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公开(公告)号：US08137334B2
公开(公告)日：2012-03-20
申请号：US10745897
申请日：2003-12-23
申请人： Kenneth T. Heruth , Mark S. Lent
发明人： Kenneth T. Heruth , Mark S. Lent
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61M5/16827 , A61M25/007 , A61M2025/0007 , A61M2025/0057 , A61M2025/0073 , A61M2202/0464 , A61M2205/0244 , A61M2205/123 , A61M2205/128 , A61M2205/3331 , A61M2205/3523 , A61M2205/50 , A61M2210/0693 , A61M2210/1003
摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc. Methods for treating diseases, including pain and spasticity are also discussed, as well as methods for screening patients and optimizing therapies. In addition, methods for delivering a drug to a brain through a spinal canal are described.
摘要翻译： 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 还讨论了治疗疾病，包括疼痛和痉挛症的方法，以及筛选患者和优化疗法的方法。 另外，描述了通过椎管将药物递送到脑的方法。
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公开(公告)号：US08244360B2
公开(公告)日：2012-08-14
申请号：US11374793
申请日：2006-03-14
IPC分类号： A61N1/32
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Systems and methods for coordinated delivery of a therapeutic agent and low (less than about 20 Hz) and high (greater than about 50 Hz) frequency stimulation therapy are described. The systems include a control unit for coordinating therapy delivery between an infusion device and a pulse generator, such that a therapeutic agent is administered at a predetermined time relative to application of either low frequency or high frequency stimulation. For example, the control unit may instruct the infusion device to deliver therapeutic agent at a predetermined time prior to delivery of low frequency stimulation. Systems that include more than one infusion device or an infusion pump capable of delivering more than one therapeutic agent are also described.
摘要翻译： 描述了用于协调递送治疗剂和低（小于约20Hz）和高（大于约50Hz）频率刺激疗法的系统和方法。 该系统包括用于协调输注装置和脉冲发生器之间的治疗递送的控制单元，使得治疗剂在相对于低频或高频刺激的施加的预定时间被施用。 例如，控制单元可以在输送低频刺激之前的预定时间指示输注装置递送治疗剂。 还描述了包括多于一个输注装置或能够递送多于一种治疗剂的输注泵的系统。
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公开(公告)号：US20090281594A1
公开(公告)日：2009-11-12
申请号：US12359001
申请日：2009-01-23
申请人： Gary W. King , Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Jordan J. Greenberg , Kenneth T. Heruth , Mark S. Lent , Paul W. Wacnik
发明人： Gary W. King , Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Jordan J. Greenberg , Kenneth T. Heruth , Mark S. Lent , Paul W. Wacnik
IPC分类号： A61N1/34
CPC分类号： A61N1/36139 , A61N1/36057 , A61N1/36071
摘要： Peripheral nerve field stimulation (PNFS) may be controlled based on detected physiological effects of the PNFS, which may be an efferent response to the PNFS. In some examples, a closed-loop therapy system may include a sensing module that senses a physiological parameter of the patient, which may be indicative of the patient's response to the PNFS. Based on a signal generated by the sensing module, the PNFS may be activated, deactivated or modified. Example physiological parameters of the patient include heart rate, respiratory rate, electrodermal activity, muscle activity, blood flow rate, sweat gland activity, pilomotor reflex, or thermal activity of the patient's body. In some examples, a patient pain state may be detected based on a signal generated by the sensing module, and therapy may be controlled based on the detection of the pain state.
摘要翻译： 可以基于PNFS的检测到的生理效应来控制外周神经区域刺激（PNFS），这可能是对PNFS的传出响应。 在一些示例中，闭环治疗系统可以包括感测患者的生理参数的感测模块，其可以指示患者对PNFS的反应。 基于由感测模块产生的信号，可以激活，去激活或修改PNFS。 患者的生理参数包括心率，呼吸频率，皮肤活动，肌肉活动，血流速度，汗腺活动，引导反射或患者身体的热活动。 在一些示例中，可以基于由感测模块生成的信号来检测患者疼痛状态，并且可以基于疼痛状态的检测来控制治疗。
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公开(公告)号：US08691258B2
公开(公告)日：2014-04-08
申请号：US11008445
申请日：2004-12-09
申请人： Kenneth T. Heruth , Christopher M. Hobot , William J. Hooper , Mark S. Lent , Ruchika Singhal , Robert M. Skime , Randall V. Sparer , Maura G. Donovan , William J. Bertrand
发明人： Kenneth T. Heruth , Christopher M. Hobot , William J. Hooper , Mark S. Lent , Ruchika Singhal , Robert M. Skime , Randall V. Sparer , Maura G. Donovan , William J. Bertrand
CPC分类号： A61N1/05 , A61N1/0568 , A61N1/375
摘要： Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.
摘要翻译： 描述具有抗感染性的植入式医疗装置（IMDS）。 抗感染剂设置在医疗装置的表面的至少一部分上，其上或附近。 抗感染剂设置在车辆中或车辆上，其可以是涂层或覆盖物的形式。 载体可以是可生物降解的，使得随着时间的推移，抗感染剂从植入装置所在的组织位置移除，降低了抗感染剂抗微生物的可能性。 还描述了其上设置有抗感染剂和抗活性剂的IMD，其上或其上。 干扰抗感染剂的活性的抗活性剂可以在不再需要抗感染剂的活性的时候从IMD的表面释放，并且可能降低抗微生物抗性的可能性 抗感染剂会发展。
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公开(公告)号：US08246602B2
公开(公告)日：2012-08-21
申请号：US10873764
申请日：2004-06-22
CPC分类号： A61M25/0043 , A61M25/003 , A61M25/0105 , A61M2025/0057 , A61M2025/0166
摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes and one or more tracking elements that may be used to place the infusions sections on the catheters in selected locations such as the spinal region.
摘要翻译： 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有可渗透膜的输注部分的导管和一个或多个跟踪元件，所述跟踪元件可用于将选定位置（例如脊柱区域）中的输液部分置于导管上。
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公开(公告)号：US07813803B2
公开(公告)日：2010-10-12
申请号：US11374852
申请日：2006-03-14
IPC分类号： A61N1/34
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The subcutaneous stimulation may be applied in proximity to a structure in the back, such as discs, facet joints, nerve roots or ganglions, sympathetic chain, ligaments, muscles, and the like. Subcutaneous stimulation at high and low frequencies applied in combination with epidural stimulation is also described.
摘要翻译： 描述了治疗疼痛的增强疗法。 这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。 皮下刺激可以应用在背部的结构附近，例如盘，小关节，神经根或神经节，交感神经链，韧带，肌肉等。 还描述了与硬膜外刺激组合施加的高频和低频下的皮下刺激。
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公开(公告)号：US06458118B1
公开(公告)日：2002-10-01
申请号：US09511438
申请日：2000-02-23
IPC分类号： A61K922
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2202/06 , A61M2202/064 , A61M2205/3523 , A61M2210/0693
摘要： An implantable drug delivery device comprising a microencapsulated drug contained within at least one capsule, a carrier fluid that will dissolve the drug when freed from the capsule, a drug releaser for freeing the microencapsulated drug from the capsule, a reservoir in which the carrier fluid dissolves the drug, and an electromechanical pump to convey the dissolved drug to a catheter, through which the drug is delivered to a target site within a patient.
摘要翻译： 一种可植入药物递送装置，其包含包含在至少一个胶囊内的微囊化药物，当从胶囊释放时将溶解药物的载体流体，用于从胶囊释放微胶囊化药物的药物释放剂，其中载体溶液溶解的储库 所述药物和机电泵将所述溶解的药物输送到导管，通过所述导管将药物输送到患者体内的目标部位。
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公开(公告)号：US07890166B2
公开(公告)日：2011-02-15
申请号：US11375492
申请日：2006-03-14
IPC分类号： A61N1/32
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The therapies further include administering a pain treating agent at a predetermined time relative to application of the high or low frequency stimulation. Delivery of the pain treating agent via an implantable infusion system is described. Coordination of output of an infusion device and a pulse generator to provide coordinated therapy is also discussed.
摘要翻译： 描述了治疗疼痛的增强疗法。 这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。 所述疗法还包括相对于施用高频或低频刺激而在预定时间施用疼痛治疗剂。 描述了通过植入式输注系统递送疼痛治疗剂。 还讨论了输液装置和脉冲发生器的输出协调以提供协调治疗。
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公开(公告)号：US07662140B2
公开(公告)日：2010-02-16
申请号：US10745731
申请日：2003-12-23
申请人： Kenneth T. Heruth , Mark S. Lent
发明人： Kenneth T. Heruth , Mark S. Lent
CPC分类号： A61M5/14276 , A61M5/16827 , A61M25/007 , A61M2025/0007 , A61M2025/0057 , A61M2025/0073 , A61M2202/0464 , A61M2205/0244 , A61M2205/123 , A61M2205/128 , A61M2205/3331 , A61M2205/3523 , A61M2205/50 , A61M2210/0693 , A61M2210/1003
摘要： In various aspects, systems and methods involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc. Methods for delivering a drug to a brain through a spinal canal include delivering hypobaric solutions containing the drug.
摘要翻译： 在各个方面，系统和方法包括具有渗透膜的输液部分的导管，其具有显着的背压以增强药物在输注部分上的均匀输送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 通过椎管将药物递送至脑的方法包括递送含有该药物的低压溶液。
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10.发明授权公开(公告)号：US07403883B2
公开(公告)日：2008-07-22
申请号：US10957359
申请日：2004-10-01
申请人： Kenneth T. Heruth , Mark S. Lent , Michael Hegland
发明人： Kenneth T. Heruth , Mark S. Lent , Michael Hegland
IPC分类号： G06G7/58
摘要： An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining a passageway that substantially mimics the size, shape, and structure of an adult human spinal canal. Also included is a cord structure that may be located and anchored within the passageway. The cord structure substantially mimics the size, shape, and structure of an adult human spinal cord. For example, the cord structure may include connecting elements that resemble nerve roots, dentate ligaments, and the septum posticum of a human spine. The passageway of the model apparatus may be filled with a first fluid that simulates cerebro-spinal fluid (CSF), and a second fluid containing a drug (or simulated drug) may be introduced into the passageway, after which the drug's distribution within the passageway may be analyzed.
摘要翻译： 人体脊柱体外模型装置及其中物质分布模式的检测和分析方法。 在一个实施例中，模型设备包括定义通道的柱体，该通道基本上模拟成年人脊柱的尺寸，形状和结构。 还包括可以位于和锚定在通道内的绳索结构。 帘线结构基本上模仿成年人脊髓的尺寸，形状和结构。 例如，绳索结构可以包括类似神经根，齿状韧带和人脊柱的隔膜的连接元件。 模型装置的通道可以填充有模拟脑脊液（CSF）的第一流体，并且可以将含有药物（或模拟药物）的第二流体引入通道中，之后药物在通道内的分布 可以分析。
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