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公开(公告)号：US4715905A
公开(公告)日：1987-12-29
申请号：US833394
申请日：1986-02-10
CPC分类号： C21D8/1211 , C21D8/1227 , C21D8/1233
摘要： Fe alloy containing Si more than 4.0 wt % is produced by a thin plate casting process. The producing condition depends upon rapid solidification of Fe alloy from a molten condition at cooling rate of more than 1.degree. C./sen to less than 10.sup.5 .degree. C./sec.The obtained thin cast plates are subjected to a hot rolling of more than 30% at the temperature range of 600.degree. to 800.degree. C., and to the cold rolling to a determined thickness, followed pickling. By the above mentioned conditions, operations of the industrial scale may be practiced without cracks on the surface in the cold rolling excellent magnetic characteristics may be provided by passing the annealing after the cold rolling.
摘要翻译： PCT No.PCT / JP85 / 00534 Sec。 371日期1986年2月10日 102（e）日期1986年2月10日PCT提交1985年9月26日PCT公布。 公开号WO86 / 02102 日期为1986年4月10日。通过薄板铸造工艺制备含有大于4.0重量％的Si的Fe合金。 制造条件取决于Fe合金从熔融条件下以大于1℃/ sec的冷却速度快速凝固至小于105℃/秒。 将得到的薄板坯在600〜800℃的温度范围内进行30％以上的热轧，并进行冷轧至确定的厚度，然后进行酸洗。 通过上述条件，可以在冷轧时在表面上没有裂纹地进行工业规模的操作，可以通过在冷轧后进行退火来提供优异的磁特性。
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2.发明授权Method of producing silicon iron sheet having excellent soft magnetic properties 失效具有优异软磁特性的硅铁片的制造方法
公开(公告)号：US4773948A
公开(公告)日：1988-09-27
申请号：US22642
申请日：1987-01-30
CPC分类号： C21D8/1222
摘要： Fe alloy containing Si: 4.0 to 7.0 wt %, Mn: not more than 0.5 wt %, P: not more than 0.1 wt %, S: not more than 0.02 wt %, Al: not more than 2 wt % is molten, and made an ingot or continuously cast into a piece. The piece is subjected to slabbing-roughing, otherwise roughing at temperature of more than 1000.degree. C. and at total reduction of more than 50%, and further a hot finish rolling. The hot finish rolling is performed at temperature of not more than 1100.degree. C. and under a total reduction which is specified by a relation between average grain diameter before the hot finish rolling and Si content, and coiled at temperature of not more than 750.degree. C. after the rolling. The hot rolled plate is performed with cold rolling or warm rolling after the descaling and hot rolled strip annealing. If required, an intermediate annealing is performed in the course of the cold (or warm) rolling.
摘要翻译： PCT No.PCT / JP86 / 00300 Sec。 371日期1987年1月30日 102（e）1987年1月30日PCT PCT 1986年6月13日PCT公布。 公开号WO86 / 07390 1986年12月18日，含有Si的Fe合金：4.0〜7.0重量％，Mn：0.5重量％以下，P：0.1重量％以下S：0.02重量％以下Al：不大于 2重量％熔融，制成锭或连铸成片。 将该片材进行板坯粗加工，否则在高于1000℃的温度下进行粗加工并总共减少50％以上，进一步进行热精轧。 热精轧在不超过1100℃的温度下进行，并且在由热精轧前的平均粒径与Si含量之间的关系规定的总还原量下进行，并且在不高于750℃的温度下盘卷 C.滚动后。 热轧板在除锈和热轧带钢退火后进行冷轧或暖轧。 如果需要，在冷（或热）轧制过程中进行中间退火。
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公开(公告)号：US4832762A
公开(公告)日：1989-05-23
申请号：US845873
申请日：1986-03-03
CPC分类号： H01F1/14783 , C21D8/1255 , C23C10/08 , H01F1/14775
摘要： An ordinarily made thin steel sheet is placed in an atmosphere bearing SiCl.sub.4, and subjecting to Si penetrating treatment at temperatures between 1100.degree. C. and 1200.degree. C. for a determined period of time. A heating rate is used which is more than 50.degree. C./sec at the temperatures of more than 1000.degree. C. in the SiCl.sub.4 atmosphere.Thereby, it is possible to manufacture thin steel sheet of high magnetic permeability without internal defects.
摘要翻译： PCT No.PCT / JP85 / 00535 Sec。 一九八六年三月三日 102（e）1986年3月3日PCT PCT日期：1985年9月26日PCT公布。 公开号WO86 / 02105 日期：1986年4月10日。将通常制成的薄钢板放置在含有SiCl 4的气氛中，并在1100℃至1200℃的温度下进行Si渗透处理一段确定的时间。 在SiCl 4气氛中，在超过1000℃的温度下使用的加热速率大于50℃/秒。 由此，可以制造高磁导率而没有内部缺陷的薄钢板。
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4.发明授权Method of preventing oxidation during water quenching of steel strip 失效钢筋水QU TING。。。。。。。。。。。。。。。。。。。。
公开(公告)号：US4052235A
公开(公告)日：1977-10-04
申请号：US617578
申请日：1975-09-29
摘要： In a continuous annealing operation of a cold rolled steel strip involving water quenching and over-aging treatments, a method employing a cooling system comprising a pair of rolls arranged to contact the surfaces of a steel strip, a pair of cooling water spray units arranged in symmetrical positions on both sides of the steel strip and a storage tank connected to the spray units. When the steel strip, heated to a temperature between 500.degree. to 800.degree. C is water quenched, the distortion of the strip during the water quenching is inhibited and the surface oxidation is reduced to such an extent that no supplementary pickling is required.
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公开(公告)号：US4986341A
公开(公告)日：1991-01-22
申请号：US294664
申请日：1988-12-15
申请人： Sadakazu Masuda , Fumio Fujita , Masamoto Kamata , Masahiko Yoshini , Takashi Ariizumi , Yuji Okami , Yoshikazu Takada , Junichi Inagaki
发明人： Sadakazu Masuda , Fumio Fujita , Masamoto Kamata , Masahiko Yoshini , Takashi Ariizumi , Yuji Okami , Yoshikazu Takada , Junichi Inagaki
IPC分类号： B21B1/00 , B21B1/02 , B21B1/26 , B21B1/46 , B21B3/00 , B21B3/02 , B22D11/12 , C21D8/12 , C22C38/00
CPC分类号： B22D11/1206 , B21B1/46 , B21B3/02 , C21D8/1222 , B21B1/26 , C21D8/1227 , Y10T29/49991
摘要： The present invention relates to a process for making non-oriented high Si steel sheet without problems during the sequence from the step of making molten steel to the step of rolling to final sheet thickness. An ingot (or a continuously cast piece) of high Si steel (containing 4.0 to 7.0% Si and specified with Al, Mn, C and P) is subjected to slabbing-hot rolling (or else directly slab rolling-hot rolling) and subsequently the hot rolled steel is reduced to thin thickness. The steel material is maintained at temperature of more than a determined temperature from the step of making molten steel to the step of hot rolling. In the step of hot rolling, information regarding finish rolling conditions and coiling conditions is used to provide structure suitable for the subsequent thin rolling. The hot rolled steel is then warm-rolled to the required thickness.
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公开(公告)号：US5583203A
公开(公告)日：1996-12-10
申请号：US400465
申请日：1995-03-07
申请人： Martin E. Hemler , Yoshikazu Takada
发明人： Martin E. Hemler , Yoshikazu Takada
IPC分类号： G01N33/53 , A61K39/395 , C07K1/14 , C07K1/22 , C07K14/435 , C07K14/705 , C07K16/28 , C12P21/08 , C12R1/91 , G01N33/577 , C07K14/725 , C07K14/78
CPC分类号： C07K14/7055 , C07K16/2842
摘要： Three new and distinct heterodimers in the very late antigen (VLA) protein family are disclosed, namely VLA-3, VLA-4 and VLA-5, as well as monoclonal antibodies therefor. The N-terminal amino acid sequence for each of the VLA .alpha. subunits is also disclosed.
摘要翻译： 公开了在晚期抗原（VLA）蛋白家族中的三种新的和明显的异源二聚体，即VLA-3，VLA-4和VLA-5，以及其单克隆抗体。 还公开了每个VLAα亚基的N-末端氨基酸序列。
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公开(公告)号：US20110212108A1
公开(公告)日：2011-09-01
申请号：US12991908
申请日：2009-05-11
申请人： Yoshikazu Takada
发明人： Yoshikazu Takada
IPC分类号： A61K39/395 , G01N33/68 , C12N5/071 , C12N5/10 , C12N1/00 , C07K14/47 , A61K38/17 , C12N15/79 , C07H21/00 , C12N15/63 , A61K31/7088 , A61P35/00 , A61K38/12 , A61K38/45
CPC分类号： A61K38/45 , A61K38/12 , A61K38/1883 , C07K16/2848 , G01N33/74 , G01N2333/4756 , G01N2333/70546 , G01N2500/02 , A61K2300/00
摘要： The present invention resides in the discovery that the specific interaction between neuregulin 1 (NRG1) and integrin is important for ErbB signaling, which in turn plays an important role in cellular signaling in various physiological processes such as cell proliferation, especially in cancer cells overexpressing ErbB family members. Thus, this invention provides for a novel method for inhibiting ErbB signaling by using an inhibitor of NRG1-integrin binding. A method for identifying inhibitors of NRG1-integrin binding is also described. Further disclosed are polypeptides, nucleic acids, and corresponding compositions for inhibiting ErbB signaling.
摘要翻译： 本发明在于发现神经调节蛋白1（NRG1）和整联蛋白之间的特异性相互作用对于ErbB信号传导是重要的，其又在各种生理过程如细胞增殖中的细胞信号传导中起重要作用，特别是在过表达ErbB的癌细胞中 家庭成员。 因此，本发明提供了通过使用NRG1整联蛋白结合抑制剂来抑制ErbB信号传导的新方法。 还描述了鉴定NRG1整联蛋白结合抑制剂的方法。 进一步公开的是用于抑制ErbB信号传导的多肽，核酸和相应的组合物。
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公开(公告)号：US06527876B2
公开(公告)日：2003-03-04
申请号：US09423509
申请日：2000-01-24
申请人： Misao Namikawa , Yoshikazu Takada , Shoji Kasai , Hironori Ninomiya , Tsunehiro Yamaji , Tatsuhiko Hiratani
发明人： Misao Namikawa , Yoshikazu Takada , Shoji Kasai , Hironori Ninomiya , Tsunehiro Yamaji , Tatsuhiko Hiratani
IPC分类号： H01F1147
CPC分类号： C23C16/56 , C21D8/1255 , C22C38/004 , C22C38/02 , C23C10/08 , C23C10/46 , C23C10/60 , C23C16/24
摘要： A silicon steel sheet having low iron loss of high frequency has a surface layer of the steel sheet which has Si concentration higher than Si concentration of a center portion of the steel sheet. Si concentration of sheet thickness center is 3.4 wt. % or more and Si concentration of the surface layer of the steel sheet is 5 wt. % or more. Si concentration in a surface layer portion is 5 to 8 wt. %. The production method comprises siliconizing treatment and diffusing treatment. Velocity of siliconizing and diffusing are controlled, and Si concentration distribution in the sheet thickness direction of the steel sheet is controlled.
摘要翻译： 具有低频铁损的硅钢板具有Si浓度高于钢板中心部分的Si浓度的钢板表面层。 板厚中心的Si浓度为3.4wt。 ％以上，钢板表层的Si浓度为5重量％。 ％ 或者更多。 表层部的Si浓度为5〜8重量％。 ％。 生产方法包括硅化处理和扩散处理。 控制硅化和扩散速度，控制钢板厚度方向的Si浓度分布。
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公开(公告)号：US06013495A
公开(公告)日：2000-01-11
申请号：US951200
申请日：1997-10-14
IPC分类号： A61K38/00 , C07K14/705 , C12N1/38 , C07K7/08 , C07K14/435 , C12N13/00
CPC分类号： C07K14/7055 , A61K38/00
摘要： The present invention provides a method for inhibiting cell proliferation in a cell comprising contacting the cell with a nucleic acid sequence or a polypeptide having essentially the sequence of the .beta..sub.1C integrin. Also included in the invention are peptides consisting of amino acid residues which are the size of or fewer than the sequence of the cytoplasmic domain of the .beta..sub.1C integrin consisting essentially of the amino acid sequence of SEQ ID NO:1 and SEQ ID NO:2, and functional fragments thereof which are useful for inhibiting cellular proliferation. Peptides, polynucleotides, and antibodies immunoreactive with the peptides, and methods of use for inhibiting cell growth are also provided.
摘要翻译： 本发明提供了抑制细胞中细胞增殖的方法，包括使细胞与基本上具有β1C整联蛋白序列的核酸序列或多肽接触。 本发明还包括由基本上由SEQ ID NO：1和SEQ ID NO：2的氨基酸序列组成的β1C整联蛋白的大小或小于其序列的氨基酸残基的肽 及其功能片段，其可用于抑制细胞增殖。 还提供了肽，多核苷酸和与肽免疫反应的抗体，以及用于抑制细胞生长的方法。
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10.发明申请Suppression of sPLA2-integrin binding for treating an inflammatory condition 审中-公开抑制sPLA2整联蛋白结合治疗炎性病症公开(公告)号：US20090092595A1
公开(公告)日：2009-04-09
申请号：US12218506
申请日：2008-07-14
申请人： Yoshikazu Takada , Jun Saegusa , Nobuaki Akakura
发明人： Yoshikazu Takada , Jun Saegusa , Nobuaki Akakura
IPC分类号： A61K39/395 , G01N33/567 , A61K31/7088
CPC分类号： G01N33/573 , A61K31/7088 , G01N33/566 , G01N2333/7055 , G01N2333/70557 , G01N2333/918 , G01N2500/02
摘要： The present invention relates to the discovery that a secretory phospholipase A2 (sPLA2-IIA) plays an active role in mediating inflammatory signaling by way of its specific binding with integrin, especially integrin αvβ3 or α4β1. More specifically, the invention provides a method for identifying inhibitors of inflammatory signaling by screening for compounds that interrupt the specific binding of sPLA2 and integrin. The invention also provides the novel use of a substance that suppresses the specific binding between sPLA2 and integrin for treating or preventing an inflammatory condition.
摘要翻译： 本发明涉及分泌型磷脂酶A2（sPLA2-IIA）通过与整联蛋白特异性结合，特别是整联蛋白α2β1β1介导炎性信号传导的活性作用。 更具体地，本发明提供了通过筛选中断sPLA2和整联蛋白特异性结合的化合物来鉴定炎性信号传导抑制剂的方法。 本发明还提供了抑制sPLA2和整联蛋白之间特异性结合以治疗或预防炎性病症的物质的新用途。
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