01N1/312 ,  B01L3/502715 ,  B01L3/523 ,  B01L2200/026 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2400/0487 ,  B01L2400/082

    Abstract: The invention relates to a cartridge (100) and an associated apparatus (150) for preparing a biological sample, particularly for staining a tissue or cell sample (1). The cartridge (100) comprises a reaction chamber (116) that can be closed by a substrate (140) carrying the sample (1), wherein the reaction chamber (116) is further connected to a fluidic inlet system (113,115) and a fluidic outlet system (123,125). When the substrate (140) closes the reaction chamber, the fluidic inlet system, the reaction chamber, and the fluidic outlet system constitute a fluidic system that is closed to the environment with respect to the exchange of liquids. A pressure-driven flow through the reaction chamber (116) may for example be induced by the actuation of deformable membranes (114,124).

    Abstract translation: 本发明涉及用于制备生物样品，特别是用于染色组织或细胞样品（1）的药筒（100）和相关装置（150）。 盒（100）包括反应室（116），该反应室可由承载样品（1）的基底（140）封闭，其中反应室（116）进一步连接到流体入口系统（113,115） 出口系统（123,125）。 当衬底（140）关闭反应室时，流体入口系统，反应室和流体出口系统构成相对于液体交换而关闭到环境的流体系统。 通过反应室（116）的压力驱动流可以例如通过致动可变形膜（114,124）而引起。

    PLAQUE DETECTION USING A STREAM PROBE
    6.
    发明申请
    PLAQUE DETECTION USING A STREAM PROBE 有权
    使用流行探测器进行岩屑检测

    公开(公告)号：US20150313697A1

    公开(公告)日：2015-11-05

    申请号：US14651409

    申请日：2013-12-20

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： MENNO WILLEM JOSE PRINS ,  JOHANNES HENDRIKUS MARIA SPRUIT ,  PETRUS THEODORUS JUTTE ,  MARK THOMAS JOHNSON ,  OLAF, THOMAS, JOHAN ANTONIE VERMEULEN ,  OKKE OUWELTJES ,  ADRIANUS WILHELMUS DIONISIUS MARIA VAN DEN BIJGAART ,  MARTIN JOHN EDWARDS ,  STEVEN CHARLES DEANE ,  EDGAR MARTINUS VAN GOOL

    IPC: A61C19/04 ,  A61C17/22

    CPC classification number: A61C17/22 ,  A61C19/04

    Abstract: An apparatus (100, 100′) is configured such that passage of a fluid (30) through an open port of a distal tip (112, 112′) enables detection of a substance (116) that may be present on a surface (31, 33), e.g., a surface of a tooth, based on measurement of a signal correlating to a substance at least partially obstructing the passage of fluid (30) through the open port. The apparatus (100, 100′) includes a proximal pump portion (124) and at least one distal probe portion (110) configured to be immersed in another fluid (11), e.g., water in toothpaste foam. A corresponding system (3000) includes one or two such apparatuses (3100, 3200). A method of detecting the presence of a substance on a surface includes probing an interaction zone (17) for at least partial obstruction of flow of the second fluid medium (30) through a distal probe tip.

    Abstract translation: 一种装置（100,100'）构造成使得流体（30）通过远侧末端（112,112'）的开放端口能够检测可能存在于表面（31）上的物质（116） ，33），例如，基于与至少部分地阻碍流体（30）通过开口的通道的物质相关的信号的测量的牙齿表面。 该装置（100,100'）包括近端泵部分（124）和至少一个远端探针部分（110），该至少一个远端探针部分（110）被配置为浸没在另一种流体（11）中，例如牙膏泡沫中的水。 相应的系统（3000）包括一个或两个这样的设备（3100,3200）。 检测物质在表面上的存在的方法包括探测相互作用区域（17），用于至少部分地阻碍第二流体介质（30）通过远端探针尖端的流动。

    REAGENTS, METHODS AND DEVICES TO PREVENT AGGREGATION IN PARTICLE BASED TESTS FOR THE DETECTION OF MULTIMERIC TARGET MOLECULES
    8.
    发明申请
    REAGENTS, METHODS AND DEVICES TO PREVENT AGGREGATION IN PARTICLE BASED TESTS FOR THE DETECTION OF MULTIMERIC TARGET MOLECULES 审中-公开
    用于检测多个目标分子的基于粒子的测试中的反应物，方法和装置

    公开(公告)号：US20160123965A1

    公开(公告)日：2016-05-05

    申请号：US14896182

    申请日：2014-06-05

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： TOON HENDRIK EVERS ,  MENNO WILLEM JOSE PRINS ,  JEROEN HANS NIEUWENHUIS

    IPC: G01N33/53

    CPC classification number: G01N33/5306 ,  G01N33/54313 ,  G01N33/54333 ,  G01N2446/00

    Abstract: The present invention relates to a method for preventing aggregation of detection particles in a test for detecting a multi-epitope target analyte comprising two or more similar or identical epitopes in a sample and/or for determining the concentration of the multi-epitope target analyte in a sample wherein the method comprises the step of applying a first capture entity which can specifically bind to at least one epitope on the multi-epitope analyte, characterized in that the first capture entity blocks the at least one epitope from binding to a detection particle. The invention further relates to a method wherein the detection of the multi-epitope target analyte comprises the use of a second capture entity, which can specifically bind to the same or similar epitope of the multi-epitope target analyte as the first capture entity. Also envisaged is a method for the detection of said multi-epitope target analyte, the performance of the method in a system comprising a sensor surface and the use of a first capture entity to block the at least one epitope from binding to a detection particle such as a magnetic detection particle.

    Abstract translation: 本发明涉及一种用于在用于检测样品中含有两个或多个相似或相同表位的多表位靶标分析物和/或用于确定多表位靶向分析物的浓度的检测中用于防止检测颗粒聚集的方法 样品，其中所述方法包括施加可以特异性结合多表位分析物上的至少一个表位的第一捕获实体的步骤，其特征在于所述第一捕获实体阻断所述至少一个表位结合到检测颗粒。 本发明还涉及一种方法，其中多表位靶标分析物的检测包括使用第二捕获实体，其可以特异性结合多表位靶分析物与第一捕获实体相同或相似的表位。 还设想了用于检测所述多表位靶分析物的方法，所述方法在包括传感器表面的系统中的应用以及使用第一捕获实体阻断所述至少一个表位结合到检测颗粒，例如 作为磁检测粒子。

    CARTRIDGE FOR UPTAKE AND PROCESSING OF A SAMPLE
    9.
    发明申请
    CARTRIDGE FOR UPTAKE AND PROCESSING OF A SAMPLE 审中-公开
    用于采样和处理样品的盒子

    公开(公告)号：US20150314288A1

    公开(公告)日：2015-11-05

    申请号：US14646826

    申请日：2013-11-26

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： MENNO WILLEM JOSE PRINS ,  GODEFRIDUS JOHANNES VERHOECKX

    IPC: B01L3/00

    CPC classification number: B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/16 ,  B01L2400/0406 ,  B01L2400/049 ,  B01L2400/0688 ,  B01L2400/0694

    Abstract: The invention relates to a cartridge (100) with an inlet portion (110) that is connected to an assay chamber (120) and a suction reservoir (140). The inlet portion (110) is designed for a direct uptake of sample medium, for example of blood from a patient. During this uptake, air is trapped in the assay chamber (120), which prevents a premature entrance of the medium into the assay chamber (120). The transfer of the medium to the assay chamber (120) can thus controllably be initiated at a later time, for example by opening a vent port (121) connected to the assay chamber (120).

    Abstract translation: 本发明涉及具有连接到分析室（120）和吸入储存器（140）的入口部分（110）的盒（100）。 入口部分（110）被设计用于直接吸收样品介质，例如来自患者的血液。 在该吸收期间，空气被捕获在分析室（120）中，这防止介质过早地进入分析室（120）。 因此，可以在稍后时间例如通过打开连接到分析室（120）的通气口（121）可控地启动介质到测定室（120）的转移。

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