公开(公告)号：US07063785B2

公开(公告)日：2006-06-20

申请号：US10902028

申请日：2004-07-30

申请人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

发明人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

IPC分类号： B01D15/08

CPC分类号： F04B11/0058 ,  B01D15/14 ,  F04B11/0083 ,  F04B13/02 ,  F04B53/06 ,  F04B2205/09 ,  G01N2030/326

摘要： The invention provides a pump for liquid chromatography excellent in feeding liquid stably at an extremely low flow rate with high accuracy and in discharging bubbles at startup.At startup, a first plunger feeds solvent at a large flow rate to discharge bubbles in a pump and to fill the solvent into the pump in a short time and in a normal operation, the first plunger is stopped and the second plunger is pushed into a second pressure chamber at a low speed to feed the solvent at a low flow rate. When the second plunger reaches full stroke, the second plunger is pulled back at a high speed and at the same time the first plunger is pushed into a first pressure chamber in synchronization with the pullback of the second plunger to control the flow rate passing a discharge passage to a constant value at all times by a controller. Further, while the second plunger feeds the solvent, the first plunger is slightly pushed into the first pressure chamber to keep pressure in the first pressure chamber at pressure equal to or less than pressure in the second pressure chamber.

摘要翻译： 本发明提供了一种液体色谱泵，其具有以极高的精度稳定地以极低的流量供给液体并在起动时排出气泡的液体色谱。 在启动时，第一柱塞以大流量供给溶剂以排出泵中的气泡并在短时间内和正常操作中将溶剂填充到泵中，使第一柱塞停止并将第二柱塞推入 第二压力室以低速进料以低流量进料溶剂。 当第二柱塞达到全行程时，第二柱塞被高速拉回，同时第一柱塞与第二柱塞的回退同步地被推入第一压力室，以控制通过排放的流量 任何时候都由控制器传递给恒定值。 此外，当第二柱塞进料溶剂时，第一柱塞稍微推入第一压力室，以将第一压力室中的压力保持在第二压力室中等于或小于压力的压力。

公开(公告)号：US20050095145A1

公开(公告)日：2005-05-05

申请号：US10998937

申请日：2004-11-30

申请人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

发明人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

IPC分类号： G01N30/32 ,  F04B11/00 ,  F04B13/00 ,  F04B49/06 ,  G01N30/34 ,  F04B49/00 ,  F04B5/00

CPC分类号： F04B13/00 ,  F04B11/0083 ,  F04B49/06 ,  F04B2205/04 ,  G01N30/34 ,  G01N30/36

摘要： In a pump for feeding a liquid for chromatography, first and second plungers form first and second volumes respectively together with first and second chambers, the first plunger is prevented from changing the first volume sufficiently for feeding the liquid between the first and second volumes when the second plunger decreases the second volume to discharge the fluid from the second volume to an outlet path of the pump for the chromatography.

公开(公告)号：US06923916B1

公开(公告)日：2005-08-02

申请号：US10608072

申请日：2003-06-30

申请人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

发明人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

IPC分类号： G01N30/32 ,  F04B11/00 ,  F04B13/00 ,  F04B49/06 ,  G01N30/34 ,  B01D15/08

CPC分类号： F04B13/00 ,  F04B11/0083 ,  F04B49/06 ,  F04B2205/04 ,  G01N30/34 ,  G01N30/36

摘要： In a pump for feeding a liquid for chromatography, first and second plungers form first and second volumes respectively together with first and second chambers, the first plunger is prevented from changing the first volume sufficiently for feeding the liquid between the first and second volumes when the second plunger decreases the second volume to discharge the fluid from the second volume to an outlet path of the pump for the chromatography.

摘要翻译： 在用于进料用于色谱的液体的泵中，第一和第二柱塞分别与第一和第二腔室一起形成第一和第二容积，防止第一柱塞改变第一体积以便在第一和第二容积之间供给液体时， 第二柱塞减小第二体积以将流体从用于色谱的泵的第二体积排出到出口路径。

公开(公告)号：US20050023205A1

公开(公告)日：2005-02-03

申请号：US10902028

申请日：2004-07-30

申请人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

发明人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

IPC分类号： G01N30/32 ,  B01D15/08 ,  B01D15/14 ,  F04B1/02 ,  F04B11/00 ,  F04B13/02 ,  F04B23/06 ,  F04B53/06

CPC分类号： F04B11/0058 ,  B01D15/14 ,  F04B11/0083 ,  F04B13/02 ,  F04B53/06 ,  F04B2205/09 ,  G01N2030/326

摘要： The invention provides a pump for liquid chromatography excellent in feeding liquid stably at an extremely low flow rate with high accuracy and in discharging bubbles at startup. At startup, a first plunger feeds solvent at a large flow rate to discharge bubbles in a pump and to fill the solvent into the pump in a short time and in a normal operation, the first plunger is stopped and the second plunger is pushed into a second pressure chamber at a low speed to feed the solvent at a low flow rate. When the second plunger reaches full stroke, the second plunger is pulled back at a high speed and at the same time the first plunger is pushed into a first pressure chamber in synchronization with the pullback of the second plunger to control the flow rate passing a discharge passage to a constant value at all times by a controller. Further, while the second plunger feeds the solvent, the first plunger is slightly pushed into the first pressure chamber to keep pressure in the first pressure chamber at pressure equal to or less than pressure in the second pressure chamber.

摘要翻译： 本发明提供了一种液体色谱泵，其具有以极高的精度稳定地以极低的流量供给液体并在起动时排出气泡的液体色谱。 在启动时，第一柱塞以大流量供给溶剂以排出泵中的气泡并在短时间内和正常操作中将溶剂填充到泵中，使第一柱塞停止，将第二柱塞推入 第二压力室以低速进料以低流量进料溶剂。 当第二柱塞达到全行程时，第二柱塞被高速拉回，同时第一柱塞与第二柱塞的回退同步地被推入第一压力室，以控制通过排放的流量 任何时候都由控制器传递给恒定值。 此外，当第二柱塞进料溶剂时，第一柱塞稍微推入第一压力室，以将第一压力室中的压力保持在第二压力室中等于或小于压力的压力。

公开(公告)号：US07588423B2

公开(公告)日：2009-09-15

申请号：US10695992

申请日：2003-10-30

申请人： Kunihiko Takao ,  Kenji Hiraku ,  Isao Hayase ,  Hironori Kaji ,  Masahito Ito

发明人： Kunihiko Takao ,  Kenji Hiraku ,  Isao Hayase ,  Hironori Kaji ,  Masahito Ito

IPC分类号： F04B3/00 ,  F04B5/00 ,  F04B25/00

CPC分类号： G01N30/32 ,  B01D15/14 ,  F04B11/0075 ,  G01N2030/326

摘要： Provided is a liquid chromatograph pump system which sucks eluent from an eluent reserving container, and which feeds pressurized high pressure eluent into a column, wherein a plunger reciprocating in a cylinder is formed on its outer peripheral surface with a stepped part along the sliding direction of the plunger in the cylinder so as to define a working chamber between the stepper part and the inner wall surface of the cylinder, the flow rate of the liquid chromatograph pump being determined by the volume of the working chamber and the traveling speed of the plunger, thereby it is possible to stably feed a liquid at an extremely low flow rate, and to satisfactorily expel air bubbles upon a start of the liquid chromatograph pump system.

摘要翻译： 提供了一种液体色谱泵系统，其从洗脱液储存容器中吸收洗脱液，并将加压的高压洗脱液进料到柱中，其中在圆筒中往复运动的柱塞沿着滑动方向的一个台阶部分形成在其外周表面上 柱塞在气缸中以便在步进部分和气缸的内壁表面之间限定工作室，液相色谱泵的流量由工作室的体积和柱塞的行进速度决定， 从而可以以极低的流量稳定地供给液体，并且在启动液相色谱泵系统时令人满意地排出气泡。

公开(公告)号：US07063513B2

公开(公告)日：2006-06-20

申请号：US10998937

申请日：2004-11-30

申请人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

发明人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

IPC分类号： F04B3/00

CPC分类号： F04B13/00 ,  F04B11/0083 ,  F04B49/06 ,  F04B2205/04 ,  G01N30/34 ,  G01N30/36

摘要： In a pump for feeding a liquid for chromatography, first and second plungers form first and second volumes respectively together with first and second chambers, the first plunger is prevented from changing the first volume sufficiently for feeding the liquid between the first and second volumes when the second plunger decreases the second volume to discharge the fluid from the second volume to an outlet path of the pump for the chromatography.

摘要翻译： 在用于进料用于色谱的液体的泵中，第一和第二柱塞分别与第一和第二腔室一起形成第一和第二容积，防止第一柱塞改变第一体积以便在第一和第二容积之间供给液体时， 第二柱塞减小第二体积以将流体从用于色谱的泵的第二体积排出到出口路径。

公开(公告)号：US20120128533A1

公开(公告)日：2012-05-24

申请号：US13386789

申请日：2010-05-26

申请人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

发明人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

IPC分类号： G01N31/00 ,  F16K15/00

CPC分类号： F04B23/06 ,  F04B13/00 ,  F04B49/08 ,  F04B49/22 ,  F04B2205/05 ,  F16K15/04 ,  F16K37/0058 ,  G01N30/32 ,  G01N30/74 ,  G01N2030/328 ,  G01N2030/8435 ,  Y10T137/7838

摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.

摘要翻译： 可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。 在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接 检测到。 止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

公开(公告)号：US08551423B2

公开(公告)日：2013-10-08

申请号：US13386789

申请日：2010-05-26

申请人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

发明人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

IPC分类号： B01L3/02

CPC分类号： F04B23/06 ,  F04B13/00 ,  F04B49/08 ,  F04B49/22 ,  F04B2205/05 ,  F16K15/04 ,  F16K37/0058 ,  G01N30/32 ,  G01N30/74 ,  G01N2030/328 ,  G01N2030/8435 ,  Y10T137/7838

摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.

摘要翻译： 可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。 在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接 检测到。 止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

公开(公告)号：US09410543B2

公开(公告)日：2016-08-09

申请号：US13808660

申请日：2011-07-20

申请人： Kenichiro Tokuo ,  Kenji Hiraku ,  Hironori Kaji ,  Daisuke Akieda ,  Kimihiko Ishii ,  Naoya Yasuhara

发明人： Kenichiro Tokuo ,  Kenji Hiraku ,  Hironori Kaji ,  Daisuke Akieda ,  Kimihiko Ishii ,  Naoya Yasuhara

IPC分类号： F04B17/03 ,  F04B13/00 ,  F04B23/06 ,  F04B49/06 ,  G01N30/32 ,  G01N30/02 ,  F04B49/08 ,  G01N30/34

CPC分类号： F04B17/03 ,  F04B13/00 ,  F04B23/06 ,  F04B49/06 ,  F04B49/065 ,  F04B49/08 ,  F04B2203/0202 ,  F04B2205/03 ,  F04B2205/05 ,  G01N30/02 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/326

摘要： A pump controller causes a first plunger pump and a second plunger pump connected in series or in parallel to perform intake and compression actions alternately at substantially constant cycles, sets a pressurizing chamber of one of the plunger pumps to a state of a higher pressure than the pressurizing chamber of the other plunger pump, and performs flow rate control by adjusting lift amounts of the first plunger and the second plunger. Thus, it is possible to provide a pump for liquid chromatograph, and a liquid chromatograph, which are capable of reducing pulsations even when an ejection flow rate is changed.

摘要翻译： 泵控制器使得串联或并联连接的第一柱塞泵和第二柱塞泵以基本恒定的循环交替进行进入和压缩动作，将柱塞泵之一的加压室设定为比 通过调节第一柱塞和第二柱塞的升程量来进行流量控制。 因此，即使在喷射流量变化的情况下，也能够提供能够降低脉动的液相色谱泵和液相色谱仪。

公开(公告)号：US20130104631A1

公开(公告)日：2013-05-02

申请号：US13808660

申请日：2011-07-20

申请人： Kenichiro Tokuo ,  Kenji Hiraku ,  Hironori Kaji ,  Daisuke Akieda ,  Kimihiko Ishii ,  Naoya Yasuhara

发明人： Kenichiro Tokuo ,  Kenji Hiraku ,  Hironori Kaji ,  Daisuke Akieda ,  Kimihiko Ishii ,  Naoya Yasuhara

IPC分类号： F04B17/03 ,  G01N30/02

CPC分类号： F04B17/03 ,  F04B13/00 ,  F04B23/06 ,  F04B49/06 ,  F04B49/065 ,  F04B49/08 ,  F04B2203/0202 ,  F04B2205/03 ,  F04B2205/05 ,  G01N30/02 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/326

摘要： A pump controller causes a first plunger pump and a second plunger pump connected in series or in parallel to perform intake and compression actions alternately at substantially constant cycles, sets a pressurizing chamber of one of the plunger pumps to a state of a higher pressure than the pressurizing chamber of the other plunger pump, and performs flow rate control by adjusting lift amounts of the first plunger and the second plunger. Thus, it is possible to provide a pump for liquid chromatograph, and a liquid chromatograph, which are capable of reducing pulsations even when an ejection flow rate is changed.

摘要翻译： 泵控制器使得串联或并联连接的第一柱塞泵和第二柱塞泵以基本恒定的循环交替进行进入和压缩动作，将柱塞泵之一的加压室设定为比 通过调节第一柱塞和第二柱塞的升程量来进行流量控制。 因此，即使在喷射流量变化的情况下也能够提供能够降低脉动的液相色谱泵和液相色谱仪。