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    Lipid peptide and hydrogel
    2.
    发明授权
    Lipid peptide and hydrogel 有权
    脂质肽和水凝胶

    公开(公告)号：US08916682B2

    公开(公告)日：2014-12-23

    申请号：US12452473

    申请日：2008-07-04

    Applicant: Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    Inventor： Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    IPC: A61K38/04 ,  C07K14/50 ,  C07K5/107 ,  C07K7/06 ,  C07K5/103 ,  C07K5/11 ,  C07K5/117

    CPC classification number: C07K7/06 ,  C07K5/1008 ,  C07K5/101 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1024

    Abstract: There is provided a lipid peptide that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A lipid peptide represented by Formula (1): (where R1 represents an aliphatic group having 9 to 23 carbon atoms; R2, R3, R4 and R5 independently represent a hydrogen atom, an alkyl group having 1 to 7 carbon atom(s) which optionally has a branched chain having 1 to 3 carbon atom(s), a phenylmethyl group, a phenylethyl group or a —(CH2)n—X group, and at least one of R2, R3, R4 and R5 represents a —(CH2)n—X group; n represents the number of 1 to 4; X represents an amino group, a guanidine group, a —CONH2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which optionally have 1 to 3 nitrogen atom(s); and in represents 1 or 2), and a hydrogel comprising the lipid peptide.

    Abstract translation: 提供了能够在从酸性到碱性的液体性质范围内形成极少量的水凝胶的脂质肽，以及具有高环境适应性，生物相容性和生物降解性的水凝胶。 由式（1）表示的脂质肽：其中，R1表示碳原子数9〜23的脂肪族基; R2，R3，R4，R5分别表示氢原子，碳原子数1〜7的烷基， 任选具有1至3个碳原子的支链，苯基甲基，苯基乙基或 - （CH 2）n -X基团，并且R 2，R 3，R 4和R 5中的至少一个表示 - （CH 2 ）n-X基; n表示1〜4的数; X表示氨基，胍基，-CONH 2基或5元环，6元环或稠合杂环，由5 含有1〜3个氮原子的6元环，代表1或2）和包含脂质肽的水凝胶。

    Lipid tripeptide-based hydrogelator and hydrogel
    3.
    发明授权
    Lipid tripeptide-based hydrogelator and hydrogel 有权
    脂质三肽基水凝胶和水凝胶

    公开(公告)号：US08486896B2

    公开(公告)日：2013-07-16

    申请号：US12452472

    申请日：2008-07-04

    Applicant: Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    Inventor： Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    IPC: C11D3/32 ,  D06P1/00 ,  C12N1/04 ,  C12N9/00 ,  C05F11/00 ,  C09K3/00

    CPC classification number: B01F17/005 ,  A23L29/20 ,  A61K8/042 ,  A61K8/64 ,  A61Q19/00 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0821

    Abstract: There is provided a hydrogelator that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A hydrogelator comprising a lipid peptide represented by Formula (1): (where R1 represents an aliphatic group having 9 to 21 carbon atoms; R2, R3 and R4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atom(s) which may have a branched chain having 1 or 2 carbon atom(s), a phenylmethyl group or a —(CH2)n—X group, and at least one of R2, R3 and R4 represents a —(CH2)n—X group; n represents the number of 1 to 4; X represents an amino group, a guanidino group, a —CONH2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which may have 1 to 3 nitrogen atom(s)) or a salt thereof, and a hydrogel comprising the hydrogelator.

    Abstract translation: 提供一种水凝胶化剂，其能够在从酸性到碱性的液体性质范围内形成极少量的水凝胶，以及具有高环境适应性，生物相容性和生物降解性的水凝胶。 包含由式（1）表示的脂质肽的水凝胶体：（其中，R1表示碳原子数为9〜21的脂肪族基; R2，R3，R4分别独立地表示氢原子，碳原子数为1〜4的烷基， 其可以具有1或2个碳原子的支链，苯甲基或 - （CH 2）n X基团，并且R 2，R 3和R 4中的至少一个表示 - （CH 2）n X基团; n表示 数1至4; X表示氨基，胍基，-CONH 2基或5元环，6元环或由5元环和6元环组成的稠合杂环 其可以具有1至3个氮原子）或其盐，以及包含水凝胶体的水凝胶。

    Neutrophilia inhibitor
    5.
    发明申请
    Neutrophilia inhibitor 审中-公开
    嗜中性粒细胞抑制剂

    公开(公告)号：US20070117806A1

    公开(公告)日：2007-05-24

    申请号：US10584222

    申请日：2004-12-22

    Applicant: Takehisa Iwama ,  Nobutomo Tsuruzoe

    Inventor： Takehisa Iwama ,  Nobutomo Tsuruzoe

    IPC: A61K31/501 ,  C07D403/02

    CPC classification number: C07D401/12 ,  A61K31/501

    Abstract: To provide an antineutrophilia agent effective for treatment of development and progress of acute infections, collagen diseases (chronic rheumatoid arthritis, Wegener's granulomatosis and Behcet's disease), chronic obstructive pulmonary disease (COPD), chronic bronchitis, pulmonary emphysema, small airway disease, gout, Cushing's syndrome, myelofibrosis, neoplastic neutrophilia, polycythemia vera and diseases caused by administration of steroid drugs. An antineutrophilia agent containing a 3(2H)-pyridazinone compound represented by the formula (I) or a pharmaceutically acceptable salt thereof [wherein each of R1, R2 and R3 is independently a hydrogen atom or a C1-6 alkyl group, X is a halogen atom, cyano or a hydrogen atom, Y is a halogen atom, trifluoromethyl or a hydrogen atom, and A is a C1-8 alkylene which may be substituted with a hydroxyl group].

    Abstract translation: 为了提供一种有效治疗急性感染发展和进展的抗营养药物，胶原病（慢性类风湿关节炎，韦格纳肉芽肿病和白塞病），慢性阻塞性肺病（COPD），慢性支气管炎，肺气肿，小气道疾病，痛风， 库兴综合征，骨髓纤维化，肿瘤性嗜中性粒细胞增多症，真性红细胞增多症和由类固醇药物引起的疾病。 一种抗中毒药，其含有式（I）所示的3（2H） - 哒嗪酮化合物或其药学上可接受的盐[其中R 1，R 2和R 2各自为 3个独立地为氢原子或C 1-6烷基，X为卤素原子，氰基或氢原子，Y为卤素原子，三氟甲基或 氢原子，A是可以被羟基取代的C 1-8烷基亚烷基]。

    NEUTROPHILIA INHIBITOR
    7.
    发明申请
    NEUTROPHILIA INHIBITOR 审中-公开
    中性抑制剂

    公开(公告)号：US20080306080A1

    公开(公告)日：2008-12-11

    申请号：US12188638

    申请日：2008-08-08

    Applicant: Takehisa Iwama ,  Nobutomo Tsuruzoe

    Inventor： Takehisa Iwama ,  Nobutomo Tsuruzoe

    IPC: A61K31/501 ,  A61P11/00

    CPC classification number: C07D401/12 ,  A61K31/501

    Abstract: To provide an antineutrophilia agent effective for treatment of development and progress of acute infections, collagen diseases (chronic rheumatoid arthritis, Wegener's granulomatosis and Behcet's disease), chronic obstructive pulmonary disease (COPD), chronic bronchitis, pulmonary emphysema, small airway disease, gout, Cushing's syndrome, myelofibrosis, neoplastic neutrophilia, polycythemia vera and diseases caused by administration of steroid drugs.An antineutrophilia agent containing a 3(2H)-pyridazinone compound represented by the formula (I) or a pharmaceutically acceptable salt thereof [wherein each of R1, R2 and R3 is independently a hydrogen atom or a C1-6 is alkyl group, X is a halogen atom, cyano or a hydrogen atom, Y is a halogen atom, trifluoromethyl or a hydrogen atom, and A is a C1-8 alkylene which may be substituted with a hydroxyl group].

    Abstract translation: 为了提供一种有效治疗急性感染发展和进展的抗营养药物，胶原病（慢性类风湿关节炎，韦格纳肉芽肿病和白塞病），慢性阻塞性肺病（COPD），慢性支气管炎，肺气肿，小气道疾病，痛风， 库兴综合征，骨髓纤维化，肿瘤性嗜中性粒细胞增多症，真性红细胞增多症和由类固醇药物引起的疾病。 含有式（I）所示的3（2H） - 哒嗪酮化合物或其药学上可接受的盐的抗中毒药，其中R1，R2和R3各自独立地为氢原子或C1-6为烷基，X为 卤原子，氰基或氢原子，Y为卤素原子，三氟甲基或氢原子，A为可被羟基取代的C 1-8亚烷基]。

    PRODUCTION METHOD OF COSMETIC, PREPARATION METHOD OF GEL FOR COSMETICS, AND METHOD OF REDUCING USE AMOUNT OF POLYMER THICKENER BLENDED IN COSMETIC RAW MATERIALS
    8.
    发明申请
    PRODUCTION METHOD OF COSMETIC, PREPARATION METHOD OF GEL FOR COSMETICS, AND METHOD OF REDUCING USE AMOUNT OF POLYMER THICKENER BLENDED IN COSMETIC RAW MATERIALS 有权
    化妆品的生产方法，化妆品凝胶的制备方法以及减少在化妆原料中混合的聚合物更大量的使用方法

    公开(公告)号：US20140113976A1

    公开(公告)日：2014-04-24

    申请号：US14008912

    申请日：2012-03-30

    Applicant: Keigo Matsumoto ,  Takayuki Imoto ,  Takehisa Iwama

    Inventor： Keigo Matsumoto ,  Takayuki Imoto ,  Takehisa Iwama

    IPC: A61K8/04 ,  A61K8/81 ,  A61K8/73 ,  A61K8/64

    CPC classification number: A61K8/042 ,  A61K8/64 ,  A61K8/73 ,  A61K8/731 ,  A61K8/8147 ,  A61K2800/10 ,  A61K2800/48 ,  A61K2800/594 ,  A61Q19/00

    Abstract: A production method of a cosmetic that includes blending at least one lipid peptide-type gelator that contains a low-molecular lipid peptide or a pharmaceutically usable salt thereof at a ratio of 0.1% by weight to 0.5% by weight based on a mass of the polymer thickener to form a thickening gel; a preparation method of a gel for cosmetics that includes blending, into an aqueous medium for cosmetics, a polymer thickener and at least one lipid peptide-type gelator that contains a low-molecular lipid peptide or a pharmaceutically usable salt thereof at the above-mentioned ratio to form a gel; and a method of reducing the use amount of a polymer thickener in production of a cosmetic that includes blending at least one lipid peptide-type gelator that contains a low-molecular lipid peptide or a pharmaceutically usable salt thereof at the above-mentioned ratio.

    Abstract translation: 一种化妆品的制备方法，其包括以0.1重量％〜0.5重量％的比例混合含有低分子量脂质肽或其药学上可用的盐的至少一种脂质肽型胶凝剂， 聚合物增稠剂形成增稠凝胶; 一种用于化妆品的凝胶的制备方法，其包括在上述化合物的水性介质中混合含有低分子量脂质肽或其药学上可用的盐的聚合物增稠剂和至少一种脂质肽型胶凝剂 比例形成凝胶; 以及减少化妆品生产中的聚合物增稠剂的使用量的方法，其包括以上述比例混合至少一种含有低分子量脂质肽或其药学上可用的盐的脂质肽型凝胶剂。

    NOVEL LIPID PEPTIDE AND HYDROGEL
    9.
    发明申请
    NOVEL LIPID PEPTIDE AND HYDROGEL 有权
    新型脂蛋白和水凝胶

    公开(公告)号：US20100291210A1

    公开(公告)日：2010-11-18

    申请号：US12452473

    申请日：2008-07-04

    Applicant: Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    Inventor： Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    IPC: A61K38/07 ,  A61K38/08 ,  A61P43/00

    CPC classification number: C07K7/06 ,  C07K5/1008 ,  C07K5/101 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1024

    Abstract: There is provided a lipid peptide that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A lipid peptide represented by Formula (1): (where R1 represents an aliphatic group having 9 to 23 carbon atoms; R2, R3, R4 and R5 independently represent a hydrogen atom, an alkyl group having 1 to 7 carbon atom(s) which optionally has a branched chain having 1 to 3 carbon atom(s), a phenylmethyl group, a phenylethyl group or a —(CH2)—X group, and at least one of R2, R3, R4 and R5 represents a —(CH2)n—X group; n represents the number of 1 to 4; X represents an amino group, a guanidine group, a —CONH2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which optionally have 1 to 3 nitrogen atom(s); and in represents 1 or 2), and a hydrogel comprising the lipid peptide.

    Abstract translation: 提供了能够在从酸性到碱性的液体性质范围内形成极少量的水凝胶的脂质肽，以及具有高环境适应性，生物相容性和生物降解性的水凝胶。 由式（1）表示的脂质肽：其中，R1表示碳原子数9〜23的脂肪族基; R2，R3，R4，R5分别表示氢原子，碳原子数1〜7的烷基， 任选具有1至3个碳原子的支链，苯基甲基，苯基乙基或 - （CH 2）-X基团，并且R 2，R 3，R 4和R 5中的至少一个表示 - （CH 2） n-X基; n表示1〜4的数; X表示氨基，胍基，-CONH 2基或5元环，6元环或稠合杂环， 含有1〜3个氮原子的6元环和6元环;代表1或2）和包含脂质肽的水凝胶。

    NOVEL LIPID TRIPEPTIDE-BASED HYDROGELATOR AND HYDROGEL
    10.
    发明申请
    NOVEL LIPID TRIPEPTIDE-BASED HYDROGELATOR AND HYDROGEL 有权
    新型脂质基于三聚磷酸盐的水凝胶和水凝胶

    公开(公告)号：US20100279955A1

    公开(公告)日：2010-11-04

    申请号：US12452472

    申请日：2008-07-04

    Applicant: Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    Inventor： Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    IPC: A61K38/06 ,  C07K5/08 ,  A61K8/64 ,  A61P43/00 ,  A61Q90/00 ,  A23L1/05 ,  C11D3/32 ,  D06P1/00 ,  C12N1/04 ,  C05F11/00 ,  C12N9/00 ,  C09K3/00

    CPC classification number: B01F17/005 ,  A23L29/20 ,  A61K8/042 ,  A61K8/64 ,  A61Q19/00 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0821

    Abstract: There is provided a hydrogelator that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A hydrogelator comprising a lipid peptide represented by Formula (1): (where R1 represents an aliphatic group having 9 to 21 carbon atoms; R2, R3 and R4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atom(s) which may have a branched chain having 1 or 2 carbon atom(s), a phenylmethyl group or a —(CH2)n—X group, and at least one of R2, R3 and R4 represents a —(CH2)n—X group; n represents the number of 1 to 4; X represents an amino group, a guanidino group, a —CONH2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which may have 1 to 3 nitrogen atom(s)) or a salt thereof, and a hydrogel comprising the hydrogelator.

    Abstract translation: 提供一种水凝胶化剂，其能够在从酸性到碱性的液体性质范围内形成极少量的水凝胶，以及具有高环境适应性，生物相容性和生物降解性的水凝胶。 包含由式（1）表示的脂质肽的水凝胶体：（其中，R1表示碳原子数为9〜21的脂肪族基; R2，R3，R4分别独立地表示氢原子，碳原子数1〜4的烷基， 其可以具有1或2个碳原子的支链，苯基甲基或 - （CH 2）n -X基团，并且R 2，R 3和R 4中的至少一个表示 - （CH 2）n -X基团 ; n表示1〜4的数; X表示氨基，胍基，-CONH 2基或5元环，6元环或5元环和 可以具有1至3个氮原子的6元环）或其盐，以及包含水凝胶体的水凝胶。

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