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    Extended depth of field imaging for high speed object analysis
    3.
    发明授权
    Extended depth of field imaging for high speed object analysis 有权
    用于高速物体分析的扩展景深成像

    公开(公告)号：US08009189B2

    公开(公告)日：2011-08-30

    申请号：US12132394

    申请日：2008-06-03

    申请人： William Ortyn ,  David Basiji ,  Keith Frost ,  Luchuan Liang ,  Richard Bauer ,  Brian Hall ,  David Perry

    发明人： William Ortyn ,  David Basiji ,  Keith Frost ,  Luchuan Liang ,  Richard Bauer ,  Brian Hall ,  David Perry

    IPC分类号： G01J3/28 ,  G01J3/51

    CPC分类号： G02B27/0075 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/6458 ,  G01N2015/1452 ,  G02B21/365 ,  G02B27/0012

    摘要： A high speed, high-resolution flow imaging system is modified to achieve extended depth of field imaging. An optical distortion element is introduced into the flow imaging system. Light from an object, such as a cell, is distorted by the distortion element, such that a point spread function (PSF) of the imaging system is invariant across an extended depth of field. The distorted light is spectrally dispersed, and the dispersed light is used to simultaneously generate a plurality of images. The images are detected, and image processing is used to enhance the detected images by compensating for the distortion, to achieve extended depth of field images of the object. The post image processing preferably involves de-convolution, and requires knowledge of the PSF of the imaging system, as modified by the optical distortion element.

    摘要翻译： 改进了高速，高分辨率流动成像系统，以实现扩展的景深成像。 光学失真元件被引入到流动成像系统中。 来自诸如单元的物体的光被失真元件扭曲，使得成像系统的点扩散函数（PSF）在扩展的景深范围内是不变的。 失真光被光谱分散，并且分散的光被用于同时产生多个图像。 检测图像，并且使用图像处理来通过补偿失真来增强检测到的图像，以实现对象的扩展景深图像。 后图像处理优选地涉及去卷积，并且需要由光学失真元件修改的成像系统的PSF的知识。

    EXTENDED DEPTH OF FIELD IMAGING FOR HIGH SPEED OBJECT ANALYSIS
    4.
    发明申请
    EXTENDED DEPTH OF FIELD IMAGING FOR HIGH SPEED OBJECT ANALYSIS 有权
    用于高速物体分析的现场成像的扩展深度

    公开(公告)号：US20080234984A1

    公开(公告)日：2008-09-25

    申请号：US12132394

    申请日：2008-06-03

    申请人： William Ortyn ,  David Basiji ,  Keith Frost ,  Luchuan Liang ,  Richard Bauer ,  Brian Hall ,  David Perry

    发明人： William Ortyn ,  David Basiji ,  Keith Frost ,  Luchuan Liang ,  Richard Bauer ,  Brian Hall ,  David Perry

    IPC分类号： G06F15/00

    CPC分类号： G02B27/0075 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/6458 ,  G01N2015/1452 ,  G02B21/365 ,  G02B27/0012

    摘要： A high speed, high-resolution flow imaging system is modified to achieve extended depth of field imaging. An optical distortion element is introduced into the flow imaging system. Light from an object, such as a cell, is distorted by the distortion element, such that a point spread function (PSF) of the imaging system is invariant across an extended depth of field. The distorted light is spectrally dispersed, and the dispersed light is used to simultaneously generate a plurality of images. The images are detected, and image processing is used to enhance the detected images by compensating for the distortion, to achieve extended depth of field images of the object. The post image processing preferably involves de-convolution, and requires knowledge of the PSF of the imaging system, as modified by the optical distortion element.

    摘要翻译： 改进了高速，高分辨率流动成像系统，以实现扩展的景深成像。 光学失真元件被引入到流动成像系统中。 来自诸如单元的物体的光被失真元件扭曲，使得成像系统的点扩散函数（PSF）在扩展的景深范围内是不变的。 失真光被光谱分散，并且分散的光被用于同时产生多个图像。 检测图像，并且使用图像处理来通过补偿失真来增强检测到的图像，以实现对象的扩展景深图像。 后图像处理优选地涉及去卷积，并且需要由光学失真元件修改的成像系统的PSF的知识。

    EXTENDED DEPTH OF FIELD IMAGING FOR HIGH SPEED OBJECT ANALYSIS
    5.
    发明申请
    EXTENDED DEPTH OF FIELD IMAGING FOR HIGH SPEED OBJECT ANALYSIS 有权
    用于高速物体分析的现场成像的扩展深度

    公开(公告)号：US20070146873A1

    公开(公告)日：2007-06-28

    申请号：US11609269

    申请日：2006-12-11

    申请人： William Ortyn ,  David Basiji ,  Keith Frost ,  Luchuan Liang ,  Richard Bauer ,  Brian Hall ,  David Perry

    发明人： William Ortyn ,  David Basiji ,  Keith Frost ,  Luchuan Liang ,  Richard Bauer ,  Brian Hall ,  David Perry

    IPC分类号： G02B21/06

    CPC分类号： G02B27/0075 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/6458 ,  G01N2015/1452 ,  G02B21/365 ,  G02B27/0012

    摘要： A high speed, high-resolution flow imaging system is modified to achieve extended depth of field imaging. An optical distortion element is introduced into the flow imaging system. Light from an object, such as a cell, is distorted by the distortion element, such that a point spread function (PSF) of the imaging system is invariant across an extended depth of field. The distorted light is spectrally dispersed, and the dispersed light is used to simultaneously generate a plurality of images. The images are detected, and image processing is used to enhance the detected images by compensating for the distortion, to achieve extended depth of field images of the object. The post image processing preferably involves de-convolution, and requires knowledge of the PSF of the imaging system, as modified by the optical distortion element.

    摘要翻译： 改进了高速，高分辨率流动成像系统，以实现扩展的景深成像。 光学失真元件被引入到流动成像系统中。 来自诸如单元的物体的光被失真元件扭曲，使得成像系统的点扩散函数（PSF）在扩展的景深范围内是不变的。 失真光被光谱分散，并且分散的光被用于同时产生多个图像。 检测图像，并且使用图像处理来通过补偿失真来增强检测到的图像，以实现对象的扩展景深图像。 后图像处理优选地涉及去卷积，并且需要由光学失真元件修改的成像系统的PSF的知识。

    Auto focus for a flow imagin system
    6.
    发明申请
    Auto focus for a flow imagin system 有权
    自动对焦一个流量想象系统

    公开(公告)号：US20050127271A1

    公开(公告)日：2005-06-16

    申请号：US11045675

    申请日：2005-01-28

    申请人： William Ortyn ,  Michael Seo ,  David Basiji ,  Keith Frost ,  David Perry

    发明人： William Ortyn ,  Michael Seo ,  David Basiji ,  Keith Frost ,  David Perry

    IPC分类号： G01N15/10 ,  G01N15/14 ,  G02B27/00 ,  G06T7/20 ,  G01N21/00 ,  G01N15/06 ,  G02B7/04

    CPC分类号： G06T7/20 ,  G01N15/1459 ,  G01N15/1463 ,  G01N2015/1018 ,  G01N2015/1443 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2015/1497 ,  G02B27/0012 ,  G06K9/00134

    摘要： A pair of optical gratings are used to modulate light from an object, and the modulated light from either grating is used to determine the velocity of the object. Each optical grating is offset from a reference focal point by the same distance, one grating being offset in a positive direction, the other in a negative direction. Signals produced in response to the modulated light can be processed to determine a direction in which a primary collection lens should be moved in order to improve a focus of the imaging system on the object. The lens is moved incrementally in the direction so determined, and the process is repeated until an optimal focus is achieved. In a preferred embodiment, the signals are weighted, so that the optical grating disposed closest to the optimal focus position contributes the most to velocity detection.

    摘要翻译： 一对光栅用于调制来自物体的光，并且来自任一光栅的调制光用于确定物体的速度。 每个光栅从参考焦点偏移相同的距离，一个光栅在正方向偏移，另一个光栅在负方向上偏移。 可以处理响应于调制光产生的信号以确定主收集透镜应该移动的方向，以便改善成像系统对物体的焦点。 透镜在如此确定的方向上逐渐移动，并重复该过程，直到达到最佳聚焦。 在优选实施例中，对信号进行加权，使得最靠近最佳聚焦位置布置的光栅最有助于速度检测。

    BLOOD AND CELL ANALYSIS USING AN IMAGING FLOW CYTOMETER
    8.
    发明申请
    BLOOD AND CELL ANALYSIS USING AN IMAGING FLOW CYTOMETER 有权
    使用成像流量测量仪进行血液和细胞分析

    公开(公告)号：US20100232675A1

    公开(公告)日：2010-09-16

    申请号：US12631795

    申请日：2009-12-04

    申请人： William Ortyn ,  David Basiji ,  Philip Morrissey ,  Thaddeus George ,  Brian Hall ,  Cathleen Zimmerman ,  David Perry

    发明人： William Ortyn ,  David Basiji ,  Philip Morrissey ,  Thaddeus George ,  Brian Hall ,  Cathleen Zimmerman ,  David Perry

    IPC分类号： G06K9/00 ,  G01N33/48

    CPC分类号： A61B1/00188 ,  G01N15/147 ,  G01N15/1475 ,  G01N2015/1488 ,  G06K9/0014

    摘要： Multimodal or multispectral images of cells comprising a population of cells are simultaneously collected. Photometric and/or morphometric image features identifiable in the images are used to identify differences between first and second populations of cells. The differences can include changes in a relative percentage of different cell types in each population, or a change in a first type of cell present in the first population of cells and the same type of cell in the second population of cells. The changes may be indicative of a disease state, indicative of a relative effectiveness of a therapy, or indicative of a health of the person from whom the cells populations were obtained.

    摘要翻译： 同时收集包含细胞群的细胞的多峰或多光谱图像。 图像中可识别的光度和/或形态测量图像特征用于识别第一和第二细胞群体之间的差异。 差异可以包括每个群体中不同细胞类型的相对百分比的变化，或第一细胞群体中存在的第一类细胞和第二细胞群体中相同类型的细胞的变化。 这些改变可以指示疾病状态，指示治疗的相对有效性或指示获得细胞群体的人的健康。

    Blood and cell analysis using an imaging flow cytometer
    9.
    发明授权
    Blood and cell analysis using an imaging flow cytometer 有权
    使用成像流式细胞仪进行血液和细胞分析

    公开(公告)号：US08406498B2

    公开(公告)日：2013-03-26

    申请号：US12631795

    申请日：2009-12-04

    申请人： William Ortyn ,  David Basiji ,  Philip Morrissey ,  Thaddeus George ,  Brian Hall ,  Cathleen Zimmerman ,  David Perry

    发明人： William Ortyn ,  David Basiji ,  Philip Morrissey ,  Thaddeus George ,  Brian Hall ,  Cathleen Zimmerman ,  David Perry

    IPC分类号： G06K9/00

    CPC分类号： A61B1/00188 ,  G01N15/147 ,  G01N15/1475 ,  G01N2015/1488 ,  G06K9/0014

    摘要： Multimodal or multispectral images of cells comprising a population of cells are simultaneously collected. Photometric and/or morphometric image features identifiable in the images are used to identify differences between first and second populations of cells. The differences can include changes in a relative percentage of different cell types in each population, or a change in a first type of cell present in the first population of cells and the same type of cell in the second population of cells. The changes may be indicative of a disease state, indicative of a relative effectiveness of a therapy, or indicative of a health of the person from whom the cells populations were obtained.

    摘要翻译： 同时收集包含细胞群的细胞的多峰或多光谱图像。 图像中可识别的光度和/或形态测量图像特征用于识别第一和第二细胞群体之间的差异。 差异可以包括每个群体中不同细胞类型的相对百分比的变化，或第一细胞群体中存在的第一类细胞和第二细胞群体中相同类型的细胞的变化。 这些改变可以指示疾病状态，指示治疗的相对有效性或指示获得细胞群体的人的健康。