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    APPARATUS FOR REDUCING VARIATION IN SAMPLE TEMPERATURES IN A LIQUID CHROMATOGRAPHY SYSTEM
    3.
    发明申请
    APPARATUS FOR REDUCING VARIATION IN SAMPLE TEMPERATURES IN A LIQUID CHROMATOGRAPHY SYSTEM 有权
    用于降低液相色谱系统中样品温度变化的设备

    公开(公告)号：US20130019695A1

    公开(公告)日：2013-01-24

    申请号：US13520189

    申请日：2011-01-11

    申请人： Joshua A. Shreve ,  James E. Usowicz ,  Miguel Soares

    发明人： Joshua A. Shreve ,  James E. Usowicz ,  Miguel Soares

    IPC分类号： G01N1/10

    CPC分类号： B01L7/02 ,  B01L2300/0829 ,  B01L2300/1838 ,  G01N30/7233 ,  G01N35/028 ,  G01N2035/00356 ,  G01N2035/00386

    摘要： Described is an apparatus for reducing a temperature variation of a liquid chromatography sample. A tray drive using at least one of linear or rotational motion moves a sample tray along a path inside a sample compartment of the liquid chromatography system. A control module coordinates the movement of the sample tray by the tray drive and the movement of a sample needle by a needle drive so that any sample in the sample tray can be injected into the mobile phase of the system during a sample load operation. The tray drive is also used to move the sample tray along the path during a temperature averaging period when no loading occurs. Differences in sample temperatures due to variations in the air temperature at different locations inside the sample compartment are reduced, leading to more accurate and repeatable chromatographic measurement results.

    摘要翻译： 描述了一种用于降低液相色谱样品的温度变化的装置。 使用线性或旋转运动中的至少一种的托盘驱动器沿着液相色谱系统的样品室内的路径移动样品盘。 控制模块通过托盘驱动器来协调样品托盘的移动和通过针驱动器移动样品针，使得样品托盘中的任何样品可以在样品加载操作期间被注入到系统的流动相中。 托盘驱动器也可用于在温度平均期间沿着路径移动样品托盘，而不会发生加载。 由于样品室内不同位置的空气温度变化导致的样品温度差异减小，从而导致更精确和可重复的色谱测量结果。

    High performance liquid chromatography sample introduction optimized with bubble detection
    4.
    发明授权
    High performance liquid chromatography sample introduction optimized with bubble detection 有权
    用气泡检测优化的高效液相色谱样品引入

    公开(公告)号：US07596988B2

    公开(公告)日：2009-10-06

    申请号：US10598071

    申请日：2005-03-02

    申请人： James E. Usowicz ,  Peyton C. Beals ,  Russell Keene ,  Richard Kent ,  Miguel Soares ,  John Heden

    发明人： James E. Usowicz ,  Peyton C. Beals ,  Russell Keene ,  Richard Kent ,  Miguel Soares ,  John Heden

    IPC分类号： G01N30/28 ,  G01N30/32

    CPC分类号： G01N21/53 ,  G01N30/32 ,  G01N2030/207

    摘要： A device (100) for detecting a condition in a fluid system (14) and initiating a response based on the condition. The device consists of a sensor (12) that responds to a first and second condition of the fluid (13) in the system and a control means (10) that receives the responses and generates command signals in based on the received response. In a liquid chromatography system, the device is used to determine the volume of components of the fluid system. In addition, the device allow leaks to be detected and permits the fluid in the system to be transported at a optimum speed. The device is well implemented utilizing to a light emitter and light receptor that are sensitive to the fluid in either a gaseous or liquid state.

    摘要翻译： 一种用于检测流体系统（14）中的状况并基于该条件启动响应的装置（100）。 该装置包括响应系统中的流体（13）的第一和第二状态的传感器（12）和接收响应的控制装置（10），并基于所接收的响应产生命令信号。 在液相色谱系统中，该装置用于确定流体系统的部件的体积。 此外，该装置允许检测泄漏，并允许系统中的流体以最佳速度被输送。 该装置利用对气体或液态的流体敏感的光发射器和光接收器良好地实现。

    Apparatus for reducing variation in sample temperatures in a liquid chromatography system
    5.
    发明授权
    Apparatus for reducing variation in sample temperatures in a liquid chromatography system 有权
    用于降低液相色谱系统中样品温度变化的装置

    公开(公告)号：US09289768B2

    公开(公告)日：2016-03-22

    申请号：US13520189

    申请日：2011-01-11

    申请人： Joshua A. Shreve ,  James E. Usowicz ,  Miguel Soares

    发明人： Joshua A. Shreve ,  James E. Usowicz ,  Miguel Soares

    IPC分类号： G01N21/13 ,  B01L7/02 ,  G01N30/72 ,  G01N35/00 ,  G01N35/02

    CPC分类号： B01L7/02 ,  B01L2300/0829 ,  B01L2300/1838 ,  G01N30/7233 ,  G01N35/028 ,  G01N2035/00356 ,  G01N2035/00386

    摘要： Described is an apparatus for reducing a temperature variation of a liquid chromatography sample. A tray drive using at least one of linear or rotational motion moves a sample tray along a path inside a sample compartment of the liquid chromatography system. A control module coordinates the movement of the sample tray by the tray drive and the movement of a sample needle by a needle drive so that any sample in the sample tray can be injected into the mobile phase of the system during a sample load operation. The tray drive is also used to move the sample tray along the path during a temperature averaging period when no loading occurs. Differences in sample temperatures due to variations in the air temperature at different locations inside the sample compartment are reduced, leading to more accurate and repeatable chromatographic measurement results.

    摘要翻译： 描述了一种用于降低液相色谱样品的温度变化的装置。 使用线性或旋转运动中的至少一种的托盘驱动器沿着液相色谱系统的样品室内的路径移动样品盘。 控制模块通过托盘驱动器来协调样品托盘的移动和通过针驱动器移动样品针，使得样品托盘中的任何样品可以在样品加载操作期间被注入到系统的流动相中。 托盘驱动器也可用于在温度平均期间沿着路径移动样品托盘，而不会发生加载。 由于样品室内不同位置的空气温度变化导致的样品温度差异减小，从而导致更精确和可重复的色谱测量结果。

    Compound sample needle for liquid chromatograph
    6.
    发明授权
    Compound sample needle for liquid chromatograph 有权
    用于液相色谱的复合样品针

    公开(公告)号：US09028780B2

    公开(公告)日：2015-05-12

    申请号：US13519687

    申请日：2011-01-11

    申请人： John Auclair ,  James E. Usowicz ,  Tony A. Lin ,  Marc Lemelin ,  Robert A. Jencks ,  Kenneth R. Plant

    发明人： John Auclair ,  James E. Usowicz ,  Tony A. Lin ,  Marc Lemelin ,  Robert A. Jencks ,  Kenneth R. Plant

    IPC分类号： G01N1/10 ,  G01N30/18 ,  B01L3/00 ,  G01N30/36 ,  G01N30/24 ,  G01N30/60

    CPC分类号： G01N30/18 ,  B01L3/561 ,  B01L3/563 ,  B01L2200/026 ,  G01N1/10 ,  G01N30/24 ,  G01N30/36 ,  G01N30/6039

    摘要： Described is a compound sample needle for a liquid chromatography system. In one embodiment, the compound sample needle includes a rigid needle having a coupling end with a face and a counterbore. The compound sample needle also includes a flexible tubing having an outer surface and a coupling end disposed in the counterbore of the rigid needle. The coupling end of the flexible tubing has a face adjacent to a base of the counterbore. The coupling ends of the rigid needle and flexible tubing are secured to each other by a weld formed along a circumference of the outer surface and the face of the rigid needle. A rigid sleeve protects the welded joint. The compound sample needle is suitable for injection into the high pressure mobile phase of ultra performance liquid chromatography systems.

    摘要翻译： 描述了用于液相色谱系统的复合样品针。 在一个实施例中，复合样品针包括刚性针，其具有带有面和联轴器的连接端。 复合样品针还包括柔性管，其具有设置在刚性针的沉孔中的外表面和联接端。 柔性管的联接端具有邻近沉孔的底部的面。 刚性针和柔性管的联接端通过沿着外表面的​​圆周和刚性针的表面形成的焊接彼此固定。 刚性套筒保护焊接接头。 复合样品针适用于高效液相色谱系统的高压流动相。

    Method and apparatus for sample injection in liquid chromatography
    7.
    发明授权
    Method and apparatus for sample injection in liquid chromatography 有权
    液相色谱中样品注入的方法和装置

    公开(公告)号：US08881582B2

    公开(公告)日：2014-11-11

    申请号：US13227078

    申请日：2011-09-07

    申请人： Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

    发明人： Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

    IPC分类号： G01N30/38 ,  G01N30/20

    CPC分类号： F16K11/0853 ,  G01N30/20 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  Y10T137/0396 ,  Y10T137/86871

    摘要： The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.

    摘要翻译： 本发明提供了用于基本上消除压力或流速的破坏性瞬变的方法和装置，其可能降低色谱柱的效率和使用寿命。 通过消除与致动样品注射阀相关联的流动阻塞间隔，本发明能够通过色谱系统保持流动相液体的基本上恒定的流动。 本发明还提供了一种方法，当将样品环引入色谱系统输送压力时，减少与样品环含量的加压相关的压力和流速瞬变。

    SAMPLE TRAY WITH MAGNETICALLY CLOSING DRAWER
    8.
    发明申请
    SAMPLE TRAY WITH MAGNETICALLY CLOSING DRAWER 有权
    带有磁力关闭抽屉的样品盘

    公开(公告)号：US20140079606A1

    公开(公告)日：2014-03-20

    申请号：US13519785

    申请日：2011-01-11

    申请人： Joshua A. Burnett ,  James E. Usowicz ,  Daniel J. Gagne ,  Keith McGrath ,  Edwin Denecke

    发明人： Joshua A. Burnett ,  James E. Usowicz ,  Daniel J. Gagne ,  Keith McGrath ,  Edwin Denecke

    IPC分类号： B01L3/00 ,  G01N30/02

    CPC分类号： G01N30/24 ,  G01N30/16 ,  G01N30/20 ,  G01N2035/00287 ,  G01N2035/00346 ,  G01N2035/0498

    摘要： A sample manager of a liquid chromatography system uses a sample tray having a base with side walls separated by a cross wall that divides the base into two compartments. The side walls and cross wall bound each compartment on three sides. A fourth side of each compartment is open. Each compartment is sized to closely receive a sample-vial carrier. Each compartment has a magnet affixed to a bottom surface at an edge of the open fourth side. Each of two drawers slides into the open fourth side of one compartment. Each drawer has a support surface with a magnet affixed at an edge of its bottom side, which aligns with the magnet affixed to the bottom surface of the compartment. The magnet of the drawer and the magnet of the compartment bias the drawer into its compartment when the magnets are brought into proximity of each other.

    摘要翻译： 液相色谱系统的样品管理器使用具有底部的样品盘，其侧壁由跨壁分隔，所述横壁将基部分成两个隔室。 侧墙和十字墙三面分隔每个隔间。 每个隔间的第四面是敞开的。 每个隔室的大小可以紧密接收样品瓶载体。 每个隔室具有固定到开放的第四侧边缘处的底表面的磁体。 两个抽屉中的每一个都滑入一个隔间的敞开的第四侧。 每个抽屉具有一个支撑表面，一个磁体固定在其底部的边缘，该磁体与固定在隔室底部表面上的磁体对准。 当磁体彼此靠近时，抽屉的磁体和室的磁体将抽屉偏置到其隔间中。

    NEEDLE SEAL FORCE SENSOR
    9.
    发明申请
    NEEDLE SEAL FORCE SENSOR 有权
    针式密封传感器

    公开(公告)号：US20130008237A1

    公开(公告)日：2013-01-10

    申请号：US13520605

    申请日：2011-01-10

    申请人： James E. Usowicz ,  Tony A. Lin ,  Joshua A. Burnett ,  Marc Lemelin

    发明人： James E. Usowicz ,  Tony A. Lin ,  Joshua A. Burnett ,  Marc Lemelin

    IPC分类号： G01N30/00

    CPC分类号： G01N30/16 ,  G01L1/00 ,  G01L5/0038 ,  G01N30/24 ,  G01N35/1011 ,  G01N2030/185

    摘要： Described are techniques for force sensing. A computing device is configured to have a desired force setting. A first vertical position of a needle is determined using the computer device. A control signal is sent from the computing device to a positioning device. In response to the control signal, the needle is positioned at the first vertical position. When in the first vertical position, surfaces of a tip of the needle are in contact with surfaces of an opening of a sealing member and positioning the needle causes application of a force at surfaces of the opening in contact with surfaces of the tip of the needle. In response to application of the force, a spring is compressed a distance that is proportional to the force. The force is measured using a force sensor.

    摘要翻译： 描述了用于力感测的技术。 计算设备被配置为具有期望的力设置。 使用计算机设备确定针的第一垂直位置。 控制信号从计算设备发送到定位设备。 响应于控制信号，针位于第一垂直位置。 当在第一垂直位置时，针的尖端的表面与密封构件的开口的表面接触，并且定位针使得在开口的表面处施加力以与针的尖端的表面接触 。 响应于施加力，弹簧被压缩与力成比例的距离。 使用力传感器测量力。