公开(公告)号：US20050023205A1

公开(公告)日：2005-02-03

申请号：US10902028

申请日：2004-07-30

申请人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

发明人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

IPC分类号： G01N30/32 ,  B01D15/08 ,  B01D15/14 ,  F04B1/02 ,  F04B11/00 ,  F04B13/02 ,  F04B23/06 ,  F04B53/06

CPC分类号： F04B11/0058 ,  B01D15/14 ,  F04B11/0083 ,  F04B13/02 ,  F04B53/06 ,  F04B2205/09 ,  G01N2030/326

摘要： The invention provides a pump for liquid chromatography excellent in feeding liquid stably at an extremely low flow rate with high accuracy and in discharging bubbles at startup. At startup, a first plunger feeds solvent at a large flow rate to discharge bubbles in a pump and to fill the solvent into the pump in a short time and in a normal operation, the first plunger is stopped and the second plunger is pushed into a second pressure chamber at a low speed to feed the solvent at a low flow rate. When the second plunger reaches full stroke, the second plunger is pulled back at a high speed and at the same time the first plunger is pushed into a first pressure chamber in synchronization with the pullback of the second plunger to control the flow rate passing a discharge passage to a constant value at all times by a controller. Further, while the second plunger feeds the solvent, the first plunger is slightly pushed into the first pressure chamber to keep pressure in the first pressure chamber at pressure equal to or less than pressure in the second pressure chamber.

摘要翻译： 本发明提供了一种液体色谱泵，其具有以极高的精度稳定地以极低的流量供给液体并在起动时排出气泡的液体色谱。 在启动时，第一柱塞以大流量供给溶剂以排出泵中的气泡并在短时间内和正常操作中将溶剂填充到泵中，使第一柱塞停止，将第二柱塞推入 第二压力室以低速进料以低流量进料溶剂。 当第二柱塞达到全行程时，第二柱塞被高速拉回，同时第一柱塞与第二柱塞的回退同步地被推入第一压力室，以控制通过排放的流量 任何时候都由控制器传递给恒定值。 此外，当第二柱塞进料溶剂时，第一柱塞稍微推入第一压力室，以将第一压力室中的压力保持在第二压力室中等于或小于压力的压力。

公开(公告)号：US06923916B1

公开(公告)日：2005-08-02

申请号：US10608072

申请日：2003-06-30

申请人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

发明人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

IPC分类号： G01N30/32 ,  F04B11/00 ,  F04B13/00 ,  F04B49/06 ,  G01N30/34 ,  B01D15/08

CPC分类号： F04B13/00 ,  F04B11/0083 ,  F04B49/06 ,  F04B2205/04 ,  G01N30/34 ,  G01N30/36

摘要： In a pump for feeding a liquid for chromatography, first and second plungers form first and second volumes respectively together with first and second chambers, the first plunger is prevented from changing the first volume sufficiently for feeding the liquid between the first and second volumes when the second plunger decreases the second volume to discharge the fluid from the second volume to an outlet path of the pump for the chromatography.

摘要翻译： 在用于进料用于色谱的液体的泵中，第一和第二柱塞分别与第一和第二腔室一起形成第一和第二容积，防止第一柱塞改变第一体积以便在第一和第二容积之间供给液体时， 第二柱塞减小第二体积以将流体从用于色谱的泵的第二体积排出到出口路径。

公开(公告)号：US07063785B2

公开(公告)日：2006-06-20

申请号：US10902028

申请日：2004-07-30

申请人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

发明人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

IPC分类号： B01D15/08

CPC分类号： F04B11/0058 ,  B01D15/14 ,  F04B11/0083 ,  F04B13/02 ,  F04B53/06 ,  F04B2205/09 ,  G01N2030/326

摘要： The invention provides a pump for liquid chromatography excellent in feeding liquid stably at an extremely low flow rate with high accuracy and in discharging bubbles at startup.At startup, a first plunger feeds solvent at a large flow rate to discharge bubbles in a pump and to fill the solvent into the pump in a short time and in a normal operation, the first plunger is stopped and the second plunger is pushed into a second pressure chamber at a low speed to feed the solvent at a low flow rate. When the second plunger reaches full stroke, the second plunger is pulled back at a high speed and at the same time the first plunger is pushed into a first pressure chamber in synchronization with the pullback of the second plunger to control the flow rate passing a discharge passage to a constant value at all times by a controller. Further, while the second plunger feeds the solvent, the first plunger is slightly pushed into the first pressure chamber to keep pressure in the first pressure chamber at pressure equal to or less than pressure in the second pressure chamber.

摘要翻译： 本发明提供了一种液体色谱泵，其具有以极高的精度稳定地以极低的流量供给液体并在起动时排出气泡的液体色谱。 在启动时，第一柱塞以大流量供给溶剂以排出泵中的气泡并在短时间内和正常操作中将溶剂填充到泵中，使第一柱塞停止并将第二柱塞推入 第二压力室以低速进料以低流量进料溶剂。 当第二柱塞达到全行程时，第二柱塞被高速拉回，同时第一柱塞与第二柱塞的回退同步地被推入第一压力室，以控制通过排放的流量 任何时候都由控制器传递给恒定值。 此外，当第二柱塞进料溶剂时，第一柱塞稍微推入第一压力室，以将第一压力室中的压力保持在第二压力室中等于或小于压力的压力。

公开(公告)号：US20050095145A1

公开(公告)日：2005-05-05

申请号：US10998937

申请日：2004-11-30

申请人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

发明人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

IPC分类号： G01N30/32 ,  F04B11/00 ,  F04B13/00 ,  F04B49/06 ,  G01N30/34 ,  F04B49/00 ,  F04B5/00

CPC分类号： F04B13/00 ,  F04B11/0083 ,  F04B49/06 ,  F04B2205/04 ,  G01N30/34 ,  G01N30/36

摘要： In a pump for feeding a liquid for chromatography, first and second plungers form first and second volumes respectively together with first and second chambers, the first plunger is prevented from changing the first volume sufficiently for feeding the liquid between the first and second volumes when the second plunger decreases the second volume to discharge the fluid from the second volume to an outlet path of the pump for the chromatography.

公开(公告)号：US07588423B2

公开(公告)日：2009-09-15

申请号：US10695992

申请日：2003-10-30

申请人： Kunihiko Takao ,  Kenji Hiraku ,  Isao Hayase ,  Hironori Kaji ,  Masahito Ito

发明人： Kunihiko Takao ,  Kenji Hiraku ,  Isao Hayase ,  Hironori Kaji ,  Masahito Ito

IPC分类号： F04B3/00 ,  F04B5/00 ,  F04B25/00

CPC分类号： G01N30/32 ,  B01D15/14 ,  F04B11/0075 ,  G01N2030/326

摘要： Provided is a liquid chromatograph pump system which sucks eluent from an eluent reserving container, and which feeds pressurized high pressure eluent into a column, wherein a plunger reciprocating in a cylinder is formed on its outer peripheral surface with a stepped part along the sliding direction of the plunger in the cylinder so as to define a working chamber between the stepper part and the inner wall surface of the cylinder, the flow rate of the liquid chromatograph pump being determined by the volume of the working chamber and the traveling speed of the plunger, thereby it is possible to stably feed a liquid at an extremely low flow rate, and to satisfactorily expel air bubbles upon a start of the liquid chromatograph pump system.

摘要翻译： 提供了一种液体色谱泵系统，其从洗脱液储存容器中吸收洗脱液，并将加压的高压洗脱液进料到柱中，其中在圆筒中往复运动的柱塞沿着滑动方向的一个台阶部分形成在其外周表面上 柱塞在气缸中以便在步进部分和气缸的内壁表面之间限定工作室，液相色谱泵的流量由工作室的体积和柱塞的行进速度决定， 从而可以以极低的流量稳定地供给液体，并且在启动液相色谱泵系统时令人满意地排出气泡。

公开(公告)号：US07063513B2

公开(公告)日：2006-06-20

申请号：US10998937

申请日：2004-11-30

申请人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

发明人： Kenji Hiraku ,  Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

IPC分类号： F04B3/00

CPC分类号： F04B13/00 ,  F04B11/0083 ,  F04B49/06 ,  F04B2205/04 ,  G01N30/34 ,  G01N30/36

摘要： In a pump for feeding a liquid for chromatography, first and second plungers form first and second volumes respectively together with first and second chambers, the first plunger is prevented from changing the first volume sufficiently for feeding the liquid between the first and second volumes when the second plunger decreases the second volume to discharge the fluid from the second volume to an outlet path of the pump for the chromatography.

摘要翻译： 在用于进料用于色谱的液体的泵中，第一和第二柱塞分别与第一和第二腔室一起形成第一和第二容积，防止第一柱塞改变第一体积以便在第一和第二容积之间供给液体时， 第二柱塞减小第二体积以将流体从用于色谱的泵的第二体积排出到出口路径。

公开(公告)号：US20120128533A1

公开(公告)日：2012-05-24

申请号：US13386789

申请日：2010-05-26

申请人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

发明人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

IPC分类号： G01N31/00 ,  F16K15/00

CPC分类号： F04B23/06 ,  F04B13/00 ,  F04B49/08 ,  F04B49/22 ,  F04B2205/05 ,  F16K15/04 ,  F16K37/0058 ,  G01N30/32 ,  G01N30/74 ,  G01N2030/328 ,  G01N2030/8435 ,  Y10T137/7838

摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.

摘要翻译： 可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。 在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接 检测到。 止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

公开(公告)号：US08551423B2

公开(公告)日：2013-10-08

申请号：US13386789

申请日：2010-05-26

申请人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

发明人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

IPC分类号： B01L3/02

CPC分类号： F04B23/06 ,  F04B13/00 ,  F04B49/08 ,  F04B49/22 ,  F04B2205/05 ,  F16K15/04 ,  F16K37/0058 ,  G01N30/32 ,  G01N30/74 ,  G01N2030/328 ,  G01N2030/8435 ,  Y10T137/7838

摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.

摘要翻译： 可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。 在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接 检测到。 止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

公开(公告)号：US20080296209A1

公开(公告)日：2008-12-04

申请号：US12037111

申请日：2008-02-26

申请人： Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

发明人： Kunihiko Takao ,  Hironori Kaji ,  Masahito Ito

IPC分类号： G01N30/38 ,  G01N30/24 ,  G01N30/62

CPC分类号： G01N30/32 ,  B01D15/14 ,  B01D15/166 ,  F04B11/0058 ,  F04B11/0083 ,  F04B13/00 ,  F04B13/02 ,  F04B53/06 ,  G01N2030/326

摘要： This liquid feeding system has the first and second pumps each of which is provided with a plunger. Liquid sucked through each of the pump suction ports is discharged out of the discharging port through the first pump and/or second pump. Under the starting operation mode, the second pump is stopped and only the first pump is operated. When the discharging pressure at the discharging port reaches up to a predetermined value, the starting operation mode is changed over to the normal operation mode. Under the normal operation mode, the first pump is stopped and only the second pump is operated.

摘要翻译： 该液体供给系统具有第一和第二泵，每个泵设有柱塞。 通过每个泵吸入口吸入的液体通过第一泵和/或第二泵排出排出口。 在启动运行模式下，第二个泵停止运转，只有第一个泵运转。 当排出口的排出压力达到预定值时，启动操作模式转换到正常操作模式。 在正常运行模式下，第一个泵停止运转，只有第二个泵运转。

公开(公告)号：US07901573B2

公开(公告)日：2011-03-08

申请号：US12081572

申请日：2008-04-17

申请人： Kimihiko Ishii ,  Hironori Kaji ,  Masahito Ito ,  Yoshihiro Nagaoka ,  Kunihiko Takao

发明人： Kimihiko Ishii ,  Hironori Kaji ,  Masahito Ito ,  Yoshihiro Nagaoka ,  Kunihiko Takao

IPC分类号： B01D15/08

CPC分类号： B01D15/22 ,  B01D15/206 ,  B01J20/3236 ,  B01J2220/82 ,  B01J2220/86 ,  G01N30/52 ,  G01N30/6017 ,  G01N30/603 ,  G01N30/6047 ,  G01N30/6052 ,  G01N2030/528

摘要： Disclosed herein is a separation column comprising a porous block covered with a coating wherein space-free adhesion is attainable therebetween by low temperature process without releasing octadecylsilyl bases and others from the porous block. A monolith rod 1 is covered with a metal or resin coating 2. Then, the monolith rod 1 covered by the coating 2 is further covered with a rod retainer 3 made of a low melting point metal (melting point 100-200 degrees C.) to form a column body 19. Since the rod retainer 3 is formed by pressure molding at low temperature (100-200 degrees C.). It is therefore possible to absorb the surface irregularities of the monolith rod 1 by the coating 2 while octadecylsilyl bases and others from are released when the retainer 3 is formed. This allows the potential separation ability of the porous block to be brought out maximally.

摘要翻译： 本文公开了一种分离柱，其包括用涂层覆盖的多孔块，其中通过低温工艺在其间实现无空隙粘合，而不从多孔块中释放十八烷基甲硅烷基等。 整料棒1被金属或树脂涂层2覆盖。然后，用由低熔点金属（熔点100-200℃）制成的棒保持器3进一步覆盖由涂层2覆盖的整料棒1。 以形成柱体19.由于杆保持器3通过在低温（100-200℃）下的模压而形成。 因此，当保持器3形成时，可以通过涂层2吸收整料棒1的表面凹凸，同时十八烷基甲硅烷基等被释放。 这允许最大限度地排出多孔块的潜在分离能力。