公开(公告)号：US20050286822A1

公开(公告)日：2005-12-29

申请号：US11158083

申请日：2005-06-22

申请人： Kazuo Maruyama ,  Motohiro Miyasaka ,  Osamu Mawatari

发明人： Kazuo Maruyama ,  Motohiro Miyasaka ,  Osamu Mawatari

IPC分类号： F16C17/02 ,  F16C33/02 ,  F16C33/10 ,  F16C33/12 ,  F16C33/24

CPC分类号： F16C33/14 ,  F16C17/02 ,  F16C33/102 ,  F16C33/1065 ,  F16C33/121 ,  F16C2204/60 ,  F16C2220/20 ,  F16C2220/62 ,  F16C2220/70 ,  F16C2223/42 ,  F16C2240/12 ,  F16C2240/30 ,  F16C2240/42 ,  F16C2240/54 ,  F16C2300/14

摘要： A sliding bearing which is suitable for and durable in the use under high load of sliding in rocking motion, and the structure of bearing is not complicated so as to facilitate the manufacturing. The alloy used for making the bearing is composed of iron-based sintered alloy having quenched structure, and the bearing surface is provided with inclined grooves of an inclination angle of 10 to 40° relative to the direction perpendicular to the sliding direction and a width of 2 to 8 mm and the area of inclined grooves is 50% or less of the total inner bearing surface and an imaginary line perpendicular to the sliding direction crosses both the inclined groove and the bearing surface at any position of the inner surface of bearing. When the bearing is used, at least the inclined grooves are impregnated with a lubricant.

摘要翻译： 一种滑动轴承，适用于在高负荷滑动运动中的使用中耐用，轴承结构不复杂，从而有利于制造。 用于制造轴承的合金由具有淬火结构的铁基烧结合金构成，并且支承表面设置有相对于与滑动方向垂直的方向倾斜角为10°至40°的倾斜槽，宽度为 2〜8mm，倾斜槽的面积为总内轴承面的50％以下，与滑动方向垂直的假想线在轴承内表面的任意位置与倾斜槽和支承面相交。 当使用轴承时，至少倾斜的槽被润滑剂浸渍。

公开(公告)号：US07234871B2

公开(公告)日：2007-06-26

申请号：US11158083

申请日：2005-06-22

申请人： Kazuo Maruyama ,  Motohiro Miyasaka ,  Osamu Mawatari

发明人： Kazuo Maruyama ,  Motohiro Miyasaka ,  Osamu Mawatari

IPC分类号： F16C33/12

CPC分类号： F16C33/14 ,  F16C17/02 ,  F16C33/102 ,  F16C33/1065 ,  F16C33/121 ,  F16C2204/60 ,  F16C2220/20 ,  F16C2220/62 ,  F16C2220/70 ,  F16C2223/42 ,  F16C2240/12 ,  F16C2240/30 ,  F16C2240/42 ,  F16C2240/54 ,  F16C2300/14

摘要： A sliding bearing which is suitable for and durable in the use under high load of sliding in rocking motion, and the structure of bearing is not complicated so as to facilitate the manufacturing. The alloy used for making the bearing is composed of iron-based sintered alloy having quenched structure, and the bearing surface is provided with inclined grooves of an inclination angle of 10 to 40° relative to the direction perpendicular to the sliding direction and a width of 2 to 8 mm and the area of inclined grooves is 50% or less of the total inner bearing surface and an imaginary line perpendicular to the sliding direction crosses both the inclined groove and the bearing surface at any position of the inner surface of bearing. When the bearing is used, at least the inclined grooves are impregnated with a lubricant.

摘要翻译： 一种滑动轴承，适用于在高负荷滑动运动中的使用中耐用，轴承结构不复杂，从而有利于制造。 用于制造轴承的合金由具有淬火结构的铁基烧结合金构成，并且支承表面设置有相对于与滑动方向垂直的方向倾斜角为10°至40°的倾斜槽，宽度为 2〜8mm，倾斜槽的面积为总内轴承面的50％以下，与滑动方向垂直的假想线在轴承内表面的任意位置与倾斜槽和支承面相交。 当使用轴承时，至少倾斜的槽被润滑剂浸渍。

公开(公告)号：US07014367B2

公开(公告)日：2006-03-21

申请号：US10500980

申请日：2003-01-20

申请人： Motohiro Miyasaka ,  Kazuo Maruyama ,  Michiharu Mogami ,  Junichi Kobayashi ,  Hideki Akita ,  Osamu Gokita

发明人： Motohiro Miyasaka ,  Kazuo Maruyama ,  Michiharu Mogami ,  Junichi Kobayashi ,  Hideki Akita ,  Osamu Gokita

IPC分类号： F16C33/02 ,  H01F3/02 ,  H01F3/04 ,  H01F3/06

CPC分类号： F16C33/104 ,  F16C33/1065 ,  F16C33/12 ,  F16C2204/60 ,  F16C2240/40 ,  Y10S384/902 ,  Y10T428/12021 ,  Y10T428/12153

摘要： An oil-impregnated sintered sliding bearing formed of a porous iron-based sintered alloy with quenched structure and receiving a high surface pressure capable of reducing the number of finishing steps by cutting and grinding and providing a bearing performance equivalent to or higher than that of conventional bearings, wherein a plurality of ridge-and-groove lines having a height difference of 2 to 12.5 μm and extending in circumferential direction are axially arranged in parallel with each other by boring the bearing surface thereof to form a wavy surface in axial direction, and the portion thereof deeper by 10 to 60 μm from the outer layer of the bearing surface is formed dense to seal surface pores so as to reduce the pores opening to the outer surface to 1 to 10 percent by area, whereby the bearing can be used at a surface pressure of 6 kgf/mm2 (58.5 MPa) or higher and a sliding speed of 2 to 5 cm/s.

摘要翻译： 一种浸油烧结滑动轴承，由具有淬火结构的多孔铁基烧结合金形成，并具有能够通过切割和研磨减少精加工步骤的数量的高表面压力，并提供与常规相当或更高的轴承性能 轴承，其中通过对其轴承表面进行钻孔而在轴向方向上彼此平行地布置具有2至12.5μm的高差为2至12.5μm并沿圆周方向延伸的多个脊沟槽线，以在轴向方向上形成波浪形表面，并且 从支承面的外层更深10〜60μm的部分形成为致密的，以密封表面孔，以便将通过外表面打开的孔减少到1至10％的面积，由此轴承可以用于 表面压力为6kgf / mm 2（58.5MPa）以上，滑动速度为2〜5cm / s。

公开(公告)号：US20050078894A1

公开(公告)日：2005-04-14

申请号：US10500980

申请日：2003-01-20

申请人： Motohiro Miyasaka ,  Kazuo Maruyama ,  Michiharu Mogami ,  Junichi Kobayashi ,  Hideki Akita ,  Osamu Gokita

发明人： Motohiro Miyasaka ,  Kazuo Maruyama ,  Michiharu Mogami ,  Junichi Kobayashi ,  Hideki Akita ,  Osamu Gokita

IPC分类号： F16C33/10 ,  F16C33/12 ,  F16C33/14 ,  F16C33/02

CPC分类号： F16C33/104 ,  F16C33/1065 ,  F16C33/12 ,  F16C2204/60 ,  F16C2240/40 ,  Y10S384/902 ,  Y10T428/12021 ,  Y10T428/12153

摘要： An oil-impregnated sintered sliding bearing formed of a porous iron-based sintered alloy with quenched structure and receiving a high surface pressure capable of reducing the number of finishing steps by cutting and grinding and providing a bearing performance equivalent to or higher than that of conventional bearings, wherein a plurality of ridge-and-groove lines having a height difference of 2 to 12.5 μm and extending in circumferential direction are axially arranged in parallel with each other by boring the bearing surface thereof to form a wavy surface in axial direction, and the portion thereof deeper by 10 to 60 μm from the outer layer of the bearing surface is formed dense to seal surface pores so as to reduce the pores opening to the outer surface to 1 to 10 percent by area, whereby the bearing can be used at a surface pressure of 6 kgf/mm2 (58.5 MPa) or higher and a sliding speed of 2 to 5 cm/s.

摘要翻译： 一种浸油烧结滑动轴承，由具有淬火结构的多孔铁基烧结合金形成，并具有能够通过切割和研磨减少精加工步骤的数量的高表面压力，并提供与常规相当或更高的轴承性能 轴承，其中通过对其轴承表面进行钻孔而在轴向方向上彼此平行地布置具有2至12.5μm的高差为2至12.5μm并沿圆周方向延伸的多个脊沟槽线，以在轴向方向上形成波浪形表面，并且 从支承面的外层更深10〜60μm的部分形成为致密的，以密封表面孔，以便将通过外表面打开的孔减少到1至10％的面积，由此轴承可以用于 表面压力为6kgf / mm 2（58.5MPa）以上，滑动速度为2〜5cm / s。

公开(公告)号：US08096709B2

公开(公告)日：2012-01-17

申请号：US12224656

申请日：2007-03-27

申请人： Kazuo Maruyama ,  Takeshi Yanase ,  Kunio Maki ,  Jun-ichi Kobayashi ,  Osamu Mawatari

发明人： Kazuo Maruyama ,  Takeshi Yanase ,  Kunio Maki ,  Jun-ichi Kobayashi ,  Osamu Mawatari

IPC分类号： F16C33/10

CPC分类号： F16C33/1065 ,  F16C17/026

摘要： A sliding bearing comprises a shaft hole for rotatably supporting a shaft that is inserted thereinto, an inner circumferential surface on which the shaft slides, and plural linearly oblique grooves. The grooves extend in a direction crossing a circumferential direction of the sliding bearing and are formed on the inner circumferential surface at intervals, and the grooves are provided with a lubricant. The oblique grooves have an oblique angle in a range of 10° to 60° with respect to a direction perpendicular to the circumferential direction and have a width B in a range of 0.5 to 5 mm in the circumferential direction. The adjacent grooves have a land with a surface as a sliding surface therebetween, and the sliding surface has a width A in a range of 1 to 7 mm in the circumferential direction. A ratio A/B of the width A of the sliding surface of the land to the width B of the groove is in a range of 0.5 to 5.0.

摘要翻译： 滑动轴承包括用于可旋转地支撑插入其中的轴的轴孔，轴滑动的内周面和多个线性倾斜槽。 这些槽沿着与滑动轴承的圆周方向交叉的方向延伸，并且在内周面上间隔地形成，并且槽设置有润滑剂。 斜槽相对于与圆周方向垂直的方向具有10°至60°的倾斜角度，并且在圆周方向上具有在0.5至5mm的范围内的宽度B. 相邻的槽具有在其间具有滑动面的表面的平台，并且滑动面的宽度A在圆周方向上在1至7mm的范围内。 槽脊的滑动面的宽度A与槽的宽度B的比A / B在0.5〜5.0的范围内。

公开(公告)号：US20090214629A1

公开(公告)日：2009-08-27

申请号：US11915474

申请日：2005-05-26

申请人： Kazuo Maruyama ,  Tomoko Takizawa ,  Kosuke Hagisawa ,  Toshihiko Nishioka ,  Hironobu Yanagie

发明人： Kazuo Maruyama ,  Tomoko Takizawa ,  Kosuke Hagisawa ,  Toshihiko Nishioka ,  Hironobu Yanagie

IPC分类号： A61K9/127 ,  C12N15/87 ,  A61K31/7088

CPC分类号： C12N15/88 ,  A61K9/0009 ,  A61K9/127 ,  A61K9/1272 ,  A61K41/0028 ,  A61K47/42 ,  A61K48/00 ,  A61K48/0008 ,  A61N7/00

摘要： A method for efficiently transferring a gene to a target cell is provided. A method of transferring a gene to a target cell, including adding or administering a positively charged complex (A) composed of the gene and a cationic substance and gas-filled microparticles (B) to a target cell-containing composition or a living body and then exposing the target cell-containing composition or the living body to a low-frequency ultrasound.

摘要翻译： 提供了将基因有效转移到靶细胞的方法。 将基因转移到靶细胞的方法，包括将由该基因构成的带正电荷的复合物（A）和阳离子性物质和充气微粒（B）添加或给予含靶细胞的组合物或活体， 然后将含靶细胞的组合物或活体暴露于低频超声波。

公开(公告)号：US5870659A

公开(公告)日：1999-02-09

申请号：US922484

申请日：1997-09-03

申请人： Kazuo Maruyama ,  Koji Masuda ,  Tsutomu Sugimoto

发明人： Kazuo Maruyama ,  Koji Masuda ,  Tsutomu Sugimoto

IPC分类号： G03G15/00 ,  G03G15/01

CPC分类号： G03G15/0194

摘要： In an image forming apparatus, three or more (four in this case) cylindrical photosensitive members 1 to 4 on which latent images are formed and developed through use of toner to thereby produce toner images, are arranged so as to share a tangential line in common, and a cylindrical intermediate transfer member 51 is provided. Alternatively, a first unit containing one or more image carriers is positioned next to a first transfer member and a second unit containing one or more image carriers is positioned next to a second transfer member such that there is reflectional symmetry between the first and second units and the transfer members.

摘要翻译： 在图像形成装置中，通过使用调色剂形成和显影潜像从而产生调色剂图像的三个或更多个（在这种情况下为四个）圆柱形感光构件1至4被布置成共享切向线 ，并且设置有圆筒状的中间转印部件51。 或者，包含一个或多个图像载体的第一单元位于第一转印构件的旁边，并且包含一个或多个图像载体的第二单元位于第二转印构件的旁边，使得在第一和第二单元之间存在反射对称， 转移成员。

公开(公告)号：US5614935A

公开(公告)日：1997-03-25

申请号：US447212

申请日：1995-05-22

申请人： Kenji Ogi ,  Hiroshi Takayama ,  Yasuo Yamamoto ,  Kazuo Maruyama ,  Eiichi Akutsu

发明人： Kenji Ogi ,  Hiroshi Takayama ,  Yasuo Yamamoto ,  Kazuo Maruyama ,  Eiichi Akutsu

IPC分类号： B41J2/325 ,  B41J31/00 ,  B41J31/14 ,  B41M5/30 ,  B41M5/392 ,  G03G15/34 ,  B41J2/315

CPC分类号： B41J2/325 ,  G03G15/344 ,  Y10S428/913 ,  Y10S428/914 ,  Y10T428/24802 ,  Y10T428/24901 ,  Y10T428/25 ,  Y10T428/254 ,  Y10T428/31504 ,  Y10T428/31786

摘要： An ink transfer medium for toner is disclosed, comprising the following layers, in this order: a heat-generating resistive layer heated by input of electrical signal, a conductive layer, and an ink release layer having a toner layer on it, an adhesion from 0.2 g/mm to 40 g/mm as measured by the 90.degree. peeling off method and consisting of a viscoelastomer having a critical surface tension of 35 dyne/cm or less. It can be re-inked by attaching toner to the portions of the ink transfer medium from which the ink has been removed, using toner held in a toner holding means.An ink transfer process for toner is also disclosed, wherein an ink transfer medium having toner layer formed on the above described ink release layer is used and the toner layer contacts the recording medium under pressure, while a recording head contacts the anisotropic conductive layer of the ink transfer medium, so that an electrical signal is input and then toner fused by heat generated by the heat-generating resistive layer is transferred to the recording medium.

摘要翻译： 公开了一种用于调色剂的油墨转印介质，包括以下层：通过电信号输入加热的发热电阻层，导电层和在其上具有调色剂层的油墨释放层， 0.2g / mm至40g / mm，通过90°剥离法测量，并由粘弹性体组成，其临界表面张力为35达因/厘米或更小。 通过使用保持在调色剂保持装置中的调色剂将调色剂附着到已经从中除去油墨的油墨转印介质的部分上，可以再次进行再墨。 还公开了一种用于调色剂的油墨转印方法，其中使用在上述油墨释放层上形成有调色剂层的油墨转印介质，并且调色剂层在压力下与记录介质接触，而记录头接触到 油墨转印介质，从而输入电信号，然后通过发热电阻层产生的热量将调色剂转印到记录介质上。

公开(公告)号：US5466654A

公开(公告)日：1995-11-14

申请号：US284999

申请日：1994-08-03

申请人： Eiichi Akutsu ,  Hiroh Soga ,  Shigehito Ando ,  Susumu Hirakata ,  Kazuo Maruyama

发明人： Eiichi Akutsu ,  Hiroh Soga ,  Shigehito Ando ,  Susumu Hirakata ,  Kazuo Maruyama

IPC分类号： B41M5/40 ,  B41M5/42

CPC分类号： B41M5/42 ,  B41M5/426

摘要： A display medium is disclosed, comprising at least the following layers, in this order: a heating resistive layer, a conductive layer, a background layer and an erasable thermochromic layer, and comprising a heating resistive layer which may comprise at least two layers. The display medium may also comprise a contact resistance reducing layer on the heating resistive layer and a protective layer on the erasable thermochromic layer.

摘要翻译： 公开了显示介质，其至少包括以下层：依次包括加热电阻层，导电层，背景层和可擦除热致变色层，并且包括可包括至少两层的加热电阻层。 显示介质还可以包括加热电阻层上的接触电阻降低层和可擦除热变色层上的保护层。

公开(公告)号：US20140155813A1

公开(公告)日：2014-06-05

申请号：US14116316

申请日：2012-04-25

申请人： Yoichi Negishi ,  Yoko Takahashi ,  Kazuo Maruyama ,  Yukihiko Aramaki

发明人： Yoichi Negishi ,  Yoko Takahashi ,  Kazuo Maruyama ,  Yukihiko Aramaki

IPC分类号： A61K47/48 ,  A61K41/00

CPC分类号： A61K47/48815 ,  A61K9/0019 ,  A61K9/1271 ,  A61K41/0028 ,  A61K47/24 ,  A61K47/6911 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/11 ,  C12N2310/3233 ,  C12N2310/3515 ,  C12N2320/32 ,  C12N2320/33

摘要： To provide a technology for introducing a PMO with remarkably enhanced cell permeability, leading to significantly enhanced introduction efficiency to thereby provide a therapeutic drug that dramatically ameliorates a medical condition of DMD. Also provided is a therapeutic drug for Duchenne muscular dystrophy, including as an active ingredient a Bubble liposome having a specific morpholino oligomer (PMO) bound to a surface thereof, in which the PMO is introduced into a muscle fiber (muscle cell) of a muscle tissue with high efficiency by administration of the therapeutic drug into the muscle tissue or into a blood vessel followed by ultrasound irradiation to the muscle tissue transcutaneously.

摘要翻译： 为了提供引入具有显着增强的细胞渗透性的PMO的技术，导致显着提高的引入效率，从而提供显着改善DMD的医学状况的治疗药物。 还提供了杜烯肌营养不良的治疗药物，其包括作为活性成分的具有与其表面结合的特异性吗啉代低聚物（PMO）的泡沫脂质体，其中将PMO引入肌肉的肌肉纤维（肌肉细胞） 通过将治疗药物施用到肌肉组织中或进入血管，然后经皮超声照射到肌肉组织，从而高效地进行组织。